TAK-733_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.271869
COL6A3 collagen, type VI, alpha 3 0.163776
VCAN versican 0.144606
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.142388
EEF2 eukaryotic translation elongation factor 2 0.136611
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.129004
TRIO trio Rho guanine nucleotide exchange factor 0.124091
HDAC9 histone deacetylase 9 0.11747
FN1 fibronectin 1 0.112035
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0877355
SOD2 superoxide dismutase 2, mitochondrial 0.0853185
DST dystonin 0.0842367
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0803486
VEGFA vascular endothelial growth factor A 0.0763258
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.075477
ANXA2 annexin A2 0.0701722
SFTPA2 surfactant protein A2 0.0652517
APP amyloid beta (A4) precursor protein 0.0637015
MACF1 microtubule-actin crosslinking factor 1 0.0633245
FLNA filamin A, alpha 0.0563839
ZBTB38 zinc finger and BTB domain containing 38 0.0551259
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0533136
CEP250 centrosomal protein 250kDa 0.0513277
NONO non-POU domain containing, octamer-binding 0.0504117
AKAP12 A kinase (PRKA) anchor protein 12 0.0504
CANX calnexin 0.0483897
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0475389
SMYD3 SET and MYND domain containing 3 0.0474154
GPC6 glypican 6 0.0462583
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0457137
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0454685
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0452376
FRMD5 FERM domain containing 5 0.0444297
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0419126
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0417424
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0416044
MLPH melanophilin 0.0410926
SMAD3 SMAD family member 3 0.0409085
PPARD peroxisome proliferator-activated receptor delta 0.0407603
RNF213 ring finger protein 213 0.0406627
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0405599
NAMPT nicotinamide phosphoribosyltransferase 0.0393839
FOXP1 forkhead box P1 0.0387493
NRP1 neuropilin 1 0.038005
FNIP1 folliculin interacting protein 1 0.037924
ASPH aspartate beta-hydroxylase 0.0365385
USP9X ubiquitin specific peptidase 9, X-linked 0.0365369
GLIS3 GLIS family zinc finger 3 0.0364764
LPP LIM domain containing preferred translocation partner in lipoma 0.0363493
IGF2R insulin-like growth factor 2 receptor 0.0359284
TGFBI transforming growth factor, beta-induced, 68kDa 0.0356314
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0352554
EHBP1 EH domain binding protein 1 0.0348609
ARRDC3 arrestin domain containing 3 0.0346669
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0346649
BICC1 BicC family RNA binding protein 1 0.0331592
MSN moesin 0.0321153
ATXN1 ataxin 1 0.0315804
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.031533
TNIP1 TNFAIP3 interacting protein 1 0.0311229
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0311188
TRAM2 translocation associated membrane protein 2 0.0310743
CTSB cathepsin B 0.0307921
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0307873
HSPA8 heat shock 70kDa protein 8 0.0304881
FLNB filamin B, beta 0.0301274
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0291935
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0291914
COL5A1 collagen, type V, alpha 1 0.0290406
LOC112694756 uncharaterized LOC112694756 0.0289639
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0284572
CD44 CD44 molecule (Indian blood group) 0.0282547
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0280626
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.027941
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0279088
STC2 stanniocalcin 2 0.0275429
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.027234
PLEC plectin 0.0271785
TPM3 tropomyosin 3 0.0271644
PRELID2 PRELI domain containing 2 0.027073
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0265529
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0262748
AFF4 AF4/FMR2 family, member 4 0.0262714
BCAR3 breast cancer anti-estrogen resistance 3 0.0262421
RUNX1 runt-related transcription factor 1 0.0262244
TRIP12 thyroid hormone receptor interactor 12 0.0261557
EXT1 exostosin glycosyltransferase 1 0.0260666
ACTN1 actinin, alpha 1 0.0260159
AHNAK AHNAK nucleoprotein 0.0259285
TUBB tubulin, beta class I 0.0257647
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.02552
MX1 MX dynamin-like GTPase 1 0.0254255
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0250341
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0250113
ANXA1 annexin A1 0.0248304
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0246077
OSBPL8 oxysterol binding protein-like 8 0.0241298
APLP2 amyloid beta (A4) precursor-like protein 2 0.0240639
