TAK-733_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the TAK-733_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.198398
EXT1 exostosin glycosyltransferase 1 0.178981
DTNA dystrobrevin, alpha 0.170279
PABPC1 poly(A) binding protein, cytoplasmic 1 0.161264
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.138537
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.127829
SAMD4A sterile alpha motif domain containing 4A 0.115987
MYH9 myosin, heavy chain 9, non-muscle 0.108451
RUNX1 runt-related transcription factor 1 0.0998719
HDAC9 histone deacetylase 9 0.0998617
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0965786
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0949519
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0848255
HSPA8 heat shock 70kDa protein 8 0.0819397
FLNA filamin A, alpha 0.0800201
LOC112694756 uncharaterized LOC112694756 0.079552
PLEC plectin 0.073979
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0729281
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0688076
MSN moesin 0.0676783
MARCHF4 membrane associated ring-CH-type finger 4 0.0656521
MYO10 myosin X 0.0651345
ACTG1 actin gamma 1 0.061684
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.057645
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0574838
BRD2 bromodomain containing 2 0.0543289
PTPRG protein tyrosine phosphatase, receptor type, G 0.0543214
ERRFI1 ERBB receptor feedback inhibitor 1 0.0525042
MCTP1 multiple C2 domains, transmembrane 1 0.0505104
TRIO trio Rho guanine nucleotide exchange factor 0.0491409
CALD1 caldesmon 1 0.0486904
CD44 CD44 molecule (Indian blood group) 0.0482812
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0480432
INTS6 integrator complex subunit 6 0.0474516
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0467108
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0457732
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0450656
NAV3 neuron navigator 3 0.0443311
APP amyloid beta (A4) precursor protein 0.0442915
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0440756
ASPH aspartate beta-hydroxylase 0.0439455
MACF1 microtubule-actin crosslinking factor 1 0.042167
APLP2 amyloid beta (A4) precursor-like protein 2 0.0419569
WNK1 WNK lysine deficient protein kinase 1 0.041678
JMJD1C jumonji domain containing 1C 0.0415754
RPL3 ribosomal protein L3 0.0413032
EIF4B eukaryotic translation initiation factor 4B 0.041002
GLS2 glutaminase 2 (liver, mitochondrial) 0.0406631
PRRC2B proline-rich coiled-coil 2B 0.0406021
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0395378
KMT2D lysine (K)-specific methyltransferase 2D 0.0392092
FRMD6 FERM domain containing 6 0.0390993
USP34 ubiquitin specific peptidase 34 0.038369
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0380914
LIMA1 LIM domain and actin binding 1 0.0380208
DST dystonin 0.0379467
PKM pyruvate kinase, muscle 0.0369266
PRKCE protein kinase C, epsilon 0.0364491
TLE4 transducin-like enhancer of split 4 0.0362671
TPM3 tropomyosin 3 0.0361591
ACTN1 actinin, alpha 1 0.0359158
NCOR2 nuclear receptor corepressor 2 0.0359023
CORO1C coronin, actin binding protein, 1C 0.0347592
TRIP12 thyroid hormone receptor interactor 12 0.0347354
FLNC filamin C, gamma 0.0343367
LDHA lactate dehydrogenase A 0.033352
TLN1 talin 1 0.0332176
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.033155
PRRC2C proline-rich coiled-coil 2C 0.0330945
ZSWIM6 zinc finger, SWIM-type containing 6 0.0327182
SRRM2 serine/arginine repetitive matrix 2 0.0318542
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0314415
PRRC2A proline-rich coiled-coil 2A 0.0314061
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0313283
CD163L1 CD163 molecule-like 1 0.0306064
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0303772
AGO2 argonaute RISC catalytic component 2 0.0302956
DSCAM Down syndrome cell adhesion molecule 0.0302925
RACK1 receptor for activated C kinase 1 0.0300077
NUP58 nucleoporin 58 0.0297844
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0297071
SATB2 SATB homeobox 2 0.0293132
HMGA2 high mobility group AT-hook 2 0.0293069
NONO non-POU domain containing, octamer-binding 0.029061
FAT1 FAT atypical cadherin 1 0.0290409
DOCK4 dedicator of cytokinesis 4 0.029031
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0289458
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0287789
CDK6 cyclin-dependent kinase 6 0.0286558
ADAM32 ADAM metallopeptidase domain 32 0.0283445
EFNA5 ephrin-A5 0.0281991
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.028118
IRS2 insulin receptor substrate 2 0.0278093
CREBBP CREB binding protein 0.0274432
TRIM44 tripartite motif containing 44 0.0273993
BPTF bromodomain PHD finger transcription factor 0.0273004
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0269424
