| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the TAK-733_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.451341 |
| COL6A3 | collagen, type VI, alpha 3 | 0.411045 |
| VEGFA | vascular endothelial growth factor A | 0.201141 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.188656 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.17277 |
| NDRG1 | N-myc downstream regulated 1 | 0.147708 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.141274 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.128775 |
| PLEC | plectin | 0.120736 |
| CALR | calreticulin | 0.0950945 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0726846 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0698587 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0610718 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0593658 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0580692 |
| FLNA | filamin A, alpha | 0.0567654 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0566234 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0542845 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0526127 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0519337 |
| CDH13 | cadherin 13 | 0.050308 |
| APP | amyloid beta (A4) precursor protein | 0.049881 |
| CADM1 | cell adhesion molecule 1 | 0.0492505 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0476695 |
| ENO1 | enolase 1, (alpha) | 0.0467387 |
| COL5A1 | collagen, type V, alpha 1 | 0.0436701 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.043179 |
| RACK1 | receptor for activated C kinase 1 | 0.0416998 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0413826 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0401983 |
| ACTG1 | actin gamma 1 | 0.0396975 |
| STC2 | stanniocalcin 2 | 0.0391247 |
| HDAC9 | histone deacetylase 9 | 0.038866 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0380343 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0362244 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0360172 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0358247 |
| CANX | calnexin | 0.0354348 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0349866 |
| B2M | beta-2-microglobulin | 0.0341153 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0328484 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0327747 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0327574 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0319465 |
| FAT1 | FAT atypical cadherin 1 | 0.0319004 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0315912 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0313983 |
| HYOU1 | hypoxia up-regulated 1 | 0.0311981 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0306577 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0305445 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0293915 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0289362 |
| SP100 | SP100 nuclear antigen | 0.0287813 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0286572 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0286488 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0285513 |
| ANXA2 | annexin A2 | 0.0283349 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0282974 |
| RPS8 | ribosomal protein S8 | 0.0281261 |
| LDHA | lactate dehydrogenase A | 0.028018 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.027928 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0276824 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0275265 |
| PGM3 | phosphoglucomutase 3 | 0.0272492 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0272446 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0271481 |
| ATXN1 | ataxin 1 | 0.0263722 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0262433 |
| ICAM1 | intercellular adhesion molecule 1 | 0.025712 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.0255822 |
| COPA | coatomer protein complex, subunit alpha | 0.0255256 |
| TUBB | tubulin, beta class I | 0.025137 |
| YBX1 | Y box binding protein 1 | 0.0250486 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0249164 |
| RPL3 | ribosomal protein L3 | 0.0246864 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0246597 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0246052 |
| HDLBP | high density lipoprotein binding protein | 0.0245655 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0244463 |
| BRD2 | bromodomain containing 2 | 0.0244235 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0241784 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0241189 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0240867 |
| ARRDC3 | arrestin domain containing 3 | 0.0240153 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | 0.0239138 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0238904 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0238549 |
| MED15 | mediator complex subunit 15 | 0.0238488 |
| INHBA | inhibin, beta A | 0.0234021 |
| LRRC59 | leucine rich repeat containing 59 | 0.0233732 |
| PKM | pyruvate kinase, muscle | 0.023268 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0232578 |
| PITPNB | phosphatidylinositol transfer protein, beta | 0.0231831 |
| RPS3 | ribosomal protein S3 | 0.0228968 |
| ACTN1 | actinin, alpha 1 | 0.0227202 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0227176 |
| CALU | calumenin | 0.022681 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0223325 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0222241 |
| NAV2 | neuron navigator 2 | 0.0215385 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.130855 |
| COL1A2 | collagen, type I, alpha 2 | -0.0954989 |
| VIM | vimentin | -0.0749283 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0712071 |
| HMGA2 | high mobility group AT-hook 2 | -0.0504703 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0414939 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0414397 |
| MT2A | metallothionein 2A | -0.0398916 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.038282 |
| ATP13A3 | ATPase type 13A3 | -0.0342428 |
| PDE10A | phosphodiesterase 10A | -0.0336239 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0334081 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0328648 |
| LOX | lysyl oxidase | -0.0327726 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0271337 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0265198 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0259694 |
| ZNF292 | zinc finger protein 292 | -0.0256757 |
| STC1 | stanniocalcin 1 | -0.0241594 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.023887 |
| MTSS1 | metastasis suppressor 1 | -0.0236248 |
| TMSB10 | thymosin beta 10 | -0.0219699 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0214381 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0213167 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0211488 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.020196 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0201959 |
| RTN4 | reticulon 4 | -0.0197342 |
| CCDC91 | coiled-coil domain containing 91 | -0.0194989 |
| TMEM165 | transmembrane protein 165 | -0.0190153 |
| S100A6 | S100 calcium binding protein A6 | -0.018595 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0184455 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.018196 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0175166 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0174727 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0171744 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0166726 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.01625 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0158541 |
| SBF2 | SET binding factor 2 | -0.0157786 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0157123 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0156445 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0152499 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0151143 |
| GNAS | GNAS complex locus | -0.0146047 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0145476 |
| PTMA | prothymosin, alpha | -0.0143028 |
| MT1X | metallothionein 1X | -0.0141437 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0139497 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0139077 |
| BNC2 | basonuclin 2 | -0.0138595 |
| RPS2 | ribosomal protein S2 | -0.0136409 |
| RNF24 | ring finger protein 24 | -0.013521 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0134186 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0133451 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0129312 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.01282 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0127339 |
| USP3 | ubiquitin specific peptidase 3 | -0.0126689 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0124892 |
| CENPF | centromere protein F, 350/400kDa | -0.0124662 |
| PRR16 | proline rich 16 | -0.0124452 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0123489 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0122312 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0121576 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0118927 |
| FRMD4A | FERM domain containing 4A | -0.0118498 |
| ASPH | aspartate beta-hydroxylase | -0.0114807 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0111519 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.010974 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.010921 |
| NREP | neuronal regeneration related protein | -0.0108718 |
| FBXO32 | F-box protein 32 | -0.010858 |
| ECE1 | endothelin converting enzyme 1 | -0.0107877 |
| SARAF | store-operated calcium entry-associated regulatory factor | -0.0106563 |
| RAI14 | retinoic acid induced 14 | -0.0106373 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0105542 |
| OSMR | oncostatin M receptor | -0.0104168 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0103899 |
| HMGA1 | high mobility group AT-hook 1 | -0.0103734 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0103115 |
| ABLIM3 | actin binding LIM protein family, member 3 | -0.0102026 |
| ADD3 | adducin 3 (gamma) | -0.0101146 |
| HAS2 | hyaluronan synthase 2 | -0.0100307 |
| SPAG9 | sperm associated antigen 9 | -0.0100211 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.00999509 |
| SQLE | squalene epoxidase | -0.00981622 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.00971369 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00959535 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.00959151 |
| CENPE | centromere protein E, 312kDa | -0.00943826 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.00939106 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.00931469 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.00919051 |
| IER3 | immediate early response 3 | -0.00918989 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.00907426 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.00903403 |
| SEPTIN7 | septin 7 | -0.00898019 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00891212 |
| RIN2 | Ras and Rab interactor 2 | -0.00882121 |
