| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-733_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.168293 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.160564 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.148037 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.124469 |
| FLNA | filamin A, alpha | 0.0777061 |
| PODXL | podocalyxin-like | 0.0773772 |
| FLNB | filamin B, beta | 0.0735254 |
| NAV2 | neuron navigator 2 | 0.0723954 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0696436 |
| ASPH | aspartate beta-hydroxylase | 0.0607792 |
| SMAD3 | SMAD family member 3 | 0.0580592 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0569871 |
| SET | SET nuclear proto-oncogene | 0.0564207 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0560011 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0548743 |
| ACTG1 | actin gamma 1 | 0.0541863 |
| PLEC | plectin | 0.0533717 |
| B2M | beta-2-microglobulin | 0.0521916 |
| CD44 | CD44 molecule (Indian blood group) | 0.0494378 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0488976 |
| MT2A | metallothionein 2A | 0.0484074 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0483908 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0471018 |
| LDHA | lactate dehydrogenase A | 0.0453106 |
| TLE4 | transducin-like enhancer of split 4 | 0.0447253 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0446679 |
| ANXA2 | annexin A2 | 0.0425691 |
| HEG1 | heart development protein with EGF-like domains 1 | 0.0421631 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0417418 |
| RNF213 | ring finger protein 213 | 0.0407004 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0403971 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0395111 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0385568 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0382877 |
| NDRG1 | N-myc downstream regulated 1 | 0.0376746 |
| ACTN1 | actinin, alpha 1 | 0.0376391 |
| MSN | moesin | 0.0376253 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0371542 |
| KRT8 | keratin 8, type II | 0.0363615 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0362575 |
| PKM | pyruvate kinase, muscle | 0.0357556 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0353936 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0348586 |
| DST | dystonin | 0.034202 |
| MKI67 | marker of proliferation Ki-67 | 0.0341742 |
| STC2 | stanniocalcin 2 | 0.0338773 |
| VEGFA | vascular endothelial growth factor A | 0.0336883 |
| TENM3 | teneurin transmembrane protein 3 | 0.0336418 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0331502 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0329736 |
| PTK2 | protein tyrosine kinase 2 | 0.0327172 |
| SEPTIN9 | septin 9 | 0.0325763 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0320829 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0320067 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0318294 |
| IL6ST | interleukin 6 signal transducer | 0.0317622 |
| ERBIN | erbb2 interacting protein | 0.0316913 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0316477 |
| FUS | FUS RNA binding protein | 0.0316275 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0314732 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0313848 |
| ZNF841 | zinc finger protein 841 | 0.0311806 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0304987 |
| ENO1 | enolase 1, (alpha) | 0.0303962 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0302753 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0302218 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0293822 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0291243 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0290185 |
| KRT18 | keratin 18, type I | 0.0288881 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0286329 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0284029 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0283987 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0281272 |
| TXNRD1 | thioredoxin reductase 1 | 0.0280488 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.027596 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0275081 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0273871 |
| YBX1 | Y box binding protein 1 | 0.0271527 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0270774 |
| RUNX1 | runt-related transcription factor 1 | 0.0268936 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0268442 |
| PLSCR1 | phospholipid scramblase 1 | 0.0267529 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0265226 |
| INTS6 | integrator complex subunit 6 | 0.0264684 |
| CEP250 | centrosomal protein 250kDa | 0.0260286 |
| TPM3 | tropomyosin 3 | 0.0259906 |
| FTL | ferritin, light polypeptide | 0.0254571 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0253999 |
| NONO | non-POU domain containing, octamer-binding | 0.0252907 |
| LIMA1 | LIM domain and actin binding 1 | 0.0252867 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0250654 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0249132 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0245161 |
| CALD1 | caldesmon 1 | 0.0244706 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0243553 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.02428 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.024222 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0240968 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0239186 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.102422 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.087466 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0847914 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0479946 |
