| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in H4 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-733_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.289486 |
| NDRG1 | N-myc downstream regulated 1 | 0.117546 |
| VEGFA | vascular endothelial growth factor A | 0.115999 |
| PLEC | plectin | 0.106076 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0969586 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0940926 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0908378 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0732638 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0640472 |
| FLNA | filamin A, alpha | 0.0617552 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0573937 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0506238 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0493608 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0475417 |
| COL5A1 | collagen, type V, alpha 1 | 0.0433891 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.04136 |
| STC1 | stanniocalcin 1 | 0.0412623 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0409756 |
| FAT1 | FAT atypical cadherin 1 | 0.0400959 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0393493 |
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 (yeast) | 0.0391262 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0375064 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0362237 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0356158 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0353255 |
| SFTPA2 | surfactant protein A2 | 0.0352703 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0346959 |
| SMAD3 | SMAD family member 3 | 0.034313 |
| C1S | complement component 1, s subcomponent | 0.0339979 |
| DTNA | dystrobrevin, alpha | 0.0338278 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0334401 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0330006 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.0326737 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0319925 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0310694 |
| RPL3 | ribosomal protein L3 | 0.0309041 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0307605 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0306385 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0302289 |
| APP | amyloid beta (A4) precursor protein | 0.0302006 |
| INTS6 | integrator complex subunit 6 | 0.030008 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0299737 |
| RUNX1 | runt-related transcription factor 1 | 0.029582 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0293193 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0292856 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0287802 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0287314 |
| WLS | wntless Wnt ligand secretion mediator | 0.0286946 |
| HDAC9 | histone deacetylase 9 | 0.0284894 |
| ZNF160 | zinc finger protein 160 | 0.0281652 |
| GLCCI1 | glucocorticoid induced 1 | 0.0274713 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0271986 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0271927 |
| B2M | beta-2-microglobulin | 0.0267384 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0267065 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0265584 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0259523 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0258054 |
| E2F7 | E2F transcription factor 7 | 0.0251574 |
| ARRDC3 | arrestin domain containing 3 | 0.0250297 |
| GYS1 | glycogen synthase 1 (muscle) | 0.0249758 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0249651 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0241451 |
| CTSB | cathepsin B | 0.0238421 |
| C1R | complement component 1, r subcomponent | 0.0235587 |
| CALN1 | calneuron 1 | 0.0233698 |
| AGPAT5 | 1-acylglycerol-3-phosphate O-acyltransferase 5 | 0.0231318 |
| IL6ST | interleukin 6 signal transducer | 0.0225722 |
| EHBP1L1 | EH domain binding protein 1-like 1 | 0.0221428 |
| SET | SET nuclear proto-oncogene | 0.0220007 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0213819 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0212821 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0212546 |
| NGLY1 | N-glycanase 1 | 0.0210706 |
| FAM219A | family with sequence similarity 219, member A | 0.021066 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0208549 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0208293 |
| BRD2 | bromodomain containing 2 | 0.020644 |
| NPAS2 | neuronal PAS domain protein 2 | 0.020561 |
| PGM3 | phosphoglucomutase 3 | 0.0201845 |
| HLA-B | major histocompatibility complex, class I, B | 0.0200232 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0199369 |
| HDAC4 | histone deacetylase 4 | 0.0198399 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.019477 |
| TLN1 | talin 1 | 0.0193 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0192104 |
| MB21D2 | Mab-21 domain containing 2 | 0.0188854 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0188401 |
| ANK2 | ankyrin 2, neuronal | 0.0185859 |
| FUS | FUS RNA binding protein | 0.0185825 |
| RACK1 | receptor for activated C kinase 1 | 0.0185708 |
| SEPTIN9 | septin 9 | 0.0184881 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0184867 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.018447 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0183833 |
| HYOU1 | hypoxia up-regulated 1 | 0.0183587 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0183446 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0181594 |
