TAK-733_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.189123
FAT1 FAT atypical cadherin 1 0.187298
LMO7 LIM domain 7 0.161798
SPTBN1 spectrin, beta, non-erythrocytic 1 0.146591
CEMIP cell migration inducing protein, hyaluronan binding 0.128245
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.115881
HSPA8 heat shock 70kDa protein 8 0.107542
EEF2 eukaryotic translation elongation factor 2 0.105478
DSPP dentin sialophosphoprotein 0.100298
KRT8 keratin 8, type II 0.0989785
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0962689
KRT18 keratin 18, type I 0.0852689
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0788466
MYH9 myosin, heavy chain 9, non-muscle 0.074568
TRIM2 tripartite motif containing 2 0.0717498
EXT1 exostosin glycosyltransferase 1 0.071234
VEGFA vascular endothelial growth factor A 0.0709287
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0648363
H1-0 H1.0 linker histone 0.0610268
NEBL nebulette 0.0602659
MUC13 mucin 13, cell surface associated 0.0572602
KLF5 Kruppel-like factor 5 (intestinal) 0.0568239
SHROOM3 shroom family member 3 0.0551764
PELI1 pellino E3 ubiquitin protein ligase 1 0.0537926
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0534718
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0531791
TXNIP thioredoxin interacting protein 0.0529487
LPP LIM domain containing preferred translocation partner in lipoma 0.0521116
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0519086
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0505016
PLEC plectin 0.0504875
ATXN1 ataxin 1 0.0493441
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0484163
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0476136
MYO1E myosin IE 0.0464484
PIGR polymeric immunoglobulin receptor 0.0463486
LOC102724023 ES1 protein homolog, mitochondrial 0.0442625
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0439431
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0421473
HDAC2 histone deacetylase 2 0.0421422
ARHGAP42 Rho GTPase activating protein 42 0.0419114
TGFBR3 transforming growth factor, beta receptor III 0.0415658
NFE2L2 nuclear factor, erythroid 2-like 2 0.0413595
LOC112694756 uncharaterized LOC112694756 0.0397611
CANX calnexin 0.039504
FTH1 ferritin, heavy polypeptide 1 0.0388942
PARD3B par-3 family cell polarity regulator beta 0.0380602
SMYD3 SET and MYND domain containing 3 0.0378916
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0376715
SOS1 son of sevenless homolog 1 (Drosophila) 0.0367636
AXIN2 axin 2 0.0365989
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0365511
STC2 stanniocalcin 2 0.036519
CEMIP2 cell migration inducing hyaluronidase 2 0.0362612
PTPRK protein tyrosine phosphatase, receptor type, K 0.0362032
TTC3 tetratricopeptide repeat domain 3 0.0360204
MYO5B myosin VB 0.0358483
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0353818
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.035301
MLEC malectin 0.0352846
SEPTIN9 septin 9 0.0349301
TSC22D1 TSC22 domain family, member 1 0.0348289
APP amyloid beta (A4) precursor protein 0.0343093
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0338407
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0337639
SRRM2 serine/arginine repetitive matrix 2 0.0335411
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0333593
FOXP1 forkhead box P1 0.0332908
SOX9 SRY (sex determining region Y)-box 9 0.0331158
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0329574
SMAD2 SMAD family member 2 0.0326461
PDZD8 PDZ domain containing 8 0.0324095
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0319352
PARP4 poly (ADP-ribose) polymerase family, member 4 0.031695
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0313355
CTBP2 C-terminal binding protein 2 0.0312318
ANXA11 annexin A11 0.0307507
MACF1 microtubule-actin crosslinking factor 1 0.0302792
MYOF myoferlin 0.0299693
AFF1 AF4/FMR2 family, member 1 0.0299223
PTBP3 polypyrimidine tract binding protein 3 0.0298768
PHF3 PHD finger protein 3 0.02983
DSCAM Down syndrome cell adhesion molecule 0.0297229
IQGAP1 IQ motif containing GTPase activating protein 1 0.0287385
ZBTB20 zinc finger and BTB domain containing 20 0.0286544
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0286475
NONO non-POU domain containing, octamer-binding 0.0285957
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0282299
NUMA1 nuclear mitotic apparatus protein 1 0.0281969
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0281568
SIM2 single-minded family bHLH transcription factor 2 0.0281424
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0277998
OSBPL10 oxysterol binding protein-like 10 0.0276429
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0274229
CUX1 cut-like homeobox 1 0.0272416
SAMD4A sterile alpha motif domain containing 4A 0.0267763
