TAK-901_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.100613
RPS6 ribosomal protein S6 0.0874496
LMO7 LIM domain 7 0.0691728
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0652169
MT2A metallothionein 2A 0.0638194
RPS8 ribosomal protein S8 0.0632046
CLU clusterin 0.0620864
RPL11 ribosomal protein L11 0.0578209
RPS3 ribosomal protein S3 0.0563776
RPS13 ribosomal protein S13 0.0561216
RPL37 ribosomal protein L37 0.0535318
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0468761
MBNL1 muscleblind-like splicing regulator 1 0.0462476
RPS12 ribosomal protein S12 0.0454196
CD44 CD44 molecule (Indian blood group) 0.0452376
RPS19 ribosomal protein S19 0.0427119
FTL ferritin, light polypeptide 0.0413527
FOXP1 forkhead box P1 0.0399123
RPL23 ribosomal protein L23 0.0398535
RPL37A ribosomal protein L37a 0.0397981
INTS6 integrator complex subunit 6 0.0386152
SRRM2 serine/arginine repetitive matrix 2 0.0385944
IFITM3 interferon induced transmembrane protein 3 0.037451
RPS23 ribosomal protein S23 0.0368402
ENO1 enolase 1, (alpha) 0.036823
MT1E metallothionein 1E 0.0356611
POTEF POTE ankyrin domain family, member F 0.0350369
RPLP2 ribosomal protein, large, P2 0.0347997
FOXO1 forkhead box O1 0.0339806
MYOF myoferlin 0.0338413
TPT1 tumor protein, translationally-controlled 1 0.0336859
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0331368
RPS14 ribosomal protein S14 0.0331254
APLP2 amyloid beta (A4) precursor-like protein 2 0.0314155
PCDH1 protocadherin 1 0.0313835
TGM2 transglutaminase 2 0.0311678
MSN moesin 0.0304927
RPL7 ribosomal protein L7 0.0299029
RPS29 ribosomal protein S29 0.0297873
KTN1 kinectin 1 (kinesin receptor) 0.0295773
SULF2 sulfatase 2 0.0295326
SQSTM1 sequestosome 1 0.0293917
B2M beta-2-microglobulin 0.0289462
PLEC plectin 0.0284896
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.028044
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0277752
STC1 stanniocalcin 1 0.0274563
RPL19 ribosomal protein L19 0.0272729
PDLIM5 PDZ and LIM domain 5 0.0271534
RPS25 ribosomal protein S25 0.0270519
RPS2 ribosomal protein S2 0.0266282
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0261685
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0248624
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0248366
DSTN destrin (actin depolymerizing factor) 0.0244898
RPS11 ribosomal protein S11 0.0242592
S100A2 S100 calcium binding protein A2 0.0241622
RPS17 ribosomal protein S17 0.0239192
SETD5 SET domain containing 5 0.0237291
ZSWIM6 zinc finger, SWIM-type containing 6 0.0235311
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0234503
KRT17 keratin 17, type I 0.023074
RPLP0 ribosomal protein, large, P0 0.0230472
RPL21 ribosomal protein L21 0.0230144
TRIP12 thyroid hormone receptor interactor 12 0.0228611
RPS21 ribosomal protein S21 0.0226705
MACF1 microtubule-actin crosslinking factor 1 0.0226313
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0226158
SET SET nuclear proto-oncogene 0.0226107
UBE2B ubiquitin-conjugating enzyme E2B 0.0225757
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0224358
RPL9 ribosomal protein L9 0.0223652
PRRC2C proline-rich coiled-coil 2C 0.0221962
PLS3 plastin 3 0.0221374
RSL1D1 ribosomal L1 domain containing 1 0.0221137
SMAD3 SMAD family member 3 0.0220452
RPL28 ribosomal protein L28 0.0220303
RPL5 ribosomal protein L5 0.0219376
EIF5B eukaryotic translation initiation factor 5B 0.0218678
HSPA8 heat shock 70kDa protein 8 0.0218613
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0213516
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0213487
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0213107
RICTOR RPTOR independent companion of MTOR, complex 2 0.0212546
AKAP13 A kinase (PRKA) anchor protein 13 0.021207
PTK2 protein tyrosine kinase 2 0.0210181
RPL36 ribosomal protein L36 0.020855
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0207499
EXT1 exostosin glycosyltransferase 1 0.020725
IRS2 insulin receptor substrate 2 0.0205404
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0203535
TPM3 tropomyosin 3 0.0200091
RPL32 ribosomal protein L32 0.0199948
RPS27 ribosomal protein S27 0.0199312
MATR3 matrin 3 0.0198982
IFITM1 interferon induced transmembrane protein 1 0.0195106
SIK3 SIK family kinase 3 0.0194401
RPL35 ribosomal protein L35 0.0192349
IPO7 importin 7 0.0192191
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.019177

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.141967
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0865277
FLNB filamin B, beta -0.0852311
PTMA prothymosin, alpha -0.0497838
IGF2 insulin-like growth factor 2 -0.0488403
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0484879
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0371663
