TAK-733_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.185448
FRMD6 FERM domain containing 6 0.183782
PABPC1 poly(A) binding protein, cytoplasmic 1 0.145782
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.138053
DLC1 DLC1 Rho GTPase activating protein 0.125954
HDAC9 histone deacetylase 9 0.125088
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.112073
SAMD4A sterile alpha motif domain containing 4A 0.106534
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.103751
ARHGAP22 Rho GTPase activating protein 22 0.0988536
HMGA2 high mobility group AT-hook 2 0.0974968
NAV2 neuron navigator 2 0.0959858
EXT1 exostosin glycosyltransferase 1 0.087591
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0828038
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0810156
FLNB filamin B, beta 0.0808818
ZNF438 zinc finger protein 438 0.0741894
PRRC2B proline-rich coiled-coil 2B 0.0684216
EFNB2 ephrin-B2 0.0645796
MACF1 microtubule-actin crosslinking factor 1 0.0616778
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0612942
LPP LIM domain containing preferred translocation partner in lipoma 0.0604491
SET SET nuclear proto-oncogene 0.0596558
SRRM2 serine/arginine repetitive matrix 2 0.0589631
SLC38A2 solute carrier family 38, member 2 0.0582887
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0577733
PTPRG protein tyrosine phosphatase, receptor type, G 0.0577148
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0558175
EXOC4 exocyst complex component 4 0.05476
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0547549
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0538236
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.053494
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0531156
HSPA8 heat shock 70kDa protein 8 0.0527082
ANK2 ankyrin 2, neuronal 0.0526504
FRMD4A FERM domain containing 4A 0.0520754
ANKRD17 ankyrin repeat domain 17 0.0508018
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0504801
SMYD3 SET and MYND domain containing 3 0.050416
INTS6 integrator complex subunit 6 0.0498275
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0490944
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.048629
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0485222
FLNA filamin A, alpha 0.0483859
FNIP1 folliculin interacting protein 1 0.0473273
DENND1A DENN/MADD domain containing 1A 0.0472469
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0462847
RAD51B RAD51 paralog B 0.0462467
RPL3 ribosomal protein L3 0.046204
FHIT fragile histidine triad 0.0458918
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0456778
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0450622
MYH9 myosin, heavy chain 9, non-muscle 0.0438705
ASPH aspartate beta-hydroxylase 0.04362
NABP1 nucleic acid binding protein 1 0.0429243
ZSWIM6 zinc finger, SWIM-type containing 6 0.0410681
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0407998
TCF12 transcription factor 12 0.0398064
SND1 staphylococcal nuclease and tudor domain containing 1 0.0388256
LRMDA leucine rich melanocyte differentiation associated 0.0383482
APP amyloid beta (A4) precursor protein 0.0382647
ALCAM activated leukocyte cell adhesion molecule 0.0382226
CORO1C coronin, actin binding protein, 1C 0.0378572
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0377108
IARS1 isoleucyl-tRNA synthetase 1 0.0376573
BNC2 basonuclin 2 0.0373827
TRIM44 tripartite motif containing 44 0.0369643
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0367449
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0364015
SGMS2 sphingomyelin synthase 2 0.036188
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0360169
SP100 SP100 nuclear antigen 0.0358029
MCL1 myeloid cell leukemia 1 0.0357518
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.034662
RCOR1 REST corepressor 1 0.0343547
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0339226
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0337173
PUM3 pumilio RNA binding family member 3 0.0335991
WNK1 WNK lysine deficient protein kinase 1 0.0331331
DGKI diacylglycerol kinase, iota 0.0329816
LARP4B La ribonucleoprotein domain family, member 4B 0.0329552
PBX3 pre-B-cell leukemia homeobox 3 0.0326725
GPHN gephyrin 0.0326418
CEP250 centrosomal protein 250kDa 0.031792
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0316296
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0314627
XRN2 5'-3' exoribonuclease 2 0.0311986
BPTF bromodomain PHD finger transcription factor 0.0309933
DOCK1 dedicator of cytokinesis 1 0.0309282
ANO6 anoctamin 6 0.0308056
NAV3 neuron navigator 3 0.0307613
FUS FUS RNA binding protein 0.0307589
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0307378
SFPQ splicing factor proline/glutamine-rich 0.0306872
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.030435
ZC3H12B zinc finger CCCH-type containing 12B 0.0298129
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0297434
