| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-901 perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-901_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.110791 |
| VMP1 | vacuole membrane protein 1 | 0.0702622 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0628074 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0613062 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0585922 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0570765 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0552876 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0535201 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0487433 |
| RPS12 | ribosomal protein S12 | 0.0483587 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0473218 |
| RPS6 | ribosomal protein S6 | 0.0454402 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0453071 |
| RPS3 | ribosomal protein S3 | 0.045282 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0430386 |
| ANXA1 | annexin A1 | 0.0403501 |
| RPL37A | ribosomal protein L37a | 0.0351822 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0351256 |
| RPS23 | ribosomal protein S23 | 0.034988 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0345989 |
| GOLGB1 | golgin B1 | 0.0335724 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0332544 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0332008 |
| YAP1 | Yes-associated protein 1 | 0.0327951 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0325415 |
| MED13L | mediator complex subunit 13-like | 0.0322968 |
| TPM3 | tropomyosin 3 | 0.0312762 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0295837 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0292632 |
| SETD5 | SET domain containing 5 | 0.0291773 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0291598 |
| RPL36 | ribosomal protein L36 | 0.0289249 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0288423 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0277282 |
| RPS29 | ribosomal protein S29 | 0.0275208 |
| ATP11A | ATPase, class VI, type 11A | 0.0274601 |
| HDAC9 | histone deacetylase 9 | 0.0268485 |
| RPS7 | ribosomal protein S7 | 0.0266389 |
| PNN | pinin, desmosome associated protein | 0.0264911 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0262451 |
| EXOC6B | exocyst complex component 6B | 0.02622 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0259908 |
| RPL26 | ribosomal protein L26 | 0.0259841 |
| ARRDC3 | arrestin domain containing 3 | 0.0257185 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.025398 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0252689 |
| HMGA2 | high mobility group AT-hook 2 | 0.0250598 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.024913 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0247817 |
| CALR | calreticulin | 0.024603 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.024333 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0241128 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0241105 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0237493 |
| TXNRD1 | thioredoxin reductase 1 | 0.0236931 |
| WWOX | WW domain containing oxidoreductase | 0.0236222 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0233975 |
| YBX1 | Y box binding protein 1 | 0.0231767 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0231218 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0225309 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0224849 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0224447 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0224305 |
| RPL7 | ribosomal protein L7 | 0.0224235 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0222236 |
| PDGFC | platelet derived growth factor C | 0.02199 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0216567 |
| CDK6 | cyclin-dependent kinase 6 | 0.0212734 |
| RPS18 | ribosomal protein S18 | 0.0212127 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0211912 |
| GOLGA4 | golgin A4 | 0.0211663 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0210878 |
| PRKCI | protein kinase C, iota | 0.0210027 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0209528 |
| IPO7 | importin 7 | 0.0208822 |
| INTS6 | integrator complex subunit 6 | 0.0208635 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0208586 |
| TENM3 | teneurin transmembrane protein 3 | 0.0208555 |
| MPG | N-methylpurine-DNA glycosylase | 0.0208474 |
| PCDH9 | protocadherin 9 | 0.0208197 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0207413 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.020665 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0205586 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.020542 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0204663 |
| CLDND1 | claudin domain containing 1 | 0.0204594 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0203368 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.020174 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0200938 |
| EZR | ezrin | 0.0197669 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0197539 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0194531 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0194077 |
| PHF3 | PHD finger protein 3 | 0.0193595 |
| BRD2 | bromodomain containing 2 | 0.0191996 |
| DENND5A | DENN/MADD domain containing 5A | 0.0190571 |
| RPS17 | ribosomal protein S17 | 0.0187167 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0186133 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0185548 |
