TAK-733_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.130387
HSPA8 heat shock 70kDa protein 8 0.0695274
FAT1 FAT atypical cadherin 1 0.0674191
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0619729
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0530871
EXT1 exostosin glycosyltransferase 1 0.0483746
RPL3 ribosomal protein L3 0.0426904
MB21D2 Mab-21 domain containing 2 0.0419886
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0395548
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0379134
INTS6 integrator complex subunit 6 0.0371394
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0350874
MYH9 myosin, heavy chain 9, non-muscle 0.0347668
LOC102724023 ES1 protein homolog, mitochondrial 0.034362
RACK1 receptor for activated C kinase 1 0.0333836
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0288497
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0287086
PARD3B par-3 family cell polarity regulator beta 0.0280719
SRRM2 serine/arginine repetitive matrix 2 0.0272335
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0270284
LOC112694756 uncharaterized LOC112694756 0.0262173
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0256482
CANX calnexin 0.0256236
VEGFA vascular endothelial growth factor A 0.0256217
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0247675
PLEC plectin 0.0240761
TNIP1 TNFAIP3 interacting protein 1 0.0233698
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0227381
TRIM2 tripartite motif containing 2 0.0224259
ZSWIM6 zinc finger, SWIM-type containing 6 0.022205
WNK1 WNK lysine deficient protein kinase 1 0.0213463
KMT2D lysine (K)-specific methyltransferase 2D 0.0211528
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0210936
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0210449
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0200938
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0198138
DSCAM Down syndrome cell adhesion molecule 0.0193563
BRD2 bromodomain containing 2 0.0192605
AEBP2 AE binding protein 2 0.0192526
EIF4A2 eukaryotic translation initiation factor 4A2 0.0189957
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0189775
CCNYL1 cyclin Y-like 1 0.0189121
LOC105378220 macrophage receptor MARCO-like 0.018841
ARRDC3 arrestin domain containing 3 0.0187152
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0183504
HSPH1 heat shock 105kDa/110kDa protein 1 0.0183053
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0177911
CCSER1 coiled-coil serine-rich protein 1 0.0177605
TMED2 transmembrane emp24 domain trafficking protein 2 0.0172478
TUFT1 tuftelin 1 0.0172319
PLK2 polo-like kinase 2 0.0171989
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0167771
CREBBP CREB binding protein 0.0167734
LRRC23 leucine rich repeat containing 23 0.0166962
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0164302
BHLHE40 basic helix-loop-helix family, member e40 0.0161137
SQSTM1 sequestosome 1 0.0160639
ADAR adenosine deaminase, RNA-specific 0.016049
FUS FUS RNA binding protein 0.0158783
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0157456
APLP2 amyloid beta (A4) precursor-like protein 2 0.0154181
RUNX1 runt-related transcription factor 1 0.0151028
SMAD3 SMAD family member 3 0.0150504
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0149731
PGM3 phosphoglucomutase 3 0.0147586
CEMIP2 cell migration inducing hyaluronidase 2 0.0146698
ATF3 activating transcription factor 3 0.0145265
NEBL nebulette 0.0144809
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0144276
PHF3 PHD finger protein 3 0.0142857
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.014123
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0139533
MTUS1 microtubule associated tumor suppressor 1 0.0137445
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0136852
PDZD8 PDZ domain containing 8 0.0135211
NDRG1 N-myc downstream regulated 1 0.0134707
DUSP4 dual specificity phosphatase 4 0.0133518
RPS18 ribosomal protein S18 0.0130346
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0128779
FTH1 ferritin, heavy polypeptide 1 0.0128524
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0127666
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0127587
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0127458
NFE2L2 nuclear factor, erythroid 2-like 2 0.0124949
PRPF8 pre-mRNA processing factor 8 0.0121992
NONO non-POU domain containing, octamer-binding 0.0121742
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0121284
TTC3 tetratricopeptide repeat domain 3 0.0120854
MEF2C myocyte enhancer factor 2C 0.0120664
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0120594
RIPK4 receptor-interacting serine-threonine kinase 4 0.0119922
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.0119554
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 0.0119109
ATXN1 ataxin 1 0.0118606
ADGRF1 adhesion G protein-coupled receptor F1 0.0117619
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0117306
