TAK-901_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.224817
RPS12 ribosomal protein S12 0.168777
TPT1 tumor protein, translationally-controlled 1 0.163904
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.132217
EEF2 eukaryotic translation elongation factor 2 0.132009
EPS8 epidermal growth factor receptor pathway substrate 8 0.122688
RPS3 ribosomal protein S3 0.118974
RPS23 ribosomal protein S23 0.101689
RPL26 ribosomal protein L26 0.100147
RPL37A ribosomal protein L37a 0.0903295
RPS17 ribosomal protein S17 0.0878267
SRRM2 serine/arginine repetitive matrix 2 0.0823847
ZSWIM6 zinc finger, SWIM-type containing 6 0.0783293
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0747886
RACK1 receptor for activated C kinase 1 0.0717967
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0717251
CTBP2 C-terminal binding protein 2 0.0714294
RBM25 RNA binding motif protein 25 0.0705399
RPS8 ribosomal protein S8 0.0703058
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0702721
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0691143
RPS19 ribosomal protein S19 0.0688491
RPL36 ribosomal protein L36 0.0674863
RPLP2 ribosomal protein, large, P2 0.0634089
FTH1 ferritin, heavy polypeptide 1 0.0608288
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0581022
RPLP1 ribosomal protein, large, P1 0.0576192
INTS6 integrator complex subunit 6 0.0562831
RPS13 ribosomal protein S13 0.05618
RPL11 ribosomal protein L11 0.0557979
LMO7 LIM domain 7 0.0556691
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0549279
RPL37 ribosomal protein L37 0.0537665
RPS14 ribosomal protein S14 0.0530206
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.052098
RPL9 ribosomal protein L9 0.0505699
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0505043
FAT1 FAT atypical cadherin 1 0.050205
ENO1 enolase 1, (alpha) 0.050124
RPL31 ribosomal protein L31 0.0498486
SFPQ splicing factor proline/glutamine-rich 0.0474451
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.046436
DIAPH1 diaphanous-related formin 1 0.046391
CEMIP2 cell migration inducing hyaluronidase 2 0.0462979
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0459289
HSPA8 heat shock 70kDa protein 8 0.0445134
RPL35A ribosomal protein L35a 0.0444644
RPS29 ribosomal protein S29 0.0442078
RPS5 ribosomal protein S5 0.0440894
PDE4D phosphodiesterase 4D, cAMP-specific 0.0439165
RPS18 ribosomal protein S18 0.0425744
LRRC23 leucine rich repeat containing 23 0.041969
BRD2 bromodomain containing 2 0.0418396
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0412684
RPS27A ribosomal protein S27a 0.0408
PRRC2C proline-rich coiled-coil 2C 0.0405116
TASOR2 transcription activation suppressor family member 2 0.0401525
CFAP161 cilia and flagella associated protein 161 0.0399688
TPI1 triosephosphate isomerase 1 0.0390197
RPL23 ribosomal protein L23 0.0388185
RPL19 ribosomal protein L19 0.0373914
FUS FUS RNA binding protein 0.0368004
RPLP0 ribosomal protein, large, P0 0.0366852
SP100 SP100 nuclear antigen 0.0365966
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.036592
ESYT2 extended synaptotagmin-like protein 2 0.0362394
ASPH aspartate beta-hydroxylase 0.0358906
CEMIP cell migration inducing protein, hyaluronan binding 0.0355521
RPL28 ribosomal protein L28 0.0355148
VEGFA vascular endothelial growth factor A 0.0351229
PKM pyruvate kinase, muscle 0.0343026
BIRC6 baculoviral IAP repeat containing 6 0.0342398
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0341128
EEF1G eukaryotic translation elongation factor 1 gamma 0.034082
BZW2 basic leucine zipper and W2 domains 2 0.034053
RPS11 ribosomal protein S11 0.0340405
EIF4B eukaryotic translation initiation factor 4B 0.0340161
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0339903
TCF12 transcription factor 12 0.0333578
MYH9 myosin, heavy chain 9, non-muscle 0.0333494
MATR3 matrin 3 0.0333492
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0329247
RPL3 ribosomal protein L3 0.0327214
RPL8 ribosomal protein L8 0.0325862
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0324911
RPL7 ribosomal protein L7 0.0323052
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0322381
NACA nascent polypeptide-associated complex alpha subunit 0.0321253
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0317723
SLC38A2 solute carrier family 38, member 2 0.0316416
LDHA lactate dehydrogenase A 0.0313423
RPL32 ribosomal protein L32 0.0304579
PNN pinin, desmosome associated protein 0.030331
RCC1 regulator of chromosome condensation 1 0.0302935
RPL30 ribosomal protein L30 0.030204
RSRC2 arginine/serine-rich coiled-coil 2 0.0298155
SPON1 spondin 1, extracellular matrix protein 0.0297065
RPS4X ribosomal protein S4, X-linked 0.029561
DST dystonin 0.0293237
SAMD5 sterile alpha motif domain containing 5 0.0292632

decreased expression

Symbol Name Standardized Value
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.142829
