TAK-901_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.121327
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0836157
PSD3 pleckstrin and Sec7 domain containing 3 0.0696922
VIM vimentin 0.061995
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0597455
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0539051
FLNB filamin B, beta 0.0500779
ZSWIM6 zinc finger, SWIM-type containing 6 0.0481383
TRIO trio Rho guanine nucleotide exchange factor 0.0456141
NDRG1 N-myc downstream regulated 1 0.0453502
ITGA6 integrin, alpha 6 0.0437601
MBNL1 muscleblind-like splicing regulator 1 0.0430735
RPS3 ribosomal protein S3 0.0427433
POTEF POTE ankyrin domain family, member F 0.0426679
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0424885
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0421074
EFNA5 ephrin-A5 0.0416749
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0409162
SMAD3 SMAD family member 3 0.0404204
SRRM2 serine/arginine repetitive matrix 2 0.0381543
EEF2 eukaryotic translation elongation factor 2 0.0369728
RPL37A ribosomal protein L37a 0.0366674
PLEC plectin 0.0355218
GRB10 growth factor receptor-bound protein 10 0.0347554
APLP2 amyloid beta (A4) precursor-like protein 2 0.0346918
TMSB10 thymosin beta 10 0.0341284
ANXA2 annexin A2 0.0337523
S100A10 S100 calcium binding protein A10 0.0332978
RPS6 ribosomal protein S6 0.0331236
MYH9 myosin, heavy chain 9, non-muscle 0.0329253
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0327311
MED13L mediator complex subunit 13-like 0.0326604
MYOF myoferlin 0.0325848
RPS12 ribosomal protein S12 0.0323011
MPRIP myosin phosphatase Rho interacting protein 0.0322785
KTN1 kinectin 1 (kinesin receptor) 0.0321391
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0314781
TGM2 transglutaminase 2 0.0314737
BAIAP2L1 BAI1-associated protein 2-like 1 0.0305529
ERBIN erbb2 interacting protein 0.0300192
CD44 CD44 molecule (Indian blood group) 0.0292378
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0292221
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0291378
DIAPH1 diaphanous-related formin 1 0.0280049
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0276357
GDA guanine deaminase 0.0276143
AKAP13 A kinase (PRKA) anchor protein 13 0.0273022
EZR ezrin 0.0270964
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0270239
RCOR1 REST corepressor 1 0.026995
SEPTIN9 septin 9 0.0263333
VMP1 vacuole membrane protein 1 0.025832
FNDC3B fibronectin type III domain containing 3B 0.0257104
SPTBN1 spectrin, beta, non-erythrocytic 1 0.024583
PTPRF protein tyrosine phosphatase, receptor type, F 0.0241475
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0240659
ABTB3 ankyrin repeat and BTB domain containing 3 0.0240585
B2M beta-2-microglobulin 0.0240325
RPL11 ribosomal protein L11 0.0238767
PTMA prothymosin, alpha 0.0237579
HSPA8 heat shock 70kDa protein 8 0.0233689
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0231311
SAMD4A sterile alpha motif domain containing 4A 0.0226516
RPL26 ribosomal protein L26 0.0225055
CAPN2 calpain 2, (m/II) large subunit 0.0224301
RPS23 ribosomal protein S23 0.0224118
TPM3 tropomyosin 3 0.0223609
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.022214
RPL7 ribosomal protein L7 0.0220722
BCL2L1 BCL2-like 1 0.0214808
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0213794
ARHGAP42 Rho GTPase activating protein 42 0.0210972
PRRC2C proline-rich coiled-coil 2C 0.0210388
EIF1 eukaryotic translation initiation factor 1 0.0209864
MT2A metallothionein 2A 0.0209833
NCEH1 neutral cholesterol ester hydrolase 1 0.0209043
RPS8 ribosomal protein S8 0.0208049
SGMS2 sphingomyelin synthase 2 0.0207447
SLC38A2 solute carrier family 38, member 2 0.0205918
MCL1 myeloid cell leukemia 1 0.0204201
AREG amphiregulin 0.0202789
INTS6 integrator complex subunit 6 0.0200907
SIK3 SIK family kinase 3 0.0200561
CTBP2 C-terminal binding protein 2 0.0200436
RACK1 receptor for activated C kinase 1 0.0199087
FMNL2 formin-like 2 0.0197818
S100A11 S100 calcium binding protein A11 0.0197008
WWC1 WW and C2 domain containing 1 0.0196292
RPS13 ribosomal protein S13 0.0194874
DSPP dentin sialophosphoprotein 0.0194789
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.019363
ACTG1 actin gamma 1 0.0189671
RPLP2 ribosomal protein, large, P2 0.018956
RPS17 ribosomal protein S17 0.0188323
RPL9 ribosomal protein L9 0.018832
HPCAL1 hippocalcin-like 1 0.0187819
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0186553
RUNX1 runt-related transcription factor 1 0.018655
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0186199
MYO1E myosin IE 0.0184146

decreased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 -0.137224
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.107706
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.105386
LMO7 LIM domain 7 -0.0904502
F3 coagulation factor III (thromboplastin, tissue factor) -0.0881031
