TAK-901_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.196006
FRMD4A FERM domain containing 4A 0.175653
FTH1 ferritin, heavy polypeptide 1 0.143327
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.101061
GPC6 glypican 6 0.0806195
RPS6 ribosomal protein S6 0.0798183
CD44 CD44 molecule (Indian blood group) 0.0724764
EXT1 exostosin glycosyltransferase 1 0.067854
VEGFA vascular endothelial growth factor A 0.0584532
RND3 Rho family GTPase 3 0.0579367
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0547379
B2M beta-2-microglobulin 0.0535561
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0528231
MT2A metallothionein 2A 0.0510155
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0494386
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0471833
HDAC9 histone deacetylase 9 0.0461532
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0442334
EGFR epidermal growth factor receptor 0.0419504
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0419483
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.041483
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0413621
SRRM2 serine/arginine repetitive matrix 2 0.0408244
ZSWIM6 zinc finger, SWIM-type containing 6 0.0404805
RPL35A ribosomal protein L35a 0.0373828
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0368613
RNF213 ring finger protein 213 0.0366064
KYNU kynureninase 0.0353184
RPS19 ribosomal protein S19 0.0350775
MGST1 microsomal glutathione S-transferase 1 0.0327216
IFI44L interferon-induced protein 44-like 0.0319052
CREB5 cAMP responsive element binding protein 5 0.0317797
WDR43 WD repeat domain 43 0.0314899
SP100 SP100 nuclear antigen 0.0313376
RPL37A ribosomal protein L37a 0.0312914
NDRG1 N-myc downstream regulated 1 0.0312858
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0303106
PDLIM5 PDZ and LIM domain 5 0.0300901
PDE4D phosphodiesterase 4D, cAMP-specific 0.0300773
RPS17 ribosomal protein S17 0.029588
TSHZ2 teashirt zinc finger homeobox 2 0.0293503
LOC102724023 ES1 protein homolog, mitochondrial 0.0290479
PLIN2 perilipin 2 0.0283349
INTS6 integrator complex subunit 6 0.0282269
GOLGB1 golgin B1 0.0276785
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0276457
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0272727
S100A11 S100 calcium binding protein A11 0.027153
MX1 MX dynamin-like GTPase 1 0.0264891
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0264186
BCL2L1 BCL2-like 1 0.0264128
CSNK1G1 casein kinase 1, gamma 1 0.0256479
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0255512
DGKI diacylglycerol kinase, iota 0.0255124
OSMR oncostatin M receptor 0.0248517
CALD1 caldesmon 1 0.0244308
LOXL2 lysyl oxidase-like 2 0.0241006
TLE4 transducin-like enhancer of split 4 0.0239774
IFITM3 interferon induced transmembrane protein 3 0.0237377
SHB Src homology 2 domain containing adaptor protein B 0.0235434
RAI14 retinoic acid induced 14 0.0235336
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0234073
RPS23 ribosomal protein S23 0.0233066
SON SON DNA binding protein 0.0233008
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0231106
CMIP c-Maf inducing protein 0.0227139
HLA-B major histocompatibility complex, class I, B 0.0224617
NAV2 neuron navigator 2 0.021664
CUX1 cut-like homeobox 1 0.0214711
SEPTIN9 septin 9 0.0213549
PAX8 paired box 8 0.020698
RAB7A RAB7A, member RAS oncogene family 0.0204995
MSR1 macrophage scavenger receptor 1 0.0201121
FOSL1 FOS-like antigen 1 0.0200873
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0200101
BNC2 basonuclin 2 0.0195936
MCL1 myeloid cell leukemia 1 0.0193337
MYOF myoferlin 0.0191874
SFTPA2 surfactant protein A2 0.0189737
AKAP9 A kinase (PRKA) anchor protein 9 0.0189011
RAD51B RAD51 paralog B 0.0188867
BPTF bromodomain PHD finger transcription factor 0.0186184
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0183305
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0181466
FBXO22 F-box protein 22 0.0179907
RIGI RNA sensor RIG-I 0.0179243
EPAS1 endothelial PAS domain protein 1 0.0177779
CDCP1 CUB domain containing protein 1 0.017746
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.017705
SAMD4A sterile alpha motif domain containing 4A 0.0174952
RPL26 ribosomal protein L26 0.017467
BHLHE40 basic helix-loop-helix family, member e40 0.0174592
PRRC2C proline-rich coiled-coil 2C 0.0173946
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0173059
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0172894
EFNA5 ephrin-A5 0.0172824
PRKCG protein kinase C, gamma 0.0172706
TBCA tubulin folding cofactor A 0.0172107
MYO1E myosin IE 0.0171321
PGM3 phosphoglucomutase 3 0.0171303

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.183189
ASPH aspartate beta-hydroxylase -0.118225
NAMPT nicotinamide phosphoribosyltransferase -0.0866595
UBC ubiquitin C -0.0854639
