| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-901 perturbation in HCT15 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the TAK-901_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.198311 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.107757 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.10155 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0963992 |
| INTS6 | integrator complex subunit 6 | 0.0858703 |
| LDHA | lactate dehydrogenase A | 0.084513 |
| KRT18 | keratin 18, type I | 0.079419 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.078078 |
| ENO1 | enolase 1, (alpha) | 0.0771802 |
| FAT1 | FAT atypical cadherin 1 | 0.0750921 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0737372 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0714998 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0714848 |
| CTBP2 | C-terminal binding protein 2 | 0.0688782 |
| VEGFA | vascular endothelial growth factor A | 0.0685881 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0674154 |
| LRRC23 | leucine rich repeat containing 23 | 0.0647329 |
| EZR | ezrin | 0.0641128 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0640136 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0632445 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0628679 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0618044 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0587833 |
| MCL1 | myeloid cell leukemia 1 | 0.0585745 |
| ANXA2 | annexin A2 | 0.0555605 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0546583 |
| BRD2 | bromodomain containing 2 | 0.0527798 |
| ZNF638 | zinc finger protein 638 | 0.0521155 |
| AHNAK | AHNAK nucleoprotein | 0.0520182 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0520138 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.051776 |
| RPS6 | ribosomal protein S6 | 0.0502891 |
| NDRG1 | N-myc downstream regulated 1 | 0.0501615 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0501237 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0500727 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0488685 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0479288 |
| ASPH | aspartate beta-hydroxylase | 0.0464302 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.045829 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0452529 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0451722 |
| RPS3 | ribosomal protein S3 | 0.0446131 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0433316 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0431556 |
| PLEC | plectin | 0.0428105 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0426397 |
| TENM3 | teneurin transmembrane protein 3 | 0.0424924 |
| FUS | FUS RNA binding protein | 0.0423427 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0415879 |
| RPS12 | ribosomal protein S12 | 0.0410191 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0410042 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0399177 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0398577 |
| GOLGB1 | golgin B1 | 0.0397273 |
| KIF5B | kinesin family member 5B | 0.0395398 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0394585 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0391996 |
| DIAPH1 | diaphanous-related formin 1 | 0.0388262 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0386819 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0386391 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0386339 |
| DST | dystonin | 0.0374771 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0372281 |
| PKM | pyruvate kinase, muscle | 0.0364375 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0364076 |
| MYO1E | myosin IE | 0.0362995 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0361975 |
| FLNA | filamin A, alpha | 0.0359652 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0357951 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0354478 |
| SEPTIN9 | septin 9 | 0.0350469 |
| RPL26 | ribosomal protein L26 | 0.0345921 |
| USP47 | ubiquitin specific peptidase 47 | 0.0345841 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0344955 |
| TPM3 | tropomyosin 3 | 0.034488 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0344197 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0339649 |
| RCC1 | regulator of chromosome condensation 1 | 0.0338892 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0334082 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0333667 |
| EGFR | epidermal growth factor receptor | 0.0333643 |
| RUNX1 | runt-related transcription factor 1 | 0.0333597 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0324684 |
| DSPP | dentin sialophosphoprotein | 0.0320483 |
| GPHN | gephyrin | 0.0319422 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0317978 |
| POTEF | POTE ankyrin domain family, member F | 0.0311721 |
| WWC1 | WW and C2 domain containing 1 | 0.0310826 |
| GTF2B | general transcription factor IIB | 0.0310606 |
| SON | SON DNA binding protein | 0.0309299 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0308053 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0306656 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0306651 |
| TPI1 | triosephosphate isomerase 1 | 0.0305632 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0305259 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0303807 |
| RPS18 | ribosomal protein S18 | 0.0302507 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0300994 |
| RPL37A | ribosomal protein L37a | 0.0297622 |
