| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-901 perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-901_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.11636 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.112603 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0988978 |
| RUNX1 | runt-related transcription factor 1 | 0.0949529 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0856299 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0830154 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0769424 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0724947 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0628499 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0595706 |
| SQSTM1 | sequestosome 1 | 0.0579137 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0544863 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0536916 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0527443 |
| FLNB | filamin B, beta | 0.0506313 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0504711 |
| NDRG1 | N-myc downstream regulated 1 | 0.0497484 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0496078 |
| TPM3 | tropomyosin 3 | 0.0494513 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0494301 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0486924 |
| RPS6 | ribosomal protein S6 | 0.0444475 |
| DST | dystonin | 0.0437088 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0432115 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0417576 |
| SON | SON DNA binding protein | 0.0415023 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0401518 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0387989 |
| RPS3 | ribosomal protein S3 | 0.0381474 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0381193 |
| ZNF292 | zinc finger protein 292 | 0.0380177 |
| LOXL2 | lysyl oxidase-like 2 | 0.0370283 |
| AHNAK | AHNAK nucleoprotein | 0.0369752 |
| CD44 | CD44 molecule (Indian blood group) | 0.0368489 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0363528 |
| SBF2 | SET binding factor 2 | 0.0363155 |
| SETD5 | SET domain containing 5 | 0.0360719 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0360166 |
| NEK7 | NIMA-related kinase 7 | 0.0354406 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0352739 |
| APP | amyloid beta (A4) precursor protein | 0.0350664 |
| MSN | moesin | 0.0348305 |
| PTK2 | protein tyrosine kinase 2 | 0.033912 |
| VEGFA | vascular endothelial growth factor A | 0.0335625 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0331778 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0321757 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0311943 |
| TLE4 | transducin-like enhancer of split 4 | 0.0308071 |
| GOLGA4 | golgin A4 | 0.0304882 |
| HDAC9 | histone deacetylase 9 | 0.0299133 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0297345 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0295082 |
| EGFR | epidermal growth factor receptor | 0.0292654 |
| USP34 | ubiquitin specific peptidase 34 | 0.0291155 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0289551 |
| GPC6 | glypican 6 | 0.0287029 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0286265 |
| RBM25 | RNA binding motif protein 25 | 0.0285436 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0284222 |
| HELZ | helicase with zinc finger | 0.0283757 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0280346 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0279502 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0275782 |
| ERBIN | erbb2 interacting protein | 0.0272542 |
| CALR | calreticulin | 0.0271347 |
| SET | SET nuclear proto-oncogene | 0.0270725 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0270685 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0268558 |
| CENPF | centromere protein F, 350/400kDa | 0.0267109 |
| RND3 | Rho family GTPase 3 | 0.0266779 |
| NAV2 | neuron navigator 2 | 0.0265696 |
| TPM4 | tropomyosin 4 | 0.0262245 |
| PKM | pyruvate kinase, muscle | 0.0256732 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0253844 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0253813 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0252595 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0252363 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0250239 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0249673 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0248452 |
| JMJD1C | jumonji domain containing 1C | 0.024776 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0246513 |
| RNF145 | ring finger protein 145 | 0.0244521 |
| ZNF638 | zinc finger protein 638 | 0.0244355 |
| MEIS2 | Meis homeobox 2 | 0.0244314 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0243692 |
| ANXA1 | annexin A1 | 0.024355 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.024294 |
| RPS12 | ribosomal protein S12 | 0.0242011 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0241886 |
| SEPTIN9 | septin 9 | 0.0241782 |
| FLNA | filamin A, alpha | 0.0239811 |
| ARRDC3 | arrestin domain containing 3 | 0.0238352 |
| POTEF | POTE ankyrin domain family, member F | 0.023829 |
| MATR3 | matrin 3 | 0.0237277 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0232728 |
| OGA | O-GlcNAcase | 0.0230697 |
| RACK1 | receptor for activated C kinase 1 | 0.0230419 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0227925 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0227651 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.153836 |
| LOX | lysyl oxidase | -0.134989 |
