TAK-733_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.214586
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.164891
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.153603
PLEC plectin 0.144496
FLNA filamin A, alpha 0.135856
EEF2 eukaryotic translation elongation factor 2 0.134056
ACTG1 actin gamma 1 0.12381
PAX8 paired box 8 0.0907576
PRELID2 PRELI domain containing 2 0.0886668
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0859971
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0849643
LPP LIM domain containing preferred translocation partner in lipoma 0.0841268
APP amyloid beta (A4) precursor protein 0.0772922
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0746879
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0734762
SMAD3 SMAD family member 3 0.0732426
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0702554
SEPTIN9 septin 9 0.0694863
HSPA8 heat shock 70kDa protein 8 0.0691997
BHLHE40 basic helix-loop-helix family, member e40 0.0680317
NCEH1 neutral cholesterol ester hydrolase 1 0.0646327
MPRIP myosin phosphatase Rho interacting protein 0.0630283
ALCAM activated leukocyte cell adhesion molecule 0.0621332
RUNX1 runt-related transcription factor 1 0.0620328
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0593141
LOC112694756 uncharaterized LOC112694756 0.0581805
INTS6 integrator complex subunit 6 0.0549831
ATXN1 ataxin 1 0.0546847
NDRG1 N-myc downstream regulated 1 0.0544694
SRRM2 serine/arginine repetitive matrix 2 0.0540358
PKM pyruvate kinase, muscle 0.0532264
RACK1 receptor for activated C kinase 1 0.0522948
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0516525
TJP1 tight junction protein 1 0.051022
MYOF myoferlin 0.0509947
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0508454
FAT1 FAT atypical cadherin 1 0.050176
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0498028
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0494905
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0482652
ANXA11 annexin A11 0.0467355
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0466688
WWC1 WW and C2 domain containing 1 0.0465501
FLNB filamin B, beta 0.0464983
MACF1 microtubule-actin crosslinking factor 1 0.0464318
RNF213 ring finger protein 213 0.0459801
ANXA2 annexin A2 0.0455381
TRIM2 tripartite motif containing 2 0.044307
GOLGB1 golgin B1 0.0440205
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.043859
MYO1E myosin IE 0.0428829
BPTF bromodomain PHD finger transcription factor 0.0423415
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0421436
B2M beta-2-microglobulin 0.0415502
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0414549
TNIP1 TNFAIP3 interacting protein 1 0.0408782
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0407132
OSBPL10 oxysterol binding protein-like 10 0.0398618
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0395649
SHB Src homology 2 domain containing adaptor protein B 0.0393765
H1-0 H1.0 linker histone 0.0389542
EGR1 early growth response 1 0.0385004
IGFBP3 insulin-like growth factor binding protein 3 0.0384023
APLP2 amyloid beta (A4) precursor-like protein 2 0.038346
MKI67 marker of proliferation Ki-67 0.0380107
ZSWIM6 zinc finger, SWIM-type containing 6 0.0377647
ANXA1 annexin A1 0.0376353
MACROD2 MACRO domain containing 2 0.0375515
SQSTM1 sequestosome 1 0.0367906
LOC102724023 ES1 protein homolog, mitochondrial 0.036677
SVIL supervillin 0.0363376
PATJ PATJ crumbs cell polarity complex component 0.0362121
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0361981
TBC1D22A TBC1 domain family, member 22A 0.0360625
EXT1 exostosin glycosyltransferase 1 0.0360525
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0359379
PRRC2B proline-rich coiled-coil 2B 0.0359114
RPL3 ribosomal protein L3 0.0358568
FHIT fragile histidine triad 0.0353783
SPAG9 sperm associated antigen 9 0.0353138
ACTN4 actinin, alpha 4 0.0349695
POU5F1 POU class 5 homeobox 1 0.034808
LAMB3 laminin, beta 3 0.034711
SNX9 sorting nexin 9 0.0346591
VEGFA vascular endothelial growth factor A 0.0346456
KRT7 keratin 7, type II 0.0344803
MACC1 metastasis associated in colon cancer 1 0.0344699
MYO1D myosin ID 0.034261
DSPP dentin sialophosphoprotein 0.034061
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0332992
TRIO trio Rho guanine nucleotide exchange factor 0.032919
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0328027
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0326594
CREBBP CREB binding protein 0.0325822
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0325554
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0320008
BRD2 bromodomain containing 2 0.0317991
ANKRD17 ankyrin repeat domain 17 0.0316822
SET SET nuclear proto-oncogene 0.0316802
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0316282

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.123916
TMSB10 thymosin beta 10 -0.0711248
AHNAK AHNAK nucleoprotein -0.0601003
PTMA prothymosin, alpha -0.0523296
