TAK-733_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.165085
PLEC plectin 0.145216
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.108391
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.107288
FLNB filamin B, beta 0.103773
EXT1 exostosin glycosyltransferase 1 0.0982804
ITPRID2 ITPR interacting domain containing 2 0.0856369
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.084083
TRRAP transformation/transcription domain-associated protein 0.0838128
PMM2 phosphomannomutase 2 0.0806522
TXNRD1 thioredoxin reductase 1 0.0764787
MYH9 myosin, heavy chain 9, non-muscle 0.0760652
SLC35F3 solute carrier family 35, member F3 0.0743907
SAMD4A sterile alpha motif domain containing 4A 0.071274
MPRIP myosin phosphatase Rho interacting protein 0.0706866
PDLIM5 PDZ and LIM domain 5 0.0702926
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.067729
F3 coagulation factor III (thromboplastin, tissue factor) 0.0673007
RASAL2 RAS protein activator like 2 0.0660932
PPARD peroxisome proliferator-activated receptor delta 0.0645979
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0635353
HSPA8 heat shock 70kDa protein 8 0.0633282
ZSWIM6 zinc finger, SWIM-type containing 6 0.0620354
LAMB3 laminin, beta 3 0.0619789
GRB10 growth factor receptor-bound protein 10 0.0597377
UBE2H ubiquitin-conjugating enzyme E2H 0.058578
SRRM2 serine/arginine repetitive matrix 2 0.0578832
SACK1A scaffolding CK1 anchoring protein A 0.0575881
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0572562
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0555282
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0551604
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0542166
ABTB3 ankyrin repeat and BTB domain containing 3 0.05415
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0536979
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.053155
MACF1 microtubule-actin crosslinking factor 1 0.0525691
DOCK5 dedicator of cytokinesis 5 0.0524953
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.052087
TPM3 tropomyosin 3 0.050371
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0499764
SVIL supervillin 0.048692
TRIO trio Rho guanine nucleotide exchange factor 0.0477863
SMAD3 SMAD family member 3 0.0475793
LAMC2 laminin, gamma 2 0.0474591
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0474527
PTK2 protein tyrosine kinase 2 0.0474085
APLP2 amyloid beta (A4) precursor-like protein 2 0.0468565
PARD3 par-3 family cell polarity regulator 0.0463779
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0460042
THSD4 thrombospondin, type I, domain containing 4 0.0458444
ZFAND3 zinc finger, AN1-type domain 3 0.0455744
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0450912
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0443515
GREB1L growth regulation by estrogen in breast cancer-like 0.044215
LARP4B La ribonucleoprotein domain family, member 4B 0.0439711
TRIP12 thyroid hormone receptor interactor 12 0.0438776
SEPTIN9 septin 9 0.0432943
SEC31A SEC31 homolog A (S. cerevisiae) 0.0432285
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0431935
EFNA5 ephrin-A5 0.0421133
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0418301
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0416869
CORO1C coronin, actin binding protein, 1C 0.0416617
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0415437
MSN moesin 0.041527
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0414253
RUNX1 runt-related transcription factor 1 0.0411283
AKAP13 A kinase (PRKA) anchor protein 13 0.0403911
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.040006
ANKRD11 ankyrin repeat domain 11 0.039544
PRELID2 PRELI domain containing 2 0.0395212
FMNL2 formin-like 2 0.0394849
EEF2 eukaryotic translation elongation factor 2 0.0393143
NFE2L2 nuclear factor, erythroid 2-like 2 0.0392516
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0391884
CLMP CXADR-like membrane protein 0.0387661
CSNK1A1 casein kinase 1, alpha 1 0.038474
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0384039
SP100 SP100 nuclear antigen 0.0381306
DSPP dentin sialophosphoprotein 0.0379992
TXNIP thioredoxin interacting protein 0.0379693
NCEH1 neutral cholesterol ester hydrolase 1 0.0378078
RNF213 ring finger protein 213 0.0376597
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0367527
EFNB2 ephrin-B2 0.0363906
ACTN4 actinin, alpha 4 0.0363128
FLNA filamin A, alpha 0.0359141
NUP98 nucleoporin 98kDa 0.0357015
LPP LIM domain containing preferred translocation partner in lipoma 0.0356815
HDLBP high density lipoprotein binding protein 0.0353731
CMIP c-Maf inducing protein 0.0351678
HDAC9 histone deacetylase 9 0.0347325
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0345095
BCAR3 breast cancer anti-estrogen resistance 3 0.0343671
RAB10 RAB10, member RAS oncogene family 0.0343093