THSD4 thrombospondin, type I, domain containing 4 -0.114428
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.106189
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0965558
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0865536
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0761548
FLNB filamin B, beta -0.0757977
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0617336
P3H2 prolyl 3-hydroxylase 2 -0.0550654
PLAC8 placenta-specific 8 -0.0496128
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0488511
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0479406
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0413091
VCL vinculin -0.0380186
F3 coagulation factor III (thromboplastin, tissue factor) -0.037407
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.03706
CALB1 calbindin 1, 28kDa -0.0346501
ACTG1 actin gamma 1 -0.0340384
MKI67 marker of proliferation Ki-67 -0.0338397
WWC1 WW and C2 domain containing 1 -0.0338018
ACTN4 actinin, alpha 4 -0.032947
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0323494
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0319212
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.031885
SHROOM3 shroom family member 3 -0.0315249
FOXO1 forkhead box O1 -0.030881
NPSR1 neuropeptide S receptor 1 -0.0306091
CALU calumenin -0.0303144
PKP2 plakophilin 2 -0.030183
MON2 MON2 homolog (S. cerevisiae) -0.0299884
MAML2 mastermind-like 2 (Drosophila) -0.0298849
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0292934
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 -0.0282694
HLA-E major histocompatibility complex, class I, E -0.0279514
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0274613
CCPG1 cell cycle progression 1 -0.0265484
HDLBP high density lipoprotein binding protein -0.0265219
SEPTIN10 septin 10 -0.0264307
IER3 immediate early response 3 -0.026325
BHLHE40 basic helix-loop-helix family, member e40 -0.0261742
GARS1 glycyl-tRNA synthetase 1 -0.025776
S100A6 S100 calcium binding protein A6 -0.0256252
TTC3 tetratricopeptide repeat domain 3 -0.0254681
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0254534
GDF15 growth differentiation factor 15 -0.0250643
PRSS3 protease, serine, 3 -0.0250141
FHL2 four and a half LIM domains 2 -0.0249142
AGR2 anterior gradient 2 -0.024837
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0246141
CXADR coxsackie virus and adenovirus receptor -0.0245958
DSG2 desmoglein 2 -0.0245082
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0244616
RAD51B RAD51 paralog B -0.0243053
SOD2 superoxide dismutase 2, mitochondrial -0.0241785
ABHD17C abhydrolase domain containing 17C -0.0241362
MYOF myoferlin -0.0240751
ARHGAP29 Rho GTPase activating protein 29 -0.0238989
CDC42SE2 CDC42 small effector 2 -0.0238052
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0236504
TMEM263 transmembrane protein 263 -0.0234907
PTPRR protein tyrosine phosphatase, receptor type, R -0.0233403
SERINC5 serine incorporator 5 -0.0232398
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0229187
FERMT1 fermitin family member 1 -0.0228245
SMC4 structural maintenance of chromosomes 4 -0.0227528
ARHGAP42 Rho GTPase activating protein 42 -0.0224607
PALLD palladin, cytoskeletal associated protein -0.022388
GLG1 golgi glycoprotein 1 -0.0222887
TPM4 tropomyosin 4 -0.0222103
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0220347
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0214585
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0214382
CLIP2 CAP-GLY domain containing linker protein 2 -0.0211039
FOSL1 FOS-like antigen 1 -0.0210517
RAB1A RAB1A, member RAS oncogene family -0.0210384
FAM114A1 family with sequence similarity 114, member A1 -0.0207885
PERP PERP, TP53 apoptosis effector -0.0207672
KLF3 Kruppel-like factor 3 (basic) -0.0206439
GOLGA4 golgin A4 -0.020549
TRIM2 tripartite motif containing 2 -0.0205392
NCOA7 nuclear receptor coactivator 7 -0.0204186
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0203315
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0202888
ANLN anillin, actin binding protein -0.0200171
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0198618
JMY junction mediating and regulatory protein, p53 cofactor -0.0198077
CCNG1 cyclin G1 -0.0197204
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0195497
EREG epiregulin -0.0192046
RRBP1 ribosome binding protein 1 -0.0192028
PLPP3 phospholipid phosphatase 3 -0.0190344
DIAPH3 diaphanous-related formin 3 -0.0190329
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.018916
NPC1 Niemann-Pick disease, type C1 -0.018911
GOLT1B golgi transport 1B -0.0187747
ARRDC3 arrestin domain containing 3 -0.018713
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0185887
DUSP16 dual specificity phosphatase 16 -0.0184898
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0182774
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0182634