TAK-901_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.514923
AKAP12 A kinase (PRKA) anchor protein 12 0.343235
GPC6 glypican 6 0.0750008
PDLIM5 PDZ and LIM domain 5 0.0747372
SVIL supervillin 0.0738875
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0734831
DST dystonin 0.0728057
FAM107B family with sequence similarity 107, member B 0.0714217
SAMD4A sterile alpha motif domain containing 4A 0.061981
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0576515
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0569457
LPP LIM domain containing preferred translocation partner in lipoma 0.0559927
IGFBP1 insulin-like growth factor binding protein 1 0.055038
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0535062
EXT1 exostosin glycosyltransferase 1 0.0505451
ENO1 enolase 1, (alpha) 0.0496895
ASPH aspartate beta-hydroxylase 0.0491996
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0491794
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.048754
FRMD5 FERM domain containing 5 0.0459575
FOXP1 forkhead box P1 0.0458823
VEGFA vascular endothelial growth factor A 0.0454484
ATXN1 ataxin 1 0.045398
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0452116
ZBTB20 zinc finger and BTB domain containing 20 0.0416003
GRB10 growth factor receptor-bound protein 10 0.0406176
VCL vinculin 0.039663
FAT1 FAT atypical cadherin 1 0.0385787
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0384393
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0371017
ITGAV integrin, alpha V 0.036814
DSPP dentin sialophosphoprotein 0.0364748
KYNU kynureninase 0.0364023
LIMS1 LIM and senescent cell antigen-like domains 1 0.0359756
PAWR PRKC, apoptosis, WT1, regulator 0.0336348
TRIO trio Rho guanine nucleotide exchange factor 0.0333439
APLP2 amyloid beta (A4) precursor-like protein 2 0.0329178
FLNB filamin B, beta 0.0319536
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0318986
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0313124
INTS6 integrator complex subunit 6 0.0310884
VMP1 vacuole membrane protein 1 0.0305436
SLC38A2 solute carrier family 38, member 2 0.0300559
MYH9 myosin, heavy chain 9, non-muscle 0.0299049
MCL1 myeloid cell leukemia 1 0.02936
AFF1 AF4/FMR2 family, member 1 0.0281674
BCL2L1 BCL2-like 1 0.0280966
AHSG alpha-2-HS-glycoprotein 0.0278767
EHBP1 EH domain binding protein 1 0.0277425
PLIN2 perilipin 2 0.0265477
ITGA6 integrin, alpha 6 0.0259585
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.025604
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0253887
GMDS GDP-mannose 4,6-dehydratase 0.0252008
DIAPH1 diaphanous-related formin 1 0.0242874
RASA2 RAS p21 protein activator 2 0.0242555
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0241797
HPCAL1 hippocalcin-like 1 0.0241719
MBNL1 muscleblind-like splicing regulator 1 0.024081
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0234423
GLIPR1 GLI pathogenesis-related 1 0.0227698
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.0225557
EEF2 eukaryotic translation elongation factor 2 0.022414
ERN1 endoplasmic reticulum to nucleus signaling 1 0.022154
MBNL2 muscleblind-like splicing regulator 2 0.0220596
PALLD palladin, cytoskeletal associated protein 0.0219741
MAST4 microtubule associated serine/threonine kinase family member 4 0.0215379
POTEF POTE ankyrin domain family, member F 0.0210906
UBASH3B ubiquitin associated and SH3 domain containing B 0.0209007
RAB3B RAB3B, member RAS oncogene family 0.0205827
ZSWIM6 zinc finger, SWIM-type containing 6 0.0205052
PRKCA protein kinase C, alpha 0.0202811
SYNE1 spectrin repeat containing, nuclear envelope 1 0.020053
CNKSR3 CNKSR family member 3 0.0199707
GCLC glutamate-cysteine ligase, catalytic subunit 0.0199003
MACF1 microtubule-actin crosslinking factor 1 0.0198346
CLIC4 chloride intracellular channel 4 0.0197058
LMO7 LIM domain 7 0.0191702
KRT8 keratin 8, type II 0.0186709
FN1 fibronectin 1 0.0186153
NABP1 nucleic acid binding protein 1 0.0186053
KRT18 keratin 18, type I 0.0185059
TMSB10 thymosin beta 10 0.0185037
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0183555
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0182456
ZFAND3 zinc finger, AN1-type domain 3 0.0181612
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0180863
RSU1 Ras suppressor protein 1 0.0180848
BRD2 bromodomain containing 2 0.018084
B2M beta-2-microglobulin 0.0180223
PTPRK protein tyrosine phosphatase, receptor type, K 0.0178725
RAI14 retinoic acid induced 14 0.0178203
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0177893
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0177621
FERMT2 fermitin family member 2 0.0177122
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0176627
MCU mitochondrial calcium uniporter 0.0170374
RAD51B RAD51 paralog B 0.0168301
SRRM2 serine/arginine repetitive matrix 2 0.016815
SP100 SP100 nuclear antigen 0.0167385

decreased expression

Symbol Name Standardized Value
APOB apolipoprotein B -0.233608
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.126121
GPC3 glypican 3 -0.0986966