LAMP2 lysosomal-associated membrane protein 2 0.0239599
CUL4B cullin 4B 0.0239535

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.233728
FTL ferritin, light polypeptide -0.100988
TMSB10 thymosin beta 10 -0.0910567
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0823739
MT2A metallothionein 2A -0.0743422
TPT1 tumor protein, translationally-controlled 1 -0.0724181
PTMA prothymosin, alpha -0.0685473
FTH1 ferritin, heavy polypeptide 1 -0.0672823
HLA-B major histocompatibility complex, class I, B -0.0620177
UGCG UDP-glucose ceramide glucosyltransferase -0.061717
RPS6 ribosomal protein S6 -0.0520198
RPL35A ribosomal protein L35a -0.0505086
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0498673
ADM adrenomedullin -0.0496061
HLA-A major histocompatibility complex, class I, A -0.0424186
RPLP2 ribosomal protein, large, P2 -0.0423956
RPLP1 ribosomal protein, large, P1 -0.0422833
IER3 immediate early response 3 -0.0404122
ZMYND8 zinc finger, MYND-type containing 8 -0.0399251
CTSD cathepsin D -0.0388968
BTG1 B-cell translocation gene 1, anti-proliferative -0.0383553
RPS24 ribosomal protein S24 -0.0351913
HMGA1 high mobility group AT-hook 1 -0.0349227
KLHL24 kelch-like family member 24 -0.0345758
RPS8 ribosomal protein S8 -0.0337827
HILPDA hypoxia inducible lipid droplet-associated -0.0331871
RPL9 ribosomal protein L9 -0.0330644
RPL31 ribosomal protein L31 -0.0312212
ENO2 enolase 2 (gamma, neuronal) -0.0309703
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0301464
RPS19 ribosomal protein S19 -0.0282714
RPS25 ribosomal protein S25 -0.0282496
RPS29 ribosomal protein S29 -0.027774
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0267026
C3 complement component 3 -0.0256719
RPL36A ribosomal protein L36a -0.025273
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0249622
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0247469
IFITM3 interferon induced transmembrane protein 3 -0.0244147
WSB1 WD repeat and SOCS box containing 1 -0.0243714
GNAS GNAS complex locus -0.022717
RPS16 ribosomal protein S16 -0.0227071
TPM1 tropomyosin 1 (alpha) -0.0225488
GDF15 growth differentiation factor 15 -0.0225456
DSTN destrin (actin depolymerizing factor) -0.0221716
PRR16 proline rich 16 -0.0218685
GOLGA4 golgin A4 -0.0217716
DEK DEK proto-oncogene -0.0216359
RPL27A ribosomal protein L27a -0.0215227
RPS13 ribosomal protein S13 -0.0210353
ACTG1 actin gamma 1 -0.0209857
IFITM1 interferon induced transmembrane protein 1 -0.020845
COL1A1 collagen, type I, alpha 1 -0.0202486
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0201478
RB1CC1 RB1-inducible coiled-coil 1 -0.020023
RPL37A ribosomal protein L37a -0.0199404
RPL28 ribosomal protein L28 -0.0197309
SDK1 sidekick cell adhesion molecule 1 -0.0196185
RPL34 ribosomal protein L34 -0.0192775
S100A9 S100 calcium binding protein A9 -0.0192697
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0189586
UBC ubiquitin C -0.0186045
RPL7A ribosomal protein L7a -0.0184574
EIF1 eukaryotic translation initiation factor 1 -0.018421
KDM5B lysine (K)-specific demethylase 5B -0.0184056
TPM4 tropomyosin 4 -0.0182834
SRGN serglycin -0.0178743
KMT2E lysine (K)-specific methyltransferase 2E -0.0177994
KDM2A lysine (K)-specific demethylase 2A -0.0176543
COL1A2 collagen, type I, alpha 2 -0.0175763
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0175014
HLA-E major histocompatibility complex, class I, E -0.0173564
LOX lysyl oxidase -0.0173535
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0172569
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0171131
ASTN2 astrotactin 2 -0.0170808
ARL4C ADP-ribosylation factor-like 4C -0.016972
RPS23 ribosomal protein S23 -0.0166595
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0164603
FBXL20 F-box and leucine-rich repeat protein 20 -0.0163676
LCORL ligand dependent nuclear receptor corepressor-like -0.0162942
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0160555
SRSF3 serine/arginine-rich splicing factor 3 -0.0160541
RPS14 ribosomal protein S14 -0.0160226
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0157945
IL6 interleukin 6 -0.0157528
EGFR epidermal growth factor receptor -0.0156961
TAPBP TAP binding protein (tapasin) -0.0156615
PNISR PNN-interacting serine/arginine-rich protein -0.0155359
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0155026
PARD3 par-3 family cell polarity regulator -0.0152691
RPL21 ribosomal protein L21 -0.0151786
RPL39 ribosomal protein L39 -0.0151294
DENND5B DENN/MADD domain containing 5B -0.0150723
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0150428
POTEF POTE ankyrin domain family, member F -0.0149497
ZNF292 zinc finger protein 292 -0.0148566
SMC4 structural maintenance of chromosomes 4 -0.0148419
S100A6 S100 calcium binding protein A6 -0.0148295
CD99 CD99 molecule -0.0147938