TAK-901_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.138679
FTH1 ferritin, heavy polypeptide 1 0.121244
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.103115
B2M beta-2-microglobulin 0.0980493
EIF1 eukaryotic translation initiation factor 1 0.0956662
TPT1 tumor protein, translationally-controlled 1 0.068634
IGFBP3 insulin-like growth factor binding protein 3 0.0647781
RPS3 ribosomal protein S3 0.0623894
ANXA2 annexin A2 0.0597383
AKAP12 A kinase (PRKA) anchor protein 12 0.0590142
LAMB3 laminin, beta 3 0.0574492
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0562842
LAMA4 laminin, alpha 4 0.0561118
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0554984
LAMC2 laminin, gamma 2 0.052622
RPL37A ribosomal protein L37a 0.050045
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0494433
VEGFA vascular endothelial growth factor A 0.0492815
RPS8 ribosomal protein S8 0.0485951
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.047817
ENO1 enolase 1, (alpha) 0.0465458
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0464848
GOLGB1 golgin B1 0.0462995
HLA-B major histocompatibility complex, class I, B 0.0443276
SQSTM1 sequestosome 1 0.0428331
LCN2 lipocalin 2 0.0423388
RPL19 ribosomal protein L19 0.0423384
ZSWIM6 zinc finger, SWIM-type containing 6 0.0419808
RPS6 ribosomal protein S6 0.041188
RPS29 ribosomal protein S29 0.0395183
SGMS2 sphingomyelin synthase 2 0.0394198
RPL23 ribosomal protein L23 0.038637
HLA-A major histocompatibility complex, class I, A 0.0386184
SP100 SP100 nuclear antigen 0.0383942
GRB10 growth factor receptor-bound protein 10 0.0378059
RPL11 ribosomal protein L11 0.0373648
VIM vimentin 0.0372245
RACK1 receptor for activated C kinase 1 0.0368052
BLZF1 basic leucine zipper nuclear factor 1 0.0364647
SRRM2 serine/arginine repetitive matrix 2 0.0355503
RPS17 ribosomal protein S17 0.0351785
APLP2 amyloid beta (A4) precursor-like protein 2 0.0346976
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0336144
RAB7A RAB7A, member RAS oncogene family 0.0324265
RPL35A ribosomal protein L35a 0.0323425
TXNIP thioredoxin interacting protein 0.0316164
G0S2 G0/G1 switch 2 0.0316127
NDRG1 N-myc downstream regulated 1 0.031292
RPS23 ribosomal protein S23 0.0309469
RPS12 ribosomal protein S12 0.030517
RPL31 ribosomal protein L31 0.0303936
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0302426
CANX calnexin 0.0300094
RPL9 ribosomal protein L9 0.0299094
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0299022
ANKRD11 ankyrin repeat domain 11 0.0298519
ANXA1 annexin A1 0.0296885
RPS19 ribosomal protein S19 0.0294078
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0288553
FAM13A family with sequence similarity 13, member A 0.0286708
FAM107B family with sequence similarity 107, member B 0.0285724
RPL37 ribosomal protein L37 0.0284702
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0283817
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0280658
PTMA prothymosin, alpha 0.0278417
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0277736
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0277245
AKAP9 A kinase (PRKA) anchor protein 9 0.0276544
ADM adrenomedullin 0.027541
DTNA dystrobrevin, alpha 0.0275102
CSNK1A1 casein kinase 1, alpha 1 0.0272402
ISG15 ISG15 ubiquitin-like modifier 0.0271322
P4HB prolyl 4-hydroxylase, beta polypeptide 0.026861
INTS6 integrator complex subunit 6 0.0266599
MYH9 myosin, heavy chain 9, non-muscle 0.026536
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0264148
BZW1 basic leucine zipper and W2 domains 1 0.0261655
SRP54 signal recognition particle 54kDa 0.0256663
RPS27A ribosomal protein S27a 0.0253312
SEC31A SEC31 homolog A (S. cerevisiae) 0.0251662
RPL26 ribosomal protein L26 0.0250543
YBX1 Y box binding protein 1 0.0250089
VDAC1 voltage-dependent anion channel 1 0.0245498
STC1 stanniocalcin 1 0.0243551
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0242722
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0242282
SON SON DNA binding protein 0.0241907
JUN jun proto-oncogene 0.0240678
MT1E metallothionein 1E 0.023943
UBC ubiquitin C 0.0235567
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.023556
FTL ferritin, light polypeptide 0.0234782
SKP1 S-phase kinase-associated protein 1 0.0233476
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0233396
FUS FUS RNA binding protein 0.0232473
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0231888
ZMIZ1 zinc finger, MIZ-type containing 1 0.022771
S100A10 S100 calcium binding protein A10 0.0223307
CSTB cystatin B (stefin B) 0.0218755
CALU calumenin 0.0218026

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.191618
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0701621
NAMPT nicotinamide phosphoribosyltransferase -0.0665215
MT1X metallothionein 1X -0.0578825
