TAK-901_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.445702
FTL ferritin, light polypeptide 0.155199
MT2A metallothionein 2A 0.142769
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.140154
CD44 CD44 molecule (Indian blood group) 0.118249
AKAP12 A kinase (PRKA) anchor protein 12 0.10575
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.105214
STC1 stanniocalcin 1 0.10264
CXCL8 chemokine (C-X-C motif) ligand 8 0.0987363
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0866581
B2M beta-2-microglobulin 0.0846331
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0843767
FTH1 ferritin, heavy polypeptide 1 0.083312
RPS6 ribosomal protein S6 0.073258
FNDC3B fibronectin type III domain containing 3B 0.0726154
VEGFA vascular endothelial growth factor A 0.0703749
KYNU kynureninase 0.0682329
NDRG1 N-myc downstream regulated 1 0.0674481
ENO1 enolase 1, (alpha) 0.0632484
CALR calreticulin 0.0604173
RACK1 receptor for activated C kinase 1 0.060104
VIM vimentin 0.0569216
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0552181
EEF2 eukaryotic translation elongation factor 2 0.0549211
EIF1 eukaryotic translation initiation factor 1 0.0537518
CANX calnexin 0.0536807
INHBA inhibin, beta A 0.0533381
ANXA2 annexin A2 0.0531718
RPS8 ribosomal protein S8 0.0517217
ERRFI1 ERBB receptor feedback inhibitor 1 0.0514538
MYH9 myosin, heavy chain 9, non-muscle 0.0510326
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.050415
PTMA prothymosin, alpha 0.0494492
CALD1 caldesmon 1 0.0461925
EXT1 exostosin glycosyltransferase 1 0.0452793
RPS3 ribosomal protein S3 0.0441064
RPL37A ribosomal protein L37a 0.0425794
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.040796
GLIS3 GLIS family zinc finger 3 0.0390745
LOC112694756 uncharaterized LOC112694756 0.0390335
LDHA lactate dehydrogenase A 0.0386762
TXNRD1 thioredoxin reductase 1 0.0381928
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0380375
ELL2 elongation factor, RNA polymerase II, 2 0.0378296
RPL35A ribosomal protein L35a 0.0369002
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0367795
RPS13 ribosomal protein S13 0.0367349
RPL11 ribosomal protein L11 0.0361972
MAP1B microtubule-associated protein 1B 0.0361871
NAP1L1 nucleosome assembly protein 1-like 1 0.0356804
RPL23 ribosomal protein L23 0.0355252
SMAD3 SMAD family member 3 0.0354936
MYO10 myosin X 0.0352794
RPL28 ribosomal protein L28 0.0344525
HDAC9 histone deacetylase 9 0.0338489
SRRM2 serine/arginine repetitive matrix 2 0.0337891
TXNIP thioredoxin interacting protein 0.0337173
RPL12 ribosomal protein L12 0.0333549
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0329784
IGFBP3 insulin-like growth factor binding protein 3 0.0323746
RPL7 ribosomal protein L7 0.032354
YBX1 Y box binding protein 1 0.0323154
PKM pyruvate kinase, muscle 0.0321032
ZSWIM6 zinc finger, SWIM-type containing 6 0.0319495
RPL19 ribosomal protein L19 0.0316801
HSPA8 heat shock 70kDa protein 8 0.0316211
MAST4 microtubule associated serine/threonine kinase family member 4 0.0315791
RPS12 ribosomal protein S12 0.0314314
PDLIM5 PDZ and LIM domain 5 0.0310129
AKAP9 A kinase (PRKA) anchor protein 9 0.0309479
MACF1 microtubule-actin crosslinking factor 1 0.0305503
RPLP2 ribosomal protein, large, P2 0.0302412
FAT1 FAT atypical cadherin 1 0.03013
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0297829
RPS19 ribosomal protein S19 0.0297634
ASPH aspartate beta-hydroxylase 0.029647
PDIA6 protein disulfide isomerase family A, member 6 0.0290331
JUN jun proto-oncogene 0.0283467
RPL31 ribosomal protein L31 0.0280499
TPI1 triosephosphate isomerase 1 0.0278464
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0278327
HYOU1 hypoxia up-regulated 1 0.0275753
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0273045
TPT1 tumor protein, translationally-controlled 1 0.0272933
RPS25 ribosomal protein S25 0.0272487
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0271026
KTN1 kinectin 1 (kinesin receptor) 0.0269383
GPHN gephyrin 0.0266994
BRD2 bromodomain containing 2 0.0265797
TPM3 tropomyosin 3 0.026564
MSN moesin 0.0260052
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0259195
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0258458
RPS27A ribosomal protein S27a 0.0257062
GOLGB1 golgin B1 0.0255776
TGFBI transforming growth factor, beta-induced, 68kDa 0.0255443
RPLP1 ribosomal protein, large, P1 0.0255269
RPLP0 ribosomal protein, large, P0 0.0255202
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0253911
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0251033

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.14546
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.127615
GRB10 growth factor receptor-bound protein 10 -0.104684
FN1 fibronectin 1 -0.0904125
PDE4D phosphodiesterase 4D, cAMP-specific -0.0828452
