TAK-733_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-733 perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-733_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.193203
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.181149
ACTG1 actin gamma 1 0.149359
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.121352
EGFR epidermal growth factor receptor 0.114309
HSPA8 heat shock 70kDa protein 8 0.100021
ATXN1 ataxin 1 0.0986063
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0949011
FAT1 FAT atypical cadherin 1 0.0935027
EGR1 early growth response 1 0.0929783
NCEH1 neutral cholesterol ester hydrolase 1 0.0832084
SRRM2 serine/arginine repetitive matrix 2 0.0743468
SEPTIN9 septin 9 0.0734627
DOCK5 dedicator of cytokinesis 5 0.0679167
LPP LIM domain containing preferred translocation partner in lipoma 0.0666211
GPHN gephyrin 0.0657738
HMGA2 high mobility group AT-hook 2 0.0655661
FHIT fragile histidine triad 0.0647503
MYH9 myosin, heavy chain 9, non-muscle 0.0633735
RAD51B RAD51 paralog B 0.0610784
SMAD3 SMAD family member 3 0.0606601
MACF1 microtubule-actin crosslinking factor 1 0.0597129
TMEM123 transmembrane protein 123 0.0592409
SMYD3 SET and MYND domain containing 3 0.0586845
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0565341
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0564648
VCL vinculin 0.0562969
TTC3 tetratricopeptide repeat domain 3 0.0546408
MTUS1 microtubule associated tumor suppressor 1 0.0516711
OSBPL10 oxysterol binding protein-like 10 0.0502781
RPL3 ribosomal protein L3 0.0499973
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0498978
CPOX coproporphyrinogen oxidase 0.04781
MPRIP myosin phosphatase Rho interacting protein 0.0477723
CREB5 cAMP responsive element binding protein 5 0.0468257
RPS12 ribosomal protein S12 0.0468128
AKAP13 A kinase (PRKA) anchor protein 13 0.0460624
EFNB2 ephrin-B2 0.0459636
PLEC plectin 0.0453762
CCSER1 coiled-coil serine-rich protein 1 0.0453472
PATJ PATJ crumbs cell polarity complex component 0.0450022
SNX9 sorting nexin 9 0.0446284
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0432383
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0423211
PRRC2C proline-rich coiled-coil 2C 0.0411165
RPS3 ribosomal protein S3 0.0408068
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0407851
FLNA filamin A, alpha 0.040597
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0403466
CUX1 cut-like homeobox 1 0.0397567
PARD3B par-3 family cell polarity regulator beta 0.038769
USP9X ubiquitin specific peptidase 9, X-linked 0.0387232
KSR2 kinase suppressor of ras 2 0.0382141
TRAF3 TNF receptor-associated factor 3 0.0380724
RPL37A ribosomal protein L37a 0.0379274
SAMD4A sterile alpha motif domain containing 4A 0.0378872
MKI67 marker of proliferation Ki-67 0.0374206
HDLBP high density lipoprotein binding protein 0.0373172
CANX calnexin 0.0372284
ABR active BCR-related 0.0372079
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0370433
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.036648
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0363826
AXIN2 axin 2 0.0363157
LOC102724023 ES1 protein homolog, mitochondrial 0.0358024
CLIP2 CAP-GLY domain containing linker protein 2 0.0355843
ANKRD17 ankyrin repeat domain 17 0.0353732
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0352554
PTPRG protein tyrosine phosphatase, receptor type, G 0.0350171
CALR calreticulin 0.0348374
RCOR1 REST corepressor 1 0.0345012
SGMS2 sphingomyelin synthase 2 0.0343996
EXOC4 exocyst complex component 4 0.0341582
RACK1 receptor for activated C kinase 1 0.0338923
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0338062
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0337968
CDK13 cyclin-dependent kinase 13 0.0336487
CMIP c-Maf inducing protein 0.0335532
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.033455
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0333435
SET SET nuclear proto-oncogene 0.0322811
ARRDC3 arrestin domain containing 3 0.0322761
IGSF9B immunoglobulin superfamily, member 9B 0.0322084
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0320793
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0319616
RPS10 ribosomal protein S10 0.0307558
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.030619
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0305298
FRAS1 Fraser extracellular matrix complex subunit 1 0.0302488
TNS3 tensin 3 0.0300281
FHL2 four and a half LIM domains 2 0.029902
GATAD2A GATA zinc finger domain containing 2A 0.0298585
RPS17 ribosomal protein S17 0.0297862
WWOX WW domain containing oxidoreductase 0.029739
DSPP dentin sialophosphoprotein 0.0297123
EXT1 exostosin glycosyltransferase 1 0.0295841
CLDND1 claudin domain containing 1 0.0292355
PRRC2B proline-rich coiled-coil 2B 0.0292184
FOSL1 FOS-like antigen 1 0.0292077
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0291781

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.196563
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.15606