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0116882
LPP LIM domain containing preferred translocation partner in lipoma 0.0116396
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0114094
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0113488

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.166162
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.164265
THSD4 thrombospondin, type I, domain containing 4 -0.159116
RPLP1 ribosomal protein, large, P1 -0.131648
TMSB10 thymosin beta 10 -0.125972
FLNB filamin B, beta -0.106348
PTMA prothymosin, alpha -0.0942536
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0942343
ANXA2 annexin A2 -0.0920614
EZR ezrin -0.0899924
MSI2 musashi RNA-binding protein 2 -0.0840519
PDE4D phosphodiesterase 4D, cAMP-specific -0.0836349
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0826591
RPS6 ribosomal protein S6 -0.0815107
ITGA6 integrin, alpha 6 -0.0777036
PTPRR protein tyrosine phosphatase, receptor type, R -0.0751758
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0714411
RPS19 ribosomal protein S19 -0.0695377
CALB1 calbindin 1, 28kDa -0.0688477
TPT1 tumor protein, translationally-controlled 1 -0.0668997
DSG3 desmoglein 3 -0.0624644
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0621305
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0613768
RPL34 ribosomal protein L34 -0.0608838
RPS24 ribosomal protein S24 -0.0590671
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0586351
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0578077
RAP1B RAP1B, member of RAS oncogene family -0.0572019
RPL35A ribosomal protein L35a -0.0569337
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0569167
ACTN4 actinin, alpha 4 -0.0565086
UBE2H ubiquitin-conjugating enzyme E2H -0.0556768
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0552332
LAMA4 laminin, alpha 4 -0.0542489
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0537014
RPLP2 ribosomal protein, large, P2 -0.052679
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0523491
RBM25 RNA binding motif protein 25 -0.0493566
FOXO1 forkhead box O1 -0.0490099
PRSS3 protease, serine, 3 -0.0481533
GMDS GDP-mannose 4,6-dehydratase -0.0477279
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0470433
F3 coagulation factor III (thromboplastin, tissue factor) -0.0463453
VCL vinculin -0.0460985
KLF3 Kruppel-like factor 3 (basic) -0.0456793
FBXO11 F-box protein 11 -0.0453661
P3H2 prolyl 3-hydroxylase 2 -0.0444566
FERMT1 fermitin family member 1 -0.0441556
RPS21 ribosomal protein S21 -0.0434104
PERP PERP, TP53 apoptosis effector -0.042959
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0412399
S100A6 S100 calcium binding protein A6 -0.0411572
PKP2 plakophilin 2 -0.0406597
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0405828
PKM pyruvate kinase, muscle -0.0405362
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0397086
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0393431
LAMB3 laminin, beta 3 -0.0391123
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.03904
AKAP13 A kinase (PRKA) anchor protein 13 -0.0385165
ACTG1 actin gamma 1 -0.0384897
NPSR1 neuropeptide S receptor 1 -0.0384723
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0384689
RPS14 ribosomal protein S14 -0.0377588
RPL23 ribosomal protein L23 -0.0377082
RPS29 ribosomal protein S29 -0.0376207
JMJD1C jumonji domain containing 1C -0.0376152
RIGI RNA sensor RIG-I -0.037469
IFI6 interferon, alpha-inducible protein 6 -0.03743
PLAUR plasminogen activator, urokinase receptor -0.037181
C6ORF132 chromosome 6 open reading frame 132 -0.0368276
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.036593
RPL12 ribosomal protein L12 -0.0365847
AOPEP aminopeptidase O (putative) -0.0364761
RPS25 ribosomal protein S25 -0.0364325
RABGAP1L RAB GTPase activating protein 1-like -0.0359441
NT5C2 5'-nucleotidase, cytosolic II -0.0358051
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0353713
CD9 CD9 molecule -0.0343769
PSD3 pleckstrin and Sec7 domain containing 3 -0.0343054
RPS23 ribosomal protein S23 -0.0340823
MCU mitochondrial calcium uniporter -0.033767
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0336989
RPL27A ribosomal protein L27a -0.03329
S100A10 S100 calcium binding protein A10 -0.0328848
ANXA11 annexin A11 -0.0328581
DSG2 desmoglein 2 -0.0325475
RPL28 ribosomal protein L28 -0.0324411
RPL19 ribosomal protein L19 -0.0320966
TMCC1 transmembrane and coiled-coil domain family 1 -0.0319298
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0317379
SH3D19 SH3 domain containing 19 -0.0317122
EMP1 epithelial membrane protein 1 -0.0311827
RPS16 ribosomal protein S16 -0.0311706
CLDN4 claudin 4 -0.0311474
COBL cordon-bleu WH2 repeat protein -0.031094
S100A9 S100 calcium binding protein A9 -0.0310324
MAML2 mastermind-like 2 (Drosophila) -0.0308078
PCDHB16 protocadherin beta 16 -0.0305735
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0305522