| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the TAK-733_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ICAM1 | intercellular adhesion molecule 1 | 0.130919 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.118949 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.112039 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.111361 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.107838 |
| FLNA | filamin A, alpha | 0.107459 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0906796 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0831547 |
| SFTPA2 | surfactant protein A2 | 0.0821407 |
| SQSTM1 | sequestosome 1 | 0.0799097 |
| PLEC | plectin | 0.0798652 |
| NDRG1 | N-myc downstream regulated 1 | 0.0797966 |
| PKM | pyruvate kinase, muscle | 0.0729586 |
| MSN | moesin | 0.0728224 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0705759 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0689242 |
| LOC112694756 | uncharaterized LOC112694756 | 0.068614 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0685804 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0650372 |
| CD44 | CD44 molecule (Indian blood group) | 0.0639566 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0629446 |
| ANGPTL4 | angiopoietin-like 4 | 0.0612884 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.059001 |
| FLNB | filamin B, beta | 0.0583365 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0572448 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.057216 |
| HSPA8 | heat shock 70kDa protein 8 | 0.056198 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0549869 |
| SEPTIN9 | septin 9 | 0.0543129 |
| RUNX1 | runt-related transcription factor 1 | 0.0538968 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0528091 |
| GOLGB1 | golgin B1 | 0.0523744 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0522288 |
| HDAC9 | histone deacetylase 9 | 0.0522208 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0509944 |
| ANXA2 | annexin A2 | 0.0508224 |
| DST | dystonin | 0.0499734 |
| NAV2 | neuron navigator 2 | 0.0497406 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0494954 |
| B2M | beta-2-microglobulin | 0.0489387 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0484684 |
| TXNRD1 | thioredoxin reductase 1 | 0.0483119 |
| RPS3 | ribosomal protein S3 | 0.0477157 |
| SMAD3 | SMAD family member 3 | 0.0474071 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0466497 |
| SOX10 | SRY (sex determining region Y)-box 10 | 0.0466118 |
| VEGFA | vascular endothelial growth factor A | 0.0463596 |
| CTSB | cathepsin B | 0.0461981 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0447729 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.044177 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0435499 |
| RACK1 | receptor for activated C kinase 1 | 0.0428227 |
| FUS | FUS RNA binding protein | 0.0427855 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0424768 |
| RPL3 | ribosomal protein L3 | 0.0422989 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.042067 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0417712 |
| NOTCH2 | notch 2 | 0.041574 |
| FAT1 | FAT atypical cadherin 1 | 0.0410775 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0402286 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0400598 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0397593 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0396918 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0394309 |
| EP300 | E1A binding protein p300 | 0.0386397 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0386093 |
| ARRDC3 | arrestin domain containing 3 | 0.0383561 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0379282 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0377514 |
| NONO | non-POU domain containing, octamer-binding | 0.0374839 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0370799 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0369611 |
| OXSR1 | oxidative stress responsive 1 | 0.0362274 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0360655 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0358857 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0357513 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0357212 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0355464 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0353745 |
| ATXN1 | ataxin 1 | 0.0353704 |
| SET | SET nuclear proto-oncogene | 0.0352862 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0348591 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0348082 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0347659 |
| NRP2 | neuropilin 2 | 0.0347159 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0346427 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0342509 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.034245 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0341835 |
| KLF6 | Kruppel-like factor 6 | 0.0334312 |
| CEP250 | centrosomal protein 250kDa | 0.0333758 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0332368 |
| TPM3 | tropomyosin 3 | 0.0331518 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0330366 |
| SSH1 | slingshot protein phosphatase 1 | 0.0330037 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.032767 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.032423 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0322556 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0320757 |
| BRD2 | bromodomain containing 2 | 0.0314365 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.22785 |
