TAK-733_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.212836
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.177799
MYH9 myosin, heavy chain 9, non-muscle 0.161868
PABPC1 poly(A) binding protein, cytoplasmic 1 0.13784
LOC112694756 uncharaterized LOC112694756 0.125164
PLEC plectin 0.100305
HSPA8 heat shock 70kDa protein 8 0.0834866
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0826477
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0762608
LDHA lactate dehydrogenase A 0.0721496
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0711576
KRT18 keratin 18, type I 0.0698502
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0695963
DSCAM Down syndrome cell adhesion molecule 0.0646215
SRRM2 serine/arginine repetitive matrix 2 0.0637807
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0591927
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0564064
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0560873
KRT8 keratin 8, type II 0.0558861
VEGFA vascular endothelial growth factor A 0.0548224
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0546072
CANX calnexin 0.0527533
FAT1 FAT atypical cadherin 1 0.0518977
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0516051
RPL3 ribosomal protein L3 0.0508512
RAB7A RAB7A, member RAS oncogene family 0.0493616
FLNA filamin A, alpha 0.0466864
WNK1 WNK lysine deficient protein kinase 1 0.0465177
RACK1 receptor for activated C kinase 1 0.0462696
AFF4 AF4/FMR2 family, member 4 0.0451445
PRRC2C proline-rich coiled-coil 2C 0.0449895
ANXA2 annexin A2 0.0447863
APLP2 amyloid beta (A4) precursor-like protein 2 0.0444984
JUN jun proto-oncogene 0.0443932
APP amyloid beta (A4) precursor protein 0.0440513
PRRC2B proline-rich coiled-coil 2B 0.0438841
EGR1 early growth response 1 0.0438036
NUMA1 nuclear mitotic apparatus protein 1 0.0420572
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0413711
PATJ PATJ crumbs cell polarity complex component 0.0405505
ICAM1 intercellular adhesion molecule 1 0.0403683
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0403596
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0392132
SET SET nuclear proto-oncogene 0.0389017
FUS FUS RNA binding protein 0.0383882
SON SON DNA binding protein 0.0380649
PRELID2 PRELI domain containing 2 0.0379062
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0375104
KIF5B kinesin family member 5B 0.0374069
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0371262
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0363222
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0363057
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0355765
EIF4B eukaryotic translation initiation factor 4B 0.0355586
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0353243
SFTPA2 surfactant protein A2 0.0347538
BRD2 bromodomain containing 2 0.0342098
CSNK1A1 casein kinase 1, alpha 1 0.0331108
HDLBP high density lipoprotein binding protein 0.0329287
LOC102724023 ES1 protein homolog, mitochondrial 0.0324441
CREBBP CREB binding protein 0.0324214
PRRC2A proline-rich coiled-coil 2A 0.0320737
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0319182
BHLHE40 basic helix-loop-helix family, member e40 0.0317096
ENO1 enolase 1, (alpha) 0.0315995
PCM1 pericentriolar material 1 0.0315586
TPM3 tropomyosin 3 0.0314891
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0313139
MED13 mediator complex subunit 13 0.0311747
PGK1 phosphoglycerate kinase 1 0.0309252
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0308773
SFPQ splicing factor proline/glutamine-rich 0.0306194
KMT2C lysine (K)-specific methyltransferase 2C 0.030347
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0302208
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0297388
MED15 mediator complex subunit 15 0.0295712
CTNND1 catenin (cadherin-associated protein), delta 1 0.0292939
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0287555
TPI1 triosephosphate isomerase 1 0.0285443
MKI67 marker of proliferation Ki-67 0.0282481
HOXB9 homeobox B9 0.0281802
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0278803
PUM1 pumilio RNA-binding family member 1 0.0277047
CTTN cortactin 0.0275193
TOR1AIP2 torsin A interacting protein 2 0.0274701
RPLP0 ribosomal protein, large, P0 0.0272735
NONO non-POU domain containing, octamer-binding 0.0272475
MAP2K1 mitogen-activated protein kinase kinase 1 0.0271374
MACF1 microtubule-actin crosslinking factor 1 0.026751
WAC WW domain containing adaptor with coiled-coil 0.0266252
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0265776
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0265228
IL6ST interleukin 6 signal transducer 0.0264617
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0263381
RBM5 RNA binding motif protein 5 0.0261963
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0260704