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0569693
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0561912
CP ceruloplasmin (ferroxidase) -0.0531179
EFNA5 ephrin-A5 -0.0512857
PARD3 par-3 family cell polarity regulator -0.0503515
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0494928
MUC4 mucin 4, cell surface associated -0.0483004
F3 coagulation factor III (thromboplastin, tissue factor) -0.0466863
PATJ PATJ crumbs cell polarity complex component -0.0440009
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0436173
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0413257
RTN4 reticulon 4 -0.0412519
OSMR oncostatin M receptor -0.0402099
PGK1 phosphoglycerate kinase 1 -0.0380786
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0375042
STRN3 striatin, calmodulin binding protein 3 -0.0340093
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0329108
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0320121
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0310716
JUP junction plakoglobin -0.0307982
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0307181
EHBP1 EH domain binding protein 1 -0.0304907
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0301521
ANXA11 annexin A11 -0.0298409
MACC1 metastasis associated in colon cancer 1 -0.0295498
NCKAP5 NCK-associated protein 5 -0.0292624
TMSB10 thymosin beta 10 -0.0289176
FAT1 FAT atypical cadherin 1 -0.028282
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.028268
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0280866
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0279452
TMEM165 transmembrane protein 165 -0.0279343
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0277399
INSIG1 insulin induced gene 1 -0.0274436
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.027408
GSK3B glycogen synthase kinase 3 beta -0.0265471
QKI QKI, KH domain containing, RNA binding -0.02644
CD46 CD46 molecule, complement regulatory protein -0.026098
TSC22D2 TSC22 domain family, member 2 -0.0258277
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0257095
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0255683
TAPBP TAP binding protein (tapasin) -0.0255487
CCNL1 cyclin L1 -0.0253622
ACTN4 actinin, alpha 4 -0.0252816
NT5C2 5'-nucleotidase, cytosolic II -0.0248596
S100A6 S100 calcium binding protein A6 -0.0244843
MAML2 mastermind-like 2 (Drosophila) -0.0238862
MSMO1 methylsterol monooxygenase 1 -0.0238527
KIF13B kinesin family member 13B -0.0237057
PCDH7 protocadherin 7 -0.0233811
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0222066
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -0.0218742
CDK6 cyclin-dependent kinase 6 -0.021763
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0216633
LMO7 LIM domain 7 -0.0215212
MUC1 mucin 1, cell surface associated -0.0214586
PDZD8 PDZ domain containing 8 -0.0213724
AGRN agrin -0.0211359
NUP58 nucleoporin 58 -0.0211204
STS steroid sulfatase (microsomal), isozyme S -0.0205313
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0202924
ADAM9 ADAM metallopeptidase domain 9 -0.0202446
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0202313
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0201031
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0196362
FDPS farnesyl diphosphate synthase -0.0195081
MCTP1 multiple C2 domains, transmembrane 1 -0.0194128
MEF2A myocyte enhancer factor 2A -0.0192907
ARL5B ADP-ribosylation factor-like 5B -0.0192791
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0192266
ALCAM activated leukocyte cell adhesion molecule -0.0191217
GLIS3 GLIS family zinc finger 3 -0.0189279
FOXO3 forkhead box O3 -0.0188202
FBXL5 F-box and leucine-rich repeat protein 5 -0.0187925
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.018648
RBM47 RNA binding motif protein 47 -0.018491
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0184263
TPM1 tropomyosin 1 (alpha) -0.0184141
TMEM123 transmembrane protein 123 -0.0182941
SESTD1 SEC14 and spectrin domains 1 -0.0181613
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0180833
FAM3C family with sequence similarity 3, member C -0.0177903
NPC1 Niemann-Pick disease, type C1 -0.0177174
DPYD dihydropyrimidine dehydrogenase -0.0176186
FAM162A family with sequence similarity 162, member A -0.0175795
ACTG1 actin gamma 1 -0.0175763
BICC1 BicC family RNA binding protein 1 -0.0175485
TC2N tandem C2 domains, nuclear -0.0174376
PTBP3 polypyrimidine tract binding protein 3 -0.0171514
RNF24 ring finger protein 24 -0.0170885
FRMD5 FERM domain containing 5 -0.0170872
ADGRF1 adhesion G protein-coupled receptor F1 -0.0170596
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0169045
LY6E lymphocyte antigen 6 complex, locus E -0.0166545
ITGA1 integrin, alpha 1 -0.016622
CDK17 cyclin-dependent kinase 17 -0.0166183