| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-901 perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-901_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.166229 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.116123 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.103705 |
| RPL19 | ribosomal protein L19 | 0.0961701 |
| VMP1 | vacuole membrane protein 1 | 0.0834672 |
| RPS3 | ribosomal protein S3 | 0.0601578 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0492707 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0467303 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0446577 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0439549 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0436258 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0430568 |
| TC2N | tandem C2 domains, nuclear | 0.0421888 |
| MT2A | metallothionein 2A | 0.0401061 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0396455 |
| SET | SET nuclear proto-oncogene | 0.0389231 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0382407 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.036601 |
| PNN | pinin, desmosome associated protein | 0.0358686 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0351287 |
| VEGFA | vascular endothelial growth factor A | 0.0350533 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.033826 |
| NCOA6 | nuclear receptor coactivator 6 | 0.0337697 |
| JMJD1C | jumonji domain containing 1C | 0.0336332 |
| MED13L | mediator complex subunit 13-like | 0.0324546 |
| RPS6 | ribosomal protein S6 | 0.0320677 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0317325 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0314088 |
| DUSP16 | dual specificity phosphatase 16 | 0.0306978 |
| SETX | senataxin | 0.0294268 |
| USP47 | ubiquitin specific peptidase 47 | 0.0293228 |
| RBM39 | RNA binding motif protein 39 | 0.0292355 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0278145 |
| ANKRD12 | ankyrin repeat domain 12 | 0.027173 |
| YAP1 | Yes-associated protein 1 | 0.0270008 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0267652 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0262418 |
| RBM25 | RNA binding motif protein 25 | 0.0262151 |
| MBD4 | methyl-CpG binding domain protein 4 | 0.0260106 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0257023 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0256199 |
| PRPF3 | pre-mRNA processing factor 3 | 0.0254758 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0253546 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0253225 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0252024 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0251784 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0251527 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0250323 |
| SETD5 | SET domain containing 5 | 0.0249561 |
| GOLGB1 | golgin B1 | 0.024805 |
| MATR3 | matrin 3 | 0.0246422 |
| KIAA1217 | KIAA1217 | 0.0244664 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0242716 |
| ZNF292 | zinc finger protein 292 | 0.0242689 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0241306 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0236396 |
| B2M | beta-2-microglobulin | 0.0234343 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0230778 |
| TPM3 | tropomyosin 3 | 0.0227371 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0227084 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0224288 |
| CUL3 | cullin 3 | 0.0220945 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0220537 |
| CCNL1 | cyclin L1 | 0.0218097 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0216482 |
| SF1 | splicing factor 1 | 0.0216417 |
| ENAH | enabled homolog (Drosophila) | 0.021318 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0211963 |
| CWC25 | CWC25 spliceosome-associated protein homolog (S. cerevisiae) | 0.0210382 |
| PTK2 | protein tyrosine kinase 2 | 0.0209266 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.020925 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0207589 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0206272 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0206057 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.020603 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0204433 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.020386 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0203408 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.020324 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0203109 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0201727 |
| S100A8 | S100 calcium binding protein A8 | 0.0199548 |
| FNBP1L | formin binding protein 1-like | 0.0199077 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0198709 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0198153 |
| GRHL1 | grainyhead-like 1 (Drosophila) | 0.0195565 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0191869 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0191757 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0191086 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0190392 |
| RPS12 | ribosomal protein S12 | 0.018981 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0189228 |
| RPS6KB1 | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 0.0184461 |
| FOXJ3 | forkhead box J3 | 0.0184134 |
| TXNRD1 | thioredoxin reductase 1 | 0.0183452 |
| CTBP2 | C-terminal binding protein 2 | 0.0180744 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0178722 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0178347 |
