TAK-901_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.306836
AKAP12 A kinase (PRKA) anchor protein 12 0.243219
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.135503
VIM vimentin 0.133446
RPS6 ribosomal protein S6 0.126128
ANXA2 annexin A2 0.122643
PDE4D phosphodiesterase 4D, cAMP-specific 0.120743
PABPC1 poly(A) binding protein, cytoplasmic 1 0.119021
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0910897
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0773296
FTL ferritin, light polypeptide 0.0761941
IGFBP3 insulin-like growth factor binding protein 3 0.0761325
MT2A metallothionein 2A 0.0742961
RPS19 ribosomal protein S19 0.0728208
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0726688
EEF2 eukaryotic translation elongation factor 2 0.0689468
FNDC3B fibronectin type III domain containing 3B 0.064391
SRRM2 serine/arginine repetitive matrix 2 0.0619483
RPS3 ribosomal protein S3 0.059904
EGFR epidermal growth factor receptor 0.0596455
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0595002
RPL26 ribosomal protein L26 0.0593952
CA12 carbonic anhydrase XII 0.0592415
AHNAK AHNAK nucleoprotein 0.0574581
RPS17 ribosomal protein S17 0.055656
ENO1 enolase 1, (alpha) 0.055112
PKM pyruvate kinase, muscle 0.055088
FLNB filamin B, beta 0.0542475
TMSB10 thymosin beta 10 0.0540922
DOCK5 dedicator of cytokinesis 5 0.0539768
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0525545
KYNU kynureninase 0.0511281
PFN1 profilin 1 0.0508462
PRRC2C proline-rich coiled-coil 2C 0.0507969
ARHGAP26 Rho GTPase activating protein 26 0.0502276
TXNRD1 thioredoxin reductase 1 0.0493568
VMP1 vacuole membrane protein 1 0.0486639
MYADM myeloid-associated differentiation marker 0.044209
RNF145 ring finger protein 145 0.0440106
ALCAM activated leukocyte cell adhesion molecule 0.0439638
EIF4A1 eukaryotic translation initiation factor 4A1 0.043809
GRB10 growth factor receptor-bound protein 10 0.0434146
RACK1 receptor for activated C kinase 1 0.0431274
CD44 CD44 molecule (Indian blood group) 0.0404211
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0403598
EHBP1 EH domain binding protein 1 0.0402037
RPL18 ribosomal protein L18 0.0395591
LDHA lactate dehydrogenase A 0.0394553
FMNL2 formin-like 2 0.0392345
RPL37A ribosomal protein L37a 0.0392303
TPI1 triosephosphate isomerase 1 0.0386992
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0381011
THSD4 thrombospondin, type I, domain containing 4 0.0375992
RPL12 ribosomal protein L12 0.0373327
RPL32 ribosomal protein L32 0.0370451
ANXA1 annexin A1 0.0367493
LIMCH1 LIM and calponin homology domains 1 0.0366876
MYOF myoferlin 0.0366349
NAP1L1 nucleosome assembly protein 1-like 1 0.0366233
MAP1B microtubule-associated protein 1B 0.0366085
AKAP13 A kinase (PRKA) anchor protein 13 0.0363409
PDLIM5 PDZ and LIM domain 5 0.0362461
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.035734
MYO1E myosin IE 0.0351111
DSTN destrin (actin depolymerizing factor) 0.0344189
RPL8 ribosomal protein L8 0.0343215
CEMIP cell migration inducing protein, hyaluronan binding 0.0339239
KIRREL3 kin of IRRE like 3 (Drosophila) 0.033599
RPL7 ribosomal protein L7 0.033598
RPS23 ribosomal protein S23 0.0328102
JMJD1C jumonji domain containing 1C 0.032736
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0327049
PTK2 protein tyrosine kinase 2 0.0325142
RPL19 ribosomal protein L19 0.0322751
AXL AXL receptor tyrosine kinase 0.032033
NDRG1 N-myc downstream regulated 1 0.031285
YBX1 Y box binding protein 1 0.0309414
LRPPRC leucine-rich pentatricopeptide repeat containing 0.030886
EFNA5 ephrin-A5 0.0304943
TPM3 tropomyosin 3 0.0304687
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0301756
AKAP9 A kinase (PRKA) anchor protein 9 0.0301137
RNF213 ring finger protein 213 0.0300102
RPL23 ribosomal protein L23 0.029965
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0298933
MAP7 microtubule-associated protein 7 0.0298828
SON SON DNA binding protein 0.0297879
EIF1 eukaryotic translation initiation factor 1 0.0292369
BPTF bromodomain PHD finger transcription factor 0.029017
CCDC88A coiled-coil domain containing 88A 0.0289501
DST dystonin 0.0287545
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0286401
TBC1D5 TBC1 domain family, member 5 0.0284435
RPS5 ribosomal protein S5 0.0282994
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0282159
LOC112694756 uncharaterized LOC112694756 0.0280018
RPL11 ribosomal protein L11 0.0279969
SBF2 SET binding factor 2 0.0279812
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0279753
RICTOR RPTOR independent companion of MTOR, complex 2 0.0276676

decreased expression

Symbol Name Standardized Value
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.115206
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0831566
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0476354
NUAK2 NUAK family, SNF1-like kinase, 2 -0.0364806