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0366906
ZMYND8 zinc finger, MYND-type containing 8 -0.0354698
NDRG1 N-myc downstream regulated 1 -0.033544
ABI3BP ABI family, member 3 (NESH) binding protein -0.0327997
CAVIN1 caveolae associated protein 1 -0.0321411
SEC31A SEC31 homolog A (S. cerevisiae) -0.0271311
BLCAP bladder cancer associated protein -0.024664
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0230856
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0225388
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0217257
EGR1 early growth response 1 -0.0208392
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0201058
DLG1 discs, large homolog 1 (Drosophila) -0.020087
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0194967
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0184422
TMEM165 transmembrane protein 165 -0.0183972
KDM3A lysine (K)-specific demethylase 3A -0.0182685
PSD3 pleckstrin and Sec7 domain containing 3 -0.0180309
GNAS GNAS complex locus -0.0178443
COL17A1 collagen, type XVII, alpha 1 -0.0174326
IFI16 interferon, gamma-inducible protein 16 -0.017421
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0173764
TMSB4X thymosin beta 4, X-linked -0.0172978
H1-0 H1.0 linker histone -0.0172615
HLA-B major histocompatibility complex, class I, B -0.017074
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0167772
IER3 immediate early response 3 -0.0167691
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0166892
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0166648
NAMPT nicotinamide phosphoribosyltransferase -0.0165852
COL5A2 collagen, type V, alpha 2 -0.0163495
ANLN anillin, actin binding protein -0.0158524
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0158381
CUX1 cut-like homeobox 1 -0.0156742
SRP54 signal recognition particle 54kDa -0.0156274
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0156242
PPARG peroxisome proliferator-activated receptor gamma -0.0154507
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0153908
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0149881
C4BPB complement component 4 binding protein, beta -0.0146721
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0146189
FSCN1 fascin actin-bundling protein 1 -0.0144945
LDLR low density lipoprotein receptor -0.0143418
F3 coagulation factor III (thromboplastin, tissue factor) -0.0143209
COL4A5 collagen, type IV, alpha 5 -0.0142555
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0141065
STAU1 staufen double-stranded RNA binding protein 1 -0.0139779
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0137259
RPL36A ribosomal protein L36a -0.0136831
PYGL phosphorylase, glycogen, liver -0.0136279
IFI6 interferon, alpha-inducible protein 6 -0.0133732
SPATS2 spermatogenesis associated, serine-rich 2 -0.0131791
PRELID2 PRELI domain containing 2 -0.0131388
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0131162
WSB1 WD repeat and SOCS box containing 1 -0.0130911
NRIP1 nuclear receptor interacting protein 1 -0.0126365
NT5C2 5'-nucleotidase, cytosolic II -0.0125359
TMEM263 transmembrane protein 263 -0.0125316
ANXA2 annexin A2 -0.0124621
DSG2 desmoglein 2 -0.0122969
CLDN1 claudin 1 -0.0121008
RAD51B RAD51 paralog B -0.0120322
HDLBP high density lipoprotein binding protein -0.0120038
DPYSL2 dihydropyrimidinase-like 2 -0.0119863
TMEM41B transmembrane protein 41B -0.0119341
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0118602
ZBTB7A zinc finger and BTB domain containing 7A -0.0118288
THBD thrombomodulin -0.0118237
IFIH1 interferon induced with helicase C domain 1 -0.0118218
NCOA3 nuclear receptor coactivator 3 -0.0118176
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.0118158
MARCHF6 membrane associated ring-CH-type finger 6 -0.0116316
ZNFX1 zinc finger, NFX1-type containing 1 -0.0115153
NPEPPS aminopeptidase puromycin sensitive -0.0113279
NDE1 nudE neurodevelopment protein 1 -0.0113083
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0112286
TRIM56 tripartite motif containing 56 -0.0110699
CDK19 cyclin-dependent kinase 19 -0.0110565
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0108712
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0108686
LMAN1 lectin, mannose-binding, 1 -0.0108243
CD82 CD82 molecule -0.0107691
HSPG2 heparan sulfate proteoglycan 2 -0.0106315
RCOR1 REST corepressor 1 -0.0106006
LOXL2 lysyl oxidase-like 2 -0.0105727
DOCK5 dedicator of cytokinesis 5 -0.010542
MON2 MON2 homolog (S. cerevisiae) -0.0103468
DNAAF9 dynein axonemal assembly factor 9 -0.0103437
SLC35F3 solute carrier family 35, member F3 -0.0103414
EPN2 epsin 2 -0.0102921
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.010286
BCL2L1 BCL2-like 1 -0.0101676
MCL1 myeloid cell leukemia 1 -0.0101226