PRRC2A proline-rich coiled-coil 2A 0.0297095
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0296718
SPIDR scaffolding protein involved in DNA repair 0.0289995

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.122791
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0574303
RPS6 ribosomal protein S6 -0.0529489
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0436287
TMSB10 thymosin beta 10 -0.0422181
HMGA1 high mobility group AT-hook 1 -0.0384952
RPLP1 ribosomal protein, large, P1 -0.0380223
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.034872
USP3 ubiquitin specific peptidase 3 -0.0348703
S100A2 S100 calcium binding protein A2 -0.0340272
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0325722
RPLP2 ribosomal protein, large, P2 -0.0312823
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0297333
ZNF292 zinc finger protein 292 -0.029661
RTN4 reticulon 4 -0.0296586
TXNRD1 thioredoxin reductase 1 -0.0296277
S100A9 S100 calcium binding protein A9 -0.0281471
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0276569
RPL35A ribosomal protein L35a -0.0264271
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0263805
GNAS GNAS complex locus -0.0262589
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0250516
ADAM9 ADAM metallopeptidase domain 9 -0.0245042
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0240601
RPS19 ribosomal protein S19 -0.0238445
RLF rearranged L-myc fusion -0.0234233
GLRX glutaredoxin (thioltransferase) -0.0233402
MIS18BP1 MIS18 binding protein 1 -0.0228664
RNMT RNA (guanine-7-) methyltransferase -0.0220602
CCNL1 cyclin L1 -0.0215797
NAMPT nicotinamide phosphoribosyltransferase -0.0214822
PFN1 profilin 1 -0.020904
TPD52 tumor protein D52 -0.0208604
FOXO3 forkhead box O3 -0.0207913
RNF145 ring finger protein 145 -0.0204033
RPL34 ribosomal protein L34 -0.0203968
FOSL1 FOS-like antigen 1 -0.0203871
RPL28 ribosomal protein L28 -0.0198594
RPS16 ribosomal protein S16 -0.0195887
SEPTIN7 septin 7 -0.0192459
RPL36 ribosomal protein L36 -0.0187118
NUP58 nucleoporin 58 -0.018514
ELL2 elongation factor, RNA polymerase II, 2 -0.0181616
TMEM87A transmembrane protein 87A -0.0181576
GARS1 glycyl-tRNA synthetase 1 -0.0181164
ZMYM2 zinc finger, MYM-type 2 -0.0180969
LRRC8C leucine rich repeat containing 8 family, member C -0.0180399
UGCG UDP-glucose ceramide glucosyltransferase -0.0178987
PNISR PNN-interacting serine/arginine-rich protein -0.0178822
RAP1B RAP1B, member of RAS oncogene family -0.0177826
TMEM156 transmembrane protein 156 -0.0176627
S100A6 S100 calcium binding protein A6 -0.0175002
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.017499
KDM2A lysine (K)-specific demethylase 2A -0.0174064
TRA2A transformer 2 alpha homolog (Drosophila) -0.017404
KDM3A lysine (K)-specific demethylase 3A -0.017279
TPX2 TPX2, microtubule-associated -0.0171879
DEK DEK proto-oncogene -0.0171579
SMC4 structural maintenance of chromosomes 4 -0.017085
PIAS1 protein inhibitor of activated STAT, 1 -0.0167326
MTF2 metal response element binding transcription factor 2 -0.0166356
NEMF nuclear export mediator factor -0.0166053
RPS21 ribosomal protein S21 -0.0165926
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0165637
FTL ferritin, light polypeptide -0.0163305
UQCRB ubiquinol-cytochrome c reductase binding protein -0.016302
HLA-A major histocompatibility complex, class I, A -0.0161698
RPL21 ribosomal protein L21 -0.016085
MYL12B myosin, light chain 12B, regulatory -0.0159063
TPT1 tumor protein, translationally-controlled 1 -0.0158791
RORA RAR-related orphan receptor A -0.0158652
BIRC2 baculoviral IAP repeat containing 2 -0.0157166
RAB6A RAB6A, member RAS oncogene family -0.0156753
RAD21 RAD21 homolog (S. pombe) -0.0156699
NEK7 NIMA-related kinase 7 -0.0156607
WDR45B WD repeat domain 45B -0.0156498
BLZF1 basic leucine zipper nuclear factor 1 -0.0154822
RPL23 ribosomal protein L23 -0.0153579
RBM25 RNA binding motif protein 25 -0.015333
TM9SF3 transmembrane 9 superfamily member 3 -0.015284
LCORL ligand dependent nuclear receptor corepressor-like -0.015096
PHIP pleckstrin homology domain interacting protein -0.0149333
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0149077
RNF24 ring finger protein 24 -0.0148821
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0148421
RPL27A ribosomal protein L27a -0.0148239
GOLGA4 golgin A4 -0.014616
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0146078
SEC24A SEC24 family member A -0.0142921
RBM27 RNA binding motif protein 27 -0.0142859
SUCO SUN domain containing ossification factor -0.0142766
ZFAND6 zinc finger, AN1-type domain 6 -0.0142042
MT1X metallothionein 1X -0.0141747
ARF4 ADP-ribosylation factor 4 -0.014157
RPS20 ribosomal protein S20 -0.01414
TBK1 TANK-binding kinase 1 -0.0140956
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0140858
VIM vimentin -0.0139189
GCC2 GRIP and coiled-coil domain containing 2 -0.0139134
BRWD3 bromodomain and WD repeat domain containing 3 -0.0138936