TAK-901_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.40274
RPS6 ribosomal protein S6 0.177817
FTL ferritin, light polypeptide 0.170241
VIM vimentin 0.118834
MT2A metallothionein 2A 0.102445
RPS3 ribosomal protein S3 0.0992132
EEF2 eukaryotic translation elongation factor 2 0.0943528
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0892652
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0875069
TXNRD1 thioredoxin reductase 1 0.0845999
JMJD1C jumonji domain containing 1C 0.0760406
TMSB10 thymosin beta 10 0.0754309
RPL23 ribosomal protein L23 0.073245
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.070584
RPL26 ribosomal protein L26 0.0694083
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.066996
EIF1 eukaryotic translation initiation factor 1 0.0644482
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0606884
RPL12 ribosomal protein L12 0.0603105
RPS19 ribosomal protein S19 0.0596668
PTK2 protein tyrosine kinase 2 0.0590638
AHNAK AHNAK nucleoprotein 0.0574888
RPS12 ribosomal protein S12 0.055938
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0554566
ACTG1 actin gamma 1 0.0547074
RPL7 ribosomal protein L7 0.0546356
RPLP2 ribosomal protein, large, P2 0.0539874
CD44 CD44 molecule (Indian blood group) 0.0535352
RPL8 ribosomal protein L8 0.0530972
ENO1 enolase 1, (alpha) 0.0524353
TRIO trio Rho guanine nucleotide exchange factor 0.0523598
TPT1 tumor protein, translationally-controlled 1 0.0521298
SON SON DNA binding protein 0.0514645
RPS4X ribosomal protein S4, X-linked 0.0509532
RACK1 receptor for activated C kinase 1 0.0507372
WDR43 WD repeat domain 43 0.0469785
NAP1L1 nucleosome assembly protein 1-like 1 0.0468176
RPL32 ribosomal protein L32 0.0459128
AKAP12 A kinase (PRKA) anchor protein 12 0.0453251
YBX3 Y box binding protein 3 0.0452561
PKM pyruvate kinase, muscle 0.0444051
RPL36 ribosomal protein L36 0.0428099
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0421968
POTEF POTE ankyrin domain family, member F 0.0414753
RPL37A ribosomal protein L37a 0.0413087
RPS23 ribosomal protein S23 0.041072
RPS17 ribosomal protein S17 0.0406955
RUNX1 runt-related transcription factor 1 0.0403713
RPL18 ribosomal protein L18 0.0401599
YBX1 Y box binding protein 1 0.0401334
PRRC2C proline-rich coiled-coil 2C 0.0398926
RPL11 ribosomal protein L11 0.0395665
TXNIP thioredoxin interacting protein 0.0386378
MED13L mediator complex subunit 13-like 0.0384289
EIF4A1 eukaryotic translation initiation factor 4A1 0.0382607
RPL5 ribosomal protein L5 0.0382052
RBM25 RNA binding motif protein 25 0.0381606
RPL19 ribosomal protein L19 0.0380869
LOC112694756 uncharaterized LOC112694756 0.0376533
ASPH aspartate beta-hydroxylase 0.0375921
NAV3 neuron navigator 3 0.0373952
RPS8 ribosomal protein S8 0.0370942
RPL35 ribosomal protein L35 0.0369577
ALCAM activated leukocyte cell adhesion molecule 0.0369508
NACA nascent polypeptide-associated complex alpha subunit 0.0368832
FTH1 ferritin, heavy polypeptide 1 0.0368742
SRRM2 serine/arginine repetitive matrix 2 0.0364668
LDHA lactate dehydrogenase A 0.0357611
USP34 ubiquitin specific peptidase 34 0.0355639
EIF5B eukaryotic translation initiation factor 5B 0.0355447
RPLP0 ribosomal protein, large, P0 0.0349963
RPS13 ribosomal protein S13 0.0347573
GPHN gephyrin 0.0346635
EFNA5 ephrin-A5 0.0340416
SLC38A2 solute carrier family 38, member 2 0.0336155
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0332592
RPL30 ribosomal protein L30 0.0330968
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0322472
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0320683
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0320472
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0317842
RAD21 RAD21 homolog (S. pombe) 0.0316314
NOP58 NOP58 ribonucleoprotein 0.0314703
TPI1 triosephosphate isomerase 1 0.0314671
EIF4B eukaryotic translation initiation factor 4B 0.0309873
RB1CC1 RB1-inducible coiled-coil 1 0.0305821
RPLP1 ribosomal protein, large, P1 0.0303073
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0301903
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0300802
RSL1D1 ribosomal L1 domain containing 1 0.0300752
MATR3 matrin 3 0.0300115
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0299584
CHD7 chromodomain helicase DNA binding protein 7 0.0298213
KDM3A lysine (K)-specific demethylase 3A 0.029763
RASAL2 RAS protein activator like 2 0.0292261
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0289957
NIPBL Nipped-B homolog (Drosophila) 0.0287601
TMEM87A transmembrane protein 87A 0.0286471
TCF12 transcription factor 12 0.0284972
RPS27A ribosomal protein S27a 0.0280409

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0771553
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0545609
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0448893
EGR1 early growth response 1 -0.0435827
