TAK-875 Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/24857286
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Genes

197 proteins with high or low expression in TAK-875 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
MYT1 myelin transcription factor 1 1.48
TTN titin 1.41
ADPRH ADP-ribosylarginine hydrolase 1.21
NAP1L1 nucleosome assembly protein 1-like 1 0.93
NEK4 NIMA-related kinase 4 0.92
TSTD1 thiosulfate sulfurtransferase (rhodanese)-like domain containing 1 0.87
KIAA1109 KIAA1109 0.84
STK40 serine/threonine kinase 40 0.7
ANK2 ankyrin 2, neuronal 0.68
CHPF chondroitin polymerizing factor 0.67
ALPK3 alpha-kinase 3 0.64
SBNO2 strawberry notch homolog 2 (Drosophila) 0.63
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.59
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.58
LRRC45 leucine rich repeat containing 45 0.58
PUM1 pumilio RNA-binding family member 1 0.57
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.57
ARFIP1 ADP-ribosylation factor interacting protein 1 0.56
TMEM64 transmembrane protein 64 0.56
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.55
TMEM199 transmembrane protein 199 0.54
COX5A cytochrome c oxidase subunit Va 0.54
KMT2B lysine (K)-specific methyltransferase 2B 0.53
UBXN8 UBX domain protein 8 0.53
ARL6IP6 ADP-ribosylation factor-like 6 interacting protein 6 0.53
TPM4 tropomyosin 4 0.5
ETV6 ets variant 6 0.5
ATP5PF ATP synthase peripheral stalk subunit F6 0.49
NTHL1 nth endonuclease III-like 1 (E. coli) 0.48
SGPP1 sphingosine-1-phosphate phosphatase 1 0.47
SUMO2 small ubiquitin-like modifier 2 0.47
TMSB10 thymosin beta 10 0.47
CCDC115 coiled-coil domain containing 115 0.46
ZNRD1 zinc ribbon domain containing 1 0.46
CKS2 CDC28 protein kinase regulatory subunit 2 0.45
PRR14L proline rich 14-like 0.45
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 0.44
MDM4 MDM4, p53 regulator 0.44
HIST2H2AA3 histone cluster 2, H2aa3 0.44
NDEL1 nudE neurodevelopment protein 1-like 1 0.43
COMMD9 COMM domain containing 9 0.43
PSAP prosaposin 0.43
KDM3A lysine (K)-specific demethylase 3A 0.42
SIRT2 sirtuin 2 0.42
H1-5 H1.5 linker histone, cluster member 0.42
PET117 PET117 homolog (S. cerevisiae) 0.4
CMC1 C-x(9)-C motif containing 1 0.4
TMEM200A transmembrane protein 200A 0.4
TRIM7 tripartite motif containing 7 0.39
ADGRF1 adhesion G protein-coupled receptor F1 0.39
KLHL11 kelch-like family member 11 0.39
RNF139 ring finger protein 139 0.39
RAB38 RAB38, member RAS oncogene family 0.39
RPGRIP1L RPGRIP1-like 0.39
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.39
TMEM39A transmembrane protein 39A 0.39
CCHCR1 coiled-coil alpha-helical rod protein 1 0.38
ZNF395 zinc finger protein 395 0.38
TMEM87B transmembrane protein 87B 0.38
CREG1 cellular repressor of E1A-stimulated genes 1 0.38
SHFL shiftless antiviral inhibitor of ribosomal frameshifting 0.37
SENP7 SUMO1/sentrin specific peptidase 7 0.37
SLC39A11 solute carrier family 39, member 11 0.37
RAB30 RAB30, member RAS oncogene family 0.36
PPHLN1 periphilin 1 0.36
RPL35 ribosomal protein L35 0.36
PIP prolactin-induced protein 0.36
MCFD2 multiple coagulation factor deficiency 2 0.36
JPT1 Jupiter microtubule associated homolog 1 0.36
SCAP SREBF chaperone 0.36
HMGN4 high mobility group nucleosomal binding domain 4 0.36
TPM3 tropomyosin 3 0.36
CCNF cyclin F 0.35
MRPL12 mitochondrial ribosomal protein L12 0.35
DISP2 dispatched homolog 2 (Drosophila) 0.35
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 0.34
GM2A GM2 ganglioside activator 0.34
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.34
THSD4 thrombospondin, type I, domain containing 4 0.34
BAIAP2 BAI1-associated protein 2 0.34
NDE1 nudE neurodevelopment protein 1 0.33
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.33
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.33
TBC1D14 TBC1 domain family, member 14 0.33
PFDN1 prefoldin subunit 1 0.33
ZYX zyxin 0.32
TPM2 tropomyosin 2 (beta) 0.32
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 0.32
SP100 SP100 nuclear antigen 0.32
SOX4 SRY (sex determining region Y)-box 4 0.31
MKS1 Meckel syndrome, type 1 0.31
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.31
DBN1 drebrin 1 0.31
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.31
HLA-F major histocompatibility complex, class I, F 0.31
FAM136A family with sequence similarity 136, member A 0.31
COX5B cytochrome c oxidase subunit Vb 0.31

low expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.9
TCAIM T cell activation inhibitor, mitochondrial -0.75
