| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-733_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.144252 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.124671 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.124447 |
| ACTG1 | actin gamma 1 | 0.115712 |
| SMAD3 | SMAD family member 3 | 0.106766 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0891281 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0864995 |
| PDE10A | phosphodiesterase 10A | 0.0805038 |
| PLEC | plectin | 0.0790638 |
| FAM107B | family with sequence similarity 107, member B | 0.0734727 |
| IGF1R | insulin-like growth factor 1 receptor | 0.073333 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0719194 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0715258 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0701513 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0680456 |
| TXNRD1 | thioredoxin reductase 1 | 0.0665385 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0641321 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0639821 |
| CA12 | carbonic anhydrase XII | 0.0632748 |
| FLNA | filamin A, alpha | 0.059003 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0550142 |
| SLC35F3 | solute carrier family 35, member F3 | 0.053236 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0526001 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0512061 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0504167 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.04753 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0469496 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0468118 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0463291 |
| DSTN | destrin (actin depolymerizing factor) | 0.0462472 |
| AOPEP | aminopeptidase O (putative) | 0.0461268 |
| EGFR | epidermal growth factor receptor | 0.0451722 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0450613 |
| MYOF | myoferlin | 0.0449931 |
| PALLD | palladin, cytoskeletal associated protein | 0.0443889 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0440507 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0439811 |
| ANXA2 | annexin A2 | 0.0432402 |
| LDHA | lactate dehydrogenase A | 0.0428137 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0424825 |
| NDRG1 | N-myc downstream regulated 1 | 0.0420381 |
| POTEF | POTE ankyrin domain family, member F | 0.0420256 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.041481 |
| LMO7 | LIM domain 7 | 0.0408077 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0407542 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0407237 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.040379 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0401508 |
| CA8 | carbonic anhydrase VIII | 0.0385563 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0385332 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0376979 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0375735 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0372707 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0366755 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0365297 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0364228 |
| FA2H | fatty acid 2-hydroxylase | 0.0357181 |
| TMEM156 | transmembrane protein 156 | 0.0340188 |
| RNF213 | ring finger protein 213 | 0.0337155 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0335927 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0332906 |
| MKI67 | marker of proliferation Ki-67 | 0.0328849 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | 0.0328761 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0325805 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0303988 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.029965 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0299631 |
| ASPH | aspartate beta-hydroxylase | 0.0298612 |
| BICC1 | BicC family RNA binding protein 1 | 0.0297227 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0292755 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0292729 |
| AHNAK | AHNAK nucleoprotein | 0.0288741 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0287535 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0285714 |
| AXL | AXL receptor tyrosine kinase | 0.0285522 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0284909 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0281885 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0278553 |
| MYO1E | myosin IE | 0.0278509 |
| SEPTIN9 | septin 9 | 0.0277449 |
| KRT7 | keratin 7, type II | 0.0273355 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0272621 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0272238 |
| MYO10 | myosin X | 0.0270223 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0269469 |
| SMYD3 | SET and MYND domain containing 3 | 0.0268012 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.026681 |
| FAT1 | FAT atypical cadherin 1 | 0.0266717 |
| RBPMS | RNA binding protein with multiple splicing | 0.0266277 |
| NAV2 | neuron navigator 2 | 0.0260299 |
| DST | dystonin | 0.0255772 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0255333 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0253404 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0252807 |
| KRT81 | keratin 81, type II | 0.0251553 |
| KRT18 | keratin 18, type I | 0.0249868 |
| SGMS1 | sphingomyelin synthase 1 | 0.0249431 |
| PKM | pyruvate kinase, muscle | 0.0247801 |
