TAK-901_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.14708
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.109776
FTH1 ferritin, heavy polypeptide 1 0.108011
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0786911
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0780709
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0754763
MT2A metallothionein 2A 0.0754036
RPL26 ribosomal protein L26 0.070323
ERRFI1 ERBB receptor feedback inhibitor 1 0.0702656
EEF2 eukaryotic translation elongation factor 2 0.06938
TXNRD1 thioredoxin reductase 1 0.0588779
AHNAK AHNAK nucleoprotein 0.0568283
MACF1 microtubule-actin crosslinking factor 1 0.0544634
FMNL2 formin-like 2 0.0533038
WWTR1 WW domain containing transcription regulator 1 0.0529489
RPS3 ribosomal protein S3 0.0523265
CAPRIN2 caprin family member 2 0.0510441
RPS6 ribosomal protein S6 0.0487016
APP amyloid beta (A4) precursor protein 0.0486143
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0468879
RPS8 ribosomal protein S8 0.0465284
RACK1 receptor for activated C kinase 1 0.0450946
RPS12 ribosomal protein S12 0.044114
EZR ezrin 0.0433602
CANX calnexin 0.0432911
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0423772
SPAG9 sperm associated antigen 9 0.0418207
SRRM2 serine/arginine repetitive matrix 2 0.0409381
FTL ferritin, light polypeptide 0.0398541
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0391858
TM4SF1 transmembrane 4 L six family member 1 0.0372974
GARS1 glycyl-tRNA synthetase 1 0.035444
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0349061
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.034771
RPL37A ribosomal protein L37a 0.0346895
ENO1 enolase 1, (alpha) 0.0345267
HSPA8 heat shock 70kDa protein 8 0.0344699
TPT1 tumor protein, translationally-controlled 1 0.0327046
EMP1 epithelial membrane protein 1 0.0326672
EREG epiregulin 0.0321534
KTN1 kinectin 1 (kinesin receptor) 0.0319899
DST dystonin 0.031128
RPL5 ribosomal protein L5 0.031113
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0306452
PSD3 pleckstrin and Sec7 domain containing 3 0.0302376
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0296023
RPS18 ribosomal protein S18 0.0295127
MYH9 myosin, heavy chain 9, non-muscle 0.0292392
LOC112694756 uncharaterized LOC112694756 0.0292077
ZBTB38 zinc finger and BTB domain containing 38 0.0290486
JMJD1C jumonji domain containing 1C 0.0288093
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0286173
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0285188
ZEB1 zinc finger E-box binding homeobox 1 0.0283128
HDLBP high density lipoprotein binding protein 0.0283044
RPS29 ribosomal protein S29 0.0277499
RPS23 ribosomal protein S23 0.0276471
EIF1 eukaryotic translation initiation factor 1 0.0271033
GOLGB1 golgin B1 0.0266343
RPL36 ribosomal protein L36 0.0265654
MYOF myoferlin 0.026143
HOMER1 homer scaffolding protein 1 0.0261098
NAP1L1 nucleosome assembly protein 1-like 1 0.0261092
KDM3A lysine (K)-specific demethylase 3A 0.025928
PRRC2C proline-rich coiled-coil 2C 0.0258296
PDIA6 protein disulfide isomerase family A, member 6 0.0258185
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0257693
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.02553
ANXA2 annexin A2 0.0253867
CALR calreticulin 0.0253287
RPL18 ribosomal protein L18 0.0251758
RPL7A ribosomal protein L7a 0.0250778
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.024793
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.02468
BZW1 basic leucine zipper and W2 domains 1 0.0246555
CFLAR CASP8 and FADD-like apoptosis regulator 0.0245348
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.02452
AREG amphiregulin 0.0242101
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0242021
LOXL2 lysyl oxidase-like 2 0.0241611
DSCAM Down syndrome cell adhesion molecule 0.0240321
HDAC9 histone deacetylase 9 0.0239764
TSC22D2 TSC22 domain family, member 2 0.0234999
BRD2 bromodomain containing 2 0.0231548
ANGPTL4 angiopoietin-like 4 0.0229723
RPL12 ribosomal protein L12 0.0227872
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0227218
BCAR3 breast cancer anti-estrogen resistance 3 0.0226127
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0225989
ZSWIM6 zinc finger, SWIM-type containing 6 0.0224447
TRIP12 thyroid hormone receptor interactor 12 0.0223687
RPS27A ribosomal protein S27a 0.0223548
KRT18 keratin 18, type I 0.0223167
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0222599
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0220892
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0220783
RPS17 ribosomal protein S17 0.0220283
PODXL podocalyxin-like 0.0219684
YBX1 Y box binding protein 1 0.0218464
SQSTM1 sequestosome 1 0.0217932

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0890035
