| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the TAK-733_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.152063 |
| HDAC9 | histone deacetylase 9 | 0.122187 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.121445 |
| COL11A1 | collagen, type XI, alpha 1 | 0.118402 |
| DST | dystonin | 0.11445 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.101293 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0985036 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0961471 |
| CADM2 | cell adhesion molecule 2 | 0.0921678 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0775393 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0714929 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0707436 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0704642 |
| RASAL2 | RAS protein activator like 2 | 0.0697936 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0664484 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.066035 |
| APP | amyloid beta (A4) precursor protein | 0.0650709 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0648061 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0629076 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0591744 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0586726 |
| TENM3 | teneurin transmembrane protein 3 | 0.0577404 |
| WDR43 | WD repeat domain 43 | 0.0567451 |
| USP25 | ubiquitin specific peptidase 25 | 0.0566207 |
| MYO10 | myosin X | 0.0556239 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0547826 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0546592 |
| COL5A2 | collagen, type V, alpha 2 | 0.0534752 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0531765 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0524924 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0516033 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0514973 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0511776 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0509471 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0501151 |
| ANK2 | ankyrin 2, neuronal | 0.0494041 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0486935 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0477842 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0466399 |
| ENAH | enabled homolog (Drosophila) | 0.0464178 |
| RBM20 | RNA binding motif protein 20 | 0.0463169 |
| NTM | neurotrimin | 0.0461335 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0453379 |
| NONO | non-POU domain containing, octamer-binding | 0.0450029 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0446069 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0445193 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0437046 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0427499 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0416953 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0413108 |
| SMYD3 | SET and MYND domain containing 3 | 0.0407952 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0403108 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.039723 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0393928 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0390442 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0377162 |
| ZNF292 | zinc finger protein 292 | 0.0377062 |
| ZFHX4 | zinc finger homeobox 4 | 0.0373848 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0373746 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0372698 |
| RPL3 | ribosomal protein L3 | 0.0368729 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0367378 |
| HMCN1 | hemicentin 1 | 0.0365776 |
| FNDC3B | fibronectin type III domain containing 3B | 0.036488 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0364393 |
| FOXP2 | forkhead box P2 | 0.0362163 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0359404 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0358887 |
| NHSL1 | NHS-like 1 | 0.0357497 |
| LRRC4C | leucine rich repeat containing 4C | 0.0356771 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0355171 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0348039 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.034754 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0347501 |
| GPC3 | glypican 3 | 0.0346808 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0346509 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0342966 |
| FUS | FUS RNA binding protein | 0.0341603 |
| TFRC | transferrin receptor | 0.0340064 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 0.0340061 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0338757 |
| ZNF217 | zinc finger protein 217 | 0.0333932 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0330695 |
| WWC2 | WW and C2 domain containing 2 | 0.0329829 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0328667 |
| ATXN2 | ataxin 2 | 0.0322406 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0320933 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.0316104 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0312637 |
| SHROOM3 | shroom family member 3 | 0.0311316 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0305965 |
| SRPK2 | SRSF protein kinase 2 | 0.030481 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.030362 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0298904 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0298624 |
| GSE1 | Gse1 coiled-coil protein | 0.0296927 |
| BRD2 | bromodomain containing 2 | 0.0296679 |