PTMA prothymosin, alpha -0.155662
AREG amphiregulin -0.123687
TMSB10 thymosin beta 10 -0.103626
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0963147
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0788674
HILPDA hypoxia inducible lipid droplet-associated -0.0608866
TOP1 topoisomerase (DNA) I -0.0575815
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0521282
USP3 ubiquitin specific peptidase 3 -0.0484012
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0477356
EREG epiregulin -0.0470972
CD36 CD36 molecule (thrombospondin receptor) -0.0461213
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.04463
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0443287
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0418395
RNF145 ring finger protein 145 -0.041703
MT2A metallothionein 2A -0.0407845
GDF15 growth differentiation factor 15 -0.0399358
TXNRD1 thioredoxin reductase 1 -0.039447
TPT1 tumor protein, translationally-controlled 1 -0.0379634
GARS1 glycyl-tRNA synthetase 1 -0.0363868
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0342083
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0337455
STRN3 striatin, calmodulin binding protein 3 -0.0333161
S100A6 S100 calcium binding protein A6 -0.0307332
OXR1 oxidation resistance 1 -0.0303956
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0301704
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0291729
NAMPT nicotinamide phosphoribosyltransferase -0.029108
IER3 immediate early response 3 -0.0289299
WAC WW domain containing adaptor with coiled-coil -0.0288419
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0285788
KDM6A lysine (K)-specific demethylase 6A -0.0280029
RPS6 ribosomal protein S6 -0.0272352
ZNF292 zinc finger protein 292 -0.0271089
TXNIP thioredoxin interacting protein -0.0266302
ANXA1 annexin A1 -0.0265432
IGFBP3 insulin-like growth factor binding protein 3 -0.0261168
ITPRID2 ITPR interacting domain containing 2 -0.0258979
RPS24 ribosomal protein S24 -0.0257731
MT1X metallothionein 1X -0.0257261
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0257213
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0255128
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.02542
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0251014
ESYT2 extended synaptotagmin-like protein 2 -0.0248725
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0244062
HMGA1 high mobility group AT-hook 1 -0.0241015
BRWD1 bromodomain and WD repeat domain containing 1 -0.0239848
PTBP2 polypyrimidine tract binding protein 2 -0.0236513
PLAUR plasminogen activator, urokinase receptor -0.0223403
NEK7 NIMA-related kinase 7 -0.0221944
RBM39 RNA binding motif protein 39 -0.0219748
ZMYM2 zinc finger, MYM-type 2 -0.0214867
FAM3C family with sequence similarity 3, member C -0.0210413
COG5 component of oligomeric golgi complex 5 -0.0209329
RAP1B RAP1B, member of RAS oncogene family -0.0206056
ADAM9 ADAM metallopeptidase domain 9 -0.0205657
PERP PERP, TP53 apoptosis effector -0.0205087
CEP152 centrosomal protein 152kDa -0.0204973
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0204499
S100A10 S100 calcium binding protein A10 -0.0202208
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0199868
PKM pyruvate kinase, muscle -0.0199487
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.01991
PUM2 pumilio RNA-binding family member 2 -0.0197528
RLF rearranged L-myc fusion -0.0196967
S100A11 S100 calcium binding protein A11 -0.0194385
SLMAP sarcolemma associated protein -0.019336
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0193027
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.019119
TRA2A transformer 2 alpha homolog (Drosophila) -0.0190827
GCLC glutamate-cysteine ligase, catalytic subunit -0.0190043
FNDC3B fibronectin type III domain containing 3B -0.0189807
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0188089
RAB6A RAB6A, member RAS oncogene family -0.0186779
GNAT3 guanine nucleotide binding protein, alpha transducing 3 -0.0185577
NUP58 nucleoporin 58 -0.0185027
CDC73 cell division cycle 73 -0.0184249
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0184127
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0183819
ATP11B ATPase, class VI, type 11B -0.0182265
KITLG KIT ligand -0.0181707
OGA O-GlcNAcase -0.0181504
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0180864
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0179767
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0176718
SBF2 SET binding factor 2 -0.017451
PNISR PNN-interacting serine/arginine-rich protein -0.0172826
KLK10 kallikrein-related peptidase 10 -0.017133
YTHDC1 YTH domain containing 1 -0.0168707
RBM25 RNA binding motif protein 25 -0.0167207
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0167077
KDM3A lysine (K)-specific demethylase 3A -0.0165031
RPL34 ribosomal protein L34 -0.0165008
RPLP1 ribosomal protein, large, P1 -0.016434
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.01623
NT5DC3 5'-nucleotidase domain containing 3 -0.016206