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0338044
MYOF myoferlin 0.0337926
EGFR epidermal growth factor receptor 0.0336952
GDA guanine deaminase 0.033694
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0332364

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.305081
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.149531
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.136672
VIM vimentin -0.111855
S100A10 S100 calcium binding protein A10 -0.0915839
HMGA1 high mobility group AT-hook 1 -0.0808469
POTEF POTE ankyrin domain family, member F -0.0729202
TPT1 tumor protein, translationally-controlled 1 -0.0658663
PTMA prothymosin, alpha -0.0647104
S100A6 S100 calcium binding protein A6 -0.0587792
ITGA6 integrin, alpha 6 -0.0585928
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0564312
RPLP1 ribosomal protein, large, P1 -0.0536867
EIF1 eukaryotic translation initiation factor 1 -0.0526885
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0512715
S100A4 S100 calcium binding protein A4 -0.0498259
ACTG1 actin gamma 1 -0.0472291
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0464837
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0450067
S100A11 S100 calcium binding protein A11 -0.0427456
SDC4 syndecan 4 -0.0416366
RIOK3 RIO kinase 3 -0.0409862
FTL ferritin, light polypeptide -0.0398956
RPL35A ribosomal protein L35a -0.0393043
RPS6 ribosomal protein S6 -0.0392455
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0384463
MYL12B myosin, light chain 12B, regulatory -0.038412
RTN4 reticulon 4 -0.0359291
TSC22D2 TSC22 domain family, member 2 -0.0353891
PSD3 pleckstrin and Sec7 domain containing 3 -0.034734
RPL34 ribosomal protein L34 -0.0346343
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0337813
MT2A metallothionein 2A -0.0332895
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0328163
EMP1 epithelial membrane protein 1 -0.0324108
WASF2 WAS protein family, member 2 -0.0311364
RPL12 ribosomal protein L12 -0.0306845
RPLP2 ribosomal protein, large, P2 -0.0303342
UBE2B ubiquitin-conjugating enzyme E2B -0.0301962
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0299097
RPS14 ribosomal protein S14 -0.0298048
SEPTIN7 septin 7 -0.0295166
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0289424
NEK7 NIMA-related kinase 7 -0.0287058
PERP PERP, TP53 apoptosis effector -0.028498
ANLN anillin, actin binding protein -0.0280569
EPCAM epithelial cell adhesion molecule -0.0278639
RPL11 ribosomal protein L11 -0.0274723
ZNF292 zinc finger protein 292 -0.0274679
LY6E lymphocyte antigen 6 complex, locus E -0.0272382
ITGB4 integrin, beta 4 -0.0247577
RPL31 ribosomal protein L31 -0.0247401
ADAM9 ADAM metallopeptidase domain 9 -0.0246183
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.024361
RPL23 ribosomal protein L23 -0.0240074
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0236325
LYZ lysozyme -0.0236197
TOP1 topoisomerase (DNA) I -0.0228172
GNAS GNAS complex locus -0.0225364
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0224208
PLAUR plasminogen activator, urokinase receptor -0.0223639
RPS25 ribosomal protein S25 -0.0221533
PNISR PNN-interacting serine/arginine-rich protein -0.0217443
TRA2A transformer 2 alpha homolog (Drosophila) -0.0215315
RPS20 ribosomal protein S20 -0.0213065
SKAP2 src kinase associated phosphoprotein 2 -0.0212813
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0210542
RPL8 ribosomal protein L8 -0.0209229
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.020769
RPS19 ribosomal protein S19 -0.020618
FOXO3 forkhead box O3 -0.0205404
RPL32 ribosomal protein L32 -0.0205179
RPS13 ribosomal protein S13 -0.0202815
RPL7A ribosomal protein L7a -0.0202222
RPL28 ribosomal protein L28 -0.0202177
RPS21 ribosomal protein S21 -0.0201784
KLF6 Kruppel-like factor 6 -0.0201698
MDK midkine (neurite growth-promoting factor 2) -0.0199087
DUSP6 dual specificity phosphatase 6 -0.019767
CENPF centromere protein F, 350/400kDa -0.0196848
RPS24 ribosomal protein S24 -0.0195741
DSTN destrin (actin depolymerizing factor) -0.019497
RPL36 ribosomal protein L36 -0.0194711
CSTB cystatin B (stefin B) -0.0190428
PFN1 profilin 1 -0.0188495
RPL37 ribosomal protein L37 -0.0187358
KRT19 keratin 19, type I -0.018498
GPX4 glutathione peroxidase 4 -0.0184938
RPL27A ribosomal protein L27a -0.0184547
VEZT vezatin, adherens junctions transmembrane protein -0.0184215
RPS16 ribosomal protein S16 -0.0182284
RPL9 ribosomal protein L9 -0.0181722
ATP5F1E ATP synthase F1 subunit epsilon -0.0180451
CD46 CD46 molecule, complement regulatory protein -0.0180291
RPS4X ribosomal protein S4, X-linked -0.0180213
TMEM41B transmembrane protein 41B -0.0180204
RPS8 ribosomal protein S8 -0.0179964
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0179373
ITGB5 integrin, beta 5 -0.0178967
RPS23 ribosomal protein S23 -0.0178563