| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/183789 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in TAK-779 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TSPAN3 | tetraspanin 3 | 1.3 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 0.85 |
| CD63 | CD63 molecule | 0.77 |
| NCOA4 | nuclear receptor coactivator 4 | 0.63 |
| APOB | apolipoprotein B | 0.58 |
| FTL | ferritin, light polypeptide | 0.56 |
| FAM117A | family with sequence similarity 117, member A | 0.53 |
| NDFIP2 | Nedd4 family interacting protein 2 | 0.51 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.49 |
| BCORL1 | BCL6 corepressor-like 1 | 0.47 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.47 |
| SHLD2 | shieldin complex subunit 2 | 0.47 |
| CCDC102A | coiled-coil domain containing 102A | 0.46 |
| TSC22D2 | TSC22 domain family, member 2 | 0.46 |
| HGFAC | HGF activator | 0.45 |
| GPANK1 | G patch domain and ankyrin repeats 1 | 0.45 |
| AHR | aryl hydrocarbon receptor | 0.45 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.44 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 0.43 |
| FHIT | fragile histidine triad | 0.43 |
| HFM1 | HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) | 0.42 |
| PLEKHH1 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | 0.42 |
| MPZL2 | myelin protein zero-like 2 | 0.42 |
| ADCY9 | adenylate cyclase 9 | 0.42 |
| MTUS2 | microtubule associated tumor suppressor candidate 2 | 0.42 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.41 |
| SON | SON DNA binding protein | 0.41 |
| CHRD | chordin | 0.41 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.4 |
| CYTH3 | cytohesin 3 | 0.4 |
| SLC38A2 | solute carrier family 38, member 2 | 0.4 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.4 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | 0.39 |
| TMEM39A | transmembrane protein 39A | 0.39 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 0.38 |
| ROBO3 | roundabout, axon guidance receptor, homolog 3 (Drosophila) | 0.38 |
| SHC4 | SHC (Src homology 2 domain containing) family, member 4 | 0.37 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.36 |
| WTIP | Wilms tumor 1 interacting protein | 0.36 |
| MSX2 | msh homeobox 2 | 0.35 |
| TMEM59 | transmembrane protein 59 | 0.35 |
| EFCAB7 | EF-hand calcium binding domain 7 | 0.34 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.34 |
| ANKRD2 | ankyrin repeat domain 2 (stretch responsive muscle) | 0.34 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.34 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.34 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.33 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.33 |
| ZNF526 | zinc finger protein 526 | 0.33 |
| CCDC66 | coiled-coil domain containing 66 | 0.33 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.33 |
| ACVR1B | activin A receptor, type IB | 0.32 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.32 |
| JPT2 | Jupiter microtubule associated homolog 2 | 0.32 |
| C1ORF52 | chromosome 1 open reading frame 52 | 0.32 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | 0.32 |
| SDCBP | syndecan binding protein (syntenin) | 0.32 |
| SLC25A29 | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 | 0.32 |
| METTL6 | methyltransferase like 6 | 0.32 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.32 |
| FAIM | Fas apoptotic inhibitory molecule | 0.31 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | 0.31 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.31 |
| TMEM104 | transmembrane protein 104 | 0.31 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.3 |
| SATB1 | SATB homeobox 1 | 0.3 |
| GATA2 | GATA binding protein 2 | 0.3 |
| NPHP1 | nephronophthisis 1 (juvenile) | 0.3 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | 0.3 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.3 |
| FAR1 | fatty acyl CoA reductase 1 | 0.3 |
| CPTP | ceramide-1-phosphate transfer protein | 0.3 |
| SLC19A1 | solute carrier family 19 (folate transporter), member 1 | 0.3 |
| ACVR2A | activin A receptor, type IIA | 0.3 |
| ODC1 | ornithine decarboxylase 1 | 0.3 |
| TTYH2 | tweety family member 2 | 0.3 |
| SPATA2 | spermatogenesis associated 2 | 0.3 |
| FRRS1 | ferric-chelate reductase 1 | 0.3 |
| SCARB2 | scavenger receptor class B, member 2 | 0.3 |
| RPGRIP1L | RPGRIP1-like | 0.29 |
| C1ORF122 | chromosome 1 open reading frame 122 | 0.29 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.29 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | 0.29 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.29 |
| ARHGAP23 | Rho GTPase activating protein 23 | 0.29 |
| ITM2B | integral membrane protein 2B | 0.28 |
| ATP6V0C | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | 0.28 |
| TUBAL3 | tubulin, alpha-like 3 | 0.28 |
| BAHCC1 | BAH domain and coiled-coil containing 1 | 0.28 |
| KLHL21 | kelch-like family member 21 | 0.28 |
| CTDNEP1 | CTD nuclear envelope phosphatase 1 | 0.28 |
| SQSTM1 | sequestosome 1 | 0.28 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.28 |
| MCPH1 | microcephalin 1 | 0.27 |
| PLPP2 | phospholipid phosphatase 2 | 0.27 |
| CA8 | carbonic anhydrase VIII | 0.27 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.27 |
| CLCN7 | chloride channel, voltage-sensitive 7 | 0.27 |
| CAB39L | calcium binding protein 39-like | 0.27 |
| CCPG1 | cell cycle progression 1 | 0.27 |
