| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the TAK-733_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DST | dystonin | 0.218809 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.12732 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0777314 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0694335 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.067471 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.064842 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.061312 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0598768 |
| PODXL | podocalyxin-like | 0.0572589 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0544443 |
| RUNX1 | runt-related transcription factor 1 | 0.0506718 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0506487 |
| APP | amyloid beta (A4) precursor protein | 0.0495779 |
| LOC112694756 | uncharaterized LOC112694756 | 0.04893 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0482909 |
| PLK2 | polo-like kinase 2 | 0.043315 |
| TP63 | tumor protein p63 | 0.0425158 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0412117 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0393807 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0393188 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0385911 |
| CMIP | c-Maf inducing protein | 0.0384452 |
| PLEC | plectin | 0.0381808 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0375278 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0369598 |
| RACK1 | receptor for activated C kinase 1 | 0.0368948 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0357188 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0349977 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.034907 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0345887 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0343169 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0342811 |
| RPS10 | ribosomal protein S10 | 0.0341169 |
| RPS12 | ribosomal protein S12 | 0.0335048 |
| MB21D2 | Mab-21 domain containing 2 | 0.0334139 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.033404 |
| ADAR | adenosine deaminase, RNA-specific | 0.033119 |
| NONO | non-POU domain containing, octamer-binding | 0.0322018 |
| COL5A2 | collagen, type V, alpha 2 | 0.0306379 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.030531 |
| CEP250 | centrosomal protein 250kDa | 0.030098 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0288949 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0287396 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0282319 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0281793 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0281221 |
| PYGL | phosphorylase, glycogen, liver | 0.0276963 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0272987 |
| GPHN | gephyrin | 0.0268616 |
| TNS3 | tensin 3 | 0.0267549 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0265067 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0265027 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | 0.0262543 |
| RNF213 | ring finger protein 213 | 0.0261912 |
| RPS3 | ribosomal protein S3 | 0.0261096 |
| SET | SET nuclear proto-oncogene | 0.0260351 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.025841 |
| ANXA1 | annexin A1 | 0.0256017 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0247064 |
| PRRC2A | proline-rich coiled-coil 2A | 0.024346 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0241407 |
| ANK2 | ankyrin 2, neuronal | 0.023986 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0238921 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.0236007 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0233916 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0233425 |
| RPL38 | ribosomal protein L38 | 0.0231092 |
| NPAS2 | neuronal PAS domain protein 2 | 0.022958 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0227988 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0226153 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0225684 |
| EGFR | epidermal growth factor receptor | 0.0224579 |
| CFB | complement factor B | 0.0224143 |
| HDAC9 | histone deacetylase 9 | 0.0223958 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0222806 |
| CANX | calnexin | 0.0222176 |
| KRT18 | keratin 18, type I | 0.0218756 |
| VEGFA | vascular endothelial growth factor A | 0.0218452 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0217291 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0216525 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0215737 |
| FAT1 | FAT atypical cadherin 1 | 0.0215556 |
| UBA1 | ubiquitin-like modifier activating enzyme 1 | 0.0212789 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0211014 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0210924 |
| ARFGEF3 | ARFGEF family member 3 | 0.0210402 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0209322 |
| RPL3 | ribosomal protein L3 | 0.0207861 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0207858 |
| MTCL1 | microtubule crosslinking factor 1 | 0.0207667 |
| INTS6 | integrator complex subunit 6 | 0.0207666 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0207608 |
| AEBP2 | AE binding protein 2 | 0.0207043 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0206159 |
| TGM2 | transglutaminase 2 | 0.0203479 |
| EREG | epiregulin | 0.0202375 |
| DICER1 | dicer 1, ribonuclease type III | 0.0202036 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0201423 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0200836 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0199352 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.353187 |
