TAK-733_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the TAK-733_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.211521
FMN1 formin 1 0.156176
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.152181
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.122942
ACTG1 actin gamma 1 0.114565
EEF2 eukaryotic translation elongation factor 2 0.106677
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0852718
DST dystonin 0.0797483
TLE4 transducin-like enhancer of split 4 0.0757556
MYH9 myosin, heavy chain 9, non-muscle 0.0739834
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0680114
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0659754
KLHL13 kelch-like family member 13 0.0606524
PRRC2C proline-rich coiled-coil 2C 0.0595425
RNF213 ring finger protein 213 0.058966
VEGFA vascular endothelial growth factor A 0.0573878
MEIS2 Meis homeobox 2 0.0566253
DGKH diacylglycerol kinase, eta 0.0541231
SEPTIN9 septin 9 0.0537811
MAP1B microtubule-associated protein 1B 0.0535283
AOPEP aminopeptidase O (putative) 0.0506784
TRIO trio Rho guanine nucleotide exchange factor 0.0478677
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0468455
TPST1 tyrosylprotein sulfotransferase 1 0.0465784
HSPA8 heat shock 70kDa protein 8 0.0451123
RPS12 ribosomal protein S12 0.0443906
GREM2 gremlin 2, DAN family BMP antagonist 0.0434672
NCAM2 neural cell adhesion molecule 2 0.0433736
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0432994
B2M beta-2-microglobulin 0.0422255
RPL23 ribosomal protein L23 0.041713
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0413768
CRH corticotropin releasing hormone 0.0408662
MRTFA myocardin related transcription factor A 0.0405074
SRRM2 serine/arginine repetitive matrix 2 0.0404098
ZMIZ1 zinc finger, MIZ-type containing 1 0.0396487
EIF1 eukaryotic translation initiation factor 1 0.037256
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0372078
BPTF bromodomain PHD finger transcription factor 0.036956
ENAH enabled homolog (Drosophila) 0.0366493
RET ret proto-oncogene 0.0363996
NRP1 neuropilin 1 0.0360544
CLTC clathrin, heavy chain (Hc) 0.035456
RPS3 ribosomal protein S3 0.0350373
ITGA1 integrin, alpha 1 0.0346504
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0345849
NPAS2 neuronal PAS domain protein 2 0.0344968
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0341964
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.0339281
LPP LIM domain containing preferred translocation partner in lipoma 0.0328527
RACK1 receptor for activated C kinase 1 0.0327645
RPL19 ribosomal protein L19 0.0324345
FNDC3A fibronectin type III domain containing 3A 0.0320197
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 0.0319769
PRRC2B proline-rich coiled-coil 2B 0.031478
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0314141
VCL vinculin 0.03135
RPS6 ribosomal protein S6 0.0306215
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0303122
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.030211
PTMA prothymosin, alpha 0.0301931
ZSWIM6 zinc finger, SWIM-type containing 6 0.0301873
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0299457
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0297832
PKM pyruvate kinase, muscle 0.0295029
LOC112694756 uncharaterized LOC112694756 0.0292542
FAM107B family with sequence similarity 107, member B 0.0291706
PRKCA protein kinase C, alpha 0.0290801
JUP junction plakoglobin 0.0289911
ACTN1 actinin, alpha 1 0.0286252
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0285412
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.028493
RPL3 ribosomal protein L3 0.0280034
TIMP3 TIMP metallopeptidase inhibitor 3 0.0279638
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0275058
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0272126
SET SET nuclear proto-oncogene 0.0271794
RPS17 ribosomal protein S17 0.0271151
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0269463
MACF1 microtubule-actin crosslinking factor 1 0.0267828
APP amyloid beta (A4) precursor protein 0.0265109
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0263885
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.026231
RPL12 ribosomal protein L12 0.0258997
RPLP0 ribosomal protein, large, P0 0.0258198
CSNK1A1 casein kinase 1, alpha 1 0.0254593
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.025425
MYO6 myosin VI 0.0253053
ITPRID2 ITPR interacting domain containing 2 0.0251777
RPL38 ribosomal protein L38 0.02498
SIK2 salt-inducible kinase 2 0.0247274
ARHGAP9 Rho GTPase activating protein 9 0.0246868
TCF12 transcription factor 12 0.0245672
PCDH9 protocadherin 9 0.0245645
ADAR adenosine deaminase, RNA-specific 0.0243401
PTEN phosphatase and tensin homolog 0.0242759
KCNK2 potassium channel, two pore domain subfamily K, member 2 0.0242705
KPNB1 karyopherin (importin) beta 1 0.0240254
AMOTL1 angiomotin like 1 0.0237169
SLC35F3 solute carrier family 35, member F3 0.0236878

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0475168
AKAP12 A kinase (PRKA) anchor protein 12 -0.0455672
