| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-733_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | 0.20494 |
| VEGFA | vascular endothelial growth factor A | 0.175633 |
| HLA-B | major histocompatibility complex, class I, B | 0.152297 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.15225 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.109069 |
| STC1 | stanniocalcin 1 | 0.105516 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0973125 |
| HDAC9 | histone deacetylase 9 | 0.0941884 |
| COL5A1 | collagen, type V, alpha 1 | 0.0900596 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0899562 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0869091 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0828643 |
| NAV1 | neuron navigator 1 | 0.079441 |
| LOXL2 | lysyl oxidase-like 2 | 0.0786811 |
| FAT1 | FAT atypical cadherin 1 | 0.0772555 |
| CDH13 | cadherin 13 | 0.0744692 |
| SP100 | SP100 nuclear antigen | 0.0711414 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0704553 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0692998 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0643061 |
| PLEC | plectin | 0.0642181 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0640086 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0636931 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0599739 |
| EGR1 | early growth response 1 | 0.0585856 |
| EXT1 | exostosin glycosyltransferase 1 | 0.057913 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.057413 |
| HLA-A | major histocompatibility complex, class I, A | 0.0572273 |
| FHIT | fragile histidine triad | 0.0566039 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0564179 |
| INHBA | inhibin, beta A | 0.0552732 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0537736 |
| MMP2 | matrix metallopeptidase 2 | 0.0535109 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0533585 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0527807 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0513865 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0513341 |
| NDRG1 | N-myc downstream regulated 1 | 0.0510142 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0507083 |
| RUNX1 | runt-related transcription factor 1 | 0.0501891 |
| IFI44L | interferon-induced protein 44-like | 0.0478951 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0473369 |
| DST | dystonin | 0.0467658 |
| TMEM178B | transmembrane protein 178B | 0.0457365 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0447622 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0443453 |
| CADM1 | cell adhesion molecule 1 | 0.0439258 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0436516 |
| FOSL1 | FOS-like antigen 1 | 0.043576 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.043329 |
| SMAD3 | SMAD family member 3 | 0.0431184 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0430481 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0420072 |
| SFTPA2 | surfactant protein A2 | 0.0411134 |
| KIAA1217 | KIAA1217 | 0.0405549 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0404491 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0404383 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.040411 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0400063 |
| EML5 | echinoderm microtubule associated protein like 5 | 0.0395881 |
| RND3 | Rho family GTPase 3 | 0.0385375 |
| CALR | calreticulin | 0.0380667 |
| APCDD1L | adenomatosis polyposis coli down-regulated 1-like | 0.0378986 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.03663 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0365934 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0361053 |
| ANXA2 | annexin A2 | 0.0358723 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0356342 |
| HLA-E | major histocompatibility complex, class I, E | 0.0356273 |
| HSPA8 | heat shock 70kDa protein 8 | 0.035585 |
| COL5A3 | collagen, type V, alpha 3 | 0.0354493 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0351904 |
| ASPH | aspartate beta-hydroxylase | 0.0346982 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0346879 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0344342 |
| MX1 | MX dynamin-like GTPase 1 | 0.0337494 |
| FLNA | filamin A, alpha | 0.0336314 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0333523 |
| ARRDC3 | arrestin domain containing 3 | 0.0327025 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0326177 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0325509 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0321429 |
| RNF213 | ring finger protein 213 | 0.0320567 |
| MTSS1 | metastasis suppressor 1 | 0.0319841 |
| PLOD1 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 0.0318799 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0317064 |
| GRB10 | growth factor receptor-bound protein 10 | 0.031648 |
| AGBL1 | ATP/GTP binding protein-like 1 | 0.0315522 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0313054 |
| TWIST2 | twist family bHLH transcription factor 2 | 0.0312618 |
| EGFR | epidermal growth factor receptor | 0.0309075 |
| FTL | ferritin, light polypeptide | 0.030834 |
| LYST | lysosomal trafficking regulator | 0.0308152 |
| CEP250 | centrosomal protein 250kDa | 0.0305805 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0305573 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0301233 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0299786 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0298203 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0298185 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0297391 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.235233 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.122203 |
