TAK-733_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FBL fibrillarin 0.166013
PABPC1 poly(A) binding protein, cytoplasmic 1 0.122554
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.107179
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.100353
EEF2 eukaryotic translation elongation factor 2 0.07499
MYH9 myosin, heavy chain 9, non-muscle 0.0727773
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0678472
DST dystonin 0.0664404
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.064303
AKAP12 A kinase (PRKA) anchor protein 12 0.061915
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0585929
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0567267
TRIO trio Rho guanine nucleotide exchange factor 0.0562861
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0538629
RPS3 ribosomal protein S3 0.0518621
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0517348
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0514267
RPS12 ribosomal protein S12 0.0505744
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 0.0501687
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.0500114
ENO1 enolase 1, (alpha) 0.0496916
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0489395
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0478357
HSPA8 heat shock 70kDa protein 8 0.0466726
LOC112694756 uncharaterized LOC112694756 0.046402
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0463757
SRRM2 serine/arginine repetitive matrix 2 0.0453833
SAMD4B sterile alpha motif domain containing 4B 0.0446913
PKM pyruvate kinase, muscle 0.0444988
SET SET nuclear proto-oncogene 0.0443816
KRT18 keratin 18, type I 0.0442375
ANXA2 annexin A2 0.0433971
PLEC plectin 0.0433289
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0428082
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0427772
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0425593
RPS16 ribosomal protein S16 0.0411329
LDHA lactate dehydrogenase A 0.0405193
MKI67 marker of proliferation Ki-67 0.0404058
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0397579
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0395204
RPS8 ribosomal protein S8 0.0392722
MACF1 microtubule-actin crosslinking factor 1 0.0389851
SFTPA2 surfactant protein A2 0.038688
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.038599
RACK1 receptor for activated C kinase 1 0.0385382
PRRC2C proline-rich coiled-coil 2C 0.0376286
RPS17 ribosomal protein S17 0.0367868
YBX1 Y box binding protein 1 0.0363135
UPP1 uridine phosphorylase 1 0.0356159
GARS1 glycyl-tRNA synthetase 1 0.035448
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0350224
SMAD3 SMAD family member 3 0.0349189
KRT8 keratin 8, type II 0.0345897
SERBP1 SERPINE1 mRNA binding protein 1 0.0345439
FRMD5 FERM domain containing 5 0.0335548
RPL37A ribosomal protein L37a 0.0333961
PA2G4 proliferation-associated 2G4, 38kDa 0.033177
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0331016
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0328912
APLP2 amyloid beta (A4) precursor-like protein 2 0.0327461
RPS10 ribosomal protein S10 0.0324821
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0324066
ENAH enabled homolog (Drosophila) 0.0323863
STC2 stanniocalcin 2 0.0320782
TPM3 tropomyosin 3 0.0317022
EIF3K eukaryotic translation initiation factor 3, subunit K 0.031524
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.031283
CANX calnexin 0.0310652
FAT1 FAT atypical cadherin 1 0.0309967
VEGFA vascular endothelial growth factor A 0.0305326
CTTN cortactin 0.0301743
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0297931
APP amyloid beta (A4) precursor protein 0.0296986
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0285073
KTN1 kinectin 1 (kinesin receptor) 0.0283662
SAMD4A sterile alpha motif domain containing 4A 0.0281596
KPNB1 karyopherin (importin) beta 1 0.0279392
TXNRD1 thioredoxin reductase 1 0.0277134
RPL11 ribosomal protein L11 0.0272818
B2M beta-2-microglobulin 0.0270375
IPO7 importin 7 0.0268968
WNK1 WNK lysine deficient protein kinase 1 0.0268103
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0264058
RPS27A ribosomal protein S27a 0.0262026
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0261715
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0260722
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0260134
CLIP1 CAP-GLY domain containing linker protein 1 0.0256149
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0252843
RPLP2 ribosomal protein, large, P2 0.0250953
NOP56 NOP56 ribonucleoprotein 0.0248689
CLTA clathrin, light chain A 0.0246066
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0245788
CYCS cytochrome c, somatic 0.024472
RPS13 ribosomal protein S13 0.0243883
NUP98 nucleoporin 98kDa 0.0243157
RPL38 ribosomal protein L38 0.0243135
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.024159
PGK1 phosphoglycerate kinase 1 0.0240985

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.113242
VCL vinculin -0.0699355
TM4SF1 transmembrane 4 L six family member 1 -0.049551
