TAK-733_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.260597
C3 complement component 3 0.223962
APOB apolipoprotein B 0.215464
FN1 fibronectin 1 0.206522
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.162451
SPTBN1 spectrin, beta, non-erythrocytic 1 0.147154
DSPP dentin sialophosphoprotein 0.129537
LRMDA leucine rich melanocyte differentiation associated 0.123671
IGFBP1 insulin-like growth factor binding protein 1 0.121828
EEF2 eukaryotic translation elongation factor 2 0.116752
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.107754
ERRFI1 ERBB receptor feedback inhibitor 1 0.100971
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0980824
MYH9 myosin, heavy chain 9, non-muscle 0.0972863
SAMD4A sterile alpha motif domain containing 4A 0.085993
SVIL supervillin 0.0800264
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0790413
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0722382
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.067124
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0643428
SOS1 son of sevenless homolog 1 (Drosophila) 0.0626726
VEGFA vascular endothelial growth factor A 0.0625331
TF transferrin 0.061055
FAT1 FAT atypical cadherin 1 0.0608412
CFB complement factor B 0.0578457
MACF1 microtubule-actin crosslinking factor 1 0.0566383
AFDN afadin, adherens junction formation factor 0.0544754
RUNX1 runt-related transcription factor 1 0.0532773
A2M alpha-2-macroglobulin 0.05313
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0527617
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.050312
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0502982
LMCD1 LIM and cysteine-rich domains 1 0.0502641
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.04893
FAM107B family with sequence similarity 107, member B 0.0486978
TRIO trio Rho guanine nucleotide exchange factor 0.0483949
SOD2 superoxide dismutase 2, mitochondrial 0.0478916
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.046921
NFE2L2 nuclear factor, erythroid 2-like 2 0.0457579
LOC112694756 uncharaterized LOC112694756 0.0451671
PAWR PRKC, apoptosis, WT1, regulator 0.0444454
ENO1 enolase 1, (alpha) 0.0442481
BHLHE40 basic helix-loop-helix family, member e40 0.0439935
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0437916
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0436213
RPL3 ribosomal protein L3 0.0416865
ITGAV integrin, alpha V 0.0397471
FNDC3B fibronectin type III domain containing 3B 0.0396013
SMAD3 SMAD family member 3 0.039567
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0383546
IGF1R insulin-like growth factor 1 receptor 0.0377642
FLNB filamin B, beta 0.0376829
PEG3 paternally expressed 3 0.0367338
LCOR ligand dependent nuclear receptor corepressor 0.036243
SFTPA2 surfactant protein A2 0.0360949
CEMIP2 cell migration inducing hyaluronidase 2 0.0352513
ELL2 elongation factor, RNA polymerase II, 2 0.0350504
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0348653
EPAS1 endothelial PAS domain protein 1 0.0346921
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0343312
DST dystonin 0.0340957
PLEC plectin 0.034057
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0338227
GRB10 growth factor receptor-bound protein 10 0.033601
DSTN destrin (actin depolymerizing factor) 0.0334839
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0334002
ENAH enabled homolog (Drosophila) 0.0327548
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0325135
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0322777
PDLIM5 PDZ and LIM domain 5 0.0317426
MYO5B myosin VB 0.0316868
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0316245
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0305423
TNIP1 TNFAIP3 interacting protein 1 0.0305349
CANX calnexin 0.030372
LPP LIM domain containing preferred translocation partner in lipoma 0.0299262
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0295798
SRRM2 serine/arginine repetitive matrix 2 0.0295415
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0295355
KLF6 Kruppel-like factor 6 0.0294106
KRT8 keratin 8, type II 0.0292209
APLP2 amyloid beta (A4) precursor-like protein 2 0.0290494
SEPTIN9 septin 9 0.0287864
EIF4B eukaryotic translation initiation factor 4B 0.0286942
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) 0.0286214
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0282805
ICAM1 intercellular adhesion molecule 1 0.0282547
PRRC2C proline-rich coiled-coil 2C 0.0280569
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0279341
CORO1C coronin, actin binding protein, 1C 0.0277077
CD109 CD109 molecule 0.0277056
JAK1 Janus kinase 1 0.0276037
DIAPH1 diaphanous-related formin 1 0.0274199
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0273964
NKD1 naked cuticle homolog 1 (Drosophila) 0.0273671
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0272936
MED13L mediator complex subunit 13-like 0.0272512
