TAK-733_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the TAK-733_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.177085
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.116972
PABPC1 poly(A) binding protein, cytoplasmic 1 0.10203
MYH9 myosin, heavy chain 9, non-muscle 0.0898769
TXNRD1 thioredoxin reductase 1 0.0838513
GRAMD1B GRAM domain containing 1B 0.0819779
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0794282
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0741235
HSPA8 heat shock 70kDa protein 8 0.0705541
WNK1 WNK lysine deficient protein kinase 1 0.0693883
ADAR adenosine deaminase, RNA-specific 0.0692071
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0688959
PLEC plectin 0.0675511
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0639446
TPM3 tropomyosin 3 0.0583049
MACF1 microtubule-actin crosslinking factor 1 0.0581112
BRD2 bromodomain containing 2 0.056139
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0530993
FUS FUS RNA binding protein 0.0520746
INTS6 integrator complex subunit 6 0.0504899
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0501705
RUNX1 runt-related transcription factor 1 0.0499479
KRT18 keratin 18, type I 0.0497648
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0491696
SFPQ splicing factor proline/glutamine-rich 0.0487117
PDE4D phosphodiesterase 4D, cAMP-specific 0.048153
KMT2D lysine (K)-specific methyltransferase 2D 0.048046
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0462928
PRRC2A proline-rich coiled-coil 2A 0.0462353
DST dystonin 0.0460327
UBAP2L ubiquitin associated protein 2-like 0.0440248
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0439758
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0426417
YAP1 Yes-associated protein 1 0.0410118
FLNA filamin A, alpha 0.0407698
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0405796
ATP11A ATPase, class VI, type 11A 0.0405191
RPL3 ribosomal protein L3 0.0402205
NONO non-POU domain containing, octamer-binding 0.0401429
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0399981
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0389116
SMAD3 SMAD family member 3 0.0388158
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0388004
NFE2L2 nuclear factor, erythroid 2-like 2 0.0387068
TRIO trio Rho guanine nucleotide exchange factor 0.038319
ZSWIM6 zinc finger, SWIM-type containing 6 0.0381362
CTTN cortactin 0.0380579
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0376483
TLN1 talin 1 0.0376309
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0369651
ACTN1 actinin, alpha 1 0.0369451
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0362858
PDLIM5 PDZ and LIM domain 5 0.0362558
HOMER1 homer scaffolding protein 1 0.0361756
EGR1 early growth response 1 0.0356952
CEP250 centrosomal protein 250kDa 0.035539
ARID1A AT rich interactive domain 1A (SWI-like) 0.0355
PDE10A phosphodiesterase 10A 0.0354784
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0353985
COPA coatomer protein complex, subunit alpha 0.0350276
CSNK1A1 casein kinase 1, alpha 1 0.0339451
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0335801
ANO6 anoctamin 6 0.0334115
IPO7 importin 7 0.0326058
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0323235
AEBP2 AE binding protein 2 0.0322207
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0318388
TRIP12 thyroid hormone receptor interactor 12 0.0313151
ZFAND3 zinc finger, AN1-type domain 3 0.0311254
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0310785
SHB Src homology 2 domain containing adaptor protein B 0.030874
ANKRD17 ankyrin repeat domain 17 0.0301583
SRRM2 serine/arginine repetitive matrix 2 0.0300928
DOCK5 dedicator of cytokinesis 5 0.0298721
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0295282
MEF2D myocyte enhancer factor 2D 0.0293533
APLP2 amyloid beta (A4) precursor-like protein 2 0.0290267
CLTC clathrin, heavy chain (Hc) 0.0289002
SNAP25 synaptosomal-associated protein, 25kDa 0.0288265
ERRFI1 ERBB receptor feedback inhibitor 1 0.0288106
NUMA1 nuclear mitotic apparatus protein 1 0.0287084
SND1 staphylococcal nuclease and tudor domain containing 1 0.0281299
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0276204
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0275163
RAB7A RAB7A, member RAS oncogene family 0.0274269
CPNE1 copine I 0.0274044
CCDC200 coiled-coil domain containing 200 0.0273908
ZBTB1 zinc finger and BTB domain containing 1 0.0273401
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0272696
DIDO1 death inducer-obliterator 1 0.0270804
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0270438
SRSF6 serine/arginine-rich splicing factor 6 0.0269166
RAD23B RAD23 homolog B (S. cerevisiae) 0.0269015
PRRC2B proline-rich coiled-coil 2B 0.0267739
DCTN1 dynactin 1 0.0267054
SET SET nuclear proto-oncogene 0.0265848