| B2M | beta-2-microglobulin | 0.0184345 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTG1 | actin gamma 1 | -0.0922595 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0911424 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0905852 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0680677 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0676931 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0674428 |
| PTMA | prothymosin, alpha | -0.0626317 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0601866 |
| TUBA1B | tubulin, alpha 1b | -0.0540055 |
| TMSB10 | thymosin beta 10 | -0.049682 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0491529 |
| NHSL1 | NHS-like 1 | -0.0472231 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.046912 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.046597 |
| HMGA1 | high mobility group AT-hook 1 | -0.0459261 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0452033 |
| CENPF | centromere protein F, 350/400kDa | -0.0442843 |
| MKI67 | marker of proliferation Ki-67 | -0.0419138 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0417914 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0384051 |
| TUBA1C | tubulin, alpha 1c | -0.0382645 |
| RPS21 | ribosomal protein S21 | -0.037313 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0371632 |
| TMEM123 | transmembrane protein 123 | -0.0346392 |
| EGR1 | early growth response 1 | -0.0341038 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0328043 |
| PFN1 | profilin 1 | -0.0326256 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0320202 |
| RPLP1 | ribosomal protein, large, P1 | -0.0307975 |
| RPS24 | ribosomal protein S24 | -0.0303546 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0302944 |
| CLDN1 | claudin 1 | -0.0302887 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0298801 |
| HMGB1 | high mobility group box 1 | -0.029633 |
| H1-0 | H1.0 linker histone | -0.0294587 |
| TPX2 | TPX2, microtubule-associated | -0.0294403 |
| TUBB | tubulin, beta class I | -0.0294173 |
| GNAS | GNAS complex locus | -0.0289694 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0285321 |
| CENPE | centromere protein E, 312kDa | -0.0278605 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0278556 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0271973 |
| TPM4 | tropomyosin 4 | -0.0267695 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0267398 |
| YBX3 | Y box binding protein 3 | -0.0263633 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0262862 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0257009 |
| RPLP0 | ribosomal protein, large, P0 | -0.0253538 |
| KIF18B | kinesin family member 18B | -0.0252738 |
| PRR11 | proline rich 11 | -0.0244301 |
| RPL35A | ribosomal protein L35a | -0.0242523 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0241301 |
| S100A6 | S100 calcium binding protein A6 | -0.0239285 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.023868 |
| PGK1 | phosphoglycerate kinase 1 | -0.0236552 |
| SGO2 | shugoshin 2 | -0.0228606 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.022132 |
| RRM2 | ribonucleotide reductase M2 | -0.0213084 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0212214 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0208273 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0207641 |
| GCG | glucagon | -0.0207257 |
| BCHE | butyrylcholinesterase | -0.0202144 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0197801 |
| ZNF804A | zinc finger protein 804A | -0.0196961 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0195216 |
| NDC80 | NDC80 kinetochore complex component | -0.0193479 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0192586 |
| RPL34 | ribosomal protein L34 | -0.019202 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0190016 |
| KHSRP | KH-type splicing regulatory protein | -0.0186831 |
| MTAP | methylthioadenosine phosphorylase | -0.0185894 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0179434 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0179152 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0177946 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0172372 |
| KIF2C | kinesin family member 2C | -0.0170208 |
| CDK12 | cyclin-dependent kinase 12 | -0.0166219 |
| KIF14 | kinesin family member 14 | -0.0163591 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0162915 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0162214 |
| LDHA | lactate dehydrogenase A | -0.0158137 |
| CBX3 | chromobox homolog 3 | -0.0157591 |
| VCL | vinculin | -0.0157561 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0157256 |
| BTG3 | BTG family, member 3 | -0.0156519 |
| PARK7 | parkinson protein 7 | -0.0155853 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.015551 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0154575 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.0154056 |
| S100A10 | S100 calcium binding protein A10 | -0.0153675 |
| NAV3 | neuron navigator 3 | -0.0152329 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0150424 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0150028 |
| BRI3BP | BRI3 binding protein | -0.0149278 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0149229 |
| TYMS | thymidylate synthetase | -0.0148846 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.014856 |
| DEK | DEK proto-oncogene | -0.0148174 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0148136 |
