TAK-901_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description TAK-901 perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the TAK-901_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.276452
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.139433
FTH1 ferritin, heavy polypeptide 1 0.097681
SLTM SAFB-like, transcription modulator 0.0953599
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0916778
TXNRD1 thioredoxin reductase 1 0.0769893
RPS3 ribosomal protein S3 0.0718495
ASPH aspartate beta-hydroxylase 0.0667638
GRAMD1B GRAM domain containing 1B 0.0613754
MT2A metallothionein 2A 0.0594377
ENO1 enolase 1, (alpha) 0.0566082
CXCL8 chemokine (C-X-C motif) ligand 8 0.0517007
TBC1D22A TBC1 domain family, member 22A 0.0506252
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0477625
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0472033
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.046661
RPL37A ribosomal protein L37a 0.0461406
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.045191
RPS6 ribosomal protein S6 0.0447842
TPT1 tumor protein, translationally-controlled 1 0.0423607
ERRFI1 ERBB receptor feedback inhibitor 1 0.0420575
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0413284
DOCK5 dedicator of cytokinesis 5 0.0387876
SRRM2 serine/arginine repetitive matrix 2 0.0382278
DSCAM Down syndrome cell adhesion molecule 0.0373047
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0367632
THSD4 thrombospondin, type I, domain containing 4 0.0367078
RPS12 ribosomal protein S12 0.0362963
INTS6 integrator complex subunit 6 0.036194
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0360063
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0352093
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0341316
SAMD4A sterile alpha motif domain containing 4A 0.0336881
GCLC glutamate-cysteine ligase, catalytic subunit 0.0334021
ANKRD12 ankyrin repeat domain 12 0.0333737
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0332968
HSPA8 heat shock 70kDa protein 8 0.0332798
SMAD3 SMAD family member 3 0.0328633
MCL1 myeloid cell leukemia 1 0.0327872
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0324621
TOP1 topoisomerase (DNA) I 0.0321056
SMYD3 SET and MYND domain containing 3 0.0319416
ANXA2 annexin A2 0.0315862
MYOF myoferlin 0.0311778
RPS8 ribosomal protein S8 0.0309326
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0301002
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0297573
LMO7 LIM domain 7 0.0296415
RPS17 ribosomal protein S17 0.0292981
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0288692
PRRC2C proline-rich coiled-coil 2C 0.0286825
RPL35A ribosomal protein L35a 0.0285181
B2M beta-2-microglobulin 0.0284502
RPL11 ribosomal protein L11 0.0282071
EXT1 exostosin glycosyltransferase 1 0.0282004
ELL2 elongation factor, RNA polymerase II, 2 0.0279504
UGDH UDP-glucose 6-dehydrogenase 0.0278791
MCTP1 multiple C2 domains, transmembrane 1 0.0276587
GOLGB1 golgin B1 0.0275474
BCAR3 breast cancer anti-estrogen resistance 3 0.0274094
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0272763
S100A10 S100 calcium binding protein A10 0.0264735
AKAP13 A kinase (PRKA) anchor protein 13 0.0263413
RPL31 ribosomal protein L31 0.0262347
PABPC1 poly(A) binding protein, cytoplasmic 1 0.026215
AREG amphiregulin 0.0258767
PKM pyruvate kinase, muscle 0.0253016
KRT18 keratin 18, type I 0.0251876
IRS2 insulin receptor substrate 2 0.0250319
ANKRD11 ankyrin repeat domain 11 0.0248967
RPL7 ribosomal protein L7 0.0248382
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0247837
RPS23 ribosomal protein S23 0.0247289
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0242811
MYH9 myosin, heavy chain 9, non-muscle 0.0236451
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0235428
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0231624
PDE4D phosphodiesterase 4D, cAMP-specific 0.0231033
RPS27A ribosomal protein S27a 0.0225397
TRIO trio Rho guanine nucleotide exchange factor 0.0223143
GPHN gephyrin 0.022252
MAP7 microtubule-associated protein 7 0.0222378
CUL4A cullin 4A 0.0219088
NPAS2 neuronal PAS domain protein 2 0.0219014
HOMER1 homer scaffolding protein 1 0.0218248
ZSWIM6 zinc finger, SWIM-type containing 6 0.0217742
RPL37 ribosomal protein L37 0.0215853
RPLP1 ribosomal protein, large, P1 0.0215749
SLC38A2 solute carrier family 38, member 2 0.0214541
STC1 stanniocalcin 1 0.0214306
RPS29 ribosomal protein S29 0.0213442
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0213421
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0210657
SON SON DNA binding protein 0.0209025
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0206233
RPL26 ribosomal protein L26 0.0206115
BPTF bromodomain PHD finger transcription factor 0.0204971
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0204236
PTPRM protein tyrosine phosphatase, receptor type, M 0.0204011
EFNA5 ephrin-A5 0.0203988

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.161277
H1-0 H1.0 linker histone -0.0349556
TMEM165 transmembrane protein 165 -0.0270617
NAMPT nicotinamide phosphoribosyltransferase -0.0243349