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0827978
GLS2 glutaminase 2 (liver, mitochondrial) -0.0729857
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0669327
PTMA prothymosin, alpha -0.0660812
SOD2 superoxide dismutase 2, mitochondrial -0.0611069
VIM vimentin -0.0576922
RHEB Ras homolog enriched in brain -0.0563757
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0548317
RAD21 RAD21 homolog (S. pombe) -0.0546188
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0535575
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0526806
JUN jun proto-oncogene -0.0491113
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0490547
POTEF POTE ankyrin domain family, member F -0.0471304
DDIT4 DNA-damage-inducible transcript 4 -0.0446609
RPS27A ribosomal protein S27a -0.0443836
APP amyloid beta (A4) precursor protein -0.0430876
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0427502
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0425316
NAP1L1 nucleosome assembly protein 1-like 1 -0.0423901
SDCBP syndecan binding protein (syntenin) -0.0408216
SPAG9 sperm associated antigen 9 -0.0408177
DENND2B DENN domain containing 2B -0.0407149
G0S2 G0/G1 switch 2 -0.0400487
NRP2 neuropilin 2 -0.0394762
OSBPL3 oxysterol binding protein-like 3 -0.0391076
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0390753
MARCHF6 membrane associated ring-CH-type finger 6 -0.0386037
HMGB2 high mobility group box 2 -0.0373833
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.036948
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.036179
ANKRD10 ankyrin repeat domain 10 -0.0359166
TMSB10 thymosin beta 10 -0.0344107
CADM1 cell adhesion molecule 1 -0.0340741
USP3 ubiquitin specific peptidase 3 -0.0338523
ANLN anillin, actin binding protein -0.0337849
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0334079
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0330779
PTBP3 polypyrimidine tract binding protein 3 -0.0323457
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0322097
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0321329
IFRD1 interferon-related developmental regulator 1 -0.0320748
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0317548
KDM3A lysine (K)-specific demethylase 3A -0.0316874
CALU calumenin -0.0311337
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0309012
ZFAND3 zinc finger, AN1-type domain 3 -0.0303542
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0302223
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0298359
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0297675
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0295674
GNAS GNAS complex locus -0.0293919
TMEM263 transmembrane protein 263 -0.029301
PKM pyruvate kinase, muscle -0.0289935
DENND4A DENN/MADD domain containing 4A -0.02824
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0280702
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0280409
TFG TRK-fused gene -0.027571
SMG7 SMG7 nonsense mediated mRNA decay factor -0.027314
COG5 component of oligomeric golgi complex 5 -0.0270268
AHNAK AHNAK nucleoprotein -0.0269039
EEF2 eukaryotic translation elongation factor 2 -0.0267244
PDIA4 protein disulfide isomerase family A, member 4 -0.0261702
HDLBP high density lipoprotein binding protein -0.0261683
WAC WW domain containing adaptor with coiled-coil -0.0260512
TKT transketolase -0.0259318
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.025849
QKI QKI, KH domain containing, RNA binding -0.0258039
SRPK2 SRSF protein kinase 2 -0.0256928
CALR calreticulin -0.0255033
PRRC1 proline-rich coiled-coil 1 -0.0254881
NPEPPS aminopeptidase puromycin sensitive -0.0254095
XPO1 exportin 1 -0.0252953
RTN4 reticulon 4 -0.0249947
LAPTM4A lysosomal protein transmembrane 4 alpha -0.0248921
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0248575
JAK1 Janus kinase 1 -0.0247262
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0242584
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0242063
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0242061
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0241956
COL4A1 collagen, type IV, alpha 1 -0.0241458
SDC4 syndecan 4 -0.0241187
HMGB1 high mobility group box 1 -0.0239757
CAVIN1 caveolae associated protein 1 -0.0239752
TAGLN2 transgelin 2 -0.0239124
PCBP2 poly(rC) binding protein 2 -0.0238789
HIP1 huntingtin interacting protein 1 -0.0233806
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.023322
GLG1 golgi glycoprotein 1 -0.0231703
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0231245
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0230979
ITGAV integrin, alpha V -0.0230758
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0230276
EPB41L2 erythrocyte membrane protein band 4.1-like 2 -0.0229672
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0229037