| DIDO1 | death inducer-obliterator 1 | 0.0295509 |
| CLTC | clathrin, heavy chain (Hc) | 0.0293618 |
| SARS1 | seryl-tRNA synthetase 1 | 0.0293083 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.165655 |
| TMSB10 | thymosin beta 10 | -0.146063 |
| PTMA | prothymosin, alpha | -0.142975 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0818935 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0746645 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.058927 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0571492 |
| DEK | DEK proto-oncogene | -0.0557823 |
| CENPF | centromere protein F, 350/400kDa | -0.0551044 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0525683 |
| FTL | ferritin, light polypeptide | -0.0495895 |
| HMGB1 | high mobility group box 1 | -0.0476862 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0439573 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0431475 |
| B2M | beta-2-microglobulin | -0.0427086 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0410742 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0407223 |
| RTN4 | reticulon 4 | -0.0393228 |
| RPLP1 | ribosomal protein, large, P1 | -0.0390945 |
| UBC | ubiquitin C | -0.0385932 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0378792 |
| SMC4 | structural maintenance of chromosomes 4 | -0.037661 |
| GNAS | GNAS complex locus | -0.0371708 |
| BBX | bobby sox homolog (Drosophila) | -0.0368797 |
| RPL31 | ribosomal protein L31 | -0.0361045 |
| COL3A1 | collagen, type III, alpha 1 | -0.0352569 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.03446 |
| DSTN | destrin (actin depolymerizing factor) | -0.0344183 |
| RPS16 | ribosomal protein S16 | -0.0344051 |
| RPS24 | ribosomal protein S24 | -0.033329 |
| AHNAK | AHNAK nucleoprotein | -0.0333054 |
| PFN1 | profilin 1 | -0.0323978 |
| PCBP2 | poly(rC) binding protein 2 | -0.0313344 |
| POTEF | POTE ankyrin domain family, member F | -0.0312757 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0311956 |
| PRR11 | proline rich 11 | -0.0306801 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0305616 |
| EMP1 | epithelial membrane protein 1 | -0.030523 |
| RBM25 | RNA binding motif protein 25 | -0.0304952 |
| CENPE | centromere protein E, 312kDa | -0.0303904 |
| TPX2 | TPX2, microtubule-associated | -0.0298021 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0296861 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0296675 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0296541 |
| RPLP2 | ribosomal protein, large, P2 | -0.0294784 |
| MKI67 | marker of proliferation Ki-67 | -0.0288969 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0282302 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0275525 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0274243 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0273418 |
| RPS25 | ribosomal protein S25 | -0.0267441 |
| RPL35A | ribosomal protein L35a | -0.0263633 |
| RPS27A | ribosomal protein S27a | -0.0263604 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0258457 |
| RSF1 | remodeling and spacing factor 1 | -0.0258121 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0256032 |
| S100A10 | S100 calcium binding protein A10 | -0.0254761 |
| RPL34 | ribosomal protein L34 | -0.0254306 |
| GPX4 | glutathione peroxidase 4 | -0.0253946 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0250612 |
| HMGA1 | high mobility group AT-hook 1 | -0.0247449 |
| NDRG1 | N-myc downstream regulated 1 | -0.0247378 |
| PRR16 | proline rich 16 | -0.0245953 |
| RPL28 | ribosomal protein L28 | -0.0242689 |
| SGO2 | shugoshin 2 | -0.0242085 |
| RLF | rearranged L-myc fusion | -0.0241523 |
| ASPH | aspartate beta-hydroxylase | -0.0236963 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0235949 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0235748 |
| MORF4L2 | mortality factor 4 like 2 | -0.0235633 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0234856 |
| TUBA1B | tubulin, alpha 1b | -0.0234785 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0228595 |
| TPM4 | tropomyosin 4 | -0.022732 |
| COL1A2 | collagen, type I, alpha 2 | -0.0226832 |
| CBX3 | chromobox homolog 3 | -0.0226322 |
| TBC1D12 | TBC1 domain family, member 12 | -0.0223004 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0221154 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0220041 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0219573 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.021771 |
| FOXO3 | forkhead box O3 | -0.0217378 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0216399 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0216117 |
| ASTN2 | astrotactin 2 | -0.0213308 |
| SERF2 | small EDRK-rich factor 2 | -0.0211618 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0210047 |
| BRDT | bromodomain, testis-specific | -0.0209218 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.020486 |
| DEPDC1 | DEP domain containing 1 | -0.0202457 |
| MORF4L1 | mortality factor 4 like 1 | -0.0201194 |
| RHOA | ras homolog family member A | -0.0200455 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0193797 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0193405 |
| FOXC1 | forkhead box C1 | -0.0191965 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0191895 |
| PCDH9 | protocadherin 9 | -0.0188791 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | -0.0186749 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0186697 |
| RPS13 | ribosomal protein S13 | -0.0186364 |
