TAK-733_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.188901
HDAC9 histone deacetylase 9 0.0995746
PDE4D phosphodiesterase 4D, cAMP-specific 0.0971639
HSPA8 heat shock 70kDa protein 8 0.0726195
SAMD4A sterile alpha motif domain containing 4A 0.0708652
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0561921
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0504385
CPED1 cadherin-like and PC-esterase domain containing 1 0.049165
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0485784
PDGFC platelet derived growth factor C 0.0465865
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0447695
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0445672
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0431345
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0408114
RPL3 ribosomal protein L3 0.0396402
EGFR epidermal growth factor receptor 0.0391478
MYO5C myosin VC 0.0382034
SSBP2 single-stranded DNA binding protein 2 0.0358709
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0358353
APP amyloid beta (A4) precursor protein 0.0354315
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0351901
MACF1 microtubule-actin crosslinking factor 1 0.0345774
LPP LIM domain containing preferred translocation partner in lipoma 0.0343883
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0332411
PRELID2 PRELI domain containing 2 0.0328361
IARS1 isoleucyl-tRNA synthetase 1 0.0325858
AMOTL2 angiomotin like 2 0.0324478
LOC112694756 uncharaterized LOC112694756 0.031709
GLI2 GLI family zinc finger 2 0.0316882
WNK1 WNK lysine deficient protein kinase 1 0.0311585
TRIM44 tripartite motif containing 44 0.0308662
CREB5 cAMP responsive element binding protein 5 0.0306823
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0303747
ARID1A AT rich interactive domain 1A (SWI-like) 0.0294676
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0290392
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0285165
MYH9 myosin, heavy chain 9, non-muscle 0.0283743
PTPRG protein tyrosine phosphatase, receptor type, G 0.0278614
PUM3 pumilio RNA binding family member 3 0.0277583
ZNF608 zinc finger protein 608 0.0276212
SMYD3 SET and MYND domain containing 3 0.02759
FAT1 FAT atypical cadherin 1 0.0274143
EML4 echinoderm microtubule associated protein like 4 0.0273946
PNN pinin, desmosome associated protein 0.0273038
ATP9B ATPase, class II, type 9B 0.0270732
SRRM2 serine/arginine repetitive matrix 2 0.0268133
ZFAND3 zinc finger, AN1-type domain 3 0.0262794
MSI2 musashi RNA-binding protein 2 0.0260844
MACROD2 MACRO domain containing 2 0.0258095
DENND1A DENN/MADD domain containing 1A 0.0255265
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0253642
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0253411
JUN jun proto-oncogene 0.0252544
EXT1 exostosin glycosyltransferase 1 0.0247129
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0246394
EIF4B eukaryotic translation initiation factor 4B 0.0244166
CCNY cyclin Y 0.0244039
RPS4Y1 ribosomal protein S4, Y-linked 1 0.023973
PRRC2A proline-rich coiled-coil 2A 0.0238886
NOP56 NOP56 ribonucleoprotein 0.0238858
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0235245
ANK2 ankyrin 2, neuronal 0.0232825
MYOF myoferlin 0.0232672
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0232478
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0229483
PDE4B phosphodiesterase 4B, cAMP-specific 0.0226762
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0226758
RACK1 receptor for activated C kinase 1 0.0225596
GPHN gephyrin 0.0225134
FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 0.0224632
AHCYL2 adenosylhomocysteinase-like 2 0.0222452
RAD50 RAD50 homolog (S. cerevisiae) 0.0220455
CLIP1 CAP-GLY domain containing linker protein 1 0.0217358
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0216892
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0215778
KMT2D lysine (K)-specific methyltransferase 2D 0.0212196
DOCK3 dedicator of cytokinesis 3 0.0209218
MAST2 microtubule associated serine/threonine kinase 2 0.020884
CTTN cortactin 0.0206391
KMT2C lysine (K)-specific methyltransferase 2C 0.0205999
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0205148
SFTPA2 surfactant protein A2 0.020459
NCOR1 nuclear receptor corepressor 1 0.0204523
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.020449
USP47 ubiquitin specific peptidase 47 0.0203047
WDR43 WD repeat domain 43 0.0201379
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0201142
AGPS alkylglycerone phosphate synthase 0.0199355
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.0197486
LRRC7 leucine rich repeat containing 7 0.0196873
TGFBR3 transforming growth factor, beta receptor III 0.0196719
CORO1C coronin, actin binding protein, 1C 0.0196201
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0196073
DSCAM Down syndrome cell adhesion molecule 0.0192067
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0191297
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0190856