| B2M | beta-2-microglobulin | 0.0296726 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.249242 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.149429 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0663169 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.064814 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0630176 |
| TMSB10 | thymosin beta 10 | -0.059662 |
| CENPF | centromere protein F, 350/400kDa | -0.0591452 |
| RPS24 | ribosomal protein S24 | -0.0531889 |
| MKI67 | marker of proliferation Ki-67 | -0.05204 |
| RAD51B | RAD51 paralog B | -0.0506989 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0487653 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0483172 |
| DIAPH3 | diaphanous-related formin 3 | -0.0472108 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0464103 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0411089 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0379402 |
| PRELID2 | PRELI domain containing 2 | -0.0355455 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0349453 |
| TUBA1B | tubulin, alpha 1b | -0.0348568 |
| TMEM263 | transmembrane protein 263 | -0.0336945 |
| RPL35A | ribosomal protein L35a | -0.0334988 |
| ANLN | anillin, actin binding protein | -0.0330912 |
| RPS21 | ribosomal protein S21 | -0.0330226 |
| FDPS | farnesyl diphosphate synthase | -0.0324286 |
| HMGA1 | high mobility group AT-hook 1 | -0.0324144 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0319929 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0311942 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0308809 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0307184 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0300618 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0296352 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.029437 |
| ZNF207 | zinc finger protein 207 | -0.0291801 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0286199 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.028346 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0281052 |
| GNAS | GNAS complex locus | -0.0279127 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0275564 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0273855 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0271728 |
| TUBB | tubulin, beta class I | -0.0271198 |
| HMGB2 | high mobility group box 2 | -0.0270306 |
| XPO1 | exportin 1 | -0.0260252 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0260013 |
| WDR45B | WD repeat domain 45B | -0.0254548 |
| S100A6 | S100 calcium binding protein A6 | -0.025444 |
| ARF4 | ADP-ribosylation factor 4 | -0.0254127 |
| HMGB1 | high mobility group box 1 | -0.0251675 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0250718 |
| S100A9 | S100 calcium binding protein A9 | -0.0249038 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0247869 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0243353 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0243341 |
| POU2F1 | POU class 2 homeobox 1 | -0.0242943 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0242367 |
| TPX2 | TPX2, microtubule-associated | -0.0241871 |
| USP3 | ubiquitin specific peptidase 3 | -0.024084 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | -0.0238522 |
| PERP | PERP, TP53 apoptosis effector | -0.0235238 |
| GLG1 | golgi glycoprotein 1 | -0.0233999 |
| SGO2 | shugoshin 2 | -0.023398 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0232902 |
| KNL1 | kinetochore scaffold 1 | -0.0231622 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0230831 |
| PGK1 | phosphoglycerate kinase 1 | -0.0230256 |
| RPLP0 | ribosomal protein, large, P0 | -0.0229986 |
| GAS2L3 | growth arrest-specific 2 like 3 | -0.0229955 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0229369 |
| CENPE | centromere protein E, 312kDa | -0.0225808 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0221665 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0221307 |
| SUCO | SUN domain containing ossification factor | -0.0219484 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0219466 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0218936 |
| CDK19 | cyclin-dependent kinase 19 | -0.0218911 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0217854 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0217349 |
| TUBA1C | tubulin, alpha 1c | -0.0216493 |
| ZNF511 | zinc finger protein 511 | -0.0216097 |
| RPL27A | ribosomal protein L27a | -0.0215456 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0214473 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0212613 |
| RAB5A | RAB5A, member RAS oncogene family | -0.021153 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0211139 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0210701 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0209969 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0209648 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0207946 |
| KIF18B | kinesin family member 18B | -0.0206781 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.020596 |
| TMEM123 | transmembrane protein 123 | -0.0205768 |
| PHIP | pleckstrin homology domain interacting protein | -0.0205567 |
| INSIG2 | insulin induced gene 2 | -0.0205344 |
| GOLT1B | golgi transport 1B | -0.0204473 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0203967 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0203069 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0202343 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.019892 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0197674 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -0.0196706 |