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0268575
EGR1 early growth response 1 0.0267018
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0266711

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.135813
VIM vimentin -0.110402
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0949746
PTMA prothymosin, alpha -0.0926241
MMP12 matrix metallopeptidase 12 -0.091943
TPT1 tumor protein, translationally-controlled 1 -0.0823531
CDH13 cadherin 13 -0.0567564
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0554114
PDE4D phosphodiesterase 4D, cAMP-specific -0.0507684
RPL35A ribosomal protein L35a -0.0497636
AKAP12 A kinase (PRKA) anchor protein 12 -0.0490775
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0472283
RPS6 ribosomal protein S6 -0.0463066
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0427903
RPS24 ribosomal protein S24 -0.0422257
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0418386
GPC6 glypican 6 -0.0411135
RPLP2 ribosomal protein, large, P2 -0.0389994
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0386214
MT2A metallothionein 2A -0.0377249
GNAS GNAS complex locus -0.0375923
AHNAK AHNAK nucleoprotein -0.0371184
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0357627
VCL vinculin -0.0357434
PTCHD4 patched domain containing 4 -0.0344857
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0334406
RPLP1 ribosomal protein, large, P1 -0.0324765
FN1 fibronectin 1 -0.0318601
IFI16 interferon, gamma-inducible protein 16 -0.0312045
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0311119
PHACTR1 phosphatase and actin regulator 1 -0.0296724
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0296258
RPS19 ribosomal protein S19 -0.0290425
DEK DEK proto-oncogene -0.0272991
FTL ferritin, light polypeptide -0.0272092
RPS21 ribosomal protein S21 -0.0261048
BNC2 basonuclin 2 -0.0260937
RPL34 ribosomal protein L34 -0.026063
C2CD2 C2 calcium-dependent domain containing 2 -0.025977
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0259234
RAD51B RAD51 paralog B -0.025311
ZNF292 zinc finger protein 292 -0.0251844
ALCAM activated leukocyte cell adhesion molecule -0.0240191
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.023936
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0238567
RPS27A ribosomal protein S27a -0.0236803
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0236443
NALF1 NALCN channel auxiliary factor 1 -0.0235122
RPL19 ribosomal protein L19 -0.0232723
NLGN1 neuroligin 1 -0.023164
RAI14 retinoic acid induced 14 -0.02253
PTPRD protein tyrosine phosphatase, receptor type, D -0.0222507
SMC4 structural maintenance of chromosomes 4 -0.0219627
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0219345
PNISR PNN-interacting serine/arginine-rich protein -0.0216121
FOXP1 forkhead box P1 -0.0208374
WSB1 WD repeat and SOCS box containing 1 -0.0206692
SBF2 SET binding factor 2 -0.0206277
HMGB1 high mobility group box 1 -0.0205155
RPL12 ribosomal protein L12 -0.0201423
IER3 immediate early response 3 -0.0200601
RPL23 ribosomal protein L23 -0.0200209
H1-0 H1.0 linker histone -0.019984
DIAPH3 diaphanous-related formin 3 -0.0196804
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0192327
RPL11 ribosomal protein L11 -0.0192188
TENM2 teneurin transmembrane protein 2 -0.0191167
TRPS1 trichorhinophalangeal syndrome I -0.0191036
RPL9 ribosomal protein L9 -0.018964
SEPTIN7 septin 7 -0.0188842
ZMYM2 zinc finger, MYM-type 2 -0.0187209
RPL26 ribosomal protein L26 -0.0184633
CENPF centromere protein F, 350/400kDa -0.0183236
RTN4 reticulon 4 -0.0182413
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0181349
NAMPT nicotinamide phosphoribosyltransferase -0.0181323
RPS25 ribosomal protein S25 -0.0180728
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0179435
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.017885
RPL32 ribosomal protein L32 -0.0178718
HMGA1 high mobility group AT-hook 1 -0.017847
LSAMP limbic system-associated membrane protein -0.0178009
FNDC3B fibronectin type III domain containing 3B -0.0177332
DNER delta/notch-like EGF repeat containing -0.0176532
MYL12B myosin, light chain 12B, regulatory -0.0176233
TPX2 TPX2, microtubule-associated -0.0175758
RPS29 ribosomal protein S29 -0.0174301
ZNF804A zinc finger protein 804A -0.0174163
TNNC1 troponin C type 1 (slow) -0.0173722
RPL31 ribosomal protein L31 -0.0172674
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0168826
RIGI RNA sensor RIG-I -0.0167613
RPS16 ribosomal protein S16 -0.0166043
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0164223
CAVIN1 caveolae associated protein 1 -0.0162278
RPS23 ribosomal protein S23 -0.0161232
TMEM263 transmembrane protein 263 -0.015849
NAP1L1 nucleosome assembly protein 1-like 1 -0.0157961
RPS14 ribosomal protein S14 -0.0152831
FAM162A family with sequence similarity 162, member A -0.015269