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0453983
NRG1 neuregulin 1 -0.0440771
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0427001
ZBTB20 zinc finger and BTB domain containing 20 -0.0355728
FBXL20 F-box and leucine-rich repeat protein 20 -0.03097
FAM13A family with sequence similarity 13, member A -0.0299522
MAML2 mastermind-like 2 (Drosophila) -0.0283943
NREP neuronal regeneration related protein -0.0277
DIAPH2 diaphanous-related formin 2 -0.0249505
KDM3A lysine (K)-specific demethylase 3A -0.0247323
FNDC3B fibronectin type III domain containing 3B -0.0244097
COL3A1 collagen, type III, alpha 1 -0.0243235
OGA O-GlcNAcase -0.0239232
CPED1 cadherin-like and PC-esterase domain containing 1 -0.023403
PRKG1 protein kinase, cGMP-dependent, type I -0.0229654
SBF2 SET binding factor 2 -0.0227067
HELZ helicase with zinc finger -0.0209083
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0206939
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0203744
DTNA dystrobrevin, alpha -0.0203282
FRMD4A FERM domain containing 4A -0.0202576
HMGB2 high mobility group box 2 -0.0195289
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0193969
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0193049
NAMPT nicotinamide phosphoribosyltransferase -0.0192949
KLHL24 kelch-like family member 24 -0.0192709
NALF1 NALCN channel auxiliary factor 1 -0.0187444
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0183586
PIBF1 progesterone immunomodulatory binding factor 1 -0.0182414
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0182013
HBP1 HMG-box transcription factor 1 -0.0181457
SPAG9 sperm associated antigen 9 -0.0181373
C1ORF21 chromosome 1 open reading frame 21 -0.0176623
CHD6 chromodomain helicase DNA binding protein 6 -0.0174574
CCNY cyclin Y -0.0170806
TMSB10 thymosin beta 10 -0.0169828
RNF150 ring finger protein 150 -0.0167752
NPEPPS aminopeptidase puromycin sensitive -0.016763
PBX1 pre-B-cell leukemia homeobox 1 -0.0165067
MAPK10 mitogen-activated protein kinase 10 -0.0162041
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0159748
PHF21A PHD finger protein 21A -0.0157368
NEK7 NIMA-related kinase 7 -0.0154222
BRWD1 bromodomain and WD repeat domain containing 1 -0.0153295
ATRNL1 attractin-like 1 -0.0152391
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0152338
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0152284
ERBIN erbb2 interacting protein -0.0151013
TNRC6B trinucleotide repeat containing 6B -0.0147779
TMEM263 transmembrane protein 263 -0.0146837
DENND4A DENN/MADD domain containing 4A -0.0146752
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.014655
WSB1 WD repeat and SOCS box containing 1 -0.0145869
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.014397
CDH10 cadherin 10, type 2 (T2-cadherin) -0.014382
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0143713
SCLT1 sodium channel and clathrin linker 1 -0.0142539
GMDS GDP-mannose 4,6-dehydratase -0.0141086
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0140881
QKI QKI, KH domain containing, RNA binding -0.0140858
CLINT1 clathrin interactor 1 -0.0138717
RTN4 reticulon 4 -0.0138297
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0137981
PRTG protogenin -0.0137585
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0136968
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0135414
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0134832
LRRC7 leucine rich repeat containing 7 -0.0134644
KDM5B lysine (K)-specific demethylase 5B -0.0134179
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0133842
USP3 ubiquitin specific peptidase 3 -0.0133712
RNF24 ring finger protein 24 -0.0132921
ANK2 ankyrin 2, neuronal -0.0132129
TRA2A transformer 2 alpha homolog (Drosophila) -0.0130435
PARD3 par-3 family cell polarity regulator -0.0129494
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0127973
IGF1R insulin-like growth factor 1 receptor -0.0126681
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0126171
URI1 URI1, prefoldin-like chaperone -0.0125589
IGFBP3 insulin-like growth factor binding protein 3 -0.0124927
PSD3 pleckstrin and Sec7 domain containing 3 -0.0124927
GPR75-ASB3 GPR75-ASB3 readthrough -0.0123696
JMY junction mediating and regulatory protein, p53 cofactor -0.011957
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0118975
SSH2 slingshot protein phosphatase 2 -0.0117444
ANTXR1 anthrax toxin receptor 1 -0.0117314
CADM2 cell adhesion molecule 2 -0.0116878
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0116757
RYBP RING1 and YY1 binding protein -0.0116695
FOXK1 forkhead box K1 -0.0116445
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0115979
MCL1 myeloid cell leukemia 1 -0.0115861
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0115746
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0114853
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0114732
NUP153 nucleoporin 153kDa -0.0114683
FNBP1 formin binding protein 1 -0.011401
KMT2E lysine (K)-specific methyltransferase 2E -0.0112739