TAK-901_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.435048
VIM vimentin 0.225981
MT2A metallothionein 2A 0.182245
CD44 CD44 molecule (Indian blood group) 0.13043
RPS6 ribosomal protein S6 0.128842
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.104459
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.103361
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0844393
ENO1 enolase 1, (alpha) 0.0814838
TPT1 tumor protein, translationally-controlled 1 0.079922
NDRG1 N-myc downstream regulated 1 0.0764452
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0731654
RPL12 ribosomal protein L12 0.0728624
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0708186
RPS8 ribosomal protein S8 0.0661067
TMSB10 thymosin beta 10 0.0630241
FTH1 ferritin, heavy polypeptide 1 0.0616365
RPS19 ribosomal protein S19 0.0591162
ERRFI1 ERBB receptor feedback inhibitor 1 0.0586185
RPL23 ribosomal protein L23 0.0553689
EIF1 eukaryotic translation initiation factor 1 0.0552513
FTL ferritin, light polypeptide 0.0546708
RPL37A ribosomal protein L37a 0.0539418
RPL11 ribosomal protein L11 0.0523602
RPS3 ribosomal protein S3 0.0515688
RPL35A ribosomal protein L35a 0.0511387
RPLP1 ribosomal protein, large, P1 0.0495931
RPL9 ribosomal protein L9 0.0489887
RPS12 ribosomal protein S12 0.0488807
B2M beta-2-microglobulin 0.0485261
VEGFA vascular endothelial growth factor A 0.0484295
STC1 stanniocalcin 1 0.0480466
RPLP2 ribosomal protein, large, P2 0.0467759
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.046393
RPL19 ribosomal protein L19 0.0445594
RPL26 ribosomal protein L26 0.0428562
EEF2 eukaryotic translation elongation factor 2 0.0426808
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0426752
RACK1 receptor for activated C kinase 1 0.0422397
RPL31 ribosomal protein L31 0.0411423
ANXA2 annexin A2 0.041136
RPS13 ribosomal protein S13 0.0396767
RPS17 ribosomal protein S17 0.0393594
RPL8 ribosomal protein L8 0.0392881
PKM pyruvate kinase, muscle 0.0392058
RPS16 ribosomal protein S16 0.0391304
ANKRD28 ankyrin repeat domain 28 0.0390571
RPL7 ribosomal protein L7 0.0387629
RPL32 ribosomal protein L32 0.0384581
FAM13A family with sequence similarity 13, member A 0.0383314
IER3 immediate early response 3 0.0374329
PTMA prothymosin, alpha 0.0367417
TIMP1 TIMP metallopeptidase inhibitor 1 0.0364304
RPS23 ribosomal protein S23 0.0363281
RPS27A ribosomal protein S27a 0.0362461
LDHA lactate dehydrogenase A 0.0356111
CDCP1 CUB domain containing protein 1 0.0352901
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0349495
PRRC2C proline-rich coiled-coil 2C 0.034591
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0340728
RPL37 ribosomal protein L37 0.0340149
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0339315
NAP1L1 nucleosome assembly protein 1-like 1 0.033289
FNDC3B fibronectin type III domain containing 3B 0.0322907
G0S2 G0/G1 switch 2 0.0315589
YBX1 Y box binding protein 1 0.0309383
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.030715
ELL2 elongation factor, RNA polymerase II, 2 0.0304744
ZNF292 zinc finger protein 292 0.0301245
SRRM2 serine/arginine repetitive matrix 2 0.0298414
RPS14 ribosomal protein S14 0.0295307
RPS4X ribosomal protein S4, X-linked 0.0293243
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.029243
GOLGA4 golgin A4 0.0292147
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0291581
ANGPTL4 angiopoietin-like 4 0.0290146
RPL5 ribosomal protein L5 0.0289491
GOLGB1 golgin B1 0.0288654
RPS29 ribosomal protein S29 0.0283595
TM4SF1 transmembrane 4 L six family member 1 0.0282136
RPL15 ribosomal protein L15 0.0281352
ADM adrenomedullin 0.0278244
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0277703
AKAP12 A kinase (PRKA) anchor protein 12 0.0275688
RPL7A ribosomal protein L7a 0.0272829
SMAD3 SMAD family member 3 0.0272139
RPL28 ribosomal protein L28 0.027022
RPLP0 ribosomal protein, large, P0 0.0270196
PDIA6 protein disulfide isomerase family A, member 6 0.0268227
RPS25 ribosomal protein S25 0.0265749
TPI1 triosephosphate isomerase 1 0.0261099
RPS27 ribosomal protein S27 0.0260995
KTN1 kinectin 1 (kinesin receptor) 0.0258624
S100A10 S100 calcium binding protein A10 0.0257669
RPL34 ribosomal protein L34 0.0250573
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0246548
RPS10 ribosomal protein S10 0.0245822
RPL36A ribosomal protein L36a 0.0245445
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0239846
RPL30 ribosomal protein L30 0.0236622

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.1437
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.118108
IGF2 insulin-like growth factor 2 -0.0796054
COL5A1 collagen, type V, alpha 1 -0.0754917
