TAK-733_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.322453
LOC112694756 uncharaterized LOC112694756 0.086525
EEF2 eukaryotic translation elongation factor 2 0.0797747
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0697094
BHLHE40 basic helix-loop-helix family, member e40 0.0694671
CD109 CD109 molecule 0.0673912
APP amyloid beta (A4) precursor protein 0.0653417
SFTPA2 surfactant protein A2 0.0631986
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0623029
IGFBP3 insulin-like growth factor binding protein 3 0.0607092
NAV2 neuron navigator 2 0.0576935
ICAM1 intercellular adhesion molecule 1 0.0567182
MYH9 myosin, heavy chain 9, non-muscle 0.0550529
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0536271
FMN1 formin 1 0.052208
MACF1 microtubule-actin crosslinking factor 1 0.0503205
ACTN1 actinin, alpha 1 0.049894
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.0490729
PLEC plectin 0.0485117
ANXA2 annexin A2 0.0465986
NAMPT nicotinamide phosphoribosyltransferase 0.0460035
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0420947
ENO1 enolase 1, (alpha) 0.0411113
VEGFA vascular endothelial growth factor A 0.0398748
IFI16 interferon, gamma-inducible protein 16 0.0381642
ACTG1 actin gamma 1 0.0379161
DST dystonin 0.0374182
FLNA filamin A, alpha 0.0371857
CPED1 cadherin-like and PC-esterase domain containing 1 0.0367046
DCT dopachrome tautomerase 0.0362602
SEPTIN9 septin 9 0.0349299
DSTYK dual serine/threonine and tyrosine protein kinase 0.0341949
CD44 CD44 molecule (Indian blood group) 0.0340738
ASPH aspartate beta-hydroxylase 0.0340461
RUNX1 runt-related transcription factor 1 0.033651
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0335934
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0333879
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.032452
LEF1 lymphoid enhancer-binding factor 1 0.0323089
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0321946
CALU calumenin 0.0318908
LOC102724023 ES1 protein homolog, mitochondrial 0.0316009
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0310381
VIM vimentin 0.0308817
MKI67 marker of proliferation Ki-67 0.0304801
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.030173
WWTR1 WW domain containing transcription regulator 1 0.0300162
APLP2 amyloid beta (A4) precursor-like protein 2 0.0298566
FLNB filamin B, beta 0.0297535
TAGLN2 transgelin 2 0.029262
B2M beta-2-microglobulin 0.0291587
SRRM2 serine/arginine repetitive matrix 2 0.0291419
MTPN myotrophin 0.0289861
UHMK1 U2AF homology motif (UHM) kinase 1 0.0287649
NAV1 neuron navigator 1 0.0286745
NUMA1 nuclear mitotic apparatus protein 1 0.028517
BACE2 beta-site APP-cleaving enzyme 2 0.0283607
LMNA lamin A/C 0.0283578
SRPK2 SRSF protein kinase 2 0.0279136
COPA coatomer protein complex, subunit alpha 0.0277467
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0274815
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0274636
EPS8 epidermal growth factor receptor pathway substrate 8 0.0270916
PRRC2C proline-rich coiled-coil 2C 0.0266884
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0266562
PKM pyruvate kinase, muscle 0.0266515
ZYX zyxin 0.0266404
IVNS1ABP influenza virus NS1A binding protein 0.0266293
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0265615
TPR translocated promoter region, nuclear basket protein 0.0264198
GAS7 growth arrest-specific 7 0.0260893
DDIT4 DNA-damage-inducible transcript 4 0.025892
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0258688
FAT1 FAT atypical cadherin 1 0.0257835
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0251199
CLIC4 chloride intracellular channel 4 0.0250825
CABIN1 calcineurin binding protein 1 0.0250227
LDHA lactate dehydrogenase A 0.0249907
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0244727
ANXA5 annexin A5 0.0242951
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0241867
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0241864
ARRDC3 arrestin domain containing 3 0.0241443
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0241281
A2M alpha-2-macroglobulin 0.0238273
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0237317
TSC22D1 TSC22 domain family, member 1 0.0235031
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0234902
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0234046
PI15 peptidase inhibitor 15 0.023183
LYST lysosomal trafficking regulator 0.0230579
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0229193
EP300 E1A binding protein p300 0.0229028
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0228862
SCARB2 scavenger receptor class B, member 2 0.0227643
SYTL2 synaptotagmin-like 2 0.0227267
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0226044
NFE2L1 nuclear factor, erythroid 2-like 1 0.0225968
SETBP1 SET binding protein 1 0.0225751
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0225417

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.156977
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.12134
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.105143
