| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-733_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CEP250 | centrosomal protein 250kDa | 0.112941 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.102843 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0996573 |
| INTS6 | integrator complex subunit 6 | 0.0929894 |
| CDK12 | cyclin-dependent kinase 12 | 0.0900154 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0886991 |
| CLTC | clathrin, heavy chain (Hc) | 0.0766231 |
| VEGFA | vascular endothelial growth factor A | 0.0760257 |
| RPL19 | ribosomal protein L19 | 0.0758499 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0746917 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0745625 |
| SET | SET nuclear proto-oncogene | 0.0712707 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0703346 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0691651 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0676415 |
| ENAH | enabled homolog (Drosophila) | 0.0630315 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0624663 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0608533 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0603846 |
| RPL23 | ribosomal protein L23 | 0.0603599 |
| LRRC59 | leucine rich repeat containing 59 | 0.0584185 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.057526 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0574846 |
| PLEC | plectin | 0.0572488 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0552572 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0540197 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0528305 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0528111 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0523813 |
| PRRC2C | proline-rich coiled-coil 2C | 0.05055 |
| RPS3 | ribosomal protein S3 | 0.0494712 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0493784 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | 0.0482623 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.047898 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0461251 |
| ADAR | adenosine deaminase, RNA-specific | 0.0434007 |
| DSPP | dentin sialophosphoprotein | 0.043213 |
| PRLR | prolactin receptor | 0.0420622 |
| KRT8 | keratin 8, type II | 0.0419529 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0403081 |
| KIF1A | kinesin family member 1A | 0.0402455 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0402072 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0398493 |
| SEPTIN9 | septin 9 | 0.0396892 |
| PNN | pinin, desmosome associated protein | 0.0384621 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0379125 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0377183 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0369003 |
| SLFN5 | schlafen family member 5 | 0.0368999 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0363599 |
| STXBP4 | syntaxin binding protein 4 | 0.035879 |
| PPP1R9B | protein phosphatase 1, regulatory subunit 9B | 0.0350797 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.0348708 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0345079 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0344647 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0343204 |
| ATXN1 | ataxin 1 | 0.0342658 |
| MED13L | mediator complex subunit 13-like | 0.0335307 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0332693 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0331307 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0329394 |
| DTNA | dystrobrevin, alpha | 0.0325347 |
| BPTF | bromodomain PHD finger transcription factor | 0.032241 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | 0.0315423 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0311042 |
| FLNA | filamin A, alpha | 0.0309501 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0306666 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0306553 |
| RPL37A | ribosomal protein L37a | 0.0304714 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0304099 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | 0.03039 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0303665 |
| NONO | non-POU domain containing, octamer-binding | 0.0302263 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0299994 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | 0.0299715 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0297796 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0297487 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0296221 |
| MSI2 | musashi RNA-binding protein 2 | 0.029535 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0293666 |
| EXT1 | exostosin glycosyltransferase 1 | 0.029313 |
| PTK2 | protein tyrosine kinase 2 | 0.0292825 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0291146 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.0289255 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0288923 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0287852 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.028503 |
| AHDC1 | AT hook, DNA binding motif, containing 1 | 0.0281959 |
| MLPH | melanophilin | 0.0280427 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0279083 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0277412 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0276086 |
| TPM3 | tropomyosin 3 | 0.0275394 |
| STX16 | syntaxin 16 | 0.0273389 |
| FUS | FUS RNA binding protein | 0.0271049 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | 0.0270509 |
| MYLIP | myosin regulatory light chain interacting protein | 0.0266557 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0265833 |
| KRT86 | keratin 86, type II | 0.0263327 |
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | 0.0262941 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.230346 |
| VMP1 | vacuole membrane protein 1 | -0.124713 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.106293 |
| ASPH | aspartate beta-hydroxylase | -0.0929424 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0712425 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0692086 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0658994 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.064037 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0610263 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0577275 |
| MT2A | metallothionein 2A | -0.0575848 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0533715 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0516003 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.0512483 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.050712 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0501129 |
| TMEM165 | transmembrane protein 165 | -0.0494576 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0484327 |
| SMYD3 | SET and MYND domain containing 3 | -0.0478508 |
| AHNAK | AHNAK nucleoprotein | -0.0477787 |
| TMEM123 | transmembrane protein 123 | -0.0475259 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0463882 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0453283 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0448866 |
| OSMR | oncostatin M receptor | -0.0426258 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0418237 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0407129 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0404893 |
| TMSB10 | thymosin beta 10 | -0.0401317 |
| NDRG1 | N-myc downstream regulated 1 | -0.0391667 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | -0.0380314 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0378423 |
| SDC4 | syndecan 4 | -0.0377165 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0370498 |
| S100A9 | S100 calcium binding protein A9 | -0.0352657 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0351459 |
| CCND1 | cyclin D1 | -0.0349932 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0349743 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0349242 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0345145 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0333227 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.032732 |
| PTMA | prothymosin, alpha | -0.0323208 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0321022 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0316768 |
| SBF2 | SET binding factor 2 | -0.0315723 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.031467 |
| CD164 | CD164 molecule, sialomucin | -0.0308108 |
| ITGB6 | integrin, beta 6 | -0.0303638 |
| TMC5 | transmembrane channel-like 5 | -0.0292682 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0290796 |
| S100A8 | S100 calcium binding protein A8 | -0.0288646 |
| S100A14 | S100 calcium binding protein A14 | -0.0288529 |
| PFDN4 | prefoldin subunit 4 | -0.0283973 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0282859 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0282004 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0281676 |
| S100A6 | S100 calcium binding protein A6 | -0.027918 |
| UBC | ubiquitin C | -0.0272202 |
| ANXA2 | annexin A2 | -0.0272084 |
| SMIM14 | small integral membrane protein 14 | -0.0266157 |
| LDLR | low density lipoprotein receptor | -0.0264112 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0261758 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0260808 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0260391 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.026039 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0255221 |
| AREG | amphiregulin | -0.0254785 |
| TPD52 | tumor protein D52 | -0.0254759 |
| GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | -0.0253915 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0253269 |
| RTN4 | reticulon 4 | -0.0248598 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0247897 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0234126 |
| NIBAN2 | niban apoptosis regulator 2 | -0.023327 |
| PRR11 | proline rich 11 | -0.0232943 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0229835 |
| RPS24 | ribosomal protein S24 | -0.022836 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0226816 |
| MSMO1 | methylsterol monooxygenase 1 | -0.0223514 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0220859 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0220089 |
| USP53 | ubiquitin specific peptidase 53 | -0.0219713 |
| GNAS | GNAS complex locus | -0.0219505 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0217636 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0217345 |
| PGK1 | phosphoglycerate kinase 1 | -0.0216985 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0214698 |
| WASL | Wiskott-Aldrich syndrome-like | -0.0214463 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0213696 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0212514 |
| TNIK | TRAF2 and NCK interacting kinase | -0.0210033 |
| FAM13A | family with sequence similarity 13, member A | -0.0207015 |
| TMEM45B | transmembrane protein 45B | -0.0206534 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0205912 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0203663 |
| DSG2 | desmoglein 2 | -0.0203248 |
| MAP1B | microtubule-associated protein 1B | -0.0202476 |
| DUSP6 | dual specificity phosphatase 6 | -0.0201023 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.0200238 |