IGFBP5 insulin-like growth factor binding protein 5 -0.0676054
SDK1 sidekick cell adhesion molecule 1 -0.0476541
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0471792
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.04576
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0446414
IGF2 insulin-like growth factor 2 -0.0434529
LOC102724023 ES1 protein homolog, mitochondrial -0.04027
FOSL1 FOS-like antigen 1 -0.0375647
NLGN1 neuroligin 1 -0.0361868
DST dystonin -0.0325807
NAV2 neuron navigator 2 -0.0319477
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.031852
TAS2R14 taste receptor, type 2, member 14 -0.0297057
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0285628
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0283768
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0275838
ZNF804A zinc finger protein 804A -0.027523
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0273966
PSD3 pleckstrin and Sec7 domain containing 3 -0.0271477
LOX lysyl oxidase -0.0263857
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0262874
FAM20C family with sequence similarity 20, member C -0.0259585
COL5A2 collagen, type V, alpha 2 -0.025946
TMSB10 thymosin beta 10 -0.0256513
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0256306
RIGI RNA sensor RIG-I -0.0255057
WARS1 tryptophanyl-tRNA synthetase 1 -0.0248186
SOX5 SRY (sex determining region Y)-box 5 -0.0247728
ARRDC3 arrestin domain containing 3 -0.0247177
SBF2 SET binding factor 2 -0.0246324
TENT5A terminal nucleotidyltransferase 5A -0.0239578
RPTOR regulatory associated protein of MTOR, complex 1 -0.0239171
CADM1 cell adhesion molecule 1 -0.0238285
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0236254
GNAS GNAS complex locus -0.0226659
KLF10 Kruppel-like factor 10 -0.0226365
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0213759
PRSS23 protease, serine, 23 -0.0209331
BHLHE40 basic helix-loop-helix family, member e40 -0.0206714
LYPD6B LY6/PLAUR domain containing 6B -0.0206661
TNS3 tensin 3 -0.0203699
TMEM45A transmembrane protein 45A -0.0201285
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0200988
SPAG9 sperm associated antigen 9 -0.0195401
SMC4 structural maintenance of chromosomes 4 -0.0194197
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0192472
CENPF centromere protein F, 350/400kDa -0.0192042
DIAPH3 diaphanous-related formin 3 -0.0186785
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0186313
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0184859
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0182705
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0182661
PTCHD4 patched domain containing 4 -0.0180702
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.018027
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0179374
ACTN4 actinin, alpha 4 -0.0179059
SYT1 synaptotagmin I -0.0178813
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0177477
KCMF1 potassium channel modulatory factor 1 -0.0176697
RLF rearranged L-myc fusion -0.0176347
ZBTB20 zinc finger and BTB domain containing 20 -0.0173845
ANLN anillin, actin binding protein -0.0169931
AUTS2 autism susceptibility candidate 2 -0.0168355
MMP12 matrix metallopeptidase 12 -0.0166852
IFIH1 interferon induced with helicase C domain 1 -0.0166208
TENM3 teneurin transmembrane protein 3 -0.0164077
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0163439
COL7A1 collagen, type VII, alpha 1 -0.0160053
CENPE centromere protein E, 312kDa -0.0156501
KDM4B lysine (K)-specific demethylase 4B -0.0156308
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 -0.0149966
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0146463
USP9Y ubiquitin specific peptidase 9, Y-linked -0.0146373
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0146316
PTPRD protein tyrosine phosphatase, receptor type, D -0.0143546
FAF1 Fas (TNFRSF6) associated factor 1 -0.0143546
AEBP2 AE binding protein 2 -0.0143182
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0141567
WSB1 WD repeat and SOCS box containing 1 -0.0137352
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0137237
KCTD16 potassium channel tetramerization domain containing 16 -0.0133638
PLCB4 phospholipase C, beta 4 -0.0133036
LARS1 leucyl-tRNA synthetase 1 -0.0132044
OASL 2'-5'-oligoadenylate synthetase-like -0.0131801
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0131709
SENP6 SUMO1/sentrin specific peptidase 6 -0.0131202
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0129581
OXR1 oxidation resistance 1 -0.0127765
PRR16 proline rich 16 -0.0127411
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.01274
ZMAT3 zinc finger, matrin-type 3 -0.0127117
PDE10A phosphodiesterase 10A -0.0125867
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.012558
CA9 carbonic anhydrase IX -0.0125323
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0125311