| PGK1 | phosphoglycerate kinase 1 | -0.0862433 |
| ZNF292 | zinc finger protein 292 | -0.0675207 |
| CENPF | centromere protein F, 350/400kDa | -0.0654951 |
| MT2A | metallothionein 2A | -0.0642995 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0524133 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0493224 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0486554 |
| TPX2 | TPX2, microtubule-associated | -0.0478307 |
| FN1 | fibronectin 1 | -0.0475519 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0471582 |
| CD44 | CD44 molecule (Indian blood group) | -0.0466702 |
| GNAS | GNAS complex locus | -0.0458508 |
| PTMA | prothymosin, alpha | -0.0449136 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0448096 |
| MKI67 | marker of proliferation Ki-67 | -0.0447258 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0446308 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0444103 |
| ANLN | anillin, actin binding protein | -0.042024 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0407369 |
| DIAPH3 | diaphanous-related formin 3 | -0.0406819 |
| RBM39 | RNA binding motif protein 39 | -0.0395104 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0393852 |
| RTN4 | reticulon 4 | -0.0383387 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0381847 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0380768 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0373004 |
| CENPE | centromere protein E, 312kDa | -0.0370023 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0361065 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0356364 |
| HMGB2 | high mobility group box 2 | -0.0338916 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0327197 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0320246 |
| GOLGA4 | golgin A4 | -0.0311136 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0308941 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0308248 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0306871 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0306277 |
| SGO2 | shugoshin 2 | -0.030393 |
| TFG | TRK-fused gene | -0.0295437 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0295351 |
| TMSB10 | thymosin beta 10 | -0.0293827 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0288478 |
| KIF4A | kinesin family member 4A | -0.0282359 |
| ECT2 | epithelial cell transforming 2 | -0.0282184 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0280387 |
| OGA | O-GlcNAcase | -0.0279091 |
| SEPTIN7 | septin 7 | -0.0277863 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.027581 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | -0.0268402 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0267161 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0263425 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0259227 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0256543 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0255471 |
| XPO1 | exportin 1 | -0.0254906 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0254746 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.025225 |
| S100A6 | S100 calcium binding protein A6 | -0.0246045 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0245948 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0245409 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0243802 |
| MORF4L2 | mortality factor 4 like 2 | -0.024242 |
| TTK | TTK protein kinase | -0.0242408 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0241305 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0237698 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0235783 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0234385 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0234335 |
| RAB2A | RAB2A, member RAS oncogene family | -0.023334 |
| NF1 | neurofibromin 1 | -0.0226342 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0226205 |
| DNAAF9 | dynein axonemal assembly factor 9 | -0.0225396 |
| CDC73 | cell division cycle 73 | -0.0224477 |
| FAM162A | family with sequence similarity 162, member A | -0.0222592 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0222571 |
| SETD5 | SET domain containing 5 | -0.0219695 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0219095 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0218625 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0218453 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0218433 |
| GPSM2 | G-protein signaling modulator 2 | -0.0214386 |
| TMEM263 | transmembrane protein 263 | -0.0214385 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0213996 |
| GLG1 | golgi glycoprotein 1 | -0.0213959 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0213656 |
| PHF21A | PHD finger protein 21A | -0.0213448 |
| SBF2 | SET binding factor 2 | -0.0211801 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0210132 |
| QKI | QKI, KH domain containing, RNA binding | -0.0209816 |
| RNF24 | ring finger protein 24 | -0.0208933 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0208714 |
| H1-0 | H1.0 linker histone | -0.0206292 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0205113 |
| KIF14 | kinesin family member 14 | -0.0204161 |
| CLINT1 | clathrin interactor 1 | -0.020282 |
| KIAA1328 | KIAA1328 | -0.0201295 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.020117 |
| KNL1 | kinetochore scaffold 1 | -0.0200191 |