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0929421
MACROD2 MACRO domain containing 2 -0.0584698
MAML3 mastermind-like 3 (Drosophila) -0.0564457
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0451878
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0431648
GPC6 glypican 6 -0.0404446
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0391015
IGFBP5 insulin-like growth factor binding protein 5 -0.0387331
CDK14 cyclin-dependent kinase 14 -0.0378234
TMSB10 thymosin beta 10 -0.0373649
GDF15 growth differentiation factor 15 -0.0367789
PTPRD protein tyrosine phosphatase, receptor type, D -0.0364643
SCFD2 sec1 family domain containing 2 -0.0335852
PTK2 protein tyrosine kinase 2 -0.0331327
AKAP12 A kinase (PRKA) anchor protein 12 -0.0322371
ZNF704 zinc finger protein 704 -0.0316718
COL19A1 collagen, type XIX, alpha 1 -0.0310461
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0304831
NPAS2 neuronal PAS domain protein 2 -0.029431
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0289364
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0286764
S100A6 S100 calcium binding protein A6 -0.0280444
OXR1 oxidation resistance 1 -0.027504
NEGR1 neuronal growth regulator 1 -0.0266428
SOX5 SRY (sex determining region Y)-box 5 -0.0265986
RFX7 regulatory factor X, 7 -0.0264662
HILPDA hypoxia inducible lipid droplet-associated -0.0264424
RNF24 ring finger protein 24 -0.0254184
HMGA2 high mobility group AT-hook 2 -0.0243529
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0234371
EHBP1 EH domain binding protein 1 -0.0219428
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0203734
TBC1D22A TBC1 domain family, member 22A -0.0201122
FTL ferritin, light polypeptide -0.0198104
PDE10A phosphodiesterase 10A -0.0192036
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0191082
KDM5B lysine (K)-specific demethylase 5B -0.0187086
BRWD1 bromodomain and WD repeat domain containing 1 -0.0184622
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0178458
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0176324
RPL35A ribosomal protein L35a -0.0169413
PLIN2 perilipin 2 -0.0169067
PTMA prothymosin, alpha -0.0168926
LSAMP limbic system-associated membrane protein -0.0167466
NBEA neurobeachin -0.0165013
CCDC91 coiled-coil domain containing 91 -0.015928
FRMD4A FERM domain containing 4A -0.0158427
IGF1R insulin-like growth factor 1 receptor -0.0155555
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0154443
ADAM19 ADAM metallopeptidase domain 19 -0.0152459
GNAS GNAS complex locus -0.0152148
GHR growth hormone receptor -0.0151914
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0149897
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0149054
TET1 tet methylcytosine dioxygenase 1 -0.0148621
FNDC3B fibronectin type III domain containing 3B -0.0148332
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0147075
WSB1 WD repeat and SOCS box containing 1 -0.0144708
PYGB phosphorylase, glycogen; brain -0.0144531
CTSD cathepsin D -0.0143221
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0142507
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0142333
CFAP20DC CFAP20 domain containing -0.0141097
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0140694
ZBTB20 zinc finger and BTB domain containing 20 -0.0140621
PHF21A PHD finger protein 21A -0.0135321
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0133755
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0133528
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) -0.0133258
NPR2 natriuretic peptide receptor 2 -0.0132473
CLMN calmin (calponin-like, transmembrane) -0.0132378
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0131815
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0130725
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -0.0129058
RPS6 ribosomal protein S6 -0.0128283
INSIG1 insulin induced gene 1 -0.0128277
TFB1M transcription factor B1, mitochondrial -0.0128098
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0125996
HMGA1 high mobility group AT-hook 1 -0.0125927
RNF150 ring finger protein 150 -0.0125675
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0124613
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0124105
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.0123918
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0123504
DIAPH2 diaphanous-related formin 2 -0.0122503
FBXL7 F-box and leucine-rich repeat protein 7 -0.0121009
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0120826
COL5A2 collagen, type V, alpha 2 -0.0119988
LRRC23 leucine rich repeat containing 23 -0.0119153
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0118967
GARS1 glycyl-tRNA synthetase 1 -0.0118717
RPLP1 ribosomal protein, large, P1 -0.0118398
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0117763
FHIT fragile histidine triad -0.011746
INSYN2B inhibitory synaptic factor family member 2B -0.011738
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0116993
TPT1 tumor protein, translationally-controlled 1 -0.0116579