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0828899
ELL2 elongation factor, RNA polymerase II, 2 -0.072463
FNDC3B fibronectin type III domain containing 3B -0.0645868
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0556228
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0554648
A2M alpha-2-macroglobulin -0.048978
FBF1 Fas (TNFRSF6) binding factor 1 -0.048242
TPT1 tumor protein, translationally-controlled 1 -0.0470612
EML4 echinoderm microtubule associated protein like 4 -0.0436265
TRIM26 tripartite motif containing 26 -0.0403105
RBM39 RNA binding motif protein 39 -0.0391799
GPAM glycerol-3-phosphate acyltransferase, mitochondrial -0.0387102
LRMDA leucine rich melanocyte differentiation associated -0.0382662
MBNL3 muscleblind-like splicing regulator 3 -0.0366956
CFB complement factor B -0.0366924
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0359241
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0353755
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0350363
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0342011
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0328179
AFDN afadin, adherens junction formation factor -0.0323644
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.032055
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0309361
KDM7A lysine (K)-specific demethylase 7A -0.0262575
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0260554
TM4SF1 transmembrane 4 L six family member 1 -0.0258149
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.025494
HLF hepatic leukemia factor -0.0253642
NCOA7 nuclear receptor coactivator 7 -0.0253543
SDC4 syndecan 4 -0.0244171
MALT1 MALT1 paracaspase -0.0241036
FOXN3 forkhead box N3 -0.023839
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0236868
RPS24 ribosomal protein S24 -0.0235961
ZMYND8 zinc finger, MYND-type containing 8 -0.0235752
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0233452
NKD1 naked cuticle homolog 1 (Drosophila) -0.0228683
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.022626
RRBP1 ribosome binding protein 1 -0.0226038
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.0223059
IGF2R insulin-like growth factor 2 receptor -0.022175
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0221468
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0219024
PUM2 pumilio RNA-binding family member 2 -0.0214435
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0214019
ACSS3 acyl-CoA synthetase short-chain family member 3 -0.0212709
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0209735
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0208087
KDM3A lysine (K)-specific demethylase 3A -0.0204671
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0203658
MTUS1 microtubule associated tumor suppressor 1 -0.0201721
SOS1 son of sevenless homolog 1 (Drosophila) -0.019875
ZNF292 zinc finger protein 292 -0.0197787
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0197155
WDR45B WD repeat domain 45B -0.0191549
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0191236
C3 complement component 3 -0.0185814
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0185283
OSMR oncostatin M receptor -0.0185161
SELENOP selenoprotein P -0.0179044
TUT4 terminal uridylyl transferase 4 -0.0178857
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0178295
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0178184
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0176929
TMEM51 transmembrane protein 51 -0.0175851
ANKRD10 ankyrin repeat domain 10 -0.0175839
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0174411
NIPBL Nipped-B homolog (Drosophila) -0.0172082
DENND4A DENN/MADD domain containing 4A -0.0171085
RPS8 ribosomal protein S8 -0.0168387
GNAS GNAS complex locus -0.0164796
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0164053
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0163737
ANGPTL8 angiopoietin like 8 -0.0163284
ICAM1 intercellular adhesion molecule 1 -0.0162979
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0162823
NFIA nuclear factor I/A -0.0161842
SOD2 superoxide dismutase 2, mitochondrial -0.0161473
TLK1 tousled-like kinase 1 -0.0161205
OGA O-GlcNAcase -0.0160644
TM9SF3 transmembrane 9 superfamily member 3 -0.0158884
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0156913
RPL12 ribosomal protein L12 -0.0156044
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0155426
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like -0.0155145
NPR2 natriuretic peptide receptor 2 -0.0154901
RBM25 RNA binding motif protein 25 -0.0154384
PEG3 paternally expressed 3 -0.0154116
NPEPPS aminopeptidase puromycin sensitive -0.0151829
RPLP1 ribosomal protein, large, P1 -0.0151209
RPL34 ribosomal protein L34 -0.0150841
CD2AP CD2-associated protein -0.0150588
WAC WW domain containing adaptor with coiled-coil -0.0150421
RPLP0 ribosomal protein, large, P0 -0.0148479
CHD6 chromodomain helicase DNA binding protein 6 -0.0147334
MATR3 matrin 3 -0.0145353
ARL5A ADP-ribosylation factor-like 5A -0.0144333