| NLGN1 | neuroligin 1 | -0.197825 |
| NRG3 | neuregulin 3 | -0.143696 |
| LSAMP | limbic system-associated membrane protein | -0.140257 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.105889 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0851896 |
| RAD51B | RAD51 paralog B | -0.0473878 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0340294 |
| PTMA | prothymosin, alpha | -0.0328222 |
| SBF2 | SET binding factor 2 | -0.0327049 |
| VIM | vimentin | -0.0317005 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0315911 |
| FMN1 | formin 1 | -0.0315105 |
| TNNC1 | troponin C type 1 (slow) | -0.0311099 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0306546 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0301002 |
| FHIT | fragile histidine triad | -0.0293944 |
| SMYD3 | SET and MYND domain containing 3 | -0.0292468 |
| TMSB10 | thymosin beta 10 | -0.028709 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0282739 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0277316 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0273144 |
| FRMD4A | FERM domain containing 4A | -0.0243226 |
| COA1 | cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) | -0.0240499 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0239394 |
| PYGB | phosphorylase, glycogen; brain | -0.023338 |
| MACROD2 | MACRO domain containing 2 | -0.0232512 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0230414 |
| EHBP1 | EH domain binding protein 1 | -0.0228587 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0220788 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0217326 |
| CDK13 | cyclin-dependent kinase 13 | -0.0216587 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0209632 |
| NHSL1 | NHS-like 1 | -0.0203196 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0202692 |
| CCND1 | cyclin D1 | -0.0200806 |
| SRPK2 | SRSF protein kinase 2 | -0.0197327 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0196922 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0195887 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0195818 |
| CTSD | cathepsin D | -0.0194627 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | -0.0192266 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0184926 |
| SPPL3 | signal peptide peptidase like 3 | -0.0183943 |
| NRN1 | neuritin 1 | -0.0183447 |
| NKTR | natural killer cell triggering receptor | -0.0179187 |
| RPS24 | ribosomal protein S24 | -0.0178143 |
| THOC2 | THO complex 2 | -0.0176807 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0176765 |
| ANKFN1 | ankyrin-repeat and fibronectin type III domain containing 1 | -0.0176095 |
| USP53 | ubiquitin specific peptidase 53 | -0.0174747 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0174539 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0174015 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0173201 |
| CCDC14 | coiled-coil domain containing 14 | -0.0169512 |
| TENM1 | teneurin transmembrane protein 1 | -0.0159225 |
| APPBP2 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2 | -0.0158599 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.015727 |
| APOD | apolipoprotein D | -0.0156997 |
| PHF14 | PHD finger protein 14 | -0.015639 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0155927 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 | -0.0155465 |
| KAZN | kazrin, periplakin interacting protein | -0.0154734 |
| PLCB4 | phospholipase C, beta 4 | -0.0153256 |
| PRELID2 | PRELI domain containing 2 | -0.015214 |
| CDH13 | cadherin 13 | -0.0149387 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0149003 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0148713 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0148523 |
| POU2F1 | POU class 2 homeobox 1 | -0.0148512 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0148314 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0147992 |
| CLEC2D | C-type lectin domain family 2, member D | -0.0146346 |
| CDK6 | cyclin-dependent kinase 6 | -0.0146328 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.0145247 |
| FBXO34 | F-box protein 34 | -0.0144437 |
| DPP6 | dipeptidyl-peptidase 6 | -0.0144023 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.0143054 |
| ZZZ3 | zinc finger, ZZ-type containing 3 | -0.0142829 |
| S100A6 | S100 calcium binding protein A6 | -0.0141386 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.014119 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0140424 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0140249 |
| GNG7 | guanine nucleotide binding protein (G protein), gamma 7 | -0.0140019 |
| CENPP | centromere protein P | -0.0139006 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -0.0138603 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0137532 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0136201 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.0135764 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0135153 |
| TCF12 | transcription factor 12 | -0.0133692 |
| PRAME | preferentially expressed antigen in melanoma | -0.0132078 |
| HDAC8 | histone deacetylase 8 | -0.0131315 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0131083 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | -0.013039 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0129397 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.0128388 |
| KIF18B | kinesin family member 18B | -0.0128345 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.012797 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0127509 |