MINK1 misshapen-like kinase 1 0.0260626
RAD23B RAD23 homolog B (S. cerevisiae) 0.0260464
MPRIP myosin phosphatase Rho interacting protein 0.0260198
COPA coatomer protein complex, subunit alpha 0.0260163

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.203405
TMSB10 thymosin beta 10 -0.12124
RAD51B RAD51 paralog B -0.0633755
RPL35A ribosomal protein L35a -0.0609407
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.050776
RPS6 ribosomal protein S6 -0.0484776
TPT1 tumor protein, translationally-controlled 1 -0.0472084
SERINC5 serine incorporator 5 -0.0438265
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0425051
RPLP1 ribosomal protein, large, P1 -0.0407596
HMGA2 high mobility group AT-hook 2 -0.0393365
RPLP2 ribosomal protein, large, P2 -0.037811
RPS24 ribosomal protein S24 -0.0371448
DIAPH3 diaphanous-related formin 3 -0.0352708
EGFR epidermal growth factor receptor -0.0336477
ARF4 ADP-ribosylation factor 4 -0.0329192
RPL34 ribosomal protein L34 -0.0325069
RPS19 ribosomal protein S19 -0.0319744
DLG1 discs, large homolog 1 (Drosophila) -0.0319352
MT2A metallothionein 2A -0.0318728
TPM4 tropomyosin 4 -0.0315027
WWOX WW domain containing oxidoreductase -0.0311878
HMGA1 high mobility group AT-hook 1 -0.0309895
SBF2 SET binding factor 2 -0.0294175
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0291358
HMGB1 high mobility group box 1 -0.0291177
TBC1D22A TBC1 domain family, member 22A -0.028406
RPS29 ribosomal protein S29 -0.0283647
CADPS Ca++-dependent secretion activator -0.0283457
POTEF POTE ankyrin domain family, member F -0.0275589
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.027235
RPS25 ribosomal protein S25 -0.0264486
RPL31 ribosomal protein L31 -0.0261096
FNDC3B fibronectin type III domain containing 3B -0.02591
RPS14 ribosomal protein S14 -0.025158
MBD5 methyl-CpG binding domain protein 5 -0.0244857
SMC4 structural maintenance of chromosomes 4 -0.0243695
RPS27A ribosomal protein S27a -0.0235497
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0234434
TUBA1B tubulin, alpha 1b -0.0230049
S100A6 S100 calcium binding protein A6 -0.0229535
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0227562
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0227344
ITGB4 integrin, beta 4 -0.0224003
RPL27 ribosomal protein L27 -0.0221872
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0215105
ACTG1 actin gamma 1 -0.021382
VIM vimentin -0.0212865
MSI2 musashi RNA-binding protein 2 -0.0201368
RPS11 ribosomal protein S11 -0.0201302
GCC2 GRIP and coiled-coil domain containing 2 -0.019895
RPL37A ribosomal protein L37a -0.0196926
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0195464
ESYT2 extended synaptotagmin-like protein 2 -0.0194144
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0192753
DEK DEK proto-oncogene -0.0192587
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0189453
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0187666
MED13L mediator complex subunit 13-like -0.0187027
IGF2 insulin-like growth factor 2 -0.0183714
CCND1 cyclin D1 -0.0182653
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0182211
RPS13 ribosomal protein S13 -0.0176931
RPL37 ribosomal protein L37 -0.0176295
RPL11 ribosomal protein L11 -0.0173787
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.017291
SCAPER S-phase cyclin A-associated protein in the ER -0.0171002
ENO2 enolase 2 (gamma, neuronal) -0.0168569
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0168331
MYOF myoferlin -0.0168093
MCL1 myeloid cell leukemia 1 -0.0167983
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0167974
PARD3 par-3 family cell polarity regulator -0.0167761
RNF43 ring finger protein 43 -0.0165843
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0165714
CLDN7 claudin 7 -0.0165564
RPL27A ribosomal protein L27a -0.0165535
RTN4 reticulon 4 -0.0165194
PTPRK protein tyrosine phosphatase, receptor type, K -0.0163965
CEP128 centrosomal protein 128kDa -0.0162427
ECT2 epithelial cell transforming 2 -0.0161991
LDHB lactate dehydrogenase B -0.0161232
NKTR natural killer cell triggering receptor -0.0159423
RPS15 ribosomal protein S15 -0.015911
NUCB2 nucleobindin 2 -0.0156865
HELLS helicase, lymphoid-specific -0.0156273
PFN1 profilin 1 -0.015578
RPS21 ribosomal protein S21 -0.0155636
AIG1 androgen-induced 1 -0.0154363
BRCA1 breast cancer 1, early onset -0.0153577
NBEAL1 neurobeachin-like 1 -0.0153083
JMJD1C jumonji domain containing 1C -0.015302
PRC1 protein regulator of cytokinesis 1 -0.0152727
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0152073
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0150428
NOP58 NOP58 ribonucleoprotein -0.0148962
TUT4 terminal uridylyl transferase 4 -0.0148171
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0147227
FTL ferritin, light polypeptide -0.0146585
RPS20 ribosomal protein S20 -0.0146372