| TMEM87A | transmembrane protein 87A | 0.0177942 |
| KMT5B | lysine methyltransferase 5B | 0.0177151 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.114261 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0574196 |
| LASP1 | LIM and SH3 protein 1 | -0.0402579 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0333931 |
| CCND1 | cyclin D1 | -0.0308324 |
| TMSB4X | thymosin beta 4, X-linked | -0.0284998 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0279746 |
| ACTG1 | actin gamma 1 | -0.0276832 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0275957 |
| TMEM123 | transmembrane protein 123 | -0.0252009 |
| EGR1 | early growth response 1 | -0.024693 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0245871 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0245663 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0228535 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0224282 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0215323 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0204138 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.020406 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0203994 |
| PGK1 | phosphoglycerate kinase 1 | -0.0186073 |
| RPS24 | ribosomal protein S24 | -0.0183856 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0171296 |
| RAD51B | RAD51 paralog B | -0.0170432 |
| H1-0 | H1.0 linker histone | -0.0167961 |
| KRT8 | keratin 8, type II | -0.0166245 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0165528 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0162189 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0161659 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.0160406 |
| ASPH | aspartate beta-hydroxylase | -0.0156163 |
| PLSCR1 | phospholipid scramblase 1 | -0.0151155 |
| MMP24OS | MMP24 opposite strand | -0.0150087 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.014723 |
| PTMA | prothymosin, alpha | -0.0145907 |
| RPL34 | ribosomal protein L34 | -0.0141426 |
| IL1RAPL2 | interleukin 1 receptor accessory protein-like 2 | -0.0141167 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0137484 |
| KRT7 | keratin 7, type II | -0.0137337 |
| RPL27A | ribosomal protein L27a | -0.013662 |
| NABP1 | nucleic acid binding protein 1 | -0.0135697 |
| HLA-C | major histocompatibility complex, class I, C | -0.0134781 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.012877 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0128512 |
| LMNA | lamin A/C | -0.0127029 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0125161 |
| RPL35A | ribosomal protein L35a | -0.0123732 |
| TMEM263 | transmembrane protein 263 | -0.0123258 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0122677 |
| TUBB | tubulin, beta class I | -0.0122025 |
| RRM2 | ribonucleotide reductase M2 | -0.0121516 |
| S100A6 | S100 calcium binding protein A6 | -0.012132 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0120501 |
| MGP | matrix Gla protein | -0.0117963 |
| PRELID2 | PRELI domain containing 2 | -0.0117918 |
| RNF213 | ring finger protein 213 | -0.0116709 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0114445 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0113907 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.0110814 |
| AEBP2 | AE binding protein 2 | -0.0110176 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.01091 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0107936 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.010658 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0105636 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0105624 |
| FBXO34 | F-box protein 34 | -0.0105568 |
| PLEKHG4B | pleckstrin homology domain containing, family G (with RhoGef domain) member 4B | -0.0105252 |
| CD164 | CD164 molecule, sialomucin | -0.0105191 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.010376 |
| CDK12 | cyclin-dependent kinase 12 | -0.0102565 |
| EXOC4 | exocyst complex component 4 | -0.00999124 |
| CALU | calumenin | -0.00984931 |
| TNS3 | tensin 3 | -0.00974073 |
| MIPOL1 | mirror-image polydactyly 1 | -0.00960997 |
| DTNA | dystrobrevin, alpha | -0.00954518 |
| TMSB10 | thymosin beta 10 | -0.00945308 |
| IRF9 | interferon regulatory factor 9 | -0.00945278 |
| TENM4 | teneurin transmembrane protein 4 | -0.00941325 |
| TRIM56 | tripartite motif containing 56 | -0.00934844 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.00927658 |
| MAP4 | microtubule-associated protein 4 | -0.00923272 |
| ZNF124 | zinc finger protein 124 | -0.00920839 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.00920006 |
| FGF13 | fibroblast growth factor 13 | -0.00912152 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.00908633 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.00903895 |
| SMC4 | structural maintenance of chromosomes 4 | -0.00893439 |
| DSG2 | desmoglein 2 | -0.0088911 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.00860487 |
| GSDMB | gasdermin B | -0.0086005 |
| RIGI | RNA sensor RIG-I | -0.00848542 |
| ANLN | anillin, actin binding protein | -0.00848047 |
| CSTF3 | cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa | -0.00847191 |
| ENOSF1 | enolase superfamily member 1 | -0.00846099 |
| KRT86 | keratin 86, type II | -0.00837608 |
| RAB1B | RAB1B, member RAS oncogene family | -0.00837024 |
| PRR11 | proline rich 11 | -0.0082977 |
| INHBA | inhibin, beta A | -0.00826627 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.00826032 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.00820425 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.00819388 |
