TAK-901_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0856865
VCL vinculin 0.0727942
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0699932
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0579931
TLE4 transducin-like enhancer of split 4 0.0567484
RPS6 ribosomal protein S6 0.0517513
FMN1 formin 1 0.0498332
ZSWIM6 zinc finger, SWIM-type containing 6 0.0463259
VMP1 vacuole membrane protein 1 0.0426495
VIM vimentin 0.042131
RPL23 ribosomal protein L23 0.0410618
LPIN1 lipin 1 0.0409695
TPT1 tumor protein, translationally-controlled 1 0.0407237
ACTG1 actin gamma 1 0.0406606
EXT1 exostosin glycosyltransferase 1 0.0392372
RPL19 ribosomal protein L19 0.0384387
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0375716
PRRC2C proline-rich coiled-coil 2C 0.0368836
RPL37A ribosomal protein L37a 0.0358401
EIF1 eukaryotic translation initiation factor 1 0.0358113
EEF2 eukaryotic translation elongation factor 2 0.0333296
RPS3 ribosomal protein S3 0.033088
DST dystonin 0.0326332
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0313704
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0311054
B2M beta-2-microglobulin 0.0307589
SLIT2 slit homolog 2 (Drosophila) 0.0303192
RPL26 ribosomal protein L26 0.0299346
CSNK1A1 casein kinase 1, alpha 1 0.0279079
SLC38A2 solute carrier family 38, member 2 0.0271703
SRRM2 serine/arginine repetitive matrix 2 0.0268089
DSCAM Down syndrome cell adhesion molecule 0.0266268
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.026591
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0262353
MYH9 myosin, heavy chain 9, non-muscle 0.0257679
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0254788
RPS12 ribosomal protein S12 0.0251506
CUL3 cullin 3 0.0248378
GPATCH8 G patch domain containing 8 0.0232918
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0230052
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.022791
ITPRID2 ITPR interacting domain containing 2 0.0225821
INTS6 integrator complex subunit 6 0.0225389
MED13 mediator complex subunit 13 0.0224275
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0221511
RPS27A ribosomal protein S27a 0.0217187
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0215386
BPTF bromodomain PHD finger transcription factor 0.0215343
VEGFA vascular endothelial growth factor A 0.0214646
GOLGB1 golgin B1 0.0213607
TPM1 tropomyosin 1 (alpha) 0.0212908
SON SON DNA binding protein 0.0212499
KLHL13 kelch-like family member 13 0.0211864
RPS17 ribosomal protein S17 0.0209229
RPL7 ribosomal protein L7 0.0206671
RPS23 ribosomal protein S23 0.020217
MCL1 myeloid cell leukemia 1 0.0194543
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0194348
MACF1 microtubule-actin crosslinking factor 1 0.0193737
RPS19 ribosomal protein S19 0.0193476
KTN1 kinectin 1 (kinesin receptor) 0.0192739
FNDC3A fibronectin type III domain containing 3A 0.0192378
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0189836
TRIO trio Rho guanine nucleotide exchange factor 0.0188518
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0187837
LPP LIM domain containing preferred translocation partner in lipoma 0.0185417
TCF12 transcription factor 12 0.0185414
RPS27 ribosomal protein S27 0.0183087
PDLIM5 PDZ and LIM domain 5 0.0182665
AKAP12 A kinase (PRKA) anchor protein 12 0.0180585
ENO1 enolase 1, (alpha) 0.0180283
GATA3 GATA binding protein 3 0.0180128
RPL32 ribosomal protein L32 0.0179049
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0175324
RACK1 receptor for activated C kinase 1 0.0174949
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0174668
RPL30 ribosomal protein L30 0.0174522
RBM39 RNA binding motif protein 39 0.0174514
TOP1 topoisomerase (DNA) I 0.0167818
RSRC2 arginine/serine-rich coiled-coil 2 0.016701
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0166345
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0166281
PTMA prothymosin, alpha 0.0164989
RPL36 ribosomal protein L36 0.0164449
ZNF292 zinc finger protein 292 0.0164326
RPL7A ribosomal protein L7a 0.0163652
MYO1E myosin IE 0.0161832
EIF4B eukaryotic translation initiation factor 4B 0.0161357
MBTD1 mbt domain containing 1 0.0160646
CTNND1 catenin (cadherin-associated protein), delta 1 0.0160532
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0160511
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.016042
TPST1 tyrosylprotein sulfotransferase 1 0.0160338
PTPRE protein tyrosine phosphatase, receptor type, E 0.0159874
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0159661
RPS8 ribosomal protein S8 0.0159231
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0158852
PLAT plasminogen activator, tissue 0.0153929
TPR translocated promoter region, nuclear basket protein 0.0153826
NIPBL Nipped-B homolog (Drosophila) 0.0153463

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.1414
NRG1 neuregulin 1 -0.0577715
LSAMP limbic system-associated membrane protein -0.0444242
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0276143
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0257693
