TAK-733_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

117 genes differentially expressed following the TAK-733_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.286816
EGFR epidermal growth factor receptor 0.176384
MACF1 microtubule-actin crosslinking factor 1 0.136251
SRRM2 serine/arginine repetitive matrix 2 0.130396
AKAP12 A kinase (PRKA) anchor protein 12 0.129327
MYH9 myosin, heavy chain 9, non-muscle 0.120616
PKM pyruvate kinase, muscle 0.119354
ERRFI1 ERBB receptor feedback inhibitor 1 0.111317
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.111246
PLEC plectin 0.108254
EPS8 epidermal growth factor receptor pathway substrate 8 0.101344
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0998288
RPLP1 ribosomal protein, large, P1 0.0979377
ARF1 ADP-ribosylation factor 1 0.0955059
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0927595
SNX9 sorting nexin 9 0.0922955
DNAH14 dynein, axonemal, heavy chain 14 0.0891069
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0825293
SMAD3 SMAD family member 3 0.081934
THSD4 thrombospondin, type I, domain containing 4 0.0812172
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0799581
SLTM SAFB-like, transcription modulator 0.0785461
MYO1E myosin IE 0.0783417
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0763022
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0750828
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0704776
COL6A3 collagen, type VI, alpha 3 0.0692531
CD44 CD44 molecule (Indian blood group) 0.0688918
B2M beta-2-microglobulin 0.0688023
VEGFA vascular endothelial growth factor A 0.0656249
TPT1 tumor protein, translationally-controlled 1 0.0644195
ANO6 anoctamin 6 0.0629746
RPS12 ribosomal protein S12 0.0618295
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0596152
THOC2 THO complex 2 0.0582227
KLF5 Kruppel-like factor 5 (intestinal) 0.0560213
FTL ferritin, light polypeptide 0.0524369
RPL12 ribosomal protein L12 0.051386
ARHGAP12 Rho GTPase activating protein 12 0.0503552
RASAL2 RAS protein activator like 2 0.0499137
EEF2 eukaryotic translation elongation factor 2 0.0475853
JMJD1C jumonji domain containing 1C 0.0474108
CLTC clathrin, heavy chain (Hc) 0.0473817
LOC112694756 uncharaterized LOC112694756 0.0440258
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0397516
RPS6 ribosomal protein S6 0.0391014
ANKRD11 ankyrin repeat domain 11 0.0366342
ASPH aspartate beta-hydroxylase 0.0355629
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0335705
ENO1 enolase 1, (alpha) 0.0332018
ACTG1 actin gamma 1 0.031768
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0295831
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0248143
INTS6 integrator complex subunit 6 0.024654
BIRC6 baculoviral IAP repeat containing 6 0.0230317
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0225521
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0209117
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0205167
PTMA prothymosin, alpha 0.0184704
GOLGA4 golgin A4 0.0169453
WDFY3 WD repeat and FYVE domain containing 3 0.0119846
TJP1 tight junction protein 1 0.0110475
IRS2 insulin receptor substrate 2 0.00623336
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.00594846
NDRG1 N-myc downstream regulated 1 0.00562815
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00548703
ZNF292 zinc finger protein 292 5.24015E-4

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.172379
ZBTB20 zinc finger and BTB domain containing 20 -0.16817
EFNA5 ephrin-A5 -0.158699
ESYT2 extended synaptotagmin-like protein 2 -0.150471
KMT2C lysine (K)-specific methyltransferase 2C -0.150347
VMP1 vacuole membrane protein 1 -0.147325
TRIO trio Rho guanine nucleotide exchange factor -0.135338
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.13378
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.131353
IGFBP3 insulin-like growth factor binding protein 3 -0.130831
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.119128
MYOF myoferlin -0.115839
NALF1 NALCN channel auxiliary factor 1 -0.109779
PDE10A phosphodiesterase 10A -0.109626
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.105348
FLNB filamin B, beta -0.0915113
SAMD4A sterile alpha motif domain containing 4A -0.0791315
PDE4D phosphodiesterase 4D, cAMP-specific -0.078367
VIM vimentin -0.0689562
FNDC3B fibronectin type III domain containing 3B -0.0688628
LIMCH1 LIM and calponin homology domains 1 -0.0583176
PSD3 pleckstrin and Sec7 domain containing 3 -0.0567375
FMNL2 formin-like 2 -0.0563546
MAML3 mastermind-like 3 (Drosophila) -0.055655
MYO9A myosin IXA -0.0530416
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0523647
MED13L mediator complex subunit 13-like -0.0521696
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.052023
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0499608
TTC3 tetratricopeptide repeat domain 3 -0.0472014
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0455632
CDH13 cadherin 13 -0.0451447
INHBA inhibin, beta A -0.0448024
NF1 neurofibromin 1 -0.044528
RBM39 RNA binding motif protein 39 -0.0438128
WSB1 WD repeat and SOCS box containing 1 -0.0406043
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0366397
SEC31A SEC31 homolog A (S. cerevisiae) -0.0361556
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0340829
ANKHD1 ankyrin repeat and KH domain containing 1 -0.032773
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0327315
ANKRD17 ankyrin repeat domain 17 -0.025229
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0214733
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0209212
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0189786
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.018031
DST dystonin -0.0111035
TMSB10 thymosin beta 10 -0.00940261
LCOR ligand dependent nuclear receptor corepressor -0.00866739
GNAS GNAS complex locus -0.00749426