| TMSB10 | thymosin beta 10 | -0.197191 |
| MT2A | metallothionein 2A | -0.174022 |
| PTMA | prothymosin, alpha | -0.154248 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0809468 |
| POTEF | POTE ankyrin domain family, member F | -0.0797706 |
| EGR1 | early growth response 1 | -0.0668429 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0567164 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.053494 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0534217 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0528723 |
| HMGA1 | high mobility group AT-hook 1 | -0.0517123 |
| RAI1 | retinoic acid induced 1 | -0.049788 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0486539 |
| SLC38A2 | solute carrier family 38, member 2 | -0.048571 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0471638 |
| JMJD1C | jumonji domain containing 1C | -0.0449798 |
| FTL | ferritin, light polypeptide | -0.0418853 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0413654 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0411738 |
| TOP1 | topoisomerase (DNA) I | -0.0409786 |
| SRGN | serglycin | -0.0408631 |
| MT1E | metallothionein 1E | -0.040529 |
| RTN4 | reticulon 4 | -0.040488 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0404228 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0387164 |
| RPL35A | ribosomal protein L35a | -0.0361794 |
| TMEM41B | transmembrane protein 41B | -0.0356656 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0355643 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0347005 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0344432 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0341973 |
| ANKRD12 | ankyrin repeat domain 12 | -0.033769 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0335649 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0329726 |
| RPS6 | ribosomal protein S6 | -0.0329172 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0306946 |
| WASF2 | WAS protein family, member 2 | -0.0305194 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.0303332 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.03028 |
| CENPF | centromere protein F, 350/400kDa | -0.0299838 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0296686 |
| RBM25 | RNA binding motif protein 25 | -0.0292899 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0285119 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0278878 |
| FOSL1 | FOS-like antigen 1 | -0.0273135 |
| S100A6 | S100 calcium binding protein A6 | -0.0270861 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0268915 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0268151 |
| TPM4 | tropomyosin 4 | -0.026373 |
| MYADM | myeloid-associated differentiation marker | -0.0258888 |
| FBXO11 | F-box protein 11 | -0.0258695 |
| RPS19 | ribosomal protein S19 | -0.0255285 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0251612 |
| DEK | DEK proto-oncogene | -0.0250267 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0250246 |
| VMP1 | vacuole membrane protein 1 | -0.0247283 |
| RPLP2 | ribosomal protein, large, P2 | -0.0247202 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0246921 |
| TMSB4X | thymosin beta 4, X-linked | -0.0245142 |
| CCNL1 | cyclin L1 | -0.024389 |
| TXNRD1 | thioredoxin reductase 1 | -0.0241358 |
| SBF2 | SET binding factor 2 | -0.0239549 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0238999 |
| PTK2 | protein tyrosine kinase 2 | -0.0236397 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0231508 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0230434 |
| GNAS | GNAS complex locus | -0.0229245 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0228084 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0227565 |
| CCDC91 | coiled-coil domain containing 91 | -0.0227215 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0225391 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0222747 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.021868 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0216299 |
| ZNF292 | zinc finger protein 292 | -0.0215951 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0215236 |
| KIAA1958 | KIAA1958 | -0.0214992 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0214078 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0211465 |
| UBC | ubiquitin C | -0.0211103 |
| S100A9 | S100 calcium binding protein A9 | -0.020934 |
| RPS24 | ribosomal protein S24 | -0.0209171 |
| RPL39 | ribosomal protein L39 | -0.0206963 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0205418 |
| DPH6 | diphthamine biosynthesis 6 | -0.0203396 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0201823 |
| TUBA1B | tubulin, alpha 1b | -0.0198606 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0198285 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0198188 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0196984 |
| HLA-A | major histocompatibility complex, class I, A | -0.01958 |
| RPLP1 | ribosomal protein, large, P1 | -0.0195561 |
| EXOC4 | exocyst complex component 4 | -0.0193894 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0193741 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0190769 |
| BSG | basigin (Ok blood group) | -0.0188027 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.018636 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.018627 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0185975 |