NCAM2 neural cell adhesion molecule 2 -0.0216607
NREP neuronal regeneration related protein -0.0215517
FRMD4A FERM domain containing 4A -0.0174805
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0161066
CADM2 cell adhesion molecule 2 -0.0153447
DLC1 DLC1 Rho GTPase activating protein -0.0149776
LIMCH1 LIM and calponin homology domains 1 -0.0145461
SYT1 synaptotagmin I -0.0135246
MAPK10 mitogen-activated protein kinase 10 -0.013293
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0129696
FHIT fragile histidine triad -0.012203
NALF1 NALCN channel auxiliary factor 1 -0.0121696
PTPRD protein tyrosine phosphatase, receptor type, D -0.0118555
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0115694
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0114194
PCDH9 protocadherin 9 -0.0109822
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0109025
GPC5 glypican 5 -0.0107233
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0106385
TENT5A terminal nucleotidyltransferase 5A -0.0106266
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0103865
AUTS2 autism susceptibility candidate 2 -0.0101887
SPAG16 sperm associated antigen 16 -0.00987795
ATRNL1 attractin-like 1 -0.00977331
POU2F1 POU class 2 homeobox 1 -0.00958225
ANGPT1 angiopoietin 1 -0.00947729
USP3 ubiquitin specific peptidase 3 -0.00947444
CNTN4 contactin 4 -0.0094428
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.00932685
TOX thymocyte selection-associated high mobility group box -0.00930084
PCDH15 protocadherin-related 15 -0.00925746
CEMIP cell migration inducing protein, hyaluronan binding -0.00920853
KCTD16 potassium channel tetramerization domain containing 16 -0.00892052
KIF26B kinesin family member 26B -0.00867996
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.00860364
RHOBTB3 Rho-related BTB domain containing 3 -0.00833245
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.00828484
GARS1 glycyl-tRNA synthetase 1 -0.00823463
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.00823361
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.00787654
IGFBP4 insulin-like growth factor binding protein 4 -0.00783805
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.00778074
NBEA neurobeachin -0.00776232
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.00774526
CDH10 cadherin 10, type 2 (T2-cadherin) -0.00771348
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.00769968
MEF2A myocyte enhancer factor 2A -0.00753453
EPHA3 EPH receptor A3 -0.0074535
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4 -0.00739477
COL3A1 collagen, type III, alpha 1 -0.00738606
GDF15 growth differentiation factor 15 -0.00736085
PRMT2 protein arginine methyltransferase 2 -0.00732114
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.00695466
LINGO2 leucine rich repeat and Ig domain containing 2 -0.00695136
ADGRG6 adhesion G protein-coupled receptor G6 -0.00694286
DNAH14 dynein, axonemal, heavy chain 14 -0.00692608
FREM1 FRAS1 related extracellular matrix 1 -0.00692402
IGFBP5 insulin-like growth factor binding protein 5 -0.0069109
PRTG protogenin -0.00678273
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.00675517
PREPL prolyl endopeptidase-like -0.00673966
AUH AU RNA binding protein/enoyl-CoA hydratase -0.00670307
EDNRA endothelin receptor type A -0.00669542
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.00663839
KCNIP4 Kv channel interacting protein 4 -0.00648217
CDON cell adhesion associated, oncogene regulated -0.0063734
COL6A6 collagen, type VI, alpha 6 -0.00635165
PRR16 proline rich 16 -0.00633056
GPC6 glypican 6 -0.00630588
NPEPPS aminopeptidase puromycin sensitive -0.00628832
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.00627393
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 -0.00619747
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0061853
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -0.00616441
RFC3 replication factor C (activator 1) 3, 38kDa -0.00612433
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like -0.00606951
EVL Enah/Vasp-like -0.00606203
CRADD CASP2 and RIPK1 domain containing adaptor with death domain -0.00606077
ZNF124 zinc finger protein 124 -0.00606043
MBD5 methyl-CpG binding domain protein 5 -0.0060303
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.00597158
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.00595281
ADGRB3 adhesion G protein-coupled receptor B3 -0.00593155
LRRC7 leucine rich repeat containing 7 -0.00592786
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -0.00591234
IFI16 interferon, gamma-inducible protein 16 -0.00588126
FAM162A family with sequence similarity 162, member A -0.00587308
KLF10 Kruppel-like factor 10 -0.00586837
ELMO1 engulfment and cell motility 1 -0.00579666
ESRRG estrogen-related receptor gamma -0.00578567
RALYL RALY RNA binding protein-like -0.00574101
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.00573633
GRK3 G protein-coupled receptor kinase 3 -0.00568841
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.00567796
MYLK myosin light chain kinase -0.00561714