FAT1 FAT atypical cadherin 1 -0.034507
EDN1 endothelin 1 -0.0330805
PTMA prothymosin, alpha -0.0280818
BHLHE40 basic helix-loop-helix family, member e40 -0.0262129
EGR1 early growth response 1 -0.0251104
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0246607
KLF10 Kruppel-like factor 10 -0.0237643
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0235312
TPT1 tumor protein, translationally-controlled 1 -0.022853
IER3 immediate early response 3 -0.0224191
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.022351
NRIP1 nuclear receptor interacting protein 1 -0.0219268
RPLP1 ribosomal protein, large, P1 -0.0211786
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0196931
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0196344
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0192559
S100A6 S100 calcium binding protein A6 -0.0192312
RIN2 Ras and Rab interactor 2 -0.0191355
FOSL1 FOS-like antigen 1 -0.018207
C15ORF48 chromosome 15 open reading frame 48 -0.0175184
HLA-E major histocompatibility complex, class I, E -0.0172341
ARRDC3 arrestin domain containing 3 -0.0171441
RPL34 ribosomal protein L34 -0.0171006
MYO10 myosin X -0.0165161
TMEM263 transmembrane protein 263 -0.0161099
HLA-B major histocompatibility complex, class I, B -0.0153676
SPAG9 sperm associated antigen 9 -0.0152436
RPS24 ribosomal protein S24 -0.0151195
NOCT nocturnin -0.0148183
NCOA7 nuclear receptor coactivator 7 -0.0145593
TRIO trio Rho guanine nucleotide exchange factor -0.0144823
DGKD diacylglycerol kinase, delta 130kDa -0.0138652
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0138107
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0137223
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0134698
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0134164
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0126404
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0124556
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0124547
CP ceruloplasmin (ferroxidase) -0.0123825
FBXO11 F-box protein 11 -0.0117583
ADM adrenomedullin -0.0116481
QKI QKI, KH domain containing, RNA binding -0.0116095
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0115488
KCMF1 potassium channel modulatory factor 1 -0.0111298
RPL6 ribosomal protein L6 -0.011122
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0109074
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0108505
IST1 increased sodium tolerance 1 homolog (yeast) -0.0108454
TRIB1 tribbles pseudokinase 1 -0.0106842
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0105915
SDC4 syndecan 4 -0.0105443
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0104692
ISG15 ISG15 ubiquitin-like modifier -0.010468
MCL1 myeloid cell leukemia 1 -0.0104419
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0101184
CSRNP1 cysteine-serine-rich nuclear protein 1 -0.0100838
GOLT1B golgi transport 1B -0.00985587
IGFBP1 insulin-like growth factor binding protein 1 -0.00985153
APOL1 apolipoprotein L, 1 -0.00980879
PANK2 pantothenate kinase 2 -0.00977014
ISG20 interferon stimulated exonuclease gene 20kDa -0.00976292
EVA1C eva-1 homolog C (C. elegans) -0.00971514
ZBTB10 zinc finger and BTB domain containing 10 -0.00962856
STX5 syntaxin 5 -0.0095945
NPEPPS aminopeptidase puromycin sensitive -0.00924559
PMP22 peripheral myelin protein 22 -0.00922361
NDFIP1 Nedd4 family interacting protein 1 -0.00919916
MANBA mannosidase, beta A, lysosomal -0.00914389
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -0.00913401
GCC2 GRIP and coiled-coil domain containing 2 -0.00912023
PLCB4 phospholipase C, beta 4 -0.00907716
MAP2K1 mitogen-activated protein kinase kinase 1 -0.00906624
APOLD1 apolipoprotein L domain containing 1 -0.00900461
IFIH1 interferon induced with helicase C domain 1 -0.00899881
SRP54 signal recognition particle 54kDa -0.00898033
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.00897272
RTN3 reticulon 3 -0.00890235
CAV1 caveolin 1, caveolae protein, 22kDa -0.00888736
IPMK inositol polyphosphate multikinase -0.00887605
RPL38 ribosomal protein L38 -0.0088234
ZMYND8 zinc finger, MYND-type containing 8 -0.00882107
XAF1 XIAP associated factor 1 -0.00878277
STAU1 staufen double-stranded RNA binding protein 1 -0.00876647
CDCP1 CUB domain containing protein 1 -0.00869642
ICAM1 intercellular adhesion molecule 1 -0.00858477
IFITM1 interferon induced transmembrane protein 1 -0.00845532
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.00840504
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0083851
TMEM41B transmembrane protein 41B -0.00835375
IFI6 interferon, alpha-inducible protein 6 -0.00828023
CEP95 centrosomal protein 95kDa -0.00824166
HELZ helicase with zinc finger -0.00822513
FRS2 fibroblast growth factor receptor substrate 2 -0.00815406
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.00811111
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.00810701