NDRG1 N-myc downstream regulated 1 -0.0216348
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0206138
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0197486
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0193087
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0181101
ZMYND8 zinc finger, MYND-type containing 8 -0.0180077
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0157891
ZMYM2 zinc finger, MYM-type 2 -0.0157289
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0149856
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0142759
RAB27B RAB27B, member RAS oncogene family -0.013774
WDR45B WD repeat domain 45B -0.0136248
KCMF1 potassium channel modulatory factor 1 -0.0133858
FAM13A family with sequence similarity 13, member A -0.0133062
TPD52 tumor protein D52 -0.0129909
NGLY1 N-glycanase 1 -0.0128984
BRWD3 bromodomain and WD repeat domain containing 3 -0.0124895
SREBF2 sterol regulatory element binding transcription factor 2 -0.0118497
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0118245
MXI1 MAX interactor 1, dimerization protein -0.0117305
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0114723
USP3 ubiquitin specific peptidase 3 -0.0113558
ARRDC3 arrestin domain containing 3 -0.0113237
HILPDA hypoxia inducible lipid droplet-associated -0.0112227
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0111469
EGR1 early growth response 1 -0.0111028
RIN2 Ras and Rab interactor 2 -0.0110143
HELZ helicase with zinc finger -0.0109351
SOD2 superoxide dismutase 2, mitochondrial -0.0108185
PDE8A phosphodiesterase 8A -0.00976031
IGFBP5 insulin-like growth factor binding protein 5 -0.00968104
SRP54 signal recognition particle 54kDa -0.00964077
BRWD1 bromodomain and WD repeat domain containing 1 -0.00947224
MARF1 meiosis regulator and mRNA stability factor 1 -0.00934221
ADAM17 ADAM metallopeptidase domain 17 -0.0092541
CCNL1 cyclin L1 -0.0091095
LRP1B low density lipoprotein receptor-related protein 1B -0.00907637
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.00905634
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.00884158
WASF2 WAS protein family, member 2 -0.00876538
LAMA4 laminin, alpha 4 -0.00838645
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.00833805
MSMO1 methylsterol monooxygenase 1 -0.00831917
PERP PERP, TP53 apoptosis effector -0.00830228
ARL5B ADP-ribosylation factor-like 5B -0.00826246
SEC24A SEC24 family member A -0.00790955
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.00779413
KDM5B lysine (K)-specific demethylase 5B -0.00777537
CAMTA1 calmodulin binding transcription activator 1 -0.00772834
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.00770616
ANKRD37 ankyrin repeat domain 37 -0.0073858
OSMR oncostatin M receptor -0.00723822
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0071046
SUCO SUN domain containing ossification factor -0.00699684
CYLD cylindromatosis (turban tumor syndrome) -0.00697864
PNRC1 proline-rich nuclear receptor coactivator 1 -0.00692809
OGA O-GlcNAcase -0.00689887
KMT2E lysine (K)-specific methyltransferase 2E -0.00688816
MGAT4C MGAT4 family, member C -0.00688548
NDFIP1 Nedd4 family interacting protein 1 -0.00684575
PHF21A PHD finger protein 21A -0.00674173
RAB6A RAB6A, member RAS oncogene family -0.00671303
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.00662665
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.00660533
TENT5A terminal nucleotidyltransferase 5A -0.00651149
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.00649644
NDE1 nudE neurodevelopment protein 1 -0.00649326
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.00647972
RNF24 ring finger protein 24 -0.00647743
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.00646786
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.00644877
SIPA1L2 signal-induced proliferation-associated 1 like 2 -0.00637797
NCOA7 nuclear receptor coactivator 7 -0.00634255
RAB1A RAB1A, member RAS oncogene family -0.00632582
MT1X metallothionein 1X -0.00626914
UVRAG UV radiation resistance associated -0.00626421
ZFC3H1 zinc finger, C3H1-type containing -0.00625202
HBP1 HMG-box transcription factor 1 -0.00605806
FRMD4B FERM domain containing 4B -0.00604881
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.00582725
ARL8B ADP-ribosylation factor-like 8B -0.00581564
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.00578062
DCAF6 DDB1 and CUL4 associated factor 6 -0.00572082
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.00570974
KDM3A lysine (K)-specific demethylase 3A -0.00570372
NUP58 nucleoporin 58 -0.00561317
INSIG2 insulin induced gene 2 -0.00545558
NEK7 NIMA-related kinase 7 -0.00537635
FBXL5 F-box and leucine-rich repeat protein 5 -0.00536963
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.00536539
STRN3 striatin, calmodulin binding protein 3 -0.00532248
NCOA2 nuclear receptor coactivator 2 -0.00530862
ESRP1 epithelial splicing regulatory protein 1 -0.0052893
CES1 carboxylesterase 1 -0.00526163
HOOK2 hook microtubule-tethering protein 2 -0.0052536
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.00522807