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0764816
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0763452
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0694464
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0665844
TPM4 tropomyosin 4 -0.0532632
SKAP2 src kinase associated phosphoprotein 2 -0.050345
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.048667
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0470555
MXD1 MAX dimerization protein 1 -0.0468708
ANTXR2 anthrax toxin receptor 2 -0.0420943
ZMYND8 zinc finger, MYND-type containing 8 -0.0406412
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0381199
NPSR1 neuropeptide S receptor 1 -0.0380644
PTPRR protein tyrosine phosphatase, receptor type, R -0.0378423
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0357592
KLK10 kallikrein-related peptidase 10 -0.0345361
MUC17 mucin 17, cell surface associated -0.0338782
TM4SF1 transmembrane 4 L six family member 1 -0.0336521
PGK1 phosphoglycerate kinase 1 -0.0335802
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0322689
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0314282
FERMT1 fermitin family member 1 -0.0310319
GNAS GNAS complex locus -0.0307727
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0301851
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0289781
GCC2 GRIP and coiled-coil domain containing 2 -0.0289117
TRRAP transformation/transcription domain-associated protein -0.0287749
UPP1 uridine phosphorylase 1 -0.0287695
TXNRD1 thioredoxin reductase 1 -0.0283467
PRSS3 protease, serine, 3 -0.0281854
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0280009
EGR1 early growth response 1 -0.0276456
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.027439
TMEM263 transmembrane protein 263 -0.0274006
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0264578
AK1 adenylate kinase 1 -0.0261752
SEC31A SEC31 homolog A (S. cerevisiae) -0.026022
RRBP1 ribosome binding protein 1 -0.0259566
CALU calumenin -0.025881
EGFR epidermal growth factor receptor -0.0251612
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0250438
WSB1 WD repeat and SOCS box containing 1 -0.0243305
PLAUR plasminogen activator, urokinase receptor -0.0243153
NBEAL1 neurobeachin-like 1 -0.0236564
VCAN versican -0.0235275
TXNIP thioredoxin interacting protein -0.0234486
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0225969
SMC3 structural maintenance of chromosomes 3 -0.0222445
IER3 immediate early response 3 -0.0219414
IGFBP3 insulin-like growth factor binding protein 3 -0.0214408
IFI16 interferon, gamma-inducible protein 16 -0.0213578
INPP5D inositol polyphosphate-5-phosphatase, 145kDa -0.0213213
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0211214
HLA-E major histocompatibility complex, class I, E -0.020954
HDLBP high density lipoprotein binding protein -0.0209188
SMNDC1 survival motor neuron domain containing 1 -0.0208573
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) -0.0208062
AKAP9 A kinase (PRKA) anchor protein 9 -0.020517
SRP54 signal recognition particle 54kDa -0.0202667
FAM3C family with sequence similarity 3, member C -0.0200969
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0198954
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0198727
SDC4 syndecan 4 -0.0198578
TTC3 tetratricopeptide repeat domain 3 -0.0196509
ARF4 ADP-ribosylation factor 4 -0.0195147
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0191712
AFF4 AF4/FMR2 family, member 4 -0.018862
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0187833
CD59 CD59 molecule, complement regulatory protein -0.0187017
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0186191
SLC35F3 solute carrier family 35, member F3 -0.0186063
MAML2 mastermind-like 2 (Drosophila) -0.0185568
SCFD2 sec1 family domain containing 2 -0.0184115
NDFIP1 Nedd4 family interacting protein 1 -0.0183031
S100A4 S100 calcium binding protein A4 -0.0180393
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0177961
BIRC6 baculoviral IAP repeat containing 6 -0.0176853
BLZF1 basic leucine zipper nuclear factor 1 -0.0175651
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0174662
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.017416
RNASET2 ribonuclease T2 -0.0172167
NPC1 Niemann-Pick disease, type C1 -0.0170187
SOD2 superoxide dismutase 2, mitochondrial -0.0169242
IGF1R insulin-like growth factor 1 receptor -0.0169209
MXI1 MAX interactor 1, dimerization protein -0.0169189
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -0.0165902
COPB1 coatomer protein complex, subunit beta 1 -0.0165463
ARF1 ADP-ribosylation factor 1 -0.0164976
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0163006
MORF4L2 mortality factor 4 like 2 -0.0162912
SPAG9 sperm associated antigen 9 -0.0161428
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.016142
SEPTIN10 septin 10 -0.0158642
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0158038
MIDN midnolin -0.0157409