TAK-733_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.180224
PM20D1 peptidase M20 domain containing 1 0.164474
EEF2 eukaryotic translation elongation factor 2 0.150733
TXNRD1 thioredoxin reductase 1 0.137247
FAM107B family with sequence similarity 107, member B 0.117057
MYH9 myosin, heavy chain 9, non-muscle 0.104637
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0999679
MT2A metallothionein 2A 0.0989819
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0894951
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0880718
MACF1 microtubule-actin crosslinking factor 1 0.0867001
PLEC plectin 0.0792069
RUNX1 runt-related transcription factor 1 0.078286
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0775979
HSPA8 heat shock 70kDa protein 8 0.074659
AKAP12 A kinase (PRKA) anchor protein 12 0.0737901
APP amyloid beta (A4) precursor protein 0.0729896
CCL5 chemokine (C-C motif) ligand 5 0.0707775
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0699914
TPM3 tropomyosin 3 0.0696611
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.069576
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.06869
MYOF myoferlin 0.0649458
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0644663
FLNA filamin A, alpha 0.0632035
BRD2 bromodomain containing 2 0.0604632
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0600607
NFE2L2 nuclear factor, erythroid 2-like 2 0.0599618
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0595318
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0581563
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0572521
STC2 stanniocalcin 2 0.0554
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0550551
RPL3 ribosomal protein L3 0.0547459
SVIL supervillin 0.0525786
SFTPA2 surfactant protein A2 0.0523551
TRIO trio Rho guanine nucleotide exchange factor 0.0516087
PDE4D phosphodiesterase 4D, cAMP-specific 0.0511626
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0511242
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0506687
AGO2 argonaute RISC catalytic component 2 0.0502493
USP36 ubiquitin specific peptidase 36 0.0500732
B2M beta-2-microglobulin 0.0496034
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0485273
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.048132
LOC112694756 uncharaterized LOC112694756 0.0480695
SAMD4A sterile alpha motif domain containing 4A 0.0472652
NAMPT nicotinamide phosphoribosyltransferase 0.0470032
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0462473
PRRC2A proline-rich coiled-coil 2A 0.0462206
NTN4 netrin 4 0.0460451
CSNK1A1 casein kinase 1, alpha 1 0.0458004
FGB fibrinogen beta chain 0.0457399
SMAD3 SMAD family member 3 0.0452679
APLP2 amyloid beta (A4) precursor-like protein 2 0.0446905
ACTN1 actinin, alpha 1 0.0444074
FLNB filamin B, beta 0.0432575
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.04213
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0419436
PDE10A phosphodiesterase 10A 0.0415186
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0414046
CYTH1 cytohesin 1 0.0413548
STC1 stanniocalcin 1 0.0411565
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0402519
NDRG1 N-myc downstream regulated 1 0.0397707
SRRM2 serine/arginine repetitive matrix 2 0.0393295
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0392837
ANKRD11 ankyrin repeat domain 11 0.0390395
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.038891
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0385888
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0385772
PRRC2C proline-rich coiled-coil 2C 0.0384427
ATP11A ATPase, class VI, type 11A 0.0383363
FAT1 FAT atypical cadherin 1 0.0379351
BASP1 brain abundant, membrane attached signal protein 1 0.0378634
HLA-B major histocompatibility complex, class I, B 0.037843
NUMA1 nuclear mitotic apparatus protein 1 0.0377857
CFLAR CASP8 and FADD-like apoptosis regulator 0.0377742
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0377233
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0373795
IGF1R insulin-like growth factor 1 receptor 0.0367569
ARHGAP26 Rho GTPase activating protein 26 0.0365739
COPA coatomer protein complex, subunit alpha 0.0363437
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0362572
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0362532
ASPH aspartate beta-hydroxylase 0.0360961
SFPQ splicing factor proline/glutamine-rich 0.0360799
PFKP phosphofructokinase, platelet 0.0357492
USP37 ubiquitin specific peptidase 37 0.0357139
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0349471
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0344169
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0342308
TNIP1 TNFAIP3 interacting protein 1 0.0341666
EFNA1 ephrin-A1 0.0335856
ARID1A AT rich interactive domain 1A (SWI-like) 0.033358
EIF4A1 eukaryotic translation initiation factor 4A1 0.0333494
MIDEAS mitotic deacetylase associated SANT domain protein 0.0329508