EGR1 early growth response 1 -0.040504
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0393711
MCL1 myeloid cell leukemia 1 -0.0317605
WWTR1 WW domain containing transcription regulator 1 -0.030506
TMSB10 thymosin beta 10 -0.0302685
S100A6 S100 calcium binding protein A6 -0.0275529
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0214108
ZFP36 ZFP36 ring finger protein -0.0211471
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0198785
THSD4 thrombospondin, type I, domain containing 4 -0.019845
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0193636
SBF2 SET binding factor 2 -0.0189169
MT2A metallothionein 2A -0.0181036
ELL2 elongation factor, RNA polymerase II, 2 -0.0177395
CTSD cathepsin D -0.0173207
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0167861
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0167859
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0164276
JMJD1C jumonji domain containing 1C -0.0163996
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0156841
ZBTB20 zinc finger and BTB domain containing 20 -0.0152869
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0146833
VMP1 vacuole membrane protein 1 -0.0146044
RAP1B RAP1B, member of RAS oncogene family -0.0145842
CD44 CD44 molecule (Indian blood group) -0.0144449
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.013969
SLC38A2 solute carrier family 38, member 2 -0.0136198
ATG7 autophagy related 7 -0.0136092
MAML3 mastermind-like 3 (Drosophila) -0.0132662
PTMA prothymosin, alpha -0.0124455
EFNA5 ephrin-A5 -0.012368
ATM ATM serine/threonine kinase -0.0121643
AHNAK AHNAK nucleoprotein -0.0120569
BMAL2 basic helix-loop-helix ARNT like 2 -0.0120159
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0118721
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0118204
HMGA2 high mobility group AT-hook 2 -0.0112057
KAT6B K(lysine) acetyltransferase 6B -0.0109915
PDE10A phosphodiesterase 10A -0.010786
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0107383
NABP1 nucleic acid binding protein 1 -0.010571
ANTXR2 anthrax toxin receptor 2 -0.0105415
C15ORF48 chromosome 15 open reading frame 48 -0.0103619
RTN4 reticulon 4 -0.0103255
MOSMO modulator of smoothened -0.0103186
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0102454
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0100529
TPT1 tumor protein, translationally-controlled 1 -0.00971917
MED29 mediator complex subunit 29 -0.00928371
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.00906037
ZMYND8 zinc finger, MYND-type containing 8 -0.00904029
BLZF1 basic leucine zipper nuclear factor 1 -0.00887408
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.00870352
RASA2 RAS p21 protein activator 2 -0.00869954
GCC2 GRIP and coiled-coil domain containing 2 -0.00849769
KLF7 Kruppel-like factor 7 (ubiquitous) -0.00840317
PNRC1 proline-rich nuclear receptor coactivator 1 -0.00836401
NPAS2 neuronal PAS domain protein 2 -0.0082756
ZNF546 zinc finger protein 546 -0.00817878
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00817624
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.00813522
MON2 MON2 homolog (S. cerevisiae) -0.00809782
ODF2L outer dense fiber of sperm tails 2-like -0.0080295
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.00787794
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.00779242
SYT1 synaptotagmin I -0.0077831
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.00769848
TMEM263 transmembrane protein 263 -0.00768406
SPRY4 sprouty homolog 4 (Drosophila) -0.00767817
MARF1 meiosis regulator and mRNA stability factor 1 -0.00760768
AKAP9 A kinase (PRKA) anchor protein 9 -0.00759899
STK17A serine/threonine kinase 17a -0.00748494
CD59 CD59 molecule, complement regulatory protein -0.00741254
OGA O-GlcNAcase -0.00739062
MCTP1 multiple C2 domains, transmembrane 1 -0.00738046
BCAS3 breast carcinoma amplified sequence 3 -0.00736893
ELF2 E74-like factor 2 (ets domain transcription factor) -0.00734088
HMGA1 high mobility group AT-hook 1 -0.00732625
LRRC49 leucine rich repeat containing 49 -0.00729034
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0072613
SMIM14 small integral membrane protein 14 -0.00721813
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.00719826
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00713287
RB1CC1 RB1-inducible coiled-coil 1 -0.00712775
RPS24 ribosomal protein S24 -0.00704307
BMP6 bone morphogenetic protein 6 -0.00698533
NT5E 5'-nucleotidase, ecto (CD73) -0.0069502
EXT1 exostosin glycosyltransferase 1 -0.00693474
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.00686014
CCDC91 coiled-coil domain containing 91 -0.00682458
BTG1 B-cell translocation gene 1, anti-proliferative -0.00671354
TUT7 terminal uridylyl transferase 7 -0.0067101
HIP1 huntingtin interacting protein 1 -0.0066781
MYADM myeloid-associated differentiation marker -0.00664263
ARB2A ARB2 cotranscriptional regulator A -0.0066385
RAB5A RAB5A, member RAS oncogene family -0.00660193
WDFY2 WD repeat and FYVE domain containing 2 -0.00657658