FKBP4 FK506 binding protein 4, 59kDa 0.0265507
SVIL supervillin 0.0263507
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0262794
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0262634

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.115355
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0814294
PTMA prothymosin, alpha -0.0801735
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0776883
VIM vimentin -0.0583314
MYL12B myosin, light chain 12B, regulatory -0.0525764
TPT1 tumor protein, translationally-controlled 1 -0.048347
RPL35A ribosomal protein L35a -0.044573
RPL37 ribosomal protein L37 -0.0438489
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0430229
ZBTB20 zinc finger and BTB domain containing 20 -0.0416451
RPLP1 ribosomal protein, large, P1 -0.041131
AKAP12 A kinase (PRKA) anchor protein 12 -0.0407787
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0398134
WSB1 WD repeat and SOCS box containing 1 -0.0388923
RPS27A ribosomal protein S27a -0.0381426
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0379376
RSF1 remodeling and spacing factor 1 -0.0364936
RPL34 ribosomal protein L34 -0.036162
GNAS GNAS complex locus -0.0360392
MT2A metallothionein 2A -0.0349549
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0344736
RPS21 ribosomal protein S21 -0.0344727
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0334208
RPL26 ribosomal protein L26 -0.0333998
TM4SF1 transmembrane 4 L six family member 1 -0.0331657
RPL12 ribosomal protein L12 -0.0327081
KDM3A lysine (K)-specific demethylase 3A -0.03231
RTN4 reticulon 4 -0.0323091
RPL31 ribosomal protein L31 -0.0315755
RPL37A ribosomal protein L37a -0.0313351
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0311824
TPM4 tropomyosin 4 -0.0303809
RPS24 ribosomal protein S24 -0.0302322
S100A6 S100 calcium binding protein A6 -0.030172
BBX bobby sox homolog (Drosophila) -0.0301303
TFPI2 tissue factor pathway inhibitor 2 -0.0292634
RPS29 ribosomal protein S29 -0.0285021
TMEM165 transmembrane protein 165 -0.0284324
ZMYND8 zinc finger, MYND-type containing 8 -0.0281949
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0275343
SEPTIN7 septin 7 -0.0273974
RPS19 ribosomal protein S19 -0.0271751
BASP1 brain abundant, membrane attached signal protein 1 -0.0269725
RPL11 ribosomal protein L11 -0.0269569
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0263514
IER3 immediate early response 3 -0.026036
RPS27 ribosomal protein S27 -0.0259599
RPL36 ribosomal protein L36 -0.0259341
FTL ferritin, light polypeptide -0.0259107
YBX3 Y box binding protein 3 -0.0257434
RPLP2 ribosomal protein, large, P2 -0.0256629
ZFR zinc finger RNA binding protein -0.0256547
RPS6 ribosomal protein S6 -0.0248641
OSMR oncostatin M receptor -0.0247543
TAS2R14 taste receptor, type 2, member 14 -0.0243554
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0242843
GCC2 GRIP and coiled-coil domain containing 2 -0.0241208
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0237224
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0237155
RYR3 ryanodine receptor 3 -0.0235627
CCDC91 coiled-coil domain containing 91 -0.0234305
RPS15 ribosomal protein S15 -0.022875
CAVIN1 caveolae associated protein 1 -0.0228582
SLC38A1 solute carrier family 38, member 1 -0.0225697
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0225049
S100A11 S100 calcium binding protein A11 -0.0221804
EHBP1 EH domain binding protein 1 -0.022138
NCOA7 nuclear receptor coactivator 7 -0.0221335
ZNF292 zinc finger protein 292 -0.0218127
ITSN1 intersectin 1 (SH3 domain protein) -0.0217015
ANKRD12 ankyrin repeat domain 12 -0.021667
RPL19 ribosomal protein L19 -0.0216354
CLDN1 claudin 1 -0.0215308
PHF21A PHD finger protein 21A -0.0213726
RBM25 RNA binding motif protein 25 -0.021137
VDAC1 voltage-dependent anion channel 1 -0.0207177
RPL23 ribosomal protein L23 -0.0204633
SMC4 structural maintenance of chromosomes 4 -0.020457
IFI6 interferon, alpha-inducible protein 6 -0.0204126
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0203649
RPS8 ribosomal protein S8 -0.0202777
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.020229
RPL9 ribosomal protein L9 -0.0201569
THOC2 THO complex 2 -0.0201399
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0199515
SBF2 SET binding factor 2 -0.0198702
KDM2A lysine (K)-specific demethylase 2A -0.0196925
RPS25 ribosomal protein S25 -0.0193357
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.019276
RPS3 ribosomal protein S3 -0.019107
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0190234
GOLGA4 golgin A4 -0.0189979
TUT4 terminal uridylyl transferase 4 -0.0185934
LATS2 large tumor suppressor kinase 2 -0.0184774
RPL36A ribosomal protein L36a -0.0184664
RPL4 ribosomal protein L4 -0.0183754
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0182543
RPS20 ribosomal protein S20 -0.0182357
PFN1 profilin 1 -0.0181197