TAK-901_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the TAK-901_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.231767
FTH1 ferritin, heavy polypeptide 1 0.218212
FN1 fibronectin 1 0.211056
CD44 CD44 molecule (Indian blood group) 0.156998
IGFBP3 insulin-like growth factor binding protein 3 0.155042
MT2A metallothionein 2A 0.143433
MYH9 myosin, heavy chain 9, non-muscle 0.125031
FNDC3B fibronectin type III domain containing 3B 0.118493
CDH13 cadherin 13 0.108684
ENO1 enolase 1, (alpha) 0.105243
EEF2 eukaryotic translation elongation factor 2 0.10015
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0925764
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0886455
EXT1 exostosin glycosyltransferase 1 0.0847943
CALR calreticulin 0.0813539
RPS6 ribosomal protein S6 0.0795143
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0792341
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0734656
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0715572
COL6A3 collagen, type VI, alpha 3 0.0694154
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0690146
LDHA lactate dehydrogenase A 0.0680981
RPS3 ribosomal protein S3 0.0667639
PTK2 protein tyrosine kinase 2 0.0612302
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0598538
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0573802
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0550655
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0548605
TRIO trio Rho guanine nucleotide exchange factor 0.054422
MBNL1 muscleblind-like splicing regulator 1 0.0541067
ALCAM activated leukocyte cell adhesion molecule 0.0519307
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0508404
RACK1 receptor for activated C kinase 1 0.0495212
B2M beta-2-microglobulin 0.049338
GOLGB1 golgin B1 0.0487642
MACF1 microtubule-actin crosslinking factor 1 0.048399
ZSWIM6 zinc finger, SWIM-type containing 6 0.0480237
SRRM2 serine/arginine repetitive matrix 2 0.0474488
RPL26 ribosomal protein L26 0.0473604
CANX calnexin 0.0472684
FAT1 FAT atypical cadherin 1 0.0468966
RPL7 ribosomal protein L7 0.0462998
ASPH aspartate beta-hydroxylase 0.0457395
IL6 interleukin 6 0.0446824
YBX1 Y box binding protein 1 0.0444722
ZBTB38 zinc finger and BTB domain containing 38 0.0443909
RPL11 ribosomal protein L11 0.0425727
RUNX1 runt-related transcription factor 1 0.0417559
ANKRD11 ankyrin repeat domain 11 0.0399732
RAB2A RAB2A, member RAS oncogene family 0.038598
WWTR1 WW domain containing transcription regulator 1 0.0385798
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0383946
SP100 SP100 nuclear antigen 0.0383894
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.038342
RPL37A ribosomal protein L37a 0.0364076
RPL5 ribosomal protein L5 0.0360115
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0355714
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0353391
RPS19 ribosomal protein S19 0.0353067
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0352238
NAP1L1 nucleosome assembly protein 1-like 1 0.0350046
PLEC plectin 0.0345653
HDAC9 histone deacetylase 9 0.0343564
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0337663
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0335305
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0335301
RPL19 ribosomal protein L19 0.0335049
SON SON DNA binding protein 0.0329562
TSC22D2 TSC22 domain family, member 2 0.032932
EIF1 eukaryotic translation initiation factor 1 0.0328462
RPL8 ribosomal protein L8 0.0326664
RPL12 ribosomal protein L12 0.0326628
NAMPT nicotinamide phosphoribosyltransferase 0.032213
AHNAK AHNAK nucleoprotein 0.0321243
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0316423
APP amyloid beta (A4) precursor protein 0.0314726
CXCL8 chemokine (C-X-C motif) ligand 8 0.0312995
VMP1 vacuole membrane protein 1 0.0311349
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0307618
RPS12 ribosomal protein S12 0.0305881
RPL36 ribosomal protein L36 0.0304511
FLNA filamin A, alpha 0.0296798
FAM107B family with sequence similarity 107, member B 0.0295704
NAV3 neuron navigator 3 0.0293204
NAV2 neuron navigator 2 0.0292278
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0291655
SQSTM1 sequestosome 1 0.0290837
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0290546
SDC2 syndecan 2 0.0289886
HSPA8 heat shock 70kDa protein 8 0.0286099
PGM3 phosphoglucomutase 3 0.0284788
SFPQ splicing factor proline/glutamine-rich 0.0282915
RPL32 ribosomal protein L32 0.028277
RND3 Rho family GTPase 3 0.0280576
RPS17 ribosomal protein S17 0.0277483
RPS8 ribosomal protein S8 0.0271306
GOLGA4 golgin A4 0.0270927
ERRFI1 ERBB receptor feedback inhibitor 1 0.0269754
PICALM phosphatidylinositol binding clathrin assembly protein 0.0266966
ATF4 activating transcription factor 4 0.0263854

decreased expression

Symbol Name Standardized Value
COL1A1 collagen, type I, alpha 1 -0.170535
COL1A2 collagen, type I, alpha 2 -0.137171
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.107426
TIMP3 TIMP metallopeptidase inhibitor 3 -0.103962