| DGKI | diacylglycerol kinase, iota | 0.0181557 |
| EPHA6 | EPH receptor A6 | 0.0178893 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.227266 |
| TMSB10 | thymosin beta 10 | -0.167117 |
| FN1 | fibronectin 1 | -0.129365 |
| VIM | vimentin | -0.12273 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0935825 |
| TPM4 | tropomyosin 4 | -0.0925251 |
| AHNAK | AHNAK nucleoprotein | -0.0897978 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0896493 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0859907 |
| FTL | ferritin, light polypeptide | -0.0784099 |
| MAP1B | microtubule-associated protein 1B | -0.0682263 |
| SBF2 | SET binding factor 2 | -0.0681947 |
| LOX | lysyl oxidase | -0.0677614 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0669745 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0666319 |
| RTN4 | reticulon 4 | -0.0665626 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0662784 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0647358 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0631871 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0587392 |
| PTMA | prothymosin, alpha | -0.0566178 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0560209 |
| NLGN1 | neuroligin 1 | -0.0552713 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0536541 |
| VMP1 | vacuole membrane protein 1 | -0.0526781 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0525003 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0519973 |
| CENPF | centromere protein F, 350/400kDa | -0.0512177 |
| MKI67 | marker of proliferation Ki-67 | -0.0498469 |
| GNAS | GNAS complex locus | -0.0479395 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0469258 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0464943 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0464615 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0461831 |
| SPAG9 | sperm associated antigen 9 | -0.0456946 |
| NAV3 | neuron navigator 3 | -0.0447398 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0417772 |
| ANLN | anillin, actin binding protein | -0.0414377 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0411332 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.040679 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0405935 |
| CENPE | centromere protein E, 312kDa | -0.0399509 |
| RPLP1 | ribosomal protein, large, P1 | -0.0393614 |
| DIAPH3 | diaphanous-related formin 3 | -0.0392558 |
| OSMR | oncostatin M receptor | -0.0391359 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0389135 |
| S100A6 | S100 calcium binding protein A6 | -0.0380991 |
| STK17A | serine/threonine kinase 17a | -0.0373517 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0371601 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0370319 |
| NAV1 | neuron navigator 1 | -0.0349511 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.034304 |
| JMJD1C | jumonji domain containing 1C | -0.0342856 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0338771 |
| TPX2 | TPX2, microtubule-associated | -0.0330177 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0328805 |
| NF1 | neurofibromin 1 | -0.0321823 |
| MAP4 | microtubule-associated protein 4 | -0.0321455 |
| HIP1 | huntingtin interacting protein 1 | -0.0318735 |
| RAI14 | retinoic acid induced 14 | -0.0318515 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0318496 |
| ENO1 | enolase 1, (alpha) | -0.0318227 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0312095 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0310855 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0310663 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0305493 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0302443 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0302403 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0302267 |
| SYT1 | synaptotagmin I | -0.030038 |
| RPLP2 | ribosomal protein, large, P2 | -0.0299294 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0298486 |
| RPS24 | ribosomal protein S24 | -0.0294509 |
| CDC27 | cell division cycle 27 | -0.0291024 |
| RBM25 | RNA binding motif protein 25 | -0.0287536 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0286987 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.028681 |
| NAV2 | neuron navigator 2 | -0.0284929 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0282874 |
| RIGI | RNA sensor RIG-I | -0.0282141 |
| SEPTIN7 | septin 7 | -0.0280004 |
| KIF14 | kinesin family member 14 | -0.0276721 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0274664 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0273474 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0270756 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.027048 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0267838 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0267207 |
| TUBB | tubulin, beta class I | -0.026667 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0264621 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0264063 |
| CAVIN1 | caveolae associated protein 1 | -0.0263916 |
| ECT2 | epithelial cell transforming 2 | -0.0262366 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0260995 |
| PRR11 | proline rich 11 | -0.0260115 |
| BMERB1 | bMERB domain containing 1 | -0.0259485 |
| USP34 | ubiquitin specific peptidase 34 | -0.0259459 |
| ATXN1 | ataxin 1 | -0.025937 |
| TXNRD1 | thioredoxin reductase 1 | -0.0258929 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0256845 |