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0188441
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.018764
APLP2 amyloid beta (A4) precursor-like protein 2 0.0186402
VWA8 von Willebrand factor A domain containing 8 0.0184758

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.404694
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.266023
VCL vinculin -0.131918
TPT1 tumor protein, translationally-controlled 1 -0.128161
RPS6 ribosomal protein S6 -0.0998258
S100A6 S100 calcium binding protein A6 -0.0960018
PKM pyruvate kinase, muscle -0.095332
FOXP1 forkhead box P1 -0.0874027
RPL35A ribosomal protein L35a -0.0815488
BMP10 bone morphogenetic protein 10 -0.0788752
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0673533
RPL34 ribosomal protein L34 -0.0657488
CCND1 cyclin D1 -0.0634418
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0622389
MYL12B myosin, light chain 12B, regulatory -0.0619512
NBEA neurobeachin -0.0609713
S100A4 S100 calcium binding protein A4 -0.060226
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0585997
PFN1 profilin 1 -0.0584685
RPLP1 ribosomal protein, large, P1 -0.0570657
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.053959
MT2A metallothionein 2A -0.0532407
DPYD dihydropyrimidine dehydrogenase -0.0530186
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0498617
RPS8 ribosomal protein S8 -0.0494123
S100A9 S100 calcium binding protein A9 -0.0494061
ARL4C ADP-ribosylation factor-like 4C -0.0488258
POTEF POTE ankyrin domain family, member F -0.0481777
CENPF centromere protein F, 350/400kDa -0.0480481
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0474682
SMC4 structural maintenance of chromosomes 4 -0.0460228
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0458457
TMSB10 thymosin beta 10 -0.0453745
ADAM10 ADAM metallopeptidase domain 10 -0.0451338
SMC3 structural maintenance of chromosomes 3 -0.0434599
TXNRD1 thioredoxin reductase 1 -0.0427034
ACTG1 actin gamma 1 -0.0422637
PRDX2 peroxiredoxin 2 -0.042046
RPS24 ribosomal protein S24 -0.0414564
FTL ferritin, light polypeptide -0.0411091
RPL27A ribosomal protein L27a -0.0401971
HSPB1 heat shock 27kDa protein 1 -0.0390194
RPS25 ribosomal protein S25 -0.0387034
RPL9 ribosomal protein L9 -0.0385409
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0372401
RPS16 ribosomal protein S16 -0.0370821
GCLM glutamate-cysteine ligase, modifier subunit -0.0361083
SMNDC1 survival motor neuron domain containing 1 -0.0360541
EVI5 ecotropic viral integration site 5 -0.035996
RPS19 ribosomal protein S19 -0.0356471
FLNB filamin B, beta -0.0353239
RBM25 RNA binding motif protein 25 -0.0344814
TMSB4X thymosin beta 4, X-linked -0.0341772
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0337874
TPX2 TPX2, microtubule-associated -0.0334128
ENO2 enolase 2 (gamma, neuronal) -0.033381
RPL19 ribosomal protein L19 -0.0329599
S100A10 S100 calcium binding protein A10 -0.0323354
RPL32 ribosomal protein L32 -0.0322601
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0321835
HEG1 heart development protein with EGF-like domains 1 -0.0316651
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0315551
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0308802
GNAS GNAS complex locus -0.0304958
TJP1 tight junction protein 1 -0.030436
PYGB phosphorylase, glycogen; brain -0.0301963
RPL7A ribosomal protein L7a -0.0300315
IGF2 insulin-like growth factor 2 -0.0298395
PTMS parathymosin -0.0295327
DEK DEK proto-oncogene -0.0291427
PHIP pleckstrin homology domain interacting protein -0.0288003
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0285937
TUBA1B tubulin, alpha 1b -0.028424
RPL36A ribosomal protein L36a -0.0284127
DUSP6 dual specificity phosphatase 6 -0.0280399
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0279789
RPS14 ribosomal protein S14 -0.0275761
LOC102724023 ES1 protein homolog, mitochondrial -0.0271957
MKI67 marker of proliferation Ki-67 -0.0270802
ZMYND8 zinc finger, MYND-type containing 8 -0.0269958
RPLP2 ribosomal protein, large, P2 -0.0268982
CBX3 chromobox homolog 3 -0.0265854
EBNA1BP2 EBNA1 binding protein 2 -0.0265429
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0259225
DSTN destrin (actin depolymerizing factor) -0.0257285
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0256533
NPAS2 neuronal PAS domain protein 2 -0.0253675
RPS21 ribosomal protein S21 -0.0253614
UBE2K ubiquitin-conjugating enzyme E2K -0.0250956
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0249685
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0247052
SEPTIN7 septin 7 -0.0246538
HLA-B major histocompatibility complex, class I, B -0.0246347
PSIP1 PC4 and SFRS1 interacting protein 1 -0.0245661
RPL11 ribosomal protein L11 -0.0240022
TXNIP thioredoxin interacting protein -0.0239416
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0239278
ATF4 activating transcription factor 4 -0.0238583
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0236504
RPLP0 ribosomal protein, large, P0 -0.0234472