| TNS3 | tensin 3 | 0.024364 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0243414 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0560277 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0539377 |
| VMP1 | vacuole membrane protein 1 | -0.0533692 |
| RTN4 | reticulon 4 | -0.0527444 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0485736 |
| OSMR | oncostatin M receptor | -0.0451321 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0446236 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0439393 |
| DUSP5 | dual specificity phosphatase 5 | -0.0413325 |
| EGR1 | early growth response 1 | -0.0405804 |
| RPS6 | ribosomal protein S6 | -0.0373115 |
| EFNA5 | ephrin-A5 | -0.0369114 |
| MCL1 | myeloid cell leukemia 1 | -0.0353961 |
| RPS19 | ribosomal protein S19 | -0.0352853 |
| MT2A | metallothionein 2A | -0.0347862 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0342487 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0319348 |
| RPLP1 | ribosomal protein, large, P1 | -0.0313974 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0313674 |
| GOLGA4 | golgin A4 | -0.0302556 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0292241 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.028111 |
| PTMA | prothymosin, alpha | -0.0278051 |
| RIN2 | Ras and Rab interactor 2 | -0.0276431 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0276072 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0274961 |
| S100A6 | S100 calcium binding protein A6 | -0.0268646 |
| RASA2 | RAS p21 protein activator 2 | -0.0254607 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0252199 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.025015 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0246348 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0245627 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0235414 |
| HMGA2 | high mobility group AT-hook 2 | -0.0228778 |
| SPAG9 | sperm associated antigen 9 | -0.0226265 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0222273 |
| RPL37A | ribosomal protein L37a | -0.0220031 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0214992 |
| TMSB10 | thymosin beta 10 | -0.0214385 |
| VCL | vinculin | -0.0212884 |
| RPLP2 | ribosomal protein, large, P2 | -0.0211554 |
| NABP1 | nucleic acid binding protein 1 | -0.0210352 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0210071 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0208784 |
| FBXO11 | F-box protein 11 | -0.0207622 |
| RND3 | Rho family GTPase 3 | -0.0207092 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0203751 |
| RPS16 | ribosomal protein S16 | -0.0203522 |
| EHBP1 | EH domain binding protein 1 | -0.0203078 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0202737 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0197808 |
| CEP95 | centrosomal protein 95kDa | -0.0197165 |
| RPS24 | ribosomal protein S24 | -0.01956 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0195189 |
| SYAP1 | synapse associated protein 1 | -0.0190818 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0188004 |
| USP34 | ubiquitin specific peptidase 34 | -0.0187919 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0184814 |
| TOP1 | topoisomerase (DNA) I | -0.0183451 |
| SRP54 | signal recognition particle 54kDa | -0.018262 |
| RIGI | RNA sensor RIG-I | -0.0179902 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0179667 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0179413 |
| RPL35A | ribosomal protein L35a | -0.0178717 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0173207 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0171451 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0171332 |
| ARF4 | ADP-ribosylation factor 4 | -0.0169461 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0168363 |
| RBM25 | RNA binding motif protein 25 | -0.0167797 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0167729 |
| FRMD6 | FERM domain containing 6 | -0.0167496 |
| UBAP1 | ubiquitin associated protein 1 | -0.0165949 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0162375 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0161139 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0160799 |
| TMEM165 | transmembrane protein 165 | -0.0160574 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0160387 |
| TBK1 | TANK-binding kinase 1 | -0.0159895 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0158018 |
| HELZ | helicase with zinc finger | -0.0157395 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0157255 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.015491 |
| GOSR1 | golgi SNAP receptor complex member 1 | -0.0153867 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.015318 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0152676 |
| RAB1A | RAB1A, member RAS oncogene family | -0.015047 |
| HM13 | histocompatibility (minor) 13 | -0.0150056 |
| HMGA1 | high mobility group AT-hook 1 | -0.0148513 |
| COPA | coatomer protein complex, subunit alpha | -0.01482 |
| ANXA5 | annexin A5 | -0.0147279 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0145104 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0144174 |
| SUCO | SUN domain containing ossification factor | -0.0144135 |
| NF1 | neurofibromin 1 | -0.014364 |
| DENND4A | DENN/MADD domain containing 4A | -0.0141669 |
| RPL12 | ribosomal protein L12 | -0.0141227 |
| ZFP36 | ZFP36 ring finger protein | -0.0139857 |
| RPS14 | ribosomal protein S14 | -0.0139407 |
| RPL31 | ribosomal protein L31 | -0.0139155 |