| Symbol | Name | Standardized Value |
|---|---|---|
| POF1B | premature ovarian failure, 1B | -2.27 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.69 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -1.58 |
| NMU | neuromedin U | -1.32 |
| NPHP3 | nephronophthisis 3 (adolescent) | -1.09 |
| DNAL4 | dynein, axonemal, light chain 4 | -1.05 |
| CCDC82 | coiled-coil domain containing 82 | -0.89 |
| CPN1 | carboxypeptidase N, polypeptide 1 | -0.86 |
| ZNF496 | zinc finger protein 496 | -0.86 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.84 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.83 |
| ZNF594 | zinc finger protein 594 | -0.83 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.78 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.77 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.77 |
| CCN2 | cellular communication network factor 2 | -0.75 |
| PLAU | plasminogen activator, urokinase | -0.65 |
| S100A2 | S100 calcium binding protein A2 | -0.65 |
| GPC4 | glypican 4 | -0.64 |
| OSBPL7 | oxysterol binding protein-like 7 | -0.61 |
| PIP | prolactin-induced protein | -0.61 |
| GDF15 | growth differentiation factor 15 | -0.59 |
| PTPN21 | protein tyrosine phosphatase, non-receptor type 21 | -0.58 |
| SUCO | SUN domain containing ossification factor | -0.56 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | -0.55 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | -0.55 |
| TRIM7 | tripartite motif containing 7 | -0.54 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | -0.54 |
| SP140 | SP140 nuclear body protein | -0.52 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | -0.51 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | -0.51 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.51 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -0.51 |
| CCDC112 | coiled-coil domain containing 112 | -0.5 |
| ALPK3 | alpha-kinase 3 | -0.5 |
| FBXL15 | F-box and leucine-rich repeat protein 15 | -0.5 |
| NAAA | N-acylethanolamine acid amidase | -0.5 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | -0.5 |
| ZSCAN32 | zinc finger and SCAN domain containing 32 | -0.5 |
| JUN | jun proto-oncogene | -0.5 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | -0.5 |
| SPIDR | scaffolding protein involved in DNA repair | -0.49 |
| NRP1 | neuropilin 1 | -0.49 |
| GPC1 | glypican 1 | -0.49 |
| LRRC46 | leucine rich repeat containing 46 | -0.49 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | -0.48 |
| ZMAT3 | zinc finger, matrin-type 3 | -0.47 |
| PLAUR | plasminogen activator, urokinase receptor | -0.47 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.46 |
| HAL | histidine ammonia-lyase | -0.46 |
| ZXDB | zinc finger, X-linked, duplicated B | -0.45 |
| CMTM4 | CKLF-like MARVEL transmembrane domain containing 4 | -0.45 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -0.44 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.44 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | -0.43 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.43 |
| HOXB8 | homeobox B8 | -0.43 |
| GLI4 | GLI family zinc finger 4 | -0.43 |
| ZNF286B | zinc finger protein 286B | -0.43 |
| TMSB10 | thymosin beta 10 | -0.42 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.42 |
| NFYA | nuclear transcription factor Y, alpha | -0.41 |
| SOX13 | SRY (sex determining region Y)-box 13 | -0.41 |
| ULBP1 | UL16 binding protein 1 | -0.4 |
| ATP8B3 | ATPase, aminophospholipid transporter, class I, type 8B, member 3 | -0.4 |
| ADCK1 | aarF domain containing kinase 1 | -0.39 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.39 |
| TEX15 | testis expressed 15 | -0.38 |
| HINT2 | histidine triad nucleotide binding protein 2 | -0.38 |
| FAM117B | family with sequence similarity 117, member B | -0.38 |
| SERPINC1 | serpin peptidase inhibitor, clade C (antithrombin), member 1 | -0.38 |
| MRPL52 | mitochondrial ribosomal protein L52 | -0.37 |
| TLL2 | tolloid-like 2 | -0.37 |
| COA6 | cytochrome c oxidase assembly factor 6 | -0.37 |
| CHCHD2P9 | coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 | -0.37 |
| KLK7 | kallikrein-related peptidase 7 | -0.37 |
| ADIRF | adipogenesis regulatory factor | -0.36 |
| FUT1 | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) | -0.36 |
| MFN2 | mitofusin 2 | -0.36 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.36 |
| CETN1 | centrin, EF-hand protein, 1 | -0.36 |
| MFN1 | mitofusin 1 | -0.35 |
| ACBD6 | acyl-CoA binding domain containing 6 | -0.35 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | -0.35 |
| MRPL50 | mitochondrial ribosomal protein L50 | -0.35 |
| SDC4 | syndecan 4 | -0.35 |
| MED8 | mediator complex subunit 8 | -0.34 |
| ATOX1 | antioxidant 1 copper chaperone | -0.34 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | -0.34 |
| TPM2 | tropomyosin 2 (beta) | -0.34 |
| COX7A2 | cytochrome c oxidase subunit VIIa polypeptide 2 (liver) | -0.34 |
| HAS3 | hyaluronan synthase 3 | -0.34 |
| ZNF696 | zinc finger protein 696 | -0.34 |
| TIGD5 | tigger transposable element derived 5 | -0.34 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.34 |
| UPP1 | uridine phosphorylase 1 | -0.34 |
| GSTA1 | glutathione S-transferase alpha 1 | -0.34 |
| NIN | ninein (GSK3B interacting protein) | -0.33 |
| LAMC2 | laminin, gamma 2 | -0.33 |
| NDUFA7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | -0.33 |