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0270344
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0270274
ABTB3 ankyrin repeat and BTB domain containing 3 0.0269777

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.116981
APOA2 apolipoprotein A-II -0.10826
MT2A metallothionein 2A -0.108078
TPT1 tumor protein, translationally-controlled 1 -0.102674
TMSB10 thymosin beta 10 -0.0686248
HMGA1 high mobility group AT-hook 1 -0.0644429
EHBP1 EH domain binding protein 1 -0.0636971
RPS24 ribosomal protein S24 -0.0550327
GMDS GDP-mannose 4,6-dehydratase -0.0480684
TM4SF1 transmembrane 4 L six family member 1 -0.0468178
GK glycerol kinase -0.0448156
SLC38A2 solute carrier family 38, member 2 -0.0431172
RPL35A ribosomal protein L35a -0.0429201
ASPH aspartate beta-hydroxylase -0.0427392
MAML2 mastermind-like 2 (Drosophila) -0.0420697
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0389385
ISG15 ISG15 ubiquitin-like modifier -0.0366108
RPS6 ribosomal protein S6 -0.0358419
RPLP1 ribosomal protein, large, P1 -0.034171
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0333472
RPLP2 ribosomal protein, large, P2 -0.0323354
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0319873
MCL1 myeloid cell leukemia 1 -0.0315346
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0312696
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0300093
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0286997
GCC2 GRIP and coiled-coil domain containing 2 -0.0285902
RIGI RNA sensor RIG-I -0.0284613
RPL34 ribosomal protein L34 -0.0283954
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0276923
RPL31 ribosomal protein L31 -0.026452
AHSG alpha-2-HS-glycoprotein -0.0262198
EGR1 early growth response 1 -0.0253257
PLIN2 perilipin 2 -0.0252038
PTMA prothymosin, alpha -0.0248783
SLC38A1 solute carrier family 38, member 1 -0.0240541
INTS6 integrator complex subunit 6 -0.0239981
RPL37A ribosomal protein L37a -0.0239822
RPS19 ribosomal protein S19 -0.0239441
IFITM1 interferon induced transmembrane protein 1 -0.0239147
IER3 immediate early response 3 -0.0238381
RPS25 ribosomal protein S25 -0.0237525
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0236368
RPL28 ribosomal protein L28 -0.0233562
LRRC23 leucine rich repeat containing 23 -0.0232661
WSB1 WD repeat and SOCS box containing 1 -0.0215105
S100A6 S100 calcium binding protein A6 -0.0213307
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0208573
RPL9 ribosomal protein L9 -0.0206529
GNAS GNAS complex locus -0.0206515
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0205584
HM13 histocompatibility (minor) 13 -0.0204113
NHSL1 NHS-like 1 -0.0202745
NDRG1 N-myc downstream regulated 1 -0.0200813
MX2 MX dynamin-like GTPase 2 -0.0198793
NPR2 natriuretic peptide receptor 2 -0.0198127
PDE4D phosphodiesterase 4D, cAMP-specific -0.0196106
RPS8 ribosomal protein S8 -0.0195976
RPS29 ribosomal protein S29 -0.0194818
GLRX glutaredoxin (thioltransferase) -0.0194364
FRMD5 FERM domain containing 5 -0.0193129
RPS16 ribosomal protein S16 -0.0192222
ATP10A ATPase, class V, type 10A -0.0192221
IFI6 interferon, alpha-inducible protein 6 -0.0190252
RPS23 ribosomal protein S23 -0.0189783
RPS27A ribosomal protein S27a -0.0189589
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0187574
TPM4 tropomyosin 4 -0.0183549
VIM vimentin -0.0182409
CP ceruloplasmin (ferroxidase) -0.0179208
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0176654
HLA-A major histocompatibility complex, class I, A -0.0174787
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0174652
IGFBP3 insulin-like growth factor binding protein 3 -0.0170552
RPS13 ribosomal protein S13 -0.0168715
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0167234
S100A9 S100 calcium binding protein A9 -0.0165865
NPAS2 neuronal PAS domain protein 2 -0.0165265
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.016217
ZMYND8 zinc finger, MYND-type containing 8 -0.0158803
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0157559
S100P S100 calcium binding protein P -0.0154581
RPS14 ribosomal protein S14 -0.0149989
DEK DEK proto-oncogene -0.0148862
UGP2 UDP-glucose pyrophosphorylase 2 -0.0148203
FERMT1 fermitin family member 1 -0.01472
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0146301
PARD3 par-3 family cell polarity regulator -0.0145719
HMGA2 high mobility group AT-hook 2 -0.0145056
ZHX2 zinc fingers and homeoboxes 2 -0.0141436
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0141117
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0141082
IFITM3 interferon induced transmembrane protein 3 -0.0140887
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0139558
NABP1 nucleic acid binding protein 1 -0.0138286
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0137321
APOC1 apolipoprotein C-I -0.01365
RPL7A ribosomal protein L7a -0.013496
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0133774
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0132305