HLA-B major histocompatibility complex, class I, B -0.0803387
TP63 tumor protein p63 -0.074107
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0723395
POTEF POTE ankyrin domain family, member F -0.0646966
CADM2 cell adhesion molecule 2 -0.0615478
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0597665
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0581598
PTMA prothymosin, alpha -0.0574497
TMSB10 thymosin beta 10 -0.0559908
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0501152
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0463249
EGR1 early growth response 1 -0.0449766
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0439957
HLA-A major histocompatibility complex, class I, A -0.0429344
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0418671
RIGI RNA sensor RIG-I -0.0378018
RAB27B RAB27B, member RAS oncogene family -0.0361842
TTC28 tetratricopeptide repeat domain 28 -0.0347213
DPYD dihydropyrimidine dehydrogenase -0.0343323
HMGA1 high mobility group AT-hook 1 -0.0317713
WARS1 tryptophanyl-tRNA synthetase 1 -0.0304792
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0297779
TAPBP TAP binding protein (tapasin) -0.029196
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.028842
RAD51B RAD51 paralog B -0.0287229
PLSCR1 phospholipid scramblase 1 -0.0279503
TNS3 tensin 3 -0.0267062
SDK1 sidekick cell adhesion molecule 1 -0.0261146
ANKRD12 ankyrin repeat domain 12 -0.0257263
CENPF centromere protein F, 350/400kDa -0.024729
DPH6 diphthamine biosynthesis 6 -0.0244911
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.024304
IFI6 interferon, alpha-inducible protein 6 -0.0235478
DIAPH3 diaphanous-related formin 3 -0.023086
FOSL1 FOS-like antigen 1 -0.0228018
ADAM10 ADAM metallopeptidase domain 10 -0.022272
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0222196
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0214412
DLG1 discs, large homolog 1 (Drosophila) -0.0205852
RNF213 ring finger protein 213 -0.0203976
EXOC4 exocyst complex component 4 -0.02034
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0203313
TPRG1 tumor protein p63 regulated 1 -0.0203023
ZMYND8 zinc finger, MYND-type containing 8 -0.0202365
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0201904
GNAS GNAS complex locus -0.0199308
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.019195
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0191528
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0185671
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0185369
HLA-E major histocompatibility complex, class I, E -0.0184999
PFN1 profilin 1 -0.0184529
ISG15 ISG15 ubiquitin-like modifier -0.0183914
SMIM44 small integral membrane protein 44 -0.0181984
VIM vimentin -0.0180836
ZMIZ2 zinc finger, MIZ-type containing 2 -0.0180671
RFC3 replication factor C (activator 1) 3, 38kDa -0.0175688
DEK DEK proto-oncogene -0.0173066
CUX1 cut-like homeobox 1 -0.0172172
TUBA1B tubulin, alpha 1b -0.0172128
EPHA4 EPH receptor A4 -0.0171926
ARL4C ADP-ribosylation factor-like 4C -0.0171702
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0171256
NPAS2 neuronal PAS domain protein 2 -0.0169318
LY6E lymphocyte antigen 6 complex, locus E -0.0168722
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0166365
RPS21 ribosomal protein S21 -0.0164154
FOXN3 forkhead box N3 -0.0161033
IFIH1 interferon induced with helicase C domain 1 -0.0160844
HMGB1 high mobility group box 1 -0.0159575
PRRC2B proline-rich coiled-coil 2B -0.0159255
CALD1 caldesmon 1 -0.0157791
COL5A2 collagen, type V, alpha 2 -0.0157257
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0154037
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0153846
PATJ PATJ crumbs cell polarity complex component -0.015254
FERMT1 fermitin family member 1 -0.0152475
RPL39 ribosomal protein L39 -0.0151941
TUBB tubulin, beta class I -0.0151771
PIAS2 protein inhibitor of activated STAT, 2 -0.0151537
EFNA5 ephrin-A5 -0.0150043
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0147629
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0146185
PTK2 protein tyrosine kinase 2 -0.0144883
EGFR epidermal growth factor receptor -0.0144758
CTSD cathepsin D -0.0144228
GATAD2B GATA zinc finger domain containing 2B -0.0143497
CSMD3 CUB and Sushi multiple domains 3 -0.0142672
IFITM1 interferon induced transmembrane protein 1 -0.0141624
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0141444
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0140187
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0140157
CTSC cathepsin C -0.0139792
TAS2R14 taste receptor, type 2, member 14 -0.0138151
PMP22 peripheral myelin protein 22 -0.0137842
SAMHD1 SAM domain and HD domain 1 -0.0137173
EHBP1 EH domain binding protein 1 -0.0137168
TPM4 tropomyosin 4 -0.0135736
PABPN1 poly(A) binding protein, nuclear 1 -0.013564