| ATP13A3 | ATPase type 13A3 | -0.0459477 |
| GLIS3 | GLIS family zinc finger 3 | -0.0422997 |
| FN1 | fibronectin 1 | -0.0344766 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0343988 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0293209 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0286374 |
| MMP12 | matrix metallopeptidase 12 | -0.0271511 |
| ARF4 | ADP-ribosylation factor 4 | -0.0270906 |
| LOX | lysyl oxidase | -0.0263206 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0259064 |
| GOLGA4 | golgin A4 | -0.0241508 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.022906 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0224625 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0220812 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0212478 |
| PLIN2 | perilipin 2 | -0.0212242 |
| CTSD | cathepsin D | -0.0210555 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0195655 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0184018 |
| NOP58 | NOP58 ribonucleoprotein | -0.0178144 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0175298 |
| SPAG9 | sperm associated antigen 9 | -0.0170552 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0160196 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0160126 |
| POSTN | periostin, osteoblast specific factor | -0.0157233 |
| OSMR | oncostatin M receptor | -0.0156198 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0151051 |
| SRP54 | signal recognition particle 54kDa | -0.0150783 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0150107 |
| CCNL1 | cyclin L1 | -0.0147033 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0146208 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0145615 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0144401 |
| TMEM41B | transmembrane protein 41B | -0.0142983 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0142016 |
| TMEM263 | transmembrane protein 263 | -0.0136413 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0136265 |
| TMEM165 | transmembrane protein 165 | -0.0133524 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0133445 |
| SUCO | SUN domain containing ossification factor | -0.013281 |
| ZNF804A | zinc finger protein 804A | -0.0130714 |
| DIPK2A | divergent protein kinase domain 2A | -0.0128554 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0128031 |
| PTX3 | pentraxin 3, long | -0.0127664 |
| ECT2 | epithelial cell transforming 2 | -0.0126444 |
| SEC24A | SEC24 family member A | -0.0125354 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0125308 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0125027 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0124607 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0124128 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0123389 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0122772 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0121961 |
| S100A6 | S100 calcium binding protein A6 | -0.0121649 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0120276 |
| CEP350 | centrosomal protein 350kDa | -0.0119942 |
| FNBP4 | formin binding protein 4 | -0.0116159 |
| HLA-A | major histocompatibility complex, class I, A | -0.0115978 |
| USP3 | ubiquitin specific peptidase 3 | -0.0115889 |
| VMP1 | vacuole membrane protein 1 | -0.0111065 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0110827 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0109611 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0108909 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0108768 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0108663 |
| NRG1 | neuregulin 1 | -0.0108537 |
| RBM25 | RNA binding motif protein 25 | -0.0108141 |
| RLF | rearranged L-myc fusion | -0.0108066 |
| EIF2A | eukaryotic translation initiation factor 2A, 65kDa | -0.0108026 |
| TGFB2 | transforming growth factor, beta 2 | -0.0107988 |
| COG5 | component of oligomeric golgi complex 5 | -0.010789 |
| WDR45B | WD repeat domain 45B | -0.0107307 |
| RBM39 | RNA binding motif protein 39 | -0.0107003 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0106602 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0105305 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0105176 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0103524 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0103145 |
| COLEC10 | collectin sub-family member 10 (C-type lectin) | -0.010289 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | -0.0102666 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0101128 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0101058 |
| DTNA | dystrobrevin, alpha | -0.010053 |
| COG6 | component of oligomeric golgi complex 6 | -0.0100173 |
| FBXO42 | F-box protein 42 | -0.0100065 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.00999946 |
| U2SURP | U2 snRNP-associated SURP domain containing | -0.00997858 |
| DIS3 | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease | -0.00996111 |
| GNAS | GNAS complex locus | -0.00993423 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.00992615 |
| COL5A2 | collagen, type V, alpha 2 | -0.00989368 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.00988115 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.00986864 |
| RAI14 | retinoic acid induced 14 | -0.00986476 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0098419 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00982599 |