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0329305
FNDC3B fibronectin type III domain containing 3B 0.0328167
KCMF1 potassium channel modulatory factor 1 0.0326395

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.133172
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.130057
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0914343
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0721173
VIM vimentin -0.0539305
THSD4 thrombospondin, type I, domain containing 4 -0.051714
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0504861
PTMA prothymosin, alpha -0.041156
TPT1 tumor protein, translationally-controlled 1 -0.0394856
VCL vinculin -0.039435
S100A6 S100 calcium binding protein A6 -0.0354314
RPS24 ribosomal protein S24 -0.0342353
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0336774
HMGA2 high mobility group AT-hook 2 -0.0332964
FTL ferritin, light polypeptide -0.0320785
RPS25 ribosomal protein S25 -0.0300901
RPLP1 ribosomal protein, large, P1 -0.0287946
RPL35A ribosomal protein L35a -0.0286175
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0277104
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0266488
GNAS GNAS complex locus -0.0265247
RAD51B RAD51 paralog B -0.0259695
RPS21 ribosomal protein S21 -0.0257218
HMGA1 high mobility group AT-hook 1 -0.0251931
EFNA5 ephrin-A5 -0.0247298
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0244735
CLDN1 claudin 1 -0.0239877
AK1 adenylate kinase 1 -0.0235957
DEK DEK proto-oncogene -0.0233389
OSMR oncostatin M receptor -0.0232975
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0232665
RPL34 ribosomal protein L34 -0.0226747
NEGR1 neuronal growth regulator 1 -0.0224726
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0222476
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0221778
ECT2 epithelial cell transforming 2 -0.0218292
IER3 immediate early response 3 -0.0210242
EGR1 early growth response 1 -0.0207756
RPS6 ribosomal protein S6 -0.0203086
RPS27A ribosomal protein S27a -0.020087
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0198864
RPS5 ribosomal protein S5 -0.0198088
RPS23 ribosomal protein S23 -0.0196925
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0190058
DOCK4 dedicator of cytokinesis 4 -0.0189462
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0188013
ZBTB20 zinc finger and BTB domain containing 20 -0.0185944
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0181687
PCED1B PC-esterase domain containing 1B -0.018108
HMGB1 high mobility group box 1 -0.0180471
MSRB3 methionine sulfoxide reductase B3 -0.0179123
RPL9 ribosomal protein L9 -0.017864
RPS16 ribosomal protein S16 -0.017785
NABP1 nucleic acid binding protein 1 -0.017769
MYL12B myosin, light chain 12B, regulatory -0.0176097
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0175858
COTL1 coactosin-like F-actin binding protein 1 -0.0174903
RPS20 ribosomal protein S20 -0.0174052
RPL26 ribosomal protein L26 -0.0172889
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0171028
AHNAK AHNAK nucleoprotein -0.017076
MAML3 mastermind-like 3 (Drosophila) -0.0165012
ATP5F1B ATP synthase F1 subunit beta -0.0163097
RPS19 ribosomal protein S19 -0.0163085
RPL31 ribosomal protein L31 -0.0157785
USP34 ubiquitin specific peptidase 34 -0.0157516
RPL12 ribosomal protein L12 -0.0157025
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.015521
MORF4L1 mortality factor 4 like 1 -0.0154093
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0153053
IGFBP4 insulin-like growth factor binding protein 4 -0.0150942
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0149967
RPL32 ribosomal protein L32 -0.0147694
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0145451
TAS2R14 taste receptor, type 2, member 14 -0.0144894
TPM4 tropomyosin 4 -0.0144245
RPS15 ribosomal protein S15 -0.0140981
RPLP2 ribosomal protein, large, P2 -0.0140392
NEMF nuclear export mediator factor -0.0139228
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0136276
RTN4 reticulon 4 -0.0134812
CCDC7 coiled-coil domain containing 7 -0.0134399
THBS1 thrombospondin 1 -0.0134084
DIAPH3 diaphanous-related formin 3 -0.0133072
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.01319
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0131249
CFAP73 cilia and flagella associated protein 73 -0.0131206
SMC4 structural maintenance of chromosomes 4 -0.0129398
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0128942
DENND4A DENN/MADD domain containing 4A -0.0128663
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0128302
BABAM2 BRISC and BRCA1 A complex member 2 -0.0128235
MAP4 microtubule-associated protein 4 -0.0127043
DMD dystrophin -0.0126913
GARS1 glycyl-tRNA synthetase 1 -0.0125643
RPL36AL ribosomal protein L36a-like -0.0124804
PRR16 proline rich 16 -0.0124753
NHSL1 NHS-like 1 -0.0124227
FBXL2 F-box and leucine-rich repeat protein 2 -0.0123766
MCTP1 multiple C2 domains, transmembrane 1 -0.0123747