UBC ubiquitin C -0.0376513
BICD1 bicaudal D homolog 1 (Drosophila) -0.0370596
RBM25 RNA binding motif protein 25 -0.0333243
RPS27A ribosomal protein S27a -0.0320443
TM9SF3 transmembrane 9 superfamily member 3 -0.0311579
DLC1 DLC1 Rho GTPase activating protein -0.0296953
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0279446
RNF145 ring finger protein 145 -0.0278311
SBF2 SET binding factor 2 -0.0275701
LIMCH1 LIM and calponin homology domains 1 -0.0274654
SMC4 structural maintenance of chromosomes 4 -0.0271563
KDM3A lysine (K)-specific demethylase 3A -0.0261564
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0247083
RTN4 reticulon 4 -0.024335
CLDN1 claudin 1 -0.0235131
DIAPH3 diaphanous-related formin 3 -0.0231476
CCND1 cyclin D1 -0.0226808
URI1 URI1, prefoldin-like chaperone -0.0215085
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0214325
DOCK4 dedicator of cytokinesis 4 -0.0213699
BRWD1 bromodomain and WD repeat domain containing 1 -0.0212898
EIF5B eukaryotic translation initiation factor 5B -0.0208971
GARS1 glycyl-tRNA synthetase 1 -0.0208802
U2SURP U2 snRNP-associated SURP domain containing -0.0208589
CEP95 centrosomal protein 95kDa -0.0205755
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0204546
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0203412
TCEA1 transcription elongation factor A (SII), 1 -0.0201794
S100A6 S100 calcium binding protein A6 -0.0194848
GMPS guanine monphosphate synthase -0.0194763
PDIA4 protein disulfide isomerase family A, member 4 -0.0192913
DEK DEK proto-oncogene -0.0192087
RPS24 ribosomal protein S24 -0.0191528
MAML2 mastermind-like 2 (Drosophila) -0.0190472
CLINT1 clathrin interactor 1 -0.018991
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0189724
PNISR PNN-interacting serine/arginine-rich protein -0.0180558
PDS5B PDS5 cohesin associated factor B -0.0179636
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0177741
DLG1 discs, large homolog 1 (Drosophila) -0.0176098
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0173949
UBE2K ubiquitin-conjugating enzyme E2K -0.017369
MIS18BP1 MIS18 binding protein 1 -0.01735
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0173378
GCC2 GRIP and coiled-coil domain containing 2 -0.0172828
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0170688
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0170436
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0170317
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0169853
HMGA1 high mobility group AT-hook 1 -0.0169797
MYL12B myosin, light chain 12B, regulatory -0.0169109
PTBP2 polypyrimidine tract binding protein 2 -0.0166969
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0166203
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.016478
SEC63 SEC63 homolog (S. cerevisiae) -0.0164542
ENO1 enolase 1, (alpha) -0.0163095
HMGA2 high mobility group AT-hook 2 -0.0159818
USP3 ubiquitin specific peptidase 3 -0.0157299
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0156018
SEPTIN10 septin 10 -0.0153832
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0152778
NOP58 NOP58 ribonucleoprotein -0.0152225
TM4SF1 transmembrane 4 L six family member 1 -0.0150331
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0148482
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0146734
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0146271
TOP2A topoisomerase (DNA) II alpha 170kDa -0.014625
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0142105
TMEM41B transmembrane protein 41B -0.0141395
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0140825
PCED1B PC-esterase domain containing 1B -0.0140108
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0140073
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0138982
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.013821
SDC4 syndecan 4 -0.0137874
F3 coagulation factor III (thromboplastin, tissue factor) -0.0137162
ZFAND3 zinc finger, AN1-type domain 3 -0.0134951
TUBA1B tubulin, alpha 1b -0.01344
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0133812
LITAF lipopolysaccharide-induced TNF factor -0.0133726
LARS1 leucyl-tRNA synthetase 1 -0.0131923
MARCHF7 membrane associated ring-CH-type finger 7 -0.0131715
SINHCAF SIN3-HDAC complex associated factor -0.0130696
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0130279
SLC38A1 solute carrier family 38, member 1 -0.0129477
MARCHF6 membrane associated ring-CH-type finger 6 -0.0129367
SRSF1 serine/arginine-rich splicing factor 1 -0.0128667
ZFC3H1 zinc finger, C3H1-type containing -0.0128247
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0128224
TPT1 tumor protein, translationally-controlled 1 -0.0128171
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0125628
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0124796
LMAN1 lectin, mannose-binding, 1 -0.0124449
HACD3 3-hydroxyacyl-CoA dehydratase 3 -0.0124348
RAD21 RAD21 homolog (S. pombe) -0.0124
RNASET2 ribonuclease T2 -0.0122744