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0433494
KIAA1217 KIAA1217 -0.0382599
PBX3 pre-B-cell leukemia homeobox 3 -0.0344227
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0340756
PHACTR1 phosphatase and actin regulator 1 -0.0328725
KLF10 Kruppel-like factor 10 -0.0308127
CDH13 cadherin 13 -0.0302396
SPAG9 sperm associated antigen 9 -0.0302216
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0299015
NUP58 nucleoporin 58 -0.0293504
ENKUR enkurin, TRPC channel interacting protein -0.0286024
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.027517
SAMD3 sterile alpha motif domain containing 3 -0.0271918
MMP12 matrix metallopeptidase 12 -0.0257993
MCTP1 multiple C2 domains, transmembrane 1 -0.0257934
CALD1 caldesmon 1 -0.0253813
CD109 CD109 molecule -0.02486
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0236691
TMEM263 transmembrane protein 263 -0.0231409
DIAPH3 diaphanous-related formin 3 -0.0225784
CFAP251 cilia and flagella associated protein 251 -0.0220559
NABP1 nucleic acid binding protein 1 -0.0217172
FOSL1 FOS-like antigen 1 -0.0203692
SAMD4A sterile alpha motif domain containing 4A -0.0198754
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0197985
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0192893
MALT1 MALT1 paracaspase -0.0183321
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0182731
WSB1 WD repeat and SOCS box containing 1 -0.0182729
FN1 fibronectin 1 -0.0177491
NAV1 neuron navigator 1 -0.0172814
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0171728
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0158362
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0157379
HILPDA hypoxia inducible lipid droplet-associated -0.0157118
SOX5 SRY (sex determining region Y)-box 5 -0.0154917
AEBP2 AE binding protein 2 -0.015437
RAD51B RAD51 paralog B -0.0151516
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0148786
PDIA3 protein disulfide isomerase family A, member 3 -0.0145697
GLS2 glutaminase 2 (liver, mitochondrial) -0.014283
EXT1 exostosin glycosyltransferase 1 -0.0142409
MIDEAS mitotic deacetylase associated SANT domain protein -0.0140559
BHLHE40 basic helix-loop-helix family, member e40 -0.0139811
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0138968
CFAP20DC CFAP20 domain containing -0.0138909
RAB1A RAB1A, member RAS oncogene family -0.0137794
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0136891
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.013632
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0135926
BIRC2 baculoviral IAP repeat containing 2 -0.013474
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0134579
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0133943
KDM4C lysine (K)-specific demethylase 4C -0.0132853
ACBD3 acyl-CoA binding domain containing 3 -0.0132473
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0126938
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0126671
TENM2 teneurin transmembrane protein 2 -0.0125544
CMIP c-Maf inducing protein -0.0124567
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0123041
EGFR epidermal growth factor receptor -0.0122692
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0122642
CASC3 cancer susceptibility candidate 3 -0.012243
LRRC23 leucine rich repeat containing 23 -0.0122053
ZFC3H1 zinc finger, C3H1-type containing -0.0121931
PTPRD protein tyrosine phosphatase, receptor type, D -0.01211
MCL1 myeloid cell leukemia 1 -0.0120697
SEC31A SEC31 homolog A (S. cerevisiae) -0.012016
NBEAL1 neurobeachin-like 1 -0.0119494
C2CD2 C2 calcium-dependent domain containing 2 -0.0119149
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0116355
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0116219
EXOC4 exocyst complex component 4 -0.0115464
BIRC3 baculoviral IAP repeat containing 3 -0.0114441
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0113051
GOLT1B golgi transport 1B -0.0112845
TRA2A transformer 2 alpha homolog (Drosophila) -0.0110779
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.010976
MOK MOK protein kinase -0.010966
MAML3 mastermind-like 3 (Drosophila) -0.0109512
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0109072
FAM168A family with sequence similarity 168, member A -0.0108474
ANTXR2 anthrax toxin receptor 2 -0.0108291
ZNF804A zinc finger protein 804A -0.0107908
DTNA dystrobrevin, alpha -0.0107439
SRP54 signal recognition particle 54kDa -0.010626
CD226 CD226 molecule -0.0105259
PRELID2 PRELI domain containing 2 -0.0104453
IL1A interleukin 1, alpha -0.0104071
PREPL prolyl endopeptidase-like -0.0103861
ADAM9 ADAM metallopeptidase domain 9 -0.0103448
TFG TRK-fused gene -0.010343
DMTF1 cyclin D binding myb-like transcription factor 1 -0.0102608
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0100428
INSIG2 insulin induced gene 2 -0.0100267
C6ORF62 chromosome 6 open reading frame 62 -0.0100237