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0977199
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0777813
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0717064
F3 coagulation factor III (thromboplastin, tissue factor) -0.0645879
TPM4 tropomyosin 4 -0.055449
PTMA prothymosin, alpha -0.0520019
LOX lysyl oxidase -0.0324815
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0265236
GNAS GNAS complex locus -0.0241896
NDRG1 N-myc downstream regulated 1 -0.022624
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.020929
TM4SF1 transmembrane 4 L six family member 1 -0.0205327
HLA-B major histocompatibility complex, class I, B -0.0204903
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0200691
VIM vimentin -0.0197787
APOLD1 apolipoprotein L domain containing 1 -0.0192217
KPNB1 karyopherin (importin) beta 1 -0.0176356
ZMYND8 zinc finger, MYND-type containing 8 -0.0174118
MT1X metallothionein 1X -0.0171507
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0170776
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0168767
OXR1 oxidation resistance 1 -0.0168535
CAVIN1 caveolae associated protein 1 -0.0165957
ABI3BP ABI family, member 3 (NESH) binding protein -0.0165153
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0163928
PRR16 proline rich 16 -0.0162791
RTN4 reticulon 4 -0.0160956
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0160419
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0160081
S100A6 S100 calcium binding protein A6 -0.0158427
SERINC3 serine incorporator 3 -0.0157284
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0155674
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0153673
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0152811
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0149255
SQLE squalene epoxidase -0.0148492
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0145453
MTSS1 metastasis suppressor 1 -0.0143565
SELENOK selenoprotein K -0.0142115
HIP1 huntingtin interacting protein 1 -0.0141343
TAGLN2 transgelin 2 -0.0138438
RNF220 ring finger protein 220 -0.013824
EGR1 early growth response 1 -0.0137123
CYB5R3 cytochrome b5 reductase 3 -0.0134654
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0134607
SENP7 SUMO1/sentrin specific peptidase 7 -0.0134134
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0134064
LAMB3 laminin, beta 3 -0.0132649
ACBD3 acyl-CoA binding domain containing 3 -0.0126866
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0125292
WSB1 WD repeat and SOCS box containing 1 -0.0125034
SKIC3 SKI3 subunit of superkiller complex -0.0123969
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0122074
MARCKS myristoylated alanine-rich protein kinase C substrate -0.012157
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0121428
NREP neuronal regeneration related protein -0.0121404
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0120974
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0120261
PLIN3 perilipin 3 -0.0120101
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0119937
PCNP PEST proteolytic signal containing nuclear protein -0.0117495
RARB retinoic acid receptor, beta -0.011505
AFAP1 actin filament associated protein 1 -0.0115012
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -0.0114117
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.011403
ZNF395 zinc finger protein 395 -0.01133
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0111916
TRAM1 translocation associated membrane protein 1 -0.0111627
DLG1 discs, large homolog 1 (Drosophila) -0.0111601
NDFIP1 Nedd4 family interacting protein 1 -0.0109974
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0109604
SEC31A SEC31 homolog A (S. cerevisiae) -0.0109488
CD109 CD109 molecule -0.0108063
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0107016
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0106764
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0105881
RPL34 ribosomal protein L34 -0.0105012
CAV1 caveolin 1, caveolae protein, 22kDa -0.0104831
GGNBP2 gametogenetin binding protein 2 -0.0104721
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -0.0104534
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -0.010447
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0103268
DNAAF9 dynein axonemal assembly factor 9 -0.0102419
USP3 ubiquitin specific peptidase 3 -0.0102369
PRR11 proline rich 11 -0.0101762
DIAPH3 diaphanous-related formin 3 -0.0101668
INSIG1 insulin induced gene 1 -0.0100954
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0100698
ZFHX3 zinc finger homeobox 3 -0.0100635
IER3IP1 immediate early response 3 interacting protein 1 -0.00991484
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.00986853
CTSA cathepsin A -0.00983807
HLA-E major histocompatibility complex, class I, E -0.00975773
RAB5A RAB5A, member RAS oncogene family -0.00972674
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.00969828
PRRC1 proline-rich coiled-coil 1 -0.00964422