AFDN afadin, adherens junction formation factor 0.0266777
USP9X ubiquitin specific peptidase 9, X-linked 0.0264545
SET SET nuclear proto-oncogene 0.026371
GAK cyclin G associated kinase 0.0262573

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.158647
NPSR1 neuropeptide S receptor 1 -0.119144
TMSB10 thymosin beta 10 -0.104967
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0904226
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0849821
RPS6 ribosomal protein S6 -0.0772683
RPL35A ribosomal protein L35a -0.0652013
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0576044
RPL37A ribosomal protein L37a -0.0502777
GREB1L growth regulation by estrogen in breast cancer-like -0.0494283
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0492551
RPS19 ribosomal protein S19 -0.048929
RPLP1 ribosomal protein, large, P1 -0.0475217
VCL vinculin -0.0473563
LAMA4 laminin, alpha 4 -0.0467393
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.046272
RPLP2 ribosomal protein, large, P2 -0.0442072
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0415741
RPS29 ribosomal protein S29 -0.0397048
RAP1B RAP1B, member of RAS oncogene family -0.0367406
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0367376
AREG amphiregulin -0.0365232
RPL23 ribosomal protein L23 -0.0360515
RPL34 ribosomal protein L34 -0.0358824
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.035375
GOLGA4 golgin A4 -0.0351069
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0332901
B2M beta-2-microglobulin -0.0327922
RPL9 ribosomal protein L9 -0.0324665
RPS24 ribosomal protein S24 -0.0324594
RPL31 ribosomal protein L31 -0.0317093
CALB1 calbindin 1, 28kDa -0.0304222
RPS25 ribosomal protein S25 -0.0303081
VMP1 vacuole membrane protein 1 -0.0300803
ANTXR2 anthrax toxin receptor 2 -0.029007
PLAUR plasminogen activator, urokinase receptor -0.0288726
HMGA1 high mobility group AT-hook 1 -0.0285124
RPL36 ribosomal protein L36 -0.0281747
S100A6 S100 calcium binding protein A6 -0.0275513
RPS13 ribosomal protein S13 -0.0275098
MT2A metallothionein 2A -0.0272795
ISG15 ISG15 ubiquitin-like modifier -0.0272096
TFF3 trefoil factor 3 (intestinal) -0.0266637
RCOR1 REST corepressor 1 -0.026618
FBXO11 F-box protein 11 -0.0261918
MAML2 mastermind-like 2 (Drosophila) -0.0261362
RPS27A ribosomal protein S27a -0.0257323
TFF1 trefoil factor 1 -0.025327
RPS11 ribosomal protein S11 -0.0247642
LSAMP limbic system-associated membrane protein -0.0245606
RPS8 ribosomal protein S8 -0.0244342
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0242468
GNAS GNAS complex locus -0.0236133
RPS23 ribosomal protein S23 -0.0231496
RPS17 ribosomal protein S17 -0.0228968
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0227382
RPL11 ribosomal protein L11 -0.0224923
ANXA2 annexin A2 -0.0224868
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0224131
RPS2 ribosomal protein S2 -0.022257
PSD3 pleckstrin and Sec7 domain containing 3 -0.0222193
S100P S100 calcium binding protein P -0.022006
S100A9 S100 calcium binding protein A9 -0.02193
RPS14 ribosomal protein S14 -0.0218858
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.02163
RPL28 ribosomal protein L28 -0.0211512
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0210765
TPT1 tumor protein, translationally-controlled 1 -0.0209766
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0207753
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0206137
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0204449
S100A14 S100 calcium binding protein A14 -0.0203276
RPL13A ribosomal protein L13a -0.0203008
USP53 ubiquitin specific peptidase 53 -0.019918
AGR2 anterior gradient 2 -0.0198551
DEK DEK proto-oncogene -0.0197309
RPS16 ribosomal protein S16 -0.019729
TMEM165 transmembrane protein 165 -0.0196751
RAB5A RAB5A, member RAS oncogene family -0.0196564
RTN4 reticulon 4 -0.019542
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0189234
HM13 histocompatibility (minor) 13 -0.0188982
EGR1 early growth response 1 -0.0187241
RPL12 ribosomal protein L12 -0.0187123
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.018666
FERMT1 fermitin family member 1 -0.0184069
GMDS GDP-mannose 4,6-dehydratase -0.0182435
CLDN7 claudin 7 -0.0181832
GCC2 GRIP and coiled-coil domain containing 2 -0.018054
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0179383
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0179028
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0178767
PNISR PNN-interacting serine/arginine-rich protein -0.0177773
RPS15 ribosomal protein S15 -0.0176849
VIM vimentin -0.017565
RNF217 ring finger protein 217 -0.0173411
RPL37 ribosomal protein L37 -0.017116
MXD1 MAX dimerization protein 1 -0.0168827
RPL26 ribosomal protein L26 -0.016821
RPL35 ribosomal protein L35 -0.0167988