TAK-901_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.198842
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.137414
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.134689
FTH1 ferritin, heavy polypeptide 1 0.133659
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.128451
NALF1 NALCN channel auxiliary factor 1 0.115661
CD44 CD44 molecule (Indian blood group) 0.0995084
EXT1 exostosin glycosyltransferase 1 0.0974602
ENO1 enolase 1, (alpha) 0.0941532
FN1 fibronectin 1 0.0887906
B2M beta-2-microglobulin 0.0884819
IGFBP3 insulin-like growth factor binding protein 3 0.0855338
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0851732
AKAP12 A kinase (PRKA) anchor protein 12 0.0783942
HLA-B major histocompatibility complex, class I, B 0.0744962
RPS6 ribosomal protein S6 0.0722893
MYH9 myosin, heavy chain 9, non-muscle 0.0674993
TRIO trio Rho guanine nucleotide exchange factor 0.0662758
ASPH aspartate beta-hydroxylase 0.0659515
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0640453
FTL ferritin, light polypeptide 0.05846
LDHA lactate dehydrogenase A 0.0556711
ANXA2 annexin A2 0.0551165
POTEF POTE ankyrin domain family, member F 0.0545064
DST dystonin 0.0542635
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0540238
VIM vimentin 0.0522061
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0502987
FNDC3B fibronectin type III domain containing 3B 0.0498938
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0474381
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0458873
ERBIN erbb2 interacting protein 0.0438777
PTK2 protein tyrosine kinase 2 0.0424384
NAV2 neuron navigator 2 0.0424278
ZSWIM6 zinc finger, SWIM-type containing 6 0.0422262
MAP1B microtubule-associated protein 1B 0.0417102
FLNB filamin B, beta 0.0411251
SRRM2 serine/arginine repetitive matrix 2 0.040002
AHNAK AHNAK nucleoprotein 0.0399925
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0399786
PKM pyruvate kinase, muscle 0.0398468
LPP LIM domain containing preferred translocation partner in lipoma 0.0392915
PODXL podocalyxin-like 0.0391005
RPS3 ribosomal protein S3 0.0390258
ACTG1 actin gamma 1 0.0383092
PHACTR1 phosphatase and actin regulator 1 0.0379275
INTS6 integrator complex subunit 6 0.0376132
SLIT2 slit homolog 2 (Drosophila) 0.036641
RAI14 retinoic acid induced 14 0.0365005
SET SET nuclear proto-oncogene 0.0357338
TPM3 tropomyosin 3 0.0355961
TPT1 tumor protein, translationally-controlled 1 0.0348904
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0348624
RPL35A ribosomal protein L35a 0.0342169
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0341437
PRRC2C proline-rich coiled-coil 2C 0.0338735
TLE4 transducin-like enhancer of split 4 0.0329375
RPLP2 ribosomal protein, large, P2 0.0322562
KTN1 kinectin 1 (kinesin receptor) 0.0317442
DIAPH3 diaphanous-related formin 3 0.0316137
GOLGB1 golgin B1 0.031489
DEK DEK proto-oncogene 0.0314151
RPS8 ribosomal protein S8 0.0308771
TMSB10 thymosin beta 10 0.030579
TXNRD1 thioredoxin reductase 1 0.030344
CALR calreticulin 0.0298118
MBNL1 muscleblind-like splicing regulator 1 0.0297685
SMYD3 SET and MYND domain containing 3 0.0296994
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0296525
RPL26 ribosomal protein L26 0.0295742
CCND1 cyclin D1 0.0294941
ZNF432 zinc finger protein 432 0.0293107
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.029243
ZBTB20 zinc finger and BTB domain containing 20 0.0292021
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0290064
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0286671
RNF213 ring finger protein 213 0.0285984
MACF1 microtubule-actin crosslinking factor 1 0.0285767
YBX1 Y box binding protein 1 0.028511
RPL11 ribosomal protein L11 0.0282881
VCL vinculin 0.0282347
TPI1 triosephosphate isomerase 1 0.0281955
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0281734
PTPRG protein tyrosine phosphatase, receptor type, G 0.027989
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0274931
ZNF841 zinc finger protein 841 0.0268144
TPM1 tropomyosin 1 (alpha) 0.0267626
PDLIM5 PDZ and LIM domain 5 0.0267623
VEGFA vascular endothelial growth factor A 0.0266068
RACK1 receptor for activated C kinase 1 0.0265371
SP100 SP100 nuclear antigen 0.0263176
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0261548
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0261514
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0261442
FLNA filamin A, alpha 0.0259341
EGFR epidermal growth factor receptor 0.0256362
CALD1 caldesmon 1 0.0255183
CLIC4 chloride intracellular channel 4 0.0254458
SQSTM1 sequestosome 1 0.025273
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0250072

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0569845
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0196033
UGCG UDP-glucose ceramide glucosyltransferase -0.0168771
MT1X metallothionein 1X -0.0163885