CDH13 cadherin 13 -0.0677916
COL6A3 collagen, type VI, alpha 3 -0.067073
COL6A1 collagen, type VI, alpha 1 -0.0662804
HMGA2 high mobility group AT-hook 2 -0.0654335
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0425623
EXT1 exostosin glycosyltransferase 1 -0.0412122
GLIS3 GLIS family zinc finger 3 -0.0369091
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0360399
LOX lysyl oxidase -0.0343322
EGR1 early growth response 1 -0.0335247
VCL vinculin -0.0331767
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0320437
TENM2 teneurin transmembrane protein 2 -0.0303191
MAML3 mastermind-like 3 (Drosophila) -0.0301937
COL6A2 collagen, type VI, alpha 2 -0.0299756
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0279413
NAV1 neuron navigator 1 -0.0274586
MYO10 myosin X -0.0270363
NALF1 NALCN channel auxiliary factor 1 -0.0266656
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0259834
COL1A1 collagen, type I, alpha 1 -0.0256866
PRSS23 protease, serine, 23 -0.0250684
COL7A1 collagen, type VII, alpha 1 -0.0248638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0240091
DIAPH2 diaphanous-related formin 2 -0.0225114
ANTXR1 anthrax toxin receptor 1 -0.0225017
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0223107
FMN1 formin 1 -0.0216336
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0210043
AFF3 AF4/FMR2 family, member 3 -0.0206829
F3 coagulation factor III (thromboplastin, tissue factor) -0.0205014
DIAPH3 diaphanous-related formin 3 -0.020389
RRM2 ribonucleotide reductase M2 -0.0199755
RAD51B RAD51 paralog B -0.0192391
LAMB3 laminin, beta 3 -0.0190374
PRELID2 PRELI domain containing 2 -0.0189823
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0188964
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0183174
RAI14 retinoic acid induced 14 -0.0177358
EFNA5 ephrin-A5 -0.0177358
CFAP20DC CFAP20 domain containing -0.0174778
TAS2R14 taste receptor, type 2, member 14 -0.0173851
CLMP CXADR-like membrane protein -0.0173631
AHNAK AHNAK nucleoprotein -0.0162825
ARHGAP22 Rho GTPase activating protein 22 -0.015892
ETV6 ets variant 6 -0.0156287
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0147286
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0144348
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0143183
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0140377
MTCL1 microtubule crosslinking factor 1 -0.0139897
ENOSF1 enolase superfamily member 1 -0.0137785
MBD5 methyl-CpG binding domain protein 5 -0.0137527
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0137299
TPM1 tropomyosin 1 (alpha) -0.0136941
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0136304
SAMD3 sterile alpha motif domain containing 3 -0.0135618
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0135467
FRMD4A FERM domain containing 4A -0.01346
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.013419
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0131388
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0126542
FBXL7 F-box and leucine-rich repeat protein 7 -0.0124257
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0123819
NSD2 nuclear receptor binding SET domain protein 2 -0.0123435
ARRDC3 arrestin domain containing 3 -0.0122229
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0121494
KIAA1549L KIAA1549-like -0.0120779
ACTG1 actin gamma 1 -0.0120705
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0120388
COL4A2 collagen, type IV, alpha 2 -0.0119674
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0119396
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0118902
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0117993
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0117685
KLF10 Kruppel-like factor 10 -0.0113574
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0113363
DNER delta/notch-like EGF repeat containing -0.0112863
LAMA4 laminin, alpha 4 -0.0112258
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0111992
THBS2 thrombospondin 2 -0.0111144
CUX1 cut-like homeobox 1 -0.0110135
MAP4 microtubule-associated protein 4 -0.0108771
ANTXR2 anthrax toxin receptor 2 -0.0108049
ZMYND8 zinc finger, MYND-type containing 8 -0.0106084
SOX5 SRY (sex determining region Y)-box 5 -0.0105674
SFRP1 secreted frizzled-related protein 1 -0.0105537
APOLD1 apolipoprotein L domain containing 1 -0.0104865
DTNA dystrobrevin, alpha -0.0104329
ACTN4 actinin, alpha 4 -0.010345
QKI QKI, KH domain containing, RNA binding -0.010278
PGK1 phosphoglycerate kinase 1 -0.0101459
TRPS1 trichorhinophalangeal syndrome I -0.0101364
CDK14 cyclin-dependent kinase 14 -0.0101165
ZFAND3 zinc finger, AN1-type domain 3 -0.0101106
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0100105