PYGM phosphorylase, glycogen, muscle -0.71
GFOD2 glucose-fructose oxidoreductase domain containing 2 -0.61
RNF220 ring finger protein 220 -0.6
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -0.58
PROS1 protein S (alpha) -0.57
MAF1 MAF1 homolog (S. cerevisiae) -0.56
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.55
CCSER1 coiled-coil serine-rich protein 1 -0.55
TCTN3 tectonic family member 3 -0.54
TENM2 teneurin transmembrane protein 2 -0.53
GREB1 growth regulation by estrogen in breast cancer 1 -0.52
RAD54L RAD54-like (S. cerevisiae) -0.5
C5ORF51 chromosome 5 open reading frame 51 -0.5
ANKRD26 ankyrin repeat domain 26 -0.49
RHOD ras homolog family member D -0.48
BAG1 BCL2-associated athanogene -0.47
COPS7B COP9 signalosome subunit 7B -0.46
MOB3A MOB kinase activator 3A -0.46
FAT2 FAT atypical cadherin 2 -0.45
SON SON DNA binding protein -0.45
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -0.45
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -0.45
BANF1 barrier to autointegration factor 1 -0.45
PRX periaxin -0.44
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 -0.43
RIPK4 receptor-interacting serine-threonine kinase 4 -0.43
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 -0.42
DLG2 discs, large homolog 2 (Drosophila) -0.42
ARL6 ADP-ribosylation factor-like 6 -0.42
LYST lysosomal trafficking regulator -0.4
TXNDC15 thioredoxin domain containing 15 -0.4
CRABP2 cellular retinoic acid binding protein 2 -0.39
SGCE sarcoglycan, epsilon -0.39
LAGE3 L antigen family, member 3 -0.39
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.39
MAU2 MAU2 sister chromatid cohesion factor -0.39
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K -0.38
RNF14 ring finger protein 14 -0.38
ZNF316 zinc finger protein 316 -0.38
RAB12 RAB12, member RAS oncogene family -0.38
ZNF460 zinc finger protein 460 -0.38
EAPP E2F-associated phosphoprotein -0.37
ENDOV endonuclease V -0.37
EXT1 exostosin glycosyltransferase 1 -0.37
RBM4B RNA binding motif protein 4B -0.37
PXDN peroxidasin -0.37
TRAF3IP2 TRAF3 interacting protein 2 -0.36
SLC35B1 solute carrier family 35, member B1 -0.36
ZFP36L2 ZFP36 ring finger protein-like 2 -0.36
CYP4F22 cytochrome P450, family 4, subfamily F, polypeptide 22 -0.36
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -0.36
FBXL3 F-box and leucine-rich repeat protein 3 -0.36
EPHA1 EPH receptor A1 -0.36
CDKN3 cyclin-dependent kinase inhibitor 3 -0.36
FAM171A1 family with sequence similarity 171, member A1 -0.35
SHB Src homology 2 domain containing adaptor protein B -0.35
SPPL2B signal peptide peptidase like 2B -0.35
RPS26P11 ribosomal protein S26 pseudogene 11 -0.35
FHL3 four and a half LIM domains 3 -0.34
COL17A1 collagen, type XVII, alpha 1 -0.34
MAGEA6 melanoma antigen family A6 -0.34
GPR107 G protein-coupled receptor 107 -0.34
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -0.34
ABRAXAS2 abraxas 2, BRISC complex subunit -0.34
ZNF317 zinc finger protein 317 -0.34
WDR25 WD repeat domain 25 -0.34
RHOB ras homolog family member B -0.34
MIGA2 mitoguardin 2 -0.33
NAA80 N-alpha-acetyltransferase 80, NatH catalytic subunit -0.33
NPEPL1 aminopeptidase-like 1 -0.33
MAPK14 mitogen-activated protein kinase 14 -0.33
HLA-E major histocompatibility complex, class I, E -0.33
TGFBR1 transforming growth factor, beta receptor 1 -0.32
AEN apoptosis enhancing nuclease -0.32
CDK18 cyclin-dependent kinase 18 -0.32
NDFIP1 Nedd4 family interacting protein 1 -0.32
KIF27 kinesin family member 27 -0.32
MUS81 MUS81 structure-specific endonuclease subunit -0.31
GPX4 glutathione peroxidase 4 -0.31
ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein -0.31
FAM102A family with sequence similarity 102, member A -0.31
KCTD5 potassium channel tetramerization domain containing 5 -0.31
CCDC77 coiled-coil domain containing 77 -0.31
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -0.31
GBA2 glucosidase, beta (bile acid) 2 -0.31
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.31
ESAM endothelial cell adhesion molecule -0.31
PLEKHA6 pleckstrin homology domain containing, family A member 6 -0.3
H3C1 H3 clustered histone 1 -0.3
CRBN cereblon -0.3
GSDME gasdermin E -0.3
MNT MAX network transcriptional repressor -0.3
ZNF600 zinc finger protein 600 -0.3
GXYLT1 glucoside xylosyltransferase 1 -0.3
ELAC1 elaC ribonuclease Z 1 -0.3
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.3
PTDSS1 phosphatidylserine synthase 1 -0.3
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -0.29