ATP13A3 ATPase type 13A3 -0.0153174
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0129766
ANKRD10 ankyrin repeat domain 10 -0.0125459
USP3 ubiquitin specific peptidase 3 -0.0123812
SOD2 superoxide dismutase 2, mitochondrial -0.0120203
NUP58 nucleoporin 58 -0.01194
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0104517
NAMPT nicotinamide phosphoribosyltransferase -0.0102515
LOX lysyl oxidase -0.0102511
SRP54 signal recognition particle 54kDa -0.00992541
PPME1 protein phosphatase methylesterase 1 -0.00990365
HILPDA hypoxia inducible lipid droplet-associated -0.00979167
RLF rearranged L-myc fusion -0.00939974
CTSD cathepsin D -0.00939592
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0093038
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.00890908
TFG TRK-fused gene -0.00889004
SUCO SUN domain containing ossification factor -0.00878963
WTAP Wilms tumor 1 associated protein -0.0085836
DENND4C DENN/MADD domain containing 4C -0.00840823
RAB18 RAB18, member RAS oncogene family -0.00767483
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.00748809
FOXO3 forkhead box O3 -0.00720662
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.00714481
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.00705746
WDR45B WD repeat domain 45B -0.00703915
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0070147
TMEM39A transmembrane protein 39A -0.0069273
ICAM1 intercellular adhesion molecule 1 -0.00679867
GOLT1B golgi transport 1B -0.00663066
SEC24A SEC24 family member A -0.00662901
ARL5B ADP-ribosylation factor-like 5B -0.00640965
SPAG9 sperm associated antigen 9 -0.00638747
QKI QKI, KH domain containing, RNA binding -0.0063739
TMEM263 transmembrane protein 263 -0.00623771
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.00622492
TMEM41B transmembrane protein 41B -0.00615828
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.00607168
TBC1D12 TBC1 domain family, member 12 -0.00605588
INSIG2 insulin induced gene 2 -0.00604924
KDM3A lysine (K)-specific demethylase 3A -0.00597033
RAB1A RAB1A, member RAS oncogene family -0.00596668
HLA-C major histocompatibility complex, class I, C -0.00596612
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.00595388
TPD52 tumor protein D52 -0.00594438
TSC22D2 TSC22 domain family, member 2 -0.00593739
ELL2 elongation factor, RNA polymerase II, 2 -0.00587585
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00585341
UFM1 ubiquitin-fold modifier 1 -0.00585248
FBXO42 F-box protein 42 -0.00584027
NUAK2 NUAK family, SNF1-like kinase, 2 -0.00580111
TTK TTK protein kinase -0.00579977
GPR107 G protein-coupled receptor 107 -0.00574619
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 -0.00573285
WSB1 WD repeat and SOCS box containing 1 -0.00570786
NUP153 nucleoporin 153kDa -0.00566897
LCORL ligand dependent nuclear receptor corepressor-like -0.00564208
PRPF39 pre-mRNA processing factor 39 -0.00561736
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.00560735
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.00534748
CD83 CD83 molecule -0.00528164
NPEPPS aminopeptidase puromycin sensitive -0.00527726
CEP95 centrosomal protein 95kDa -0.00523469
POSTN periostin, osteoblast specific factor -0.00521401
COG6 component of oligomeric golgi complex 6 -0.00518955
PRRC1 proline-rich coiled-coil 1 -0.00517735
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.00517635
IER3IP1 immediate early response 3 interacting protein 1 -0.00517374
ODF2 outer dense fiber of sperm tails 2 -0.00516034
EED embryonic ectoderm development -0.00513836
RAB6A RAB6A, member RAS oncogene family -0.00508676
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa -0.00508398
RAB8B RAB8B, member RAS oncogene family -0.00506763
OSER1 oxidative stress responsive serine-rich 1 -0.00504767
MORF4L1 mortality factor 4 like 1 -0.00498496
CLEC1B C-type lectin domain family 1, member B -0.00495983
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -0.00494179
FOXK2 forkhead box K2 -0.00492971
IL1A interleukin 1, alpha -0.00490965
MON2 MON2 homolog (S. cerevisiae) -0.00488188
CDA cytidine deaminase -0.00486569
KIAA2012 KIAA2012 -0.00484639
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.00479883
SCFD2 sec1 family domain containing 2 -0.00477347
MARCHF6 membrane associated ring-CH-type finger 6 -0.00473957
KDM5B lysine (K)-specific demethylase 5B -0.0047361
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.00468557
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -0.00464624
CLINT1 clathrin interactor 1 -0.00464369
ELP2 elongator acetyltransferase complex subunit 2 -0.00462274
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.00460458
TENT4A terminal nucleotidyltransferase 4A -0.00458791
PTX3 pentraxin 3, long -0.00457909
MIMS1 mitochondrial inner membrane scaffold 1 -0.00456108
INSIG1 insulin induced gene 1 -0.00454122
TP53BP2 tumor protein p53 binding protein 2 -0.00454056