| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | TAK-901 perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the TAK-901_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.135466 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.102508 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0958818 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0941581 |
| APP | amyloid beta (A4) precursor protein | 0.0741126 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0736469 |
| B2M | beta-2-microglobulin | 0.0716177 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0677616 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0557509 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0528439 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0521673 |
| ZNF292 | zinc finger protein 292 | 0.0511643 |
| MATR3 | matrin 3 | 0.0509818 |
| ANXA1 | annexin A1 | 0.0492775 |
| YBX1 | Y box binding protein 1 | 0.049061 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0462997 |
| RPL32 | ribosomal protein L32 | 0.0428542 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0423119 |
| RPL18 | ribosomal protein L18 | 0.0419845 |
| HELZ | helicase with zinc finger | 0.0406443 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0402004 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0386295 |
| SMAD3 | SMAD family member 3 | 0.0374491 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0369771 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0365292 |
| SET | SET nuclear proto-oncogene | 0.0362044 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0358707 |
| SON | SON DNA binding protein | 0.0329351 |
| RACK1 | receptor for activated C kinase 1 | 0.0322789 |
| EZR | ezrin | 0.0314983 |
| DIAPH1 | diaphanous-related formin 1 | 0.0314506 |
| RPL26 | ribosomal protein L26 | 0.0311732 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0309488 |
| RLF | rearranged L-myc fusion | 0.0307747 |
| BBX | bobby sox homolog (Drosophila) | 0.0306994 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0305134 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0301953 |
| RPS3 | ribosomal protein S3 | 0.0301692 |
| RPS6 | ribosomal protein S6 | 0.0301013 |
| TPM3 | tropomyosin 3 | 0.0297287 |
| RPL12 | ribosomal protein L12 | 0.0297051 |
| GOLGA4 | golgin A4 | 0.0294982 |
| GOLGB1 | golgin B1 | 0.0284099 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.028375 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.027884 |
| TMSB4X | thymosin beta 4, X-linked | 0.0278011 |
| JMJD1C | jumonji domain containing 1C | 0.0272654 |
| KIF5B | kinesin family member 5B | 0.0271239 |
| SNX9 | sorting nexin 9 | 0.0264101 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0262629 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0261493 |
| FNBP1L | formin binding protein 1-like | 0.0258364 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0258238 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0255612 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0254734 |
| RPL36 | ribosomal protein L36 | 0.0253648 |
| RNF145 | ring finger protein 145 | 0.02513 |
| ECT2 | epithelial cell transforming 2 | 0.0249839 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0244335 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.024327 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0241825 |
| TXNRD1 | thioredoxin reductase 1 | 0.0239876 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0238714 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0237788 |
| SLTM | SAFB-like, transcription modulator | 0.0236353 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0235306 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0232395 |
| OGA | O-GlcNAcase | 0.0232042 |
| DSG2 | desmoglein 2 | 0.0231857 |
| ITGB8 | integrin, beta 8 | 0.0231494 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0230931 |
| ORC4 | origin recognition complex, subunit 4 | 0.0229497 |
| RNF213 | ring finger protein 213 | 0.0228532 |
| DSPP | dentin sialophosphoprotein | 0.0227121 |
| BPTF | bromodomain PHD finger transcription factor | 0.0226675 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0225686 |
| PNN | pinin, desmosome associated protein | 0.0224772 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0224311 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0221914 |
| IRS2 | insulin receptor substrate 2 | 0.0219251 |
| TPR | translocated promoter region, nuclear basket protein | 0.0218641 |
| RPS12 | ribosomal protein S12 | 0.0218417 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0217747 |
| IER3 | immediate early response 3 | 0.0214402 |
| NCKAP1 | NCK-associated protein 1 | 0.0210913 |
| AFDN | afadin, adherens junction formation factor | 0.0210504 |
| RPL35 | ribosomal protein L35 | 0.0209979 |
| RPS7 | ribosomal protein S7 | 0.0209773 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0209542 |
| TUSC3 | tumor suppressor candidate 3 | 0.0207464 |
| PHF3 | PHD finger protein 3 | 0.0206787 |
| RUNX1 | runt-related transcription factor 1 | 0.0206427 |
| PARD6B | par-6 family cell polarity regulator beta | 0.0203968 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0202683 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0202668 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0202261 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.020209 |
| CDC27 | cell division cycle 27 | 0.020187 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.0200181 |
| TJP1 | tight junction protein 1 | 0.0199895 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.217071 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.140024 |
| PTMA | prothymosin, alpha | -0.109409 |
| RPL35A | ribosomal protein L35a | -0.102732 |
| NDRG1 | N-myc downstream regulated 1 | -0.0899805 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0898825 |
| MT2A | metallothionein 2A | -0.0896015 |
| ASPH | aspartate beta-hydroxylase | -0.0892559 |
| ACTG1 | actin gamma 1 | -0.0815186 |
| TPM4 | tropomyosin 4 | -0.0736507 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.066662 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0648843 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0626974 |
| HMGA1 | high mobility group AT-hook 1 | -0.0617344 |
| RAD51B | RAD51 paralog B | -0.0593976 |
| HMGA2 | high mobility group AT-hook 2 | -0.0545658 |
| PKM | pyruvate kinase, muscle | -0.0539693 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0522696 |
| RPL34 | ribosomal protein L34 | -0.0519218 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0511038 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0489247 |
| FTL | ferritin, light polypeptide | -0.0480059 |
| RHEX | regulator of hemoglobinization and erythroid cell expansion | -0.0468409 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0465562 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0464664 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.046259 |
| S100A6 | S100 calcium binding protein A6 | -0.044209 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0436222 |
| POTEF | POTE ankyrin domain family, member F | -0.0399776 |
| UPP1 | uridine phosphorylase 1 | -0.0399282 |
| FHIT | fragile histidine triad | -0.0393772 |
| CCND1 | cyclin D1 | -0.0393225 |
| RPS24 | ribosomal protein S24 | -0.039011 |
| ATG7 | autophagy related 7 | -0.038058 |
| PCED1B | PC-esterase domain containing 1B | -0.0373167 |
| PGK1 | phosphoglycerate kinase 1 | -0.0368944 |
| KRT19 | keratin 19, type I | -0.0365549 |
| HMGB1 | high mobility group box 1 | -0.0361518 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0352043 |
| LAMB3 | laminin, beta 3 | -0.0342404 |
| RPL23 | ribosomal protein L23 | -0.0339316 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0335614 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0333313 |
| DIAPH3 | diaphanous-related formin 3 | -0.032292 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0321685 |
| CD44 | CD44 molecule (Indian blood group) | -0.0321467 |
| PCNX4 | pecanex 4 | -0.0317772 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0317337 |
| MAP4 | microtubule-associated protein 4 | -0.0312983 |
| GNAS | GNAS complex locus | -0.0308989 |
| RPLP1 | ribosomal protein, large, P1 | -0.0306717 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0301783 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0296888 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.029332 |
| S100A9 | S100 calcium binding protein A9 | -0.0287916 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0287851 |
| EGFR | epidermal growth factor receptor | -0.0287493 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0283908 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0282508 |
| LDHA | lactate dehydrogenase A | -0.0279861 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.027757 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0271441 |
| VCL | vinculin | -0.0271351 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0267889 |
| SEPTIN9 | septin 9 | -0.0262 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0260356 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0258389 |
| RPS8 | ribosomal protein S8 | -0.0258105 |
| PRELID2 | PRELI domain containing 2 | -0.0247275 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.024678 |
| RPL38 | ribosomal protein L38 | -0.0245676 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0245271 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0244483 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0244392 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0243327 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0243047 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0241496 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | -0.02392 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0235794 |
| TUBA1B | tubulin, alpha 1b | -0.0235566 |
| KRT7 | keratin 7, type II | -0.0235092 |
| FOSL1 | FOS-like antigen 1 | -0.0234379 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0233806 |
| ITGA6 | integrin, alpha 6 | -0.0232749 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.023141 |
| CLDN1 | claudin 1 | -0.0230869 |
| ACTN4 | actinin, alpha 4 | -0.0230792 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0230273 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0230159 |
| ZNF609 | zinc finger protein 609 | -0.0230148 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | -0.022933 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0228684 |
| RPL31 | ribosomal protein L31 | -0.0228675 |
| RPS25 | ribosomal protein S25 | -0.0224362 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0224003 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0218153 |
| LASP1 | LIM and SH3 protein 1 | -0.0218015 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0217382 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0216628 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0216162 |