| PLAT | plasminogen activator, tissue | -0.12639 |
| TMSB10 | thymosin beta 10 | -0.11116 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.105192 |
| FN1 | fibronectin 1 | -0.0996853 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.091948 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0860071 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0838687 |
| PRSS23 | protease, serine, 23 | -0.0812526 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.07487 |
| PODXL | podocalyxin-like | -0.0727418 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0725563 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0723975 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0716233 |
| S100A6 | S100 calcium binding protein A6 | -0.0704016 |
| HLA-B | major histocompatibility complex, class I, B | -0.0680468 |
| SUCNR1 | succinate receptor 1 | -0.0647807 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0608952 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0595987 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0578046 |
| RIGI | RNA sensor RIG-I | -0.0566211 |
| LMNA | lamin A/C | -0.054744 |
| CAVIN1 | caveolae associated protein 1 | -0.050515 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0494668 |
| MX2 | MX dynamin-like GTPase 2 | -0.0494549 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0459449 |
| MT1X | metallothionein 1X | -0.0450823 |
| S100A4 | S100 calcium binding protein A4 | -0.0449919 |
| TAGLN2 | transgelin 2 | -0.0429609 |
| THBS2 | thrombospondin 2 | -0.0420867 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0407944 |
| HLA-C | major histocompatibility complex, class I, C | -0.0403971 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0387019 |
| LRRC17 | leucine rich repeat containing 17 | -0.0366803 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0360878 |
| COL1A2 | collagen, type I, alpha 2 | -0.0360156 |
| KRT81 | keratin 81, type II | -0.0334077 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0329158 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0327079 |
| COL3A1 | collagen, type III, alpha 1 | -0.0322955 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0319676 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0313351 |
| NUAK2 | NUAK family, SNF1-like kinase, 2 | -0.0310998 |
| PGK1 | phosphoglycerate kinase 1 | -0.0299926 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0295959 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0293627 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0281379 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0273182 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.027066 |
| COL1A1 | collagen, type I, alpha 1 | -0.0269603 |
| CSTB | cystatin B (stefin B) | -0.0264677 |
| COL5A1 | collagen, type V, alpha 1 | -0.0262377 |
| IL7R | interleukin 7 receptor | -0.0256734 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0251009 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0250866 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0249839 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.02432 |
| GNAS | GNAS complex locus | -0.0240774 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0239997 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0237475 |
| NPR2 | natriuretic peptide receptor 2 | -0.0234215 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0230606 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.022354 |
| S100A10 | S100 calcium binding protein A10 | -0.0214766 |
| SAMD9L | sterile alpha motif domain containing 9-like | -0.0212679 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0211379 |
| HLA-E | major histocompatibility complex, class I, E | -0.020639 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.0202776 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.019727 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0196905 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0190997 |
| TMEM263 | transmembrane protein 263 | -0.0189681 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0189198 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0186323 |
| FNDC3A | fibronectin type III domain containing 3A | -0.018596 |
| SAR1A | secretion associated, Ras related GTPase 1A | -0.0184015 |
| TUBA1C | tubulin, alpha 1c | -0.018397 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0179544 |
| CD59 | CD59 molecule, complement regulatory protein | -0.017867 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0176483 |
| SPAG9 | sperm associated antigen 9 | -0.0174809 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | -0.0172395 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0169368 |
| FBN1 | fibrillin 1 | -0.0167093 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.016563 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0165365 |
| ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein-like 2 | -0.0162444 |
| NAV1 | neuron navigator 1 | -0.016217 |
| CCND1 | cyclin D1 | -0.0161722 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0161099 |
| MYADM | myeloid-associated differentiation marker | -0.0160513 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0159386 |
| PLXNA2 | plexin A2 | -0.0157707 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0156211 |
| ZNF217 | zinc finger protein 217 | -0.0152093 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0151874 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0151328 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0149455 |
| H3-3B | H3.3 histone B | -0.0147223 |
