| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-733 perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the TAK-733_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.179818 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.111876 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0943731 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0882664 |
| FAT1 | FAT atypical cadherin 1 | 0.0852702 |
| PLEC | plectin | 0.0850586 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.077568 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0761875 |
| DSPP | dentin sialophosphoprotein | 0.074212 |
| ANXA2 | annexin A2 | 0.0653611 |
| KRT18 | keratin 18, type I | 0.0649256 |
| ACTG1 | actin gamma 1 | 0.0637833 |
| NEBL | nebulette | 0.0628383 |
| FLNA | filamin A, alpha | 0.0599085 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0589106 |
| MKI67 | marker of proliferation Ki-67 | 0.0564226 |
| H1-0 | H1.0 linker histone | 0.0537007 |
| APP | amyloid beta (A4) precursor protein | 0.0524948 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0502885 |
| KRT8 | keratin 8, type II | 0.0470589 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0465564 |
| AXIN2 | axin 2 | 0.0462527 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0458756 |
| TMEM123 | transmembrane protein 123 | 0.0455584 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0442698 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0441267 |
| NONO | non-POU domain containing, octamer-binding | 0.0432702 |
| TRIM2 | tripartite motif containing 2 | 0.0416288 |
| SMAD3 | SMAD family member 3 | 0.0404377 |
| STC2 | stanniocalcin 2 | 0.0400201 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0383489 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0381988 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0366193 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0363436 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0358801 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.035386 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0352205 |
| LDHA | lactate dehydrogenase A | 0.0348196 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | 0.0347969 |
| RACK1 | receptor for activated C kinase 1 | 0.0345506 |
| AFDN | afadin, adherens junction formation factor | 0.0345 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0343577 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0342672 |
| SNX9 | sorting nexin 9 | 0.0333244 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0332572 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0329353 |
| ARRDC3 | arrestin domain containing 3 | 0.0326421 |
| RPL3 | ribosomal protein L3 | 0.032131 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.032106 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0316304 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0315987 |
| MYOF | myoferlin | 0.0311304 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0308385 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0306686 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0302415 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0298243 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0295987 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0293527 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0292574 |
| SET | SET nuclear proto-oncogene | 0.0292358 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0290406 |
| CAPRIN1 | cell cycle associated protein 1 | 0.028886 |
| RAD21 | RAD21 homolog (S. pombe) | 0.028759 |
| STIP1 | stress-induced phosphoprotein 1 | 0.0287105 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0286131 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0285086 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0283395 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0280142 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0279186 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0275634 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0272799 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0271403 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0271183 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0270635 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.026884 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0266183 |
| SYK | spleen tyrosine kinase | 0.0260754 |
| FUS | FUS RNA binding protein | 0.0260307 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.025952 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0258158 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.025676 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0255509 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0254841 |
| RPS3 | ribosomal protein S3 | 0.0254626 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0253884 |
| CTTN | cortactin | 0.0250819 |
| MED15 | mediator complex subunit 15 | 0.0246305 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0245987 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0244872 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0244774 |
| CEP250 | centrosomal protein 250kDa | 0.0244577 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0242383 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0240621 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0239023 |
| MYO1B | myosin IB | 0.0236331 |
| YBX1 | Y box binding protein 1 | 0.0236308 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0235013 |
| AMOTL2 | angiomotin like 2 | 0.0234986 |
| MLEC | malectin | 0.0234593 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0229468 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.156477 |
| TMSB10 | thymosin beta 10 | -0.131482 |
| BCL2L1 | BCL2-like 1 | -0.125668 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.104244 |
| EZR | ezrin | -0.0958149 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0840979 |
| RPS6 | ribosomal protein S6 | -0.0721107 |
| FTL | ferritin, light polypeptide | -0.0687073 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0595389 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0523583 |
| TOP1 | topoisomerase (DNA) I | -0.0510639 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.050625 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0492391 |
| EGR1 | early growth response 1 | -0.047564 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0472486 |
| RPS21 | ribosomal protein S21 | -0.0463115 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0449193 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0437911 |
| ITGA6 | integrin, alpha 6 | -0.0427347 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0422149 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0421611 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0421283 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0414566 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0396991 |
| TMEM41B | transmembrane protein 41B | -0.0389773 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0382049 |
| EHBP1 | EH domain binding protein 1 | -0.0374101 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0364329 |
| RPLP1 | ribosomal protein, large, P1 | -0.0356198 |
| RPL35A | ribosomal protein L35a | -0.0352317 |
| S100A6 | S100 calcium binding protein A6 | -0.0349491 |
| RPLP2 | ribosomal protein, large, P2 | -0.0336197 |
| HM13 | histocompatibility (minor) 13 | -0.0333115 |
| HLA-A | major histocompatibility complex, class I, A | -0.0327908 |
| GNAS | GNAS complex locus | -0.0314171 |
| HMGA1 | high mobility group AT-hook 1 | -0.0304092 |
| ITGB4 | integrin, beta 4 | -0.0292797 |
| RPL34 | ribosomal protein L34 | -0.0291324 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0283868 |
| TPM4 | tropomyosin 4 | -0.028011 |
| CCND1 | cyclin D1 | -0.0279863 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0276683 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0275817 |
| SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 | -0.027521 |
| LAMA4 | laminin, alpha 4 | -0.027385 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0272316 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.027065 |
| CDK13 | cyclin-dependent kinase 13 | -0.0269446 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0268606 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0264047 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0263956 |
| ACTN4 | actinin, alpha 4 | -0.0260849 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0260338 |
| RPS24 | ribosomal protein S24 | -0.0260028 |
| RBM25 | RNA binding motif protein 25 | -0.0257056 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.025492 |
| CTSD | cathepsin D | -0.0253925 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0253346 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0253099 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.025232 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0252032 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0251066 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0249868 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0248375 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0245308 |
| VMP1 | vacuole membrane protein 1 | -0.0245086 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0242832 |
| RPS14 | ribosomal protein S14 | -0.0241251 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0236665 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | -0.0234394 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0233639 |
| USP34 | ubiquitin specific peptidase 34 | -0.0233451 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0233406 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0232556 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0232508 |
| RTN4 | reticulon 4 | -0.0231756 |
| RPS16 | ribosomal protein S16 | -0.0229145 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0228602 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0227832 |
| TNS4 | tensin 4 | -0.0226539 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0223583 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0221809 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0221755 |
| SBF2 | SET binding factor 2 | -0.0221394 |
| PERP | PERP, TP53 apoptosis effector | -0.0219121 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.021622 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0215454 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0214801 |
| RPS19 | ribosomal protein S19 | -0.0212333 |
| VCL | vinculin | -0.0212115 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0211824 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0211013 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0209785 |
| NFIA | nuclear factor I/A | -0.0208573 |
| MAP4 | microtubule-associated protein 4 | -0.0207347 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0207249 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0206935 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0206624 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0206434 |
| NEMF | nuclear export mediator factor | -0.0205768 |
