TAK-733_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.126032
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0952358
GPC6 glypican 6 0.0916714
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.089786
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0814768
NALF1 NALCN channel auxiliary factor 1 0.0775036
MYH9 myosin, heavy chain 9, non-muscle 0.0743666
SNTG1 syntrophin, gamma 1 0.0685223
RUNX1 runt-related transcription factor 1 0.0653578
RIMS2 regulating synaptic membrane exocytosis 2 0.0635454
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0620838
TRIO trio Rho guanine nucleotide exchange factor 0.0611534
NBEA neurobeachin 0.0587209
VEGFA vascular endothelial growth factor A 0.0580967
RPTOR regulatory associated protein of MTOR, complex 1 0.055463
IGFBP5 insulin-like growth factor binding protein 5 0.0545957
MACF1 microtubule-actin crosslinking factor 1 0.0535199
CNKSR3 CNKSR family member 3 0.0530753
COL22A1 collagen, type XXII, alpha 1 0.052721
STC1 stanniocalcin 1 0.0516148
SNAP25 synaptosomal-associated protein, 25kDa 0.0513511
FAT1 FAT atypical cadherin 1 0.0513428
SMYD3 SET and MYND domain containing 3 0.0510031
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.050888
ST18 suppression of tumorigenicity 18, zinc finger 0.0505767
BACE2 beta-site APP-cleaving enzyme 2 0.0504257
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0500376
GMDS GDP-mannose 4,6-dehydratase 0.048339
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0482454
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0479924
KIF26B kinesin family member 26B 0.0477494
TTC19 tetratricopeptide repeat domain 19 0.0469971
NCKAP5 NCK-associated protein 5 0.0468622
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0468161
TSHZ2 teashirt zinc finger homeobox 2 0.0465791
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.044679
EEF2 eukaryotic translation elongation factor 2 0.0440553
RPH3AL rabphilin 3A-like (without C2 domains) 0.0430798
DOCK5 dedicator of cytokinesis 5 0.0430707
ASIC2 acid sensing (proton gated) ion channel 2 0.0427897
AHRR aryl-hydrocarbon receptor repressor 0.0425199
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0420768
MPRIP myosin phosphatase Rho interacting protein 0.041515
FNDC3A fibronectin type III domain containing 3A 0.0415068
MYLIP myosin regulatory light chain interacting protein 0.0414291
ARFGEF3 ARFGEF family member 3 0.0408351
CHGB chromogranin B 0.0406402
SETX senataxin 0.0406156
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0403228
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0391233
CNTNAP2 contactin associated protein-like 2 0.0388422
PARM1 prostate androgen-regulated mucin-like protein 1 0.0386608
SCG2 secretogranin II 0.0381961
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.037887
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0376403
MAP1B microtubule-associated protein 1B 0.036569
ASPH aspartate beta-hydroxylase 0.0358856
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0358556
RORA RAR-related orphan receptor A 0.0354344
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0351335
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0347403
EYA2 EYA transcriptional coactivator and phosphatase 2 0.0347053
LRP5 low density lipoprotein receptor-related protein 5 0.034326
RNF213 ring finger protein 213 0.0337464
SRRM2 serine/arginine repetitive matrix 2 0.0335882
SMOC1 SPARC related modular calcium binding 1 0.0335222
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0333873
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0333407
INHBA inhibin, beta A 0.0331444
PDE10A phosphodiesterase 10A 0.0330959
CEMIP2 cell migration inducing hyaluronidase 2 0.0330949
GPC5 glypican 5 0.0330098
TRAPPC9 trafficking protein particle complex 9 0.0326982
HSPA8 heat shock 70kDa protein 8 0.0324089
ANKH ANKH inorganic pyrophosphate transport regulator 0.0321971
EFNA5 ephrin-A5 0.0321156
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.0316966
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0314377
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.031234
ACTG1 actin gamma 1 0.0312113
TBC1D22A TBC1 domain family, member 22A 0.0311269
ANKRD17 ankyrin repeat domain 17 0.031076
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0310322
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.0310146
AGO2 argonaute RISC catalytic component 2 0.0308912
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0308265
KLHL29 kelch-like family member 29 0.0307577
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0305914
NRG1 neuregulin 1 0.0304464
BIRC6 baculoviral IAP repeat containing 6 0.0304217
DST dystonin 0.0300353
CPE carboxypeptidase E 0.029863
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0296724
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0296688
TXNRD1 thioredoxin reductase 1 0.029664
APP amyloid beta (A4) precursor protein 0.029314
SDK1 sidekick cell adhesion molecule 1 0.0286894
PDIA3 protein disulfide isomerase family A, member 3 0.0286634
TPM3 tropomyosin 3 0.0283578
SIK3 SIK family kinase 3 0.0282663

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.174375
MT2A metallothionein 2A -0.0831708
FTL ferritin, light polypeptide -0.078046
PEG10 paternally expressed 10 -0.0656674
RPLP1 ribosomal protein, large, P1 -0.0591737
RPS21 ribosomal protein S21 -0.0583081
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0578529
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0480393
ATP5F1E ATP synthase F1 subunit epsilon -0.0442753
CALCA calcitonin-related polypeptide alpha -0.0434239
TMSB10 thymosin beta 10 -0.0423324
RPL26 ribosomal protein L26 -0.0412554
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0411191
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0400934
S100A9 S100 calcium binding protein A9 -0.0391232
RPS8 ribosomal protein S8 -0.0379256
MIS18BP1 MIS18 binding protein 1 -0.0379218
RPL23 ribosomal protein L23 -0.0371732
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0367439
RPS16 ribosomal protein S16 -0.0365413
RPS19 ribosomal protein S19 -0.0361969
RPL32 ribosomal protein L32 -0.0358004
RPS6 ribosomal protein S6 -0.0350722
CENPF centromere protein F, 350/400kDa -0.0346302
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0343774
HMGB1 high mobility group box 1 -0.0334754
SMC4 structural maintenance of chromosomes 4 -0.0330462
RPL8 ribosomal protein L8 -0.0326827
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0326723
UBB ubiquitin B -0.0325263
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0305124
RPL35 ribosomal protein L35 -0.0303175
RPLP2 ribosomal protein, large, P2 -0.0295862
RPS25 ribosomal protein S25 -0.0295401
RPL38 ribosomal protein L38 -0.0292189
RPL34 ribosomal protein L34 -0.0289924
RPS29 ribosomal protein S29 -0.0289905
RPL12 ribosomal protein L12 -0.0287178
TPT1 tumor protein, translationally-controlled 1 -0.0284984
RBM25 RNA binding motif protein 25 -0.0282447
NAP1L1 nucleosome assembly protein 1-like 1 -0.0278593
RPL36 ribosomal protein L36 -0.0276969
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0275526
RPS24 ribosomal protein S24 -0.0274424
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0273342
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0271257
RPL37 ribosomal protein L37 -0.0270221
OGA O-GlcNAcase -0.0266296
RPL19 ribosomal protein L19 -0.0263392
GNAS GNAS complex locus -0.0259939
ANAPC5 anaphase promoting complex subunit 5 -0.0256192
SGO2 shugoshin 2 -0.0253087
RPL11 ribosomal protein L11 -0.0248577
ISG15 ISG15 ubiquitin-like modifier -0.0246975
RPL36AL ribosomal protein L36a-like -0.024648
RPL35A ribosomal protein L35a -0.0245917
NUF2 NUF2, NDC80 kinetochore complex component -0.0242606
TENT5A terminal nucleotidyltransferase 5A -0.0241516
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.024143
HMGB2 high mobility group box 2 -0.0240216
GSTP1 glutathione S-transferase pi 1 -0.0239523
RAD21 RAD21 homolog (S. pombe) -0.0238105
DEK DEK proto-oncogene -0.0238056
RPS3 ribosomal protein S3 -0.0237417
IFI6 interferon, alpha-inducible protein 6 -0.0235802
WSB1 WD repeat and SOCS box containing 1 -0.0235123
RPS5 ribosomal protein S5 -0.0233729
RPL5 ribosomal protein L5 -0.0232588
MATR3 matrin 3 -0.0232179
TUBB4B tubulin, beta 4B class IVb -0.0231252
RPLP0 ribosomal protein, large, P0 -0.0227395
CDCA2 cell division cycle associated 2 -0.0225458
TXNIP thioredoxin interacting protein -0.0224438
RPL7A ribosomal protein L7a -0.0219852
RPL31 ribosomal protein L31 -0.0217997
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.021512
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.021494
RPS27A ribosomal protein S27a -0.0214851
RPS11 ribosomal protein S11 -0.0213293
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0212517
NFIA nuclear factor I/A -0.0209178
KNL1 kinetochore scaffold 1 -0.0209054
TNRC6B trinucleotide repeat containing 6B -0.0208645
ZNF292 zinc finger protein 292 -0.0207777
RPL37A ribosomal protein L37a -0.0207627
SINHCAF SIN3-HDAC complex associated factor -0.02074
TPX2 TPX2, microtubule-associated -0.0205901
RPL30 ribosomal protein L30 -0.0205154
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0204167
CAMTA1 calmodulin binding transcription activator 1 -0.0203245
RPS23 ribosomal protein S23 -0.0202813
RPS20 ribosomal protein S20 -0.0200989
KANTR KDM5C adjacent non-coding transcript -0.0200258
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0199481
RPL13A ribosomal protein L13a -0.0199172
RPL36A ribosomal protein L36a -0.0198427
PNISR PNN-interacting serine/arginine-rich protein -0.0197567
RPS27 ribosomal protein S27 -0.0197459
COX6C cytochrome c oxidase subunit VIc -0.0194207
KDM3A